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Oxidative Stress
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ALX-804-812 Revised 20-Jun-08
Monoclonal Antibody to BAP31 (CC-1)
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SYNONYMS anti-B Cell Receptor-associated Protein BAP31 MAb (CC-1)
anti-BCR-associated Protein BAP31 MAb (CC-1)
anti-p28 BAP31 MAb (CC-1)
anti-CDM Protein MAb (CC-1)
anti-6C6-AG Tumor-associated Antigen MAb (CC-1)
anti-DXS1357E MAb (CC-1)
PRODUCT LINE Immunology
PRODUCT CATEGORY B Cell Receptor [BCR] & Co-Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-812-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Goat
Sheep
Monkey
Others
CLONE: CC-1
ISOTYPE: Rat IgG2a
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 0.5mg/ml
PURITY: >95% (SDS-PAGE)
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: Solubilized membranes of the IMR-32 human neuroblastoma cell line.
SPECIFICITY: Recognizes an epitope (aa 230-246) encompassing a caspase recognition site and the ER-homing motif (KKEE), present at the C-terminus of human, primate, bovine and hamster BAP31. Does not recognize mouse and rat BAP31.
APPLICATION: ELISA (capture)
Immunocytochemistry (1:1'000-1:10'000; works on endogenous)
Immunohistochemistry (frozen sections (1:1'000-1:10'000); works on endogenous)
Immunoprecipitation
Western Blot (1:1'000-1:6'000; works on endogenous).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Endoplasmic reticulum membrane-sorting protein of lymphocytes (BAP31) is highly expressed in neurons and discrete endocrine cells: H.A. Manley and V.A. Lennon; J. Histochem. Cytochem. 49, 1235 (2001) Abstract; Full Text
Association of BAP31 with CD11b/CD18. Potential role in intracellular trafficking of CD11b/CD18 in neutrophils: K. Zen, et al.; J. Biol. Chem. 279, 44924 (2004) Abstract; Full Text
Bap31 enhances the endoplasmic reticulum export and quality control of human class I MHC molecules: J.J. Ladasky, et al.; J. Immunol. 177, 6172 (2006) Abstract
General Information
BAP31 (B cell receptor-associated protein 31) is an integral protein of the ER membrane that forms a large hetero-oligomeric complex with the related BAP29. The cytosolic domain of BAP31 contains two identical caspase recognition sites that are preferentially cleaved by initiator caspases, including caspase-8. After activation of cell surface death receptors, human BAP31 is cleaved into a membrane-embedded fragment called p20, which induces apoptosis when expressed ectopically. The p20 fragment can mediate Ca2+-dependent apoptotic cross-talk between the ER and mitochondria, stimulating cytochrome c release. In addition to its role in apoptosis, BAP31 is a component of the ER quality control compartment and functions as a cargo receptor for ER export of transmembrane proteins such as cellubrevin, MHC class I molecules, and cytochrome P450 2C2.
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Caspase-resistant BAP31 inhibits fas-mediated apoptotic membrane fragmentation and release of cytochrome c from mitochondria: M. Nguyen, et al.; Mol. Cell. Biol. 20, 6731 (2000) Abstract; Full Text
Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol: D.G. Breckenridge, et al.; J. Cell. Biol. 160, 1115 (2003) Abstract; Full Text
Bap31 Is an Itinerant Protein that Moves between the Peripheral ER and a Juxtanuclear Compartment Related to ER-associated Degradation: Y. Wakana, et al.; Mol. Biol. Cell 19, 1825 (2008) Abstract; Full Text
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • ER-Golgi Intermediate Compartment [ERGIC]/Related Products • Monoclonal Antibodies
 
 
ALX-804-647 Revised 13-Oct-06
Monoclonal Antibody to Bradykinin (MBK3)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor/Related Products
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ALX-804-647-R100   100 µl 210.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: MBK3
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Undiluted ascites.
IMMUNOGEN: Bradykinin (H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH).
SPECIFICITY: Recognizes bradykinin from various species.
APPLICATION: Western Blot (1:1’000-1:4’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Anti-idiotypic antibodies bearing the internal image of a bradykinin epitope. Production, characterization, and interaction with the kinin receptor: M. Haasemann, et al.; J. Immunol. 147, 3882 (1991) Abstract
Related Products
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products • NOS Regulation • Monoclonal Antibodies
 
