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Antioxidants, Flavonoids & Free Radical Scavengers
You are here: Product Lines > Oxidative Stress > Antioxidants, Flavonoids & Free Radical Scavengers
 
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ALX-430-154 Revised 03-Apr-08
Cannabigerol
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SYNONYMS CBG
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
not sold in USA
Product Specification
FORMULA: C21H32O2
MW: 316.5
SOURCE/HOST: Natural product.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Analog of cannabidiol (Prod. No. ALX-430-152) with similar pharmacological properties.
Product Specific Literature References
Cannabigerol monomethyl ether, a new component of hemp: T. Yamauchi, et al.; Chem. Pharm. Bull 16, 1164 (1968) Abstract
In vitro metabolism of cannabigerol in several mammalian species: D.J. Harvey and N.K. Brown; Biomed. Environ. Mass Spectrom. 19, 545 (1990) Abstract
Further Categories Containing This Product:
Cannabinoid Receptor Agonists & Antagonists / Related Products • Natural Products - Antioxidants
 
 
ALX-350-052 Revised 21-May-08
Dihydrocapsaicin
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SYNONYMS 8-Methyl-N-vanillylnonanamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-350-052-M010   10 mg 28.00 USD Add To Cart
ALX-350-052-M050   50 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C18H29NO3
MW: 307.4
CAS NUMBER: 19408-84-5
RTECS: RA5998000
SOURCE/HOST: Isolated from Capsicum fruit.
PURITY: ≥85%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform, DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT. POTENT NEUROTOXIN.

Product Description
Dihydro-analog and congener of capsaicin (Prod. No. ALX-550-066) in chili peppers (Capsicum). Like capsaicin it is irritant. Dihydrocapsaicin accounts for about 22% of the total capsaicinoids mixture and has about the same pungency as capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic.
Product Specific Literature References
The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells: T. Lawson & P. Gannett; Cancer Lett. 48, 109 (1989) Abstract
Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep: R. Ramirez-Romero, et al.; Regul. Pept. 91, 97 (2000) Abstract
Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II): S. Singh, et al.; Cancer Lett. 169, 139 (2001) Abstract
Determination of capsaicin and dihydrocapsaicin in capsicum fruits by liquid chromatography-electrospray/time-of-flight mass spectrometry: A. Garces-Claver, et al.; J. Agric. Food Chem. 54, 9303 (2006) Abstract
Effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids: K.D. Ahuja, et al.; J. Agric. Food Chem. 54, 6436 (2006) Abstract
Further Categories Containing This Product:
Alkaloids • TRPV1 Agonists and Antagonists / Related Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Natural Products for Neurological Research
 
 
ALX-350-253 Revised 28-Sep-07
Carazostatin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-253-C100   100 µg 45.00 USD Add To Cart
ALX-350-253-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C20H25NO
MW: 295.4
CAS NUMBER: 126168-32-9
SOURCE/HOST: Isolated from Streptomyces chrestomyceticus.
APPEARANCE: Pale yellow solid.
SOLUBILITY: Soluble in methanol, abs. ethanol or DMSO. Insoluble in water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and air. Keep under inert gas

Product Description
Antioxidant. Free radical scavenger. Potent inhibitor of lipid peroxidation.
Product Specific Literature References
Studies on free radical scavenging substances from microorganisms. I. Carazostatin, a new free radical scavenger produced by Streptomyces chromofuscus DC 118: S. Kato, et al.; J. Antibiot. (Tokyo) 42, 1879 (1989) Abstract
Antioxidant activities of natural and synthetic carbazoles: M. Iwatsuki, et al.; Biofactors 4, 123 (1993) Abstract
In vitro and ex vivo free radical scavenging activities of carazostatin, carbazomycin B and their derivatives: S. Kato, et al.; J. Antibiot. (Tokyo) 46, 1859 (1993) Abstract
Total Syntheses of Carazostatin, Hyellazole, and Carbazoquinocins B-F: T. Choshi, et al.; J. Org. Chem. 62, 2535 (1997) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Lipid Peroxidation
 
 
ALX-270-264 Revised 17-Apr-08
Carnosic acid
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-264-M010   10 mg 45.00 USD Add To Cart
ALX-270-264-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C20H28O4
MW: 332.4
CAS NUMBER: 3650-09-7
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥95%
APPEARANCE: Yellow powder.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.
Product Specific Literature References
Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes: K. Schwarz & W. Ternes; Z. Lebensm. Unters. Forsch. 195, 99 (1992) Abstract
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids: M. Geoffroy, et al.; Free Radic. Res. 21, 247 (1994) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells: E.A. Offord, et al.; Carcinogenesis 16, 2057 (1995) Abstract
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Active Substances from Fruit and Vegetables • Natural Products with Antibiotic Activity • Natural Products - Anti-inflammatory Agents • PPAR Agonists
 
