• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Oxidative Stress
You are here: Product Lines > Oxidative Stress
 
Toolbar - View Selection
 
 Items 100-120 of 336 Page 6 of 17 Select Page: << 1 2 3 4 5 6 7 8 9 10  >>  
ALX-270-405 Revised 14-Jul-08
(E)-4-Hydroxyhexenal
Add to Clipboard
SYNONYMS 4-HHE
(E)-(±)-4-Hydroxy-2-hexenal
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-405-M001   1 mg 45.00 USD Add To Cart
ALX-270-405-M005   5 mg 199.00 USD Add To Cart
ALX-270-405-M010   10 mg 354.00 USD Add To Cart
Product Specification
FORMULA: C6H10O2
MW: 114.1
CAS NUMBER: 160708-91-8
CONCENTRATION: 10mg/ml 
PURITY: ≥98%
FORMULATION: Liquid. Solution in ethanol.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or acetonitrile.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -80°C.

Product Description
Lipid peroxidation product derived from oxidized ω-3 fatty acids such as docosahexaneoic acid.
Product Specific Literature References
4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid: F.J. Van Kuijk, et al.; Biochim. Biophys. Acta 1043, 116 (1990) Abstract
Quantitative measurement of 4-hydroxyalkenals in oxidized low-density lipoprotein by gas chromatography-mass spectrometry: F.J. van Kuijk, et al.; Anal. Biochem. 224, 420 (1995) Abstract
Induction of endothelial iNOS by 4-hydroxyhexenal through NF-kappaB activation: J.Y. Lee, et al.; Free Radic Biol. Med. 37, 539 (2004) Abstract
NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway: J.H. Je, et al.; FEBS Lett. 566, 183 (2004) Abstract
Induction of endothelial apoptosis by 4-hydroxyhexenal: J.Y. Lee, et al.; Eur. J. Biochem. 271, 1339 (2004) Abstract
Specific markers of lipid peroxidation issued from n-3 and n-6 fatty acids: M. Guichardant, et al.; Biochem. Soc. Trans. 32, 139 (2004) Abstract
4-Hydroxyhexenal is a potent inducer of the mitochondrial permeability transition: B.S. Kristal, et al.; J. Biol. Chem. 271, 6033 (1996) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
 
 
ALX-270-406 Revised 07-Jul-08
(E)-4-Hydroxynonenal-d3
Add to Clipboard
SYNONYMS HNE-d3
(±)-4-Hydroxy-9,9,9-d3-non-2E-enal
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-406-C050   50 µg 55.00 USD Add To Cart
Product Specification
FORMULA: C9H13D3O2
MW: 159.2
PURITY: ≥99%
FORMULATION: Liquid. Solution in methyl acetate.
SOLUBILITY: Soluble in DMSO (25mg/ml), dimethyl formamide (25mg/ml) or 100% ethanol (50mg/ml).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -80°C.

Product Description
Internal standard for the quantification of hydroxynonenal (HNE) (Prod. No. ALX-270-245) by GC- or LC-mass spectometry. Contains three deuterium atoms at the terminal methyl position.
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.
Related Products
Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-270-407 Revised 24-Jul-08
4-Oxo-2-nonenal
Add to Clipboard
SYNONYMS 4-ONE
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-407-M001   1 mg 108.00 USD Add To Cart
ALX-270-407-M005   5 mg 483.00 USD Add To Cart
Product Specification
FORMULA: C9H14O2
MW: 154.2
CAS NUMBER: 103560-62-9
CONCENTRATION: 10mg/ml
PURITY: ≥98%
FORMULATION: Liquid. Solution in methyl acetate.
SOLUBILITY: 50mg/ml soluble in 100% ethanol, dimethyl formamide or DMSO; sparingly soluble in PBS, pH 7.2 (0.5mg/ml).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -80°C. Keep aqueous solutions on ice and use within 12 hours.

Product Description
Lipid peroxidation product. Modifies histidine and lysine residues in proteins and causes protein cross-linking, modifies 2'-deoxyguanosine, and implicates lipid peroxidation in mutagenesis and carcinogenesis.
Product Specific Literature References
Covalent modifications to 2'-deoxyguanosine by 4-oxo-2-nonenal, a novel product of lipid peroxidation: D. Rindgen, et al.; Chem. Res. Toxicol. 12, 1195 (1999) Abstract
Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation: S.H. Lee, et al.; Chem. Res. Toxicol. 13, 698 (2000) Abstract
Aldehydic lipid peroxidation products derived from linoleic acid: P. Spiteller, et al.; Biochem. Biophys. Acta 1531, 188 (2001) Abstract
Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal: Z. Liu, et al.; Chem. Res. Toxicol. 16, 901 (2003) Abstract
Model studies on protein side chain modification by 4-oxo-2-nonenal: W.H. Zhang, et al.; Chem. Res Toxicol. 16, 512 (2003) Abstract
Induction of apoptosis in colorectal carcinoma cells treated with 4-hydroxy-2-nonenal and structurally related aldehydic products of lipid peroxidation: J.D. West, et al.; Chem. Res. Toxicol. 17, 453 (2004) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments.
 
 
ALX-270-412 Revised 23-Mar-06
N-Oxalylglycine
Add to Clipboard
SYNONYMS NOG
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hypoxia-inducible Factor [HIF] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-412-M010   10 mg 40.00 USD Add To Cart
ALX-270-412-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C4H5NO5
MW: 147.1
CAS NUMBER: 5262-39-5
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HAZARD: IRRITANT.

