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Oxidative Stress
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ALX-385-010 Revised 08-Apr-08
(±)-Naringenin
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SYNONYMS (±)-4',5,7-Trihydroxyflavanone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-010-G001   1 g 15.00 USD Add To Cart
Product Specification
FORMULA: C15H12O5
MW: 272.3
CAS NUMBER: 67604-48-2
MERCK INDEX: 14: 6424
PURITY: ≥95%
APPEARANCE: Light yellow to tan powder.
SOLUBILITY: Soluble in 100% ethanol; almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Has anti-inflammatory and antitumor properties. Induces apoptosis. Stimulates DNA repair following oxidative damage. Inhibits the activity of phosphoinositide 3-kinase (PI(3)K).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes: A. W. Harmon & Y. M. Patel; BBRC 305, 229 (2003) Abstract
The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells: K. Gao, et al.; J. Nutr. Biochem. 17, 89 (2006) Abstract
Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells: S. Kanno, et al.; Toxicol. Lett. 166, 131 (2006) Abstract
Inhibitory effect of naringenin chalcone on inflammatory changes in the interaction between adipocytes and macrophages: S. Hirai, et al.; Life Sci. 81, 1272 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables
 
 
ALX-350-146 Revised 03-Oct-07
Neobavaisoflavone
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-146-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C20H18O4
MW: 322.4
CAS NUMBER: 41060-15-5
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibits platelet aggregation. DNA polymerase inhibitor. Shows antifungal activity.
Product Specific Literature References
Prenylated isoflavanone from the roots of Erythrina sigmoidea: A.E. Nkengfack, et al.; Phytochemistry 36, 1047 (1994) Abstract
Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Studies on the chemical constituents of Psoralea corylifolia L.: B. Ruan, et al.; J. Asian Nat. Prod. Res. 9, 41 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Topoisomerase Inhibitors • Natural Products - DNA Replication Inhibitors • DNA Replication Inhibitors • Natural Products - Antifungal Agents • Flavonoids/Related Products
 
 
ALX-460-008 Revised 02-Jun-06
Nicotinamide
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SYNONYMS Niacinamide
3-Pyridinecarboxylic amide
Vitamin PP
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism/Related Products
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ALX-460-008-G010   10 g 10.00 USD Add To Cart
Product Specification
FORMULA: C6H6N2O
MW: 122.1
CAS NUMBER: 98-92-0
MERCK INDEX: 14: 6523
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water; also soluble in 100 % ethanol or glycerol; slightly soluble in chloroform; almost insoluble in ether or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Susceptible to hydrolysis in acidic or alkaline solution.
HANDLING: Protect from light.
HAZARD: IRRITANT. MAY BE MUTAGENIC.

Further Categories Containing This Product:
DNA Repair Other Products • Vitamins • PARP Inhibitors
 
 
ALX-460-009 Revised 08-Jan-03
Nicotinic acid
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SYNONYMS Niacin
3-Pyridinecarboxylic acid
Vitamin B
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism/Related Products
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ALX-460-009-G010   10 g 13.00 USD Add To Cart
Product Specification
FORMULA: C6H5NO2
MW: 123.1
CAS NUMBER: 59-67-6
MERCK INDEX: 14: 6525
PURITY: ≥98% (HPLC)
SOLUBILITY: Soluble in water or 96% ethanol (1g/100ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Further Categories Containing This Product:
Vitamins
 
 
ALX-480-058 Revised 18-Jun-08
8-Nitroguanine
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Nucleobases
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ALX-480-058-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C5H4N6O3
MW: 196.1
CAS NUMBER: 168701-80-2
PURITY: ≥98% (HPLC)
SOLUBILITY: Slightly soluble in water (sonification).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, MS and UV.

Product Description
Oxidative DNA degradation product.
Product Specific Literature References
Formation of 8-nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination: V. Yermilov, et al.; FEBS Lett. 376, 207 (1995) Abstract
Antioxidant and pro-oxidant actions of flavonoids: effects on DNA damage induced by nitric oxide, peroxynitrite and nitroxyl anion: H. Ohshima, et al.; Free Radic. Biol. Med. 25, 1057 (1998) Abstract
Importance of guanine nitration and hydroxylation in DNA in vitro and in vivo: J. Tuo, et al.; Free Radic. Biol. Med. 29, 147 (2000) Abstract
Further Categories Containing This Product:
DNA Repair Other Products • Oxidative Stress Markers & Reagents/Related Products
 
 
ALX-850-037 Revised 26-Jun-08
Nitroso-thiol (RSNOs) Detection Kit
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents/Related Products
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ALX-850-037-KI01   1 Kit 590.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Store kit at +4°C. Store standard (vial 5) at -20°C
Product Description
The assay of nitroso-thiols in many biological fluids, appears to provide a very useful index of NOS activity. The concentration of RSNOs has been shown to increase with localized induction of NOS and to fall rapidly upon administration of NOS inhibitors.
The kit provides a complete solution for the assay of high or low MW RSNOs. The assay is divided essentially into two steps. In the first step, the sample is prepared according to which subgroup of RSNO is desired. The S-N bond is then cleaved, resulting in the formation of an equivalent of nitrite, which is assayed using the Griess reaction. The intensity of the color formed is linearly related to the concentration of nitrite, and hence, to the original RSNO concentration.
Product Specific Literature References
Increased nitrosothiols in exhaled breath condensate in inflammatory airway diseases: M. Corradi, et al.; Am. J. Respir. Crit. Care Med. 163, 854 (2001) Abstract; Full Text
Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma: S.A. Kharitonov, et al.; Thorax 57, 889 (2002) Abstract
General Information
MANUFACTURER Manufactured by Oxonon.
General Literature References
Detection of S-nitrosothiols by fluorometric and colorimetric methods: D.A. Wink, et al.; Methods Enzymol. 301, 201 (1999) Abstract
Fluorometric detection of S-nitrosothiols: P. Kostka and J.K. Park; Methods Enzymol. 301, 227 (1999) Abstract
Mechanisms of biological S-nitrosation and its measurement: T. Akaike; Free Radic. Res. 33, 461 (2000) Abstract
Further Categories Containing This Product:
Nitric Oxide & NOS Detection/Related Products • Quantification Kits
 
 
ALX-201-237 Revised 12-Aug-08
NMNAT1 (human) (recombinant) (His)
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SYNONYMS NMN Adenylyltransferase 1 (human) (recombinant) (His)
Nicotinamide Mononucleotide Adenylyltransferase 1 (human) (recombinant) (His)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism/Related Products
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ALX-201-237-C100   100 µg 390.00 USD Add To Cart
Product Specification
MW: 33.3kDa (monomer)
EC: 2.7.7.1
SOURCE/HOST: Produced in E. coli. Full length human NMNAT1 is fused at the N-terminus to a His-tag.
CONCENTRATION:

~1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 50mM sodium phosphate, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol.
SPECIFIC ACTIVITY: 10-20U/mg
APPLICATION: Well suited for the synthesis of NAD due to high specific activity (10-20U/mg) and high substrate selectivity compared to NMNAT3 (human) (recombinant) (Prod. No. ALX-201-238).
Note: When loss of activity is observed add 10mM DTT to the working buffer and incubate for at least 15 min. before the assay.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 months after receipt when stored at -20°C. Unstable in solutions containing less than 250mM salt.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase: M. Emanuelli, et al.; J. Biol. Chem. 276, 406 (2001) Abstract; Full Text
Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis: M. Schweiger, et al.; FEBS Lett. 492, 95 (2001) Abstract; Full Text
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms: F. Berger, et al.; J. Biol. Chem. 280, 36334 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9HAN9: NMNAT1 (human)
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Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins
 
