ALEXIS Biochemicals: Omentin 1 (human) (recombinant)

ALX-522-108

Revised 27-Mar-08

Omentin 1 (human) (recombinant)
SYNONYMS	Intelectin-1 (human) (recombinant) Intestinal Lactoferrin Receptor (human) (recombinant) Galactofuranose-binding Lectin (human) (recombinant) Endothelial Lectin HL-1 (human) (recombinant)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Omentin / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-108-C010		10 µg	300.00 USD

Product Specification

MW:	~30-40kDa
SOURCE/HOST:	Produced in HEK 293 cells. Human omentin 1 (intelectin-1) (aa 17-313) is fused at the N-terminus to a FLAG^®-tag.
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
BIOLOGICAL ACTIVITY:	Enhances insulin-mediated glucose transport in 3T3-L1 adipocytes.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

General Information

Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been recently identified as a novel visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q8WWA0: Intelectin-1 (human) [Precursor] FLAG is a registered trademark of Sigma-Aldrich Co.
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

Human homologs of the Xenopus oocyte cortical granule lectin XL35: J.K. Lee, et al.; Glycobiology 11, 65 (2001) Abstract; Full Text
Molecular cloning and functional expression of a human intestinal lactoferrin receptor: Y.A. Suzuki, et al.; Biochemistry 40, 15771 (2001) Abstract
Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall: S. Tsuji, et al.; J. Biol. Chem. 276, 23456 (2001) Abstract; Full Text
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract; Full Text

APO-54N-034	Omentin 1 (human) ELISA Kit
ALX-201-371	Omentin 1 (human) (recombinant) (His)
ALX-210-454	Polyclonal Antibody to Omentin 1 (human)
ALX-210-941	Polyclonal Antibody to Omentin 1 (AT117)
ALX-804-850	Monoclonal Antibody to Omentin 1 (human) (Saly-1)
ALX-804-852	Monoclonal Antibody to Omentin 1 (Saly-2)
APO-54N-026	Omentin 1 (human) Detection Set [For ELISA Application]