Product Description
Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).
Product Specific Literature References
Novel inhibitors of prolyl 4-hydroxylase. 3. Inhibition by the substrate analogue N-oxaloglycine and its derivatives: C.J. Cunliffe, et al.; J. Med. Chem. 35, 2652 (1992) Abstract
General Literature References
Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues: E. Baader, et al.; Biochem. J. 300, 525 (1994) Abstract
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science 292, 468 (2001) Abstract
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation: A.C. Epstein, et al.; Cell 107, 43 (2001) Abstract
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha: J.M. Elkins, et al.; J. Biol. Chem. 278, 1802 (2003) Abstract
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases: P. Koivunen, et al.; J. Biol. Chem. 279, 9899 (2004) Abstract
 
 
ALX-270-413 Revised 23-Mar-06
N-Oxalyl-L-alanine
Add to Clipboard
SYNONYMS NOLA
N-Oxalyl-2S-alanine
NOxSA
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hypoxia-inducible Factor [HIF] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-413-M010   10 mg 60.00 USD Add To Cart
ALX-270-413-M050   50 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C5H7NO5 . H2O
MW: 161.1 . 18.0
PURITY: ≥98% (TLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.

Product Description
Cell permeable, competitive inhibitor of PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs). Less potent inhibitor of factor inhibiting HIF asparagine hydroxylase (FIH, IC50=2.5mM).
Product Specific Literature References
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science 292, 468 (2001) Abstract
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha: J.M. Elkins, et al.; J. Biol. Chem. 278, 1802 (2003) Abstract
 
 
ALX-270-414 Revised 06-Jul-06
N-Oxalyl-D-alanine
Add to Clipboard
SYNONYMS NODA
N-Oxalyl-2R-alanine
NOxRA
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hypoxia-inducible Factor [HIF] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-414-M010   10 mg 80.00 USD Add To Cart
ALX-270-414-M050   50 mg 240.00 USD Add To Cart
Product Specification
FORMULA: C5H7NO5 . H2O
MW: 161.1 . 18.0
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic.

Product Description
Cell permeable, potent competitive inhibitor of factor inhibiting HIF asparagine hydroxylase (FIH, IC50<0.4mM). Does not inhibit PHDs (prolyl hydroxylase domain-containing proteins; HIF-PHs).
Product Specific Literature References
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation: P. Jaakkola, et al.; Science 292, 468 (2001) Abstract
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha: J.M. Elkins, et al.; J. Biol. Chem. 278, 1802 (2003) Abstract
 
 
ALX-270-418 Revised 16-Jun-08
Gallotannin
Add to Clipboard
SYNONYMS Tannic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-418-G001   1 g 10.00 USD Add To Cart
Product Specification
FORMULA: C76H52O46
MW: 1701.2
CAS NUMBER: 1401-55-4
MERCK INDEX: 14: 9052
RTECS: WW5075000
SOURCE/HOST: Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.
PURITY: >95%
APPEARANCE: Beige to light brown powder.
SOLUBILITY: Soluble in water, 100% ethanol, acetone or warm glycerol.
SHIPPING: AMBIENT
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.
Product Specific Literature References
Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995) Abstract
The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000) Abstract
Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000) Abstract
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004) Abstract
Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005) Abstract
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • PARG / Related Products • DNA Repair Other Products • Free Radical Scavengers • Natural Products - Nitric Oxide Pathway Modulators • Phenolic Acids
 
 
ALX-270-428 Revised 25-Feb-08
Salubrinal
Add to Clipboard
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-428-M001   1 mg 30.00 USD Add To Cart
ALX-270-428-M005   5 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C21H20Cl3N4OS
MW: 479.8
CAS NUMBER: 405060-95-9
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Product may darken when exposed to air. Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING: Protect from light. Keep under inert gas.

Product Description
Cell permeable and selective inhibitor of the phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF-2α). Protects ER stress-induced apoptosis (EC50~15µM in PC12 cells stimulated with 750ng/ml of tunicamycin (Prod. No. ALX-380-047)).
Product Specific Literature References
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress: M. Boyce, et al.; Science 307, 935 (2005) Abstract
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death: M. Boyce, et al.; Cell Death Differ. 15, 589 (2008) Abstract
Related Products
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Endoplasmatic Reticulum Stress • Translation Initiation Factors / Related Products
 
 
ALX-270-447 Revised 11-Jul-08
4-Hydroperoxy-2-nonenal
Add to Clipboard
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-447-M001   1 mg 91.00 USD Add To Cart
ALX-270-447-M005   5 mg 407.00 USD Add To Cart
Product Specification
FORMULA: C9H16O3
MW: 172.2
CAS NUMBER: 7439-43-2
CONCENTRATION: 10mg/ml
PURITY: ≥95%
FORMULATION: Liquid. Solution in acetone.
SOLUBILITY: 30mg/ml soluble in DMSO, dimethyl formamide or 100% ethanol; 0.5mg/ml soluble in a 1:6 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -80°C. We do not recommend storing the aqueous solution for more than one day.
HAZARD: IRRITANT.

Product Description
Precursor compound of (E)-4-Hydroxynonenal (Prod. No. ALX-270-245) formed from the cleavage of the ω-6 hydroperoxides 9(S)-HpODE and 13(S)-HpODE.
General Information