 
ALX-201-429 Revised 05-Aug-08 New product
NMNAT1 (human) (recombinant) (His)
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SYNONYMS NMN Adenylyltransferase 1 (human) (recombinant) (His)
Nicotinamide Mononucleotide Adenylyltransferase 1 (human) (recombinant) (His)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism/Related Products
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ALX-201-429-C010   10 µg 140.00 USD Add To Cart
ALX-201-429-C050   50 µg 280.00 USD Add To Cart
Product Specification
EC: 2.7.7.1
SOURCE/HOST: Produced in E. coli. The mature peptide of human NMNAT1 (aa 2-279) is fused at the N-terminus to a His-tag.
PURITY: ≥90% (SDS-PAGE)
FORMULATION: Liquid. 0.2μm-filtered solution in 55mM TRIS, pH 8.2, containing 150mM sodium chloride.
ENDOTOXIN CONTENT: <1EU/μg protein (LAL-test).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9HAN9: NMNAT1 (human)
MANUFACTURER Manufactured by AdipoGen, Inc.
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Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins • Enzymes
 
 
ALX-201-238 Revised 18-Mar-08
NMNAT3 (human) (recombinant)
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SYNONYMS NMN Adenylyltransferase 3 (human) (recombinant)
Nicotinamide Mononucleotide Adenylyltransferase 3 (human) (recombinant)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY NAD+ Metabolism/Related Products
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ALX-201-238-C100   100 µg 390.00 USD Add To Cart
Product Specification
MW: 30.3kDa (monomer)
EC: 2.7.7.1
SOURCE/HOST: Produced in E. coli. Full length human NMNAT3 is fused at the N-terminus to a His-tag.
CONCENTRATION: 0.8mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In 50mM sodium phosphate, pH 8.0, containing 300mM sodium chloride, 1mM DTT and 10% glycerol.
APPLICATION: Well suited for the synthesis of NAD analogs due to lower substrate selectivity compared to NMNAT1 (human) (recombinant) (Prod. No. ALX-201-237).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 months after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis: X. Zhang, et al.; J. Biol. Chem. 278, 13503 (2003) Abstract; Full Text
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms: F. Berger, et al.; J. Biol. Chem. 280, 36334 (2005) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q96T66: NMNAT3 (human)
Related Products
Further Categories Containing This Product:
Enzymes • Recombinant Proteins/Fusion Proteins
 
 
ALX-385-026 Revised 22-Apr-08
Nobiletin
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SYNONYMS 3’,4’,5,6,7,8-Hexamethoxyflavone
2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
CCRIS 9012
NSC 76751
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-385-026-M010   10 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C21H22O8
MW: 402.4
CAS NUMBER: 478-01-3
PURITY: ≥98% (HPLC)
SOLUBILITY: Sparingly soluble in water or ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antioxidant and anti-inflammatory. Inhibits the phosphorylation of mitogen-activated protein kinase MEK. Suppresses the expression of matrix metalloproteinases (MMP) 1, 3 and 9, that are involved in the breakdown of the extracellular matrix during tumor metastasis. Suppresses NF-κB transcriptional activation, nitric oxide (NO) and PGE2 production, inducible nitric oxide synthase (iNOS; NOS II) and cyclooxygenase-2 (COX-2) expression in LPS-activated RAW cells.
Product Specific Literature References
The citrus flavonoid, nobiletin, inhibits peritoneal dissemination of human gastric carcinoma in SCID mice: A. Minagawa, et al.; Jpn. J. Cancer Res. 92, 1322 (2001) Abstract
Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages: N. Lin, et al.; Biochem. Pharmacol. 65, 2065 (2003) Abstract
Inhibition of cell proliferation by nobiletin, a dietary phytochemical, associated with apoptosis and characteristic gene expression, but lack of effect on early rat hepatocarcinogenesis in vivo: H. Ohnishi, et al.; Cancer Sci. 95, 936 (2004) Abstract; Full Text
Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7 cells: S.Y. Choi, et al.; J. Ethnopharmacol. 113, 149 (2007) Abstract
Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells: K.L. Morley, et al.; Cancer Lett. 251, 168 (2007) Abstract
Nobiletin, a citrus flavonoid that improves memory impairment, rescues bulbectomy-induced cholinergic neurodegeneration in mice: A. Nakajima, et al.; J. Pharmacol. Sci. 105, 122 (2007) Abstract; Full Text
Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes: T. Saito, et al.; BBRC 357, 371 (2007)