 
ALX-804-014 Revised 09-Aug-07
Monoclonal Antibody to Calnexin (human) (AF18)
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SYNONYMS anti-p88 (human) MAb (AF18)
anti-IP90 (human) MAb (AF18)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Endoplasmatic Reticulum Stress
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-014-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: AF18
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Ascites diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Focus human hepatoma cell line.
SPECIFICITY: Recognizes human calnexin. Detects a band of ~90kDa by Western blot.
APPLICATION: Immunocytochemistry (1:500)
Immunoprecipitation
Western Blot (1:4’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene: K. Galvin, et al.; PNAS 89, 8452 (1992) Abstract; Full Text
Formation of transitory intrachain and interchain disulfide bonds accompanies the folding and oligomerization of simian virus 40 Vp1 in the cytoplasm: P.P. Li, et al.; PNAS 99, 1353 (2002) Abstract; Full Text
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction: B.N. Desai, et al.; PNAS 99, 4319 (2002) Abstract; Full Text
c-erbB-3: a nuclear protein in mammary epithelial cells: M. Offterdinger, et al.; J. Cell Biol. 157, 929 (2002) Abstract; Full Text
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator: H. Zhang, et al.; J. Biol. Chem. 277, 28948 (2002) Abstract; Full Text
Sec13 shuttles between the nucleus and the cytoplasm and stably interacts with Nup96 at the nuclear pore complex: J. Enninga, et al.; Mol. Cell. Biol. 23, 7271 (2003) Abstract; Full Text
Transient calnexin interaction confers long-term stability on folded K+ channel protein in the ER: R. Khanna, et al.; J. Cell Sci. 117, 2897 (2004) Abstract; Full Text
An LQT mutant minK alters KvLQT1 trafficking: A. Krumerman, et al.; Am. J. Physiol. Cell Physiol. 286, C1453 (2004) Abstract
The stop transfer sequence of the human UDP-glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms: L. Barre, et al.; Febs J. 272, 1063 (2005) Abstract; Full Text
The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma: K.T. Chin, et al.; Nucl. Acids Res. 33, 1859 (2005) Abstract; Full Text
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis: H. Zhang, et al.; J. Biol. Chem. 281, 11312 (2006) Abstract; Full Text
General Information
Calnexin, also referred to as IP90 or p88, is a ~88kDa chaperone protein found in the endoplastmic reticulum. It binds with partially folded immunoglobulin proteins and retains them in the endoplastmic reticulum until they are completely folded.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-509 Revised 14-Aug-07
Monoclonal Antibody to Caspase-12 (mouse) (11F10)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-509-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 11F10
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N183KKFDYLFDRDNADTDILNMQEL205) of mouse caspase-12.
SPECIFICITY: Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Images
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Product Specific Literature References
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006) Abstract; Full Text
General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Monoclonal Antibodies
 
 
ALX-804-511 Revised 10-Mar-06
Monoclonal Antibody to Caspase-12 (mouse) (12G6)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Antibodies
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ALX-804-511-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE: 12G6
ISOTYPE: Rat IgG1
CONCENTRATION: 1mg/ml.
FORMULATION: Liquid. Protein G affinity purified antibody in PBS containing 0.02% sodium azide.
IMMUNOGEN: p20 fragment of mouse caspase-12 and synthetic peptide corresponding to aa 183-205 (N183KKFDYLFDRDNADTDILNMQEL205) of mouse caspase-12.
SPECIFICITY: Recognizes an epitope within the p20 fragment of mouse caspase-12. Detects a band of ~51kDa by Western blot. Does not cross-react with mouse caspase-1 or -11.
APPLICATION: ELISA
Flow Cytometry
Western Blot
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Images
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General Information
Caspase-12 is a member of the ICE/CED-3 family of caspases and is detected as a protein of ~51kDa. Overexpression of caspase-12 in cells induces apoptosis. Capase-12 is localised to the endoplasmatic reticulum (ER) and activated by ER stress and specifically cleaves and activates pro-caspase-9 and is also thought to be involved in the apoptosis induced by viral infection. Caspase-12-deficient mice are resistant to ER stress-induced apoptosis. Caspase-12 is probably expressed in many and perhaps all mouse tissues; and is expressed at high levels in skeletal muscle, heart, lung and kidney, and at moderate levels in brain and liver. In many humans caspase-12 is a pseudo gene and not expressed.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Monoclonal Antibodies
 
