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ALX-201-371 Revised 06-Feb-08
Omentin 1 (human) (recombinant) (His)
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SYNONYMS Intelectin-1 (human) (recombinant) (His)
Intestinal Lactoferrin Receptor (human) (recombinant) (His)
Galactofuranose-binding Lectin (human) (recombinant) (His)
Endothelial Lectin HL-1 (human) (recombinant) (His)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Omentin / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-201-371-C010   10 µg 310.00 USD Add To Cart
ALX-201-371-C050   50 µg 520.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli. Mature human omentin 1 (intelectin-1) (aa 17-313) is fused at the C-terminus to a His-tag.
CONCENTRATION: 0.5mg/ml
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/µg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Working aliquots are stable for up to 3 months when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
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General Information
Omentin 1 (also named Intelectin-1, Endothelial Lectin HL-1 and Intestinal Lactoferrin Receptor) has been recently identified as a novel visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q8WWA0: Intelectin-1 (human) [Precursor]
MANUFACTURER Manufactured by AdipoGen, Inc.
General Literature References
Human homologs of the Xenopus oocyte cortical granule lectin XL35: J.K. Lee, et al.; Glycobiology 11, 65 (2001) Abstract
Molecular cloning and functional expression of a human intestinal lactoferrin receptor: Y.A. Suzuki, et al.; Biochemistry 40, 15771 (2001) Abstract
Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall: S. Tsuji, et al.; J. Biol. Chem. 276, 23456 (2001) Abstract
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab. 290, E1253 (2006) Abstract
Related Products
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • PI(3)K-Akt-mTOR Pathway Other Products
 
 
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