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ALX-385-009
Revised 03-Apr-08
Chrysin
SYNONYMS
5,7-Dihydroxyflavone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavones
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ALX-385-009-G001
1 g
15.00 USD
Product Specification
FORMULA:
C
15
H
10
O
4
MW:
254.2
CAS NUMBER:
480-40-0
MERCK INDEX:
14:
2256
RTECS:
LK8329050
PURITY:
≥96%
APPEARANCE:
Yellow to tan solid.
SOLUBILITY:
Soluble in pyridine or alkaline solutions; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Antioxidant flavonoid. Shows anti-inflammatory and antitumor properties. Inhibits hypoxia-inducible factor-1α (HIF-1α). Induces apoptosis.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids:
C.A. Rice-Evans, et al.; Free Radical Biol. & Med.
20
, 933 (1996), (Review)
Abstract
Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells:
K.J. Woo, et al.; Biochem. Biophys. Res. Commun.
325
, 1215 (2004)
Abstract
Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase:
M.S. Weng, et al.; Biochem. Pharmacol.
69
, 1815 (2005)
Abstract
Dietary flavonoids: effects on xenobiotic and carcinogen metabolism::
Y.J. Moon, et al.; Toxicol. In Vitro
20
, 187 (2006), (Review)
Abstract
Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis:
B. Fu, et al.; Mol. Cancer Ther.
6
, 220 (2007)
Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents
•
Hypoxia-inducible Factor [HIF] / