Advanced Search
© 2008 Alexis Corporation
You are here:
Product Lines
>
Oxidative Stress
> Endoplasmatic Reticulum Stress
Toolbar - View Selection
Current View:
Price List
Brief
Detail
Search Results
Current Sort:
Sort by Product Name
Sort by Product ID
Sort by Result Relevance
Sort by Class
Show:
20 Products
50 Products
100 Products
All Products
Show Selected Products Only
Show
Products Only
Items
1-20
of 33
Page 1
of 2
Select Page:
1
2
>>
ALX-201-093
Revised 15-Apr-08
Caspase-4 (active) (human) (recombinant)
PRODUCT LINE
Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY
Caspases
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-093-U025
25 U
203.00 USD
ALX-201-093-U100
100 U
371.00 USD
Product Specification
EC:
3.4.22.57
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute with PBS containing 15% glycerol to 1U/µl.
SPECIFIC ACTIVITY:
~5'000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate WEHD-pNA per hour at 37°C in reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
APPLICATION:
Useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Caspase-4 is a member of the caspase family of cysteine proteases. It exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. The expressed caspase-4 spontaneously undergoes auto-processing to yield subunits characteristic of the native enzyme. The active caspase-4 is routinely tested for its ability to enzymatically cleave the substrate WEHD-AFC or WEHD-pNA.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P49662:
Caspase-4 (human) (precursor)
AfCS Signalling Gateway link A000499:
Caspase-4 (mouse)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
Enzymes
•
Endoplasmatic Reticulum Stress
ALX-201-152
Revised 17-Jan-08
PDIA2 (human) (recombinant)
SYNONYMS
Protein Disulfide-isomerase A2 (human) (recombinant)
PRODUCT LINE
Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY
Protein Synthesis, Modification & Degradation Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-152-C025
25 µg
155.00 USD
Product Specification
EC:
5.3.4.1
SOURCE/HOST:
Produced in
E. coli
.
CONCENTRATION:
3.3mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In PBS.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Specific Literature References
BiP and PDI cooperate in the oxidative folding of antibodies in vitro
:
M. Mayer, et al.; J. Biol. Chem.
275
, 29421 (2000)
Abstract
;
Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q13087:
Protein disulfide isomerase A2 (Precursor) (human)
General Literature References
Proteins of the PDI family: unpredicted non-ER locations and functions
:
C. Turano, et al.; J. Cell. Physiol.
193
, 154 (2002), (Review)
Abstract
;
Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
Endoplasmatic Reticulum Stress
ALX-201-219
Revised 22-Mar-07
BiP (mouse) (recombinant)
SYNONYMS
GRP78 (mouse) (recombinant)
Glucose Regulated Protein 78 (mouse) (recombinant)
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
HSP70 / DnaK / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-219-C025
25 µg
170.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥99% (SDS-PAGE; MS)
FORMULATION:
Liquid. In 50mM HEPES, pH 7.5, containing 150mM KCl and 10mM MgCl
2
.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Specific Literature References
Influence of the oxidoreductase ER57 on the folding of an antibody fab fragment
:
M. Mayer, et al.; J. Mol. Biol.
341
, 1077 (2004)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
Endoplasmatic Reticulum Stress
ALX-201-220
Revised 18-Feb-05
Calnexin (dog) (recombinant)
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
Endoplasmatic Reticulum Stress
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-220-C025
25 µg
170.00 USD
Product Specification
SOURCE/HOST:
Produced in
E.coli
.
PURITY:
≥99% (SDS-PAGE; MS)
FORMULATION:
Liquid. In 40mM HEPES, pH 7.5, containing 150mM sodium chloride, 5mM calcium chloride.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Product Specific Literature References
Roles of N-linked glycans in the endoplasmic reticulum
:
A. Helenius and M. Aebi; Annu. Rev. Biochem.
73
, 1019 (2004)
Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
ALX-201-269
Revised 18-Mar-08
Calreticulin (rabbit) (recombinant)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calreticulin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-269-C025
25 µg
170.00 USD
Product Specification
SOURCE/HOST:
Produced in
E. coli
.
CONCENTRATION:
1.2mg/ml
PURITY:
≥99%
FORMULATION:
Liquid. In 100mM HEPES, pH 7.5, containing 150mM NaCl and 5mM CaCl
2
.
SHIPPING:
SHIPPED ON DRY ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Delineation of the lectin site of the molecular chaperone calreticulin:
S.P. Thomson and D.B. Williams; Cell Stress Chaperones
10
, 242 (2005)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P15253:
Calreticulin (rabbit)
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
•
ER-Golgi Intermediate Compartment [ERGIC] / Related Products
•
Endoplasmatic Reticulum Stress
ALX-210-024
Revised 29-Jun-05
Polyclonal Antibody to TRAF2 (human) (Bur 34)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (human) PAb (Bur 34)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-024-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 6-31(V
6
TPPGSLELLQPGFSKTLLGTKLEAK
31
) of human TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2).
SPECIFICITY:
Recognizes human TRAF2. Detects endogenous protein by IHC and WB. Detects a band of ~60-64kDa by Western blot. Does not cross-react with other members of the TRAF family.
