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ALX-105-005
Revised 20-May-08
N-Acetyl-L-cysteine
SYNONYMS
LNAL
N-Acetyl-3-mercaptoalanine
L-α-Acetamido-β-mercaptopropionic acid
NAC
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-105-005-G001
1 g
16.00 USD
ALX-105-005-G005
5 g
27.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
3
S
MW:
163.2
CAS NUMBER:
616-91-1
MERCK INDEX:
14:
88
RTECS:
HA1660000
PURITY:
≥99%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 5M hydrochloric acid (hot) (100mg/ml); also soluble in water or 100% ethanol; insoluble in chloroform or ether.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Modulation of platelet function by free radicals and free-radical scavengers:
D. Salvemini & R. Botting; TIPS
14
, 36 (1993), (Review)
Abstract
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells:
D. Salvemini, et al.; Br. J. Pharmacol.
108
, 162 (1993)
Abstract
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1:
H. Schenk, et al.; PNAS
91
, 1672 (1994)
Abstract
Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells:
J.C. Tsai, et al.; J. Biol. Chem.
271
, 3667 (1996)
Abstract
;
Full Text
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice:
E. Ho, et al.; Faseb. J.
13
, 1845 (1999)
Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells:
A. Iseki, et al.; Biochem. Biophys. Res. Commun.
276
, 88 (2000)
Abstract
Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells:
H. Kim, et al.; Free Radic. Biol. Med.
29
, 674 (2000)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-101-003
Revised 07-May-03
β-Alanine
SYNONYMS
3-Aminopropionic acid
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-101-003-G001
1 g
15.00 USD
Product Specification
FORMULA:
C
3
H
7
NO
2
MW:
89.1
CAS NUMBER:
107-95-9
MERCK INDEX:
14:
205
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
ALX-106-027
Revised 07-May-03
D-α-Aminoadipic acid
SYNONYMS
D-2-Aminohexanedioic acid
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-027-M050
50 mg
20.00 USD
ALX-106-027-M250
250 mg
70.00 USD
Product Specification
FORMULA:
C
6
H
11
NO
4
MW:
161.2
CAS NUMBER:
7620-28-2
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Amino acid antagonist. Glutamine synthethase inhibitor
in vivo
.
ALX-106-026
Revised 11-Jul-07
L-α-Aminoadipic acid
SYNONYMS
L-2-Aminohexanedioic acid
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-026-M050
50 mg
10.00 USD
ALX-106-026-M250
250 mg
30.00 USD
Product Specification
FORMULA:
C
6
H
11
NO
4
MW:
161.2
CAS NUMBER:
1118-90-7
MERCK INDEX:
14:
416
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in 1N HCl.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Increases intracellular free Ca
2+
concentration. Competitive inhibitor of glutamine synthase and γ-glutamylcysteine synthase. Competitive glutamate receptor antagonist.
Product Specific Literature References
Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors:
J.W. Ferkany, et al.; Nature
298
, 757 (1982)
Abstract
Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate:
G.J. McBean; Br. J. Pharmacol.
113
, 536 (1994)
Abstract
ALX-106-025
Revised 07-May-03
γ-Aminobutyric acid
SYNONYMS
GABA
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
GABA-ergics & GABA Receptors/Related Products
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ALX-106-025-G010
10 g
7.00 USD
Product Specification
FORMULA:
C
4
H
9
NO
2
MW:
103.1
CAS NUMBER:
56-12-2
MERCK INDEX:
14:
430
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water; slightly soluble in ethanol; insoluble in most organic solvents.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Further Categories Containing This Product:
Special Amino Acids
ALX-550-016
Revised 08-Nov-07
(S)-AMPA
SYNONYMS
(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
AMPA Receptors/Related Products
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ALX-550-016-M005
5 mg
95.00 USD
ALX-550-016-M025
25 mg
380.00 USD
Product Specification
FORMULA:
C
7
H
10
N
2
O
4
MW:
186.2
CAS NUMBER:
83643-88-3
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Active enantiomer of (R,S)-AMPA (Prod. No.
ALX-550-023
).
Product Specific Literature References
Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid:
J.J. Hansen, et al.; J. Med. Chem.
26
, 901 (1983)
Abstract
Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors:
J. Lauridsen, et al.; J. Med. Chem.
28
, 668 (1985)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-106-031
Revised 06-Dec-04
p-Chloro-L-phenylalanine
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-031-M050
50 mg
15.00 USD
ALX-106-031-M250
250 mg
45.00 USD
Product Specification
FORMULA:
C
9
H
10
ClN
2
O
2
MW:
199.6
CAS NUMBER:
14173-39-8
PURITY:
≥99%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
ALX-106-030
Revised 01-Jul-03
p-Chloro-DL-phenylalanine
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-030-G001
1 g
15.00 USD
Product Specification
FORMULA:
C
9
H
10
ClNO
2
MW:
199.6
CAS NUMBER:
7424-00-2
PURITY:
≥98%
APPEARANCE:
White hygroscopic solid.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
ALX-106-028
Revised 03-Apr-08
D-Cycloserine
SYNONYMS
R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-106-028-M050
50 mg
20.00 USD
ALX-106-028-M250
250 mg
80.00 USD
Product Specification
FORMULA:
C
3
H
6
N
2
O
2
MW:
102.1
CAS NUMBER:
68-41-7
RTECS:
NY2975000
SOURCE/HOST:
Synthetic.
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Hygroscopic.
Product Description
Excitatory amino acid. Partial agonist at the glycine modulatory site of the NMDA receptor.
Further Categories Containing This Product:
Special Amino Acids
•
Excitatory Amino Acids
•
NMDA Receptors/Related Products
ALX-106-037
Revised 09-Oct-07
L-Cycloserine
SYNONYMS
S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Neurological Research
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ALX-106-037-M025
25 mg
50.00 USD
ALX-106-037-M100
100 mg
150.00 USD
Product Specification
FORMULA:
C
3
H
6
N
2
O
2
MW:
102.1
CAS NUMBER:
339-72-0; 4834-58-6
MERCK INDEX:
14:
2751
RTECS:
NY2976000
PURITY:
≥98%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Hygroscopic.
Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo:
K.S. Sundaram & M. Lev; J. Neurochem.
42
, 577 (1984)
Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine
:
R.D. Williams, et al.; J. Lipid Res.
28
, 1478 (1987)
Abstract
;
Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes:
G.B. Watson, et al.; Brain Res.
510
, 158 (1990)
Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain:
I.P. Chessell, et al.; Brain Res.
565
, 345 (1991)
Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor:
G.S. Shukla, et al.; Biochim. Biophys. Acta
1083
, 101 (1991)
Abstract
Further Categories Containing This Product:
NMDA Receptors/Related Products
•
Excitatory Amino Acids
•
Special Amino Acids
ALX-106-035
Revised 13-Dec-02
4-Hydroxy-D-phenylglycine
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-035-G001
1 g
20.00 USD
Product Specification
FORMULA:
C
8
H
9
NO
3
MW:
167.2
CAS NUMBER:
22818-40-2
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in alkalies.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HAZARD:
IRRITANT.
Further Categories Containing This Product:
Excitatory Amino Acids
ALX-106-023
Revised 13-Dec-02
5-Hydroxy-L-tryptophan
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors/Related Products
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ALX-106-023-M500
500 mg
20.00 USD
Product Specification
FORMULA:
C
11
H
12
N
2
O
3
MW:
220.2
CAS NUMBER:
56-69-9
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
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