 
ALX-804-551 Revised 12-Nov-07
Monoclonal Antibody to CHOP (9C8)
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SYNONYMS anti-C/EBP Homology Protein MAb (9C8)
anti-GADD153 MAb (9C8)
anti-Growth Arrest and DNA Damage Inducible Protein 153 MAb (9C8)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Endoplasmatic Reticulum Stress
Ordering Information
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ALX-804-551-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 9C8
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Recombinant mouse CHOP (C/EBP homology protein).
SPECIFICITY: Recognizes an N-terminal epitope of human and mouse CHOP. Detects a band of ~31kDa by Western blot.
APPLICATION: Immunoprecipitation
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153): N. Batchvarova, et al.; EMBO J. 14, 4654 (1995) Abstract
Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153): X.Z. Wang, et al.; Mol. Cell. Biol. 16, 4273 (1996) Abstract; Full Text
Regulation of the pro-B-cell-specific enhancer of the Id1 gene involves the C/EBP family of proteins: S. Saisanit and X.H. Sun; Mol. Cell. Biol. 17, 844 (1997) Abstract; Full Text
Identification of novel stress-induced genes downstream of chop: X.Z. Wang, et al.; EMBO J. 17, 3619 (1998) Abstract; Full Text
Cloning of mammalian Ire1 reveals diversity in the ER stress responses: X.Z. Wang, et al.; EMBO J. 17, 5708 (1998) Abstract; Full Text
Induction of a secreted protein by the myxoid liposarcoma oncogene: M. Kuroda, et al.; PNAS 96, 5025 (1999) Abstract; Full Text
CHOP-Dependent stress-inducible expression of a novel form of carbonic anhydrase VI: J. Sok, et al.; Mol. Cell. Biol. 19, 495 (1999) Abstract; Full Text
General Information
CHOP is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP α and β. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP-CHOP dimer gains binding activity to other non-classical C/EBP stress related targets.
Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of CHOP inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-803-302 Revised 06-Aug-07
Monoclonal Antibody to CHP1 (5E9G5)
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SYNONYMS anti-CHORD Containing Protein-1 MAb (5E9G5)
anti-CHORDC1 MAb (5E9G5)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Cell Stress, Oxidative Stress & Redox Signalling Other Products
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ALX-803-302-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 5E9G5
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml
PURITY: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
PURITY DETAIL: Protein A-affinity purified.
IMMUNOGEN: Recombinant mouse CHP1 (CHORD containing protein-1).
SPECIFICITY: Recognizes human and mouse CHP1.
APPLICATION: ELISA
Immunocytochemistry (5µg/ml)
Immunohistochemistry (5µg/ml)
Immunoprecipitation (5µg per 5x106 cells)
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Literature References
Chp-1 and melusin, two CHORD containing proteins in vertebrates: M. Brancaccio, et al.; FEBS Lett. 551, 47 (2003) Abstract; Full Text
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins/Related Products • Nod-complex/Related Products • Monoclonal Antibodies
 
 
ALX-804-122 Revised 26-Feb-07
Monoclonal Antibody to Cytochrome c (apo) (SJL2-4(apo))
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SYNONYMS anti-Cyt c (apo) MAb (SJL2-4(apo))
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cytochrome c
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-122-C100   100 µg 260.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Goat
Sheep
Monkey
CLONE: SJL2-4(apo)
ISOTYPE: Mouse IgG2b
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Horse cytochrome c.
SPECIFICITY: Recognizes human, mouse, rat, sheep, goat and monkey apocytochrome c.
APPLICATION: Western Blot
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at +4°C undiluted.
HANDLING: Do not freeze/thaw.
Product Images
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Product Specific Literature References
Differential effects of two anti-apo-cytochrome c-specific monoclonal antibodies on the function of apo-cytochrome c-specific murine T cell clones: G. Corradin, et al.; J. Immunol. 133, 2915 (1984) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade: P. Li, et al.; Cell 91, 479 (1997) Abstract
Cytochrome c: can't live with it-can't live without it: J.C. Reed; Cell 91, 559 (1997) Abstract
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked: J. Yang, et al.; Science 275, 1129 (1997) Abstract
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3: H. Zou, et al.; Cell 90, 405 (1997) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-804-245 Revised 19-May-08
Monoclonal Antibody to Cytochrome c (denatured) (7H8.2C12)
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SYNONYMS anti-Cyt c (denatured) MAb (7H8.2C12)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cytochrome c
Ordering Information
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ALX-804-245-C100   100 µg 293.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Pig
Others
CLONE: 7H8.2C12
ISOTYPE: Mouse IgG2b
CONCENTRATION: 0.5mg/ml
PURITY DETAIL: Protein G-affinity-purified.
FORMULATION: Liquid. In PBS containing 0.5% BSA and 0.05% sodium azide.
IMMUNOGEN: Non-native horse cytochrome c.
SPECIFICITY: Recognizes denatured cytochrome c from human, mouse, rat, pig, hamster, pigeon, horse, Drosophila and other species. Recognizes total cytochrome C which includes both apocytochrome c (in the cytosol without heme attached) and holocytochrome c (in the mitochondria with heme attached). Detects a band of ~15kDa by Western blot.
APPLICATION: Western Blot (1:500-1:1’000).
For immunocytochemistry, immunoprecipitation and functional application use MAb to Cytochrome c (native) (Blocking) (6H2.B4) (Prod. No. ALX-804-295).
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 6 months when stored at +4°C.