APPLICATION:
Immunohistochemistry (paraffin sections (1:2'000)
Immunoprecipitation (1:50)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
:
J.M. Zapata, et al.; J. Immunol.
165
, 5084 (2000)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
•
Endoplasmatic Reticulum Stress
•
Autophagy Other Products
ALX-210-029
Revised 01-Jun-06
Polyclonal Antibody to TRAF2 (mouse) (AR-63)
SYNONYMS
anti-Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (mouse) PAb (AR-63)
PRODUCT LINE
Inflammation
PRODUCT CATEGORY
TRAFs / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-029-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 250-271 (S
250
FLEAQASPG
TLNQVGPELLQR
271
) of mouse TRAF2 (tumor necrosis factor (TNF) receptor-associated factor 2).
SPECIFICITY:
Recognizes mouse TRAF2. Detects a band of ~60-64kDa by Western blot.
APPLICATION:
Immunoprecipitation (1:50)
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies
:
J.M. Zapata, et al.; J. Immunol.
165
, 5084 (2000)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Polyclonal Antibodies
•
Endoplasmatic Reticulum Stress
•
Autophagy Other Products
ALX-210-126
Revised 07-Aug-07
Polyclonal Antibody to Calreticulin
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calreticulin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-126-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant human calreticulin.
SPECIFICITY:
Recognizes human, mouse, rat, rabbit and monkey calreticulin.
APPLICATION:
Immunohistochemistry (1:100)
Immunocytochemistry
Immunoprecipitation
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils:
O. Stendahl, et al.; Science
265
, 1439 (1994)
Abstract
Cell surface calreticulin is a putative mannoside lectin which triggers mouse melanoma cell spreading:
T.K. White, et al.; J. Biol. Chem.
270
, 15926 (1995)
Abstract
;
Full Text
Calreticulin interacts with newly synthesized human immunodeficiency virus type 1 envelope glycoprotein, suggesting a chaperone function similar to that of calnexin:
A. Otteken & B. Moss; J. Biol. Chem.
271
, 97 (1996)
Abstract
;
Full Text
Further Categories Containing This Product:
ER-Golgi Intermediate Compartment [ERGIC] / Related Products
•
Polyclonal Antibodies
•
Endoplasmatic Reticulum Stress
ALX-210-137/1
Revised 21-Aug-07
Polyclonal Antibody to BiP
SYNONYMS
anti-GRP78 PAb
anti-Glucose Regulated Protein 78 PAb
PRODUCT LINE
Stress & Heat Shock Proteins
PRODUCT CATEGORY
HSP70 / DnaK / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-137/1-C100
100 µg
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
Rat
Others
SOURCE/HOST:
From rabbit.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Lyophilized. Contains 0.05% sodium azide.
RECONSTITUTION:
Reconstitute with PBS.
IMMUNOGEN:
Synthetic peptide corresponding to aa 643-654 (T
643
GEEDTSEKDEL
654
) of rat BiP (GRP78; glucose regulated protein 78kDa).
SPECIFICITY:
Recognizes mouse and rat BiP. Does not detect BiP from human cell lines or COS cells.
APPLICATION:
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Images
Please click on thumbnails to enlarge.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
Polyclonal Antibodies
ALX-210-170/1
Revised 19-May-08
Polyclonal Antibody to Calreticulin (NT)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calreticulin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-170/1-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST:
From chicken.
CONCENTRATION:
1.1mg/ml
PURITY DETAIL:
Epitope-affinity purified IgY.
FORMULATION:
Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 24-43 (K
24
EQFLDGDAWTNRWVESKHK
43
) of mouse calreticulin.
SPECIFICITY:
Recognizes human, mouse, rat, dog and hamster calreticulin. Detects a band of ~60-66kDa by Western blot.
APPLICATION:
Immunocytochemistry
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide See Prod. No.
ALX-153-017
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-153-017
Blocking Peptide for PAb to Calreticulin (NT) (Prod. No.
ALX-210-170/1
)
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
ER-Golgi Intermediate Compartment [ERGIC] / Related Products
•
Polyclonal Antibodies
ALX-210-171
Revised 03-Jun-05
Polyclonal Antibody to Calreticulin (CT)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calreticulin / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-210-171-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Dog
Others
SOURCE/HOST:
From chicken.
FORMULATION:
Liquid. Contains 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 399-414 (D
399
EKEEDEEESPGQAKD
414
) of mouse calreticulin.
SPECIFICITY:
Recognizes human, mouse, rat, rabbit, dog and hamster calreticulin. Detects a band of ~60kDa and and unidentified band of ~120kDa by Western blot.
APPLICATION:
Western Blot.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-016
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-153-016
Blocking Peptide for PAb to Calreticulin (CT) (Prod. No.
ALX-210-171
)
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress
•
ER-Golgi Intermediate Compartment [ERGIC] / Related Products
•
Polyclonal Antibodies
ALX-210-404
Revised 30-Oct-06
Polyclonal Antibody to ERp29
