ALEXIS Biochemicals: Olomoucine II

ALX-270-396

Revised 07-Mar-08

Olomoucine II
SYNONYMS	6-(2-Hydroxybenzylamino)-2(R)-[[1-hydroxymethyl)propyl]amino]-9-isopropylpurine
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-396-M001		1 mg	42.00 USD
ALX-270-396-M005		5 mg	145.00 USD

Product Specification

FORMULA:	C₁₉H₂₆N₆O₂
MW:	370.5
CAS NUMBER:	500735-47-7
PURITY:	≥98%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Selective inhibitor of CDK1/cyclin B (IC₅₀=20nM). Potent cytotoxin in tumor cells: IC₅₀=5.3µM against MCF7 cells, IC₅₀=11.1µM against K562 cells, IC₅₀=3.0µM against CEM cells, IC₅₀=6.3µM against HOS cells, and IC₅₀=6.3µM against G361 cells.

Product Specific Literature References

Synthesis and biological activity of olomoucine II: V. Krystof, et al.; Bioorg. Med. Chem. Lett. 12, 3283 (2002) Abstract
Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor: V. Krystof, et al.; Cell Mol. Life Sci. 62, 1763 (2005) Abstract

Further Categories Containing This Product:

Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers)

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.