ALEXIS Biochemicals: Oligomycin

ALX-380-037

Revised 20-Jun-08

Oligomycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Apoptosis Inducers & Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-037-M005		5 mg	50.00 USD
ALX-380-037-M010		10 mg	95.00 USD

Product Specification

MW:	789.3
CAS NUMBER:	1404-19-9
MERCK INDEX:	14: 6833
RTECS:	RK3325000
SOURCE/HOST:	Isolated from Streptomyces diastatochromogens.
PURITY:	≥90% (mixture of oligomycin A, B, and C (~65% oligomycin A))
APPEARANCE:	White to faint yellow powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol (10mg/ml) or acetone (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL. MAY BE MUTAGENIC.

Product Description

Macrolide antibiotic that inhibits membrane bound mitochondrial ATPase (F₁), preventing phosphoryl group transfer. Induces apoptosis.

Product Specific Literature References

Inhibition of the Na(+)-Ca++ exchanger enhances anoxia and glucopenia- induced [3H]aspartate release in hippocampal slices: S. Amoroso, et al.; J. Pharmacol. Exp. Ther. 264, 515 (1993) Abstract
Cyclosporin A suppression of uncoupling in liver mitochondria of ground squirrel during arousal from hibernation: N.N. Brustovetsky, et al.; FEBS Lett. 315, 233 (1993) Abstract
The lipophilic weak base (Z)-5-methyl-2-[2-(1-naphthyl)ethenyl]-4- piperidinopyridine (AU-1421) is a potent protonophore type cationic uncoupler of oxidative phosphorylation in mitochondria: H. Nagamune, et al.; Biochim. Biophys. Acta 1141, 231 (1993) Abstract
Mitochondrial respiratory chain inhibitors induce apoptosis: E.J. Wolvetang, et al.; FEBS Lett. 339, 40 (1994) Abstract
Dissociation of phagocyte recognition of cells undergoing apoptosis from other features of the apoptotic program: J. Zhuang, et al.; J. Biol. Chem. 273, 15628 (1998) Abstract; Full Text
Apoptosis in factor-dependent haematopoietic cells is linked to calcium- sensitive mitochondrial rearrangements and cytoskeletal modulation: J. Garland, et al.; Br. J. Haematol. 109, 221 (2000) Abstract
Properties of DNA fragmentation activity generated by ATP depletion: N. Nakamura & Y. Wada; Cell Death Differ. 7, 477 (2000) Abstract

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