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ALX-380-297 Revised 07-Aug-08 New product
Ofloxacin
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SYNONYMS 9-Fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazin-6-carboxylic acid
DL 8280
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-297-G005   5 g 45.00 USD Add To Cart
Product Specification
FORMULA: C18H20FN3O4
MW: 361.4
CAS NUMBER: 82419-36-1
MERCK INDEX: 14: 6771
RTECS: UU8815500
PURITY: ≥98% (Assay)
APPEARANCE: White to yellow crystalline solid.
SOLUBILITY: Slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Fluoroquinolone with broad-spectrum antibacterial activity against most Gram-negative and Gram-positive bacteria. Effective against Mycobacterium tuberculosis.
Product Specific Literature References
In vitro and in vivo activity of DL-8280, a new oxazine derivative: K. Sato, et al.; Antimicrob. Agents Chemother. 22, 548 (1982) Abstract; Full Text
Comparison of the antibacterial in vitro and in vivo activity of ofloxacin (HOE 280 DL 8280) and nalidixic acid analogues: G. Seibert, et al.; Eur. J. Clin. Microbiol. 2, 548 (1983) Abstract
A new synthesis of 7H-pyrido[1,2,3-de][1,4]benzoxazine derivatives including an antibacterial agent, ofloxacin: H. Egawa, et al.; Chem. Pharm. Bull. 34, 4098 (1986) Abstract
Synthesis and antibacterial activities of optically active ofloxacin and its fluoromethyl derivative: S. Atarashi, et al.; Chem. Pharm. Bull. 35, 1896 (1987) Abstract
Ofloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use: J.P. Monk & D.M. Campoli-Richards; Drugs 33, 346 (1987) Abstract
Mechanism of differential activities of ofloxacin enantiomers: I. Morrissey, et al.; Antimicrob. Agents Chemother. 40, 1775 (1996) Abstract; Full Text
Mechanism of fluoroquinolone action: K. Drlica; Curr. Opin. Microbiol. 2, 504 (1999) Abstract
Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors: C. Fernandez-Tornero, et al.; J. Biol. Chem. 280, 19948 (2005) Abstract; Full Text
Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing: R. Shi, et al.; J. Clin. Microbiol. 44, 4566 (2006) Abstract; Full Text
Moxifloxacin, ofloxacin, sparfloxacin, and ciprofloxacin against Mycobacterium tuberculosis: evaluation of in vitro and pharmacodynamic indices that best predict in vivo efficacy: R.K. Shandil, et al.; Antimicrob. Agents Chemother. 51, 576 (2007) Abstract; Full Text
 
 

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