 
ALX-153-055 Revised 25-May-07
Carnosine
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SYNONYMS β-Alanyl-L-histidine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-153-055-G001   1 g 55.00 USD Add To Cart
Product Specification
SEQUENCE: H-β-Ala-His-OH
FORMULA: C9H14N4O3
MW: 226.2
CAS NUMBER: 305-84-0
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 80% acetic acid (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antioxidant. Inhibits soluble guanylyl cyclase (sGC) by interacting with the heme iron to form a chelate complex.
Product Specific Literature References
Carnosine as a regulator of soluble guanylate cyclase: I.S. Severina, et al.; Biochemistry (Mosc) 65, 783 (2000) Abstract; Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-270-254 Revised 22-Sep-08
Carnosol
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SYNONYMS 1,3,4,9,10,10aS-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-254-M001   1 mg 60.00 USD Add To Cart
ALX-270-254-M005   5 mg 269.00 USD Add To Cart
Product Specification
FORMULA: C20H26O4
MW: 330.4
CAS NUMBER: 5957-80-2
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥96%
APPEARANCE: White to beige solid.
SOLUBILITY: Soluble in 100% ethanol (8mg/ml), DMSO (250mg/ml) or dimethyl formamide (35mg/ml); sparingly soluble in aqueous PBS, pH 7.2 (<30μg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C. We do not recommend storing aqueous solutions for more than one day.
HANDLING: Protect from light.

Product Description
Naturally occurring phenolic compound with antioxidant and anti-inflammatory properties. Suppresses nitric oxide (NO) production and inducible nitric oxide synthase (iNOS; NOS II) gene expression by inhibiting NF-κB activation. Inhibits lipid peroxidation. Antimicrobial. Anticarcinogenic. Inhibits cyclooxygenase-2 (COX-2).
Product Specific Literature References
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production: M.M. Chan, et al.; Cancer Lett. 96, 23 (1995) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation: K. Singletary, et al.; Cancer Lett. 104, 43 (1996) Abstract
Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention: K. Macé, et al.; Arch. Toxicol. Suppl. 20, 227 (1998) Abstract
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages: A.H. Lo, et al.; Carcinogenesis 23, 983 (2002) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Chemopreventive Agents • Natural Products - NF-kB Pathway Inhibitors • Lipid Peroxidation • Active Substances from Fruit and Vegetables • COX Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products - Nitric Oxide Pathway Modulators
 
 
ALX-460-004 Revised 11-Jul-07
β-Carotene
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SYNONYMS Provitamin A
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Retinol [Vitamin A] & Retinol Derivatives / Related Products
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ALX-460-004-G005   5 g 65.00 USD Add To Cart
Product Specification
FORMULA: C40H56
MW: 536.9
CAS NUMBER: 7235-40-7
MERCK INDEX: 14: 1853
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Red powder.
SOLUBILITY: Soluble in DMSO, n-hexane, carbon disulfide, benzene or vegetable oils; slightly soluble in ether, petroleum ether or oils; almost insoluble in 100% ethanol, methanol, water, diluted acidic or alkaline solutions.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Absorbs oxygen from air. Keep under inert gas.

Further Categories Containing This Product:
Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Vitamins
 
 
ALX-385-017 Revised 01-Apr-08
(+)-Catechin . monohydrate
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SYNONYMS (+)-3,3',4',5,7-Flavanpentol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-385-017-G001   1 g 20.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6 . H2O
MW: 290.3 . 18.0
CAS NUMBER: 88191-48-4, 225937-10-0
MERCK INDEX: 14: 1902
PURITY: ≥98% (TLC)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in 100% ethanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.
Product Specific Literature References
Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract
Further Categories Containing This Product:
Free Radical Scavengers • Active Substances from Fruit and Vegetables • Natural Products - Chemopreventive Agents • Flavanols • Natural Products - Antitumor Reagents
 
 
ALX-385-002 Revised 19-Nov-07
(±)-Catechin
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SYNONYMS (±)-3,3',4',5,7-Flavanpentol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-385-002-G001   1 g 80.00 USD Add To Cart
Product Specification
FORMULA: C15H14O6
MW: 290.3 (anhydrous basis)
CAS NUMBER: 7295-85-4
MERCK INDEX: 14: 1902
PURITY: ≥98% (HPLC)
APPEARANCE: White to yellow powder.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Free radical scavenger. Has chemopreventive and antitumor properties.
Product Specific Literature References
Adjuvant chemoprevention of experimental cancer: catechin and dietary turmeric in forestomach and oral cancer models: M.A. Azuine & S.V. Bhide; J. Ethnopharmacol. 44, 211 (1994) Abstract
Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products: S.V. Bhide, et al.; Breast Cancer Res. Treat. 30, 233 (1994) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002), (Review) Abstract
In vitro biological properties of flavonoid conjugates found in vivo: G. Williamson, et al.; Free Radic. Res. 39, 457 (2005), (Review) Abstract
(+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) Abstract
Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Free Radical Scavengers • Natural Products - Chemopreventive Agents • Flavanols • Natural Products - Antitumor Reagents
 
 
ALX-350-332 Revised 03-Apr-08
Celastrol
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SYNONYMS Tripterine
3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-332-M005   5 mg 65.00 USD Add To Cart
ALX-350-332-M025   25 mg 260.00 USD