ALEXIS Biochemicals: Olomoucine (high purity)

ALX-350-013

Revised 23-Oct-07

Olomoucine (high purity)
SYNONYMS	6-Benzylamino-2-(2-hydroxyethylamino)-9-methylpurine
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-013-M005		5 mg	65.00 USD
ALX-350-013-M025		25 mg	260.00 USD

Product Specification

FORMULA:	C₁₅H₁₈N₆O
MW:	298.4
CAS NUMBER:	101622-51-9
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in methanol or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent and very selective inhibitor of cdc2, CDK and other cyclin-related kinases by competing for the ATP-binding domain of the kinase. Inhibits CDK1/cyclin B (IC50=7µM), CDK2 (IC50=7µM) and CDK5/p35 (IC50=3µM). Also inhibits DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons.

Product Specific Literature References

Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases: R.T. Abraham, et al.; Biol. Cell 83, 105 (1995) Abstract
Mitotic disassembly of the Golgi apparatus in vivo: T. Mistelli & G. Warren; J. Cell Sci. 108, 2715 (1995) Abstract
Chemical inhibitors of cyclin-dependent kinases: L. Meijer, et al.; Meth. Enzymol. 283, 113 (1997) Abstract
Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds: L. Havlicek, et al.; J. Med. Chem. 40, 408 (1997) Abstract
The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity: F. Alessi, et al.; Exp. Cell Res. 245, 8 (1998) Abstract
Roscovitine, olomoucine, purvalanol: inducers of apoptosis in maturing cerebellar granule neurons: E.A. Monaco, 3rd, et al.; Biochem. Pharmacol. 67, 1947 (2004) Abstract

Further Categories Containing This Product:

Cell Cycle Blockers & Inhibitors/Related Products • Antitumor Agents (Apoptosis Inducers)

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