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ALX-350-232 Revised 17-Jul-08
DL-Sulforaphane
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SYNONYMS R,S-Sulforaphane
1-Isothiocyanato-4-methylsulfinyl-butane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-232-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C6H11NOS2
MW: 177.3
CAS NUMBER: 142825-10-3; 4478-93-7 (unspecified stereo)
MERCK INDEX: 14: 8962
SOURCE/HOST: Synthetic.
PURITY: ≥98% (UPLC)
APPEARANCE: Slightly yellowish liquid.
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR and MS.

Product Description
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats. Inhibits LPS-induced HMGB1 (high mobility group box 1) secretion.
Product Specific Literature References
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992) Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994) Abstract; Full Text
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak, et al.; Cancer Res. 64, 5767 (2004) Abstract; Full Text
The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells: M.E. Killeen, et al.; J. Pharmacol. Exp. Ther. 316, 1070 (2006) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Glutathione S-Transferase • Respiratory Chain Other Products • Cytochrome P450 [CYP450] / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Active Substances from Fruit and Vegetables
 
 
ALX-350-230 Revised 11-Aug-08
L-Sulforaphane
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SYNONYMS R-Sulforaphane
(-)-1-Isothiocyanato-(4R)-(methylsulfinyl)butane
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-230-M010   10 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C6H11NOS2
MW: 177.3
CAS NUMBER: 142825-10-3; 4478-93-7
MERCK INDEX: 14: 8962
SOURCE/HOST: Chiral natural product isolated from broccoli.
PURITY: ≥98% (UPLC)
APPEARANCE: Slightly yellowish liquid.
SOLUBILITY: Soluble in methanol, DMSO or ethyl acetate.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent, selective inducer of phase II detoxification enzymes. Inhibits chemically induced mammary tumor formation in rats.
Product Specific Literature References
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure: Y. Zhang, et al.; PNAS 89, 2399 (1992) Abstract; Full Text
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates: Y. Zhang, et al.; PNAS 91, 3147 (1994) Abstract; Full Text
Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors: J.W. Fahey, et al.; PNAS 99, 7610 (2002) Abstract; Full Text
A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase: M.C. Myzak ,et al.; Cancer Res. 64, 5767 (2004) Abstract; Full Text
Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex: M.L. Kerns, et al.; PNAS 104, 14460 (2007) Abstract
Further Categories Containing This Product:
Antitumor Agents (Enzyme Activators & Inducers) • Glutathione S-Transferase • Respiratory Chain Other Products • Natural Products - Apoptosis Inducers & Inhibitors • Cytochrome P450 [CYP450] / Related Products • Active Substances from Fruit and Vegetables
 
 
ALX-380-211 Revised 19-Feb-08
Venturicidin A
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SYNONYMS Aabomycin A1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-211-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C41H67NO11
MW: 750.0
CAS NUMBER: 33538-71-5
MERCK INDEX: 14: 9947
RTECS: YX4556000
SOURCE/HOST: Isolated from Streptomyces sp. MST-117594.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Macrolide antibiotic. Potent inhibitor of mitochondrial ATP synthase complex, acting on the F0 membrane sector. Shows antifungal activity.
Product Specific Literature References
Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature 192, 952 (1961) Abstract
Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D.S. Perlin, et al.; Biochim. Biophys. Acta 807, 238 (1985) Abstract
Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance: M. Galanis, et al.; FEBS Lett. 249, 333 (1989) Abstract; Full Text
Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi and Y. Hatefi; J. Biol. Chem. 268, 6168 (1993) Abstract; Full Text
Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers: H. Miedema, et al.; BBRC 203, 1005 (1994) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
 
 
ALX-380-223 Revised 19-Feb-08
Venturicidin B
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SYNONYMS Aabomycin A2
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
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ALX-380-223-MC25   0.25 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C40H66O10
MW: 706.9
CAS NUMBER: 33538-72-6
MERCK INDEX: 14: 9947
SOURCE/HOST: Isolated from Streptomyces sp. MST-117594.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Macrolide antibiotic. Potent inhibitor of mitochondrial ATP synthase complex, acting on the F0 membrane sector. Shows antifungal activity.
Product Specific Literature References
Venturicidin: a new antifungal antibiotic of potential use in agriculture: A. Rhodes, et al.; Nature 192, 952 (1961) Abstract
Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin: D.S. Perlin, et al.; Biochim. Biophys. Acta 807, 238 (1985) Abstract
Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance: M. Galanis, et al.; FEBS Lett. 249, 333 (1989) Abstract; Full Text
Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds: A. Matsuno-Yagi and Y. Hatefi; J. Biol. Chem. 268, 6158 (1993) Abstract; Full Text
Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers: H. Miedema, et al.; BBRC 203, 1005 (1994) Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
 
 
ALX-350-280 Revised 03-Jul-08
Xanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-280-M005   5 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
CAS NUMBER: 569-83-5, 6754-58-1
SOURCE/HOST: Isolated from hops (Humulus lupulus).
PURITY: ≥98% (NMR)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in DMSO (25mg/ml) or methanol (10mg/ml); soluble in aqueous buffers up to 20μM.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable as powder for at least 6 months when stored at +4°C in the dark. Stock solution made in DMSO should not be stored for longer than one month. Working solution is stable for 24 hours at 37°C and up to one week when stored at +4°C. Unstable in acidic (pH < 4.5) and alkaline (pH > 7.5) systems.
IDENTITY: Identity determined by 1H-NMR.

Product Description
Prenylated chalcone found in beer. Potent inhibitor of diacylglycerol acetyltransferase (DGAT), which catalyzes the final step in mammalian triacylglycerol synthesis. Inhibits DNA polymerase and induces cell differentiation. Has antiproliferative and cytotoxic effects in human cancer cell lines. Inhibits human P450 enzymes. Induces quinone reductase. Inhibits the expression of HIF-1α and VEGF under hypoxic conditions. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus: N. Tabata, et al.; Phytochemistry 46, 683 (1997) Abstract
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines: C.L. Miranda, et al.; Food Chem. Toxicol. 37, 271 (1999) Abstract
In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus: M.C. Henderson, et al.; Xenobiotica 30, 235 (2000) Abstract
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells: C.L. Miranda, et al.; Cancer Lett. 149, 21 (2000) Abstract
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop: C. Gerhauser, et al.; Mol. Cancer Ther. 1, 959 (2002) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Natural Products - Antitumor Reagents • Estrogen & Estrogen Receptors / Related Products • Hypoxia-inducible Factor [HIF] / Related Products • Cell Differentiation • Natural Products - Apoptosis Inducers & Inhibitors • Respiratory Chain Other Products • Antitumor Agents (Anti-proliferative) • Obesity & Diabetes Other Products • Lipid Metabolism Other Products • Flavonoids / Related Products • VEGFs
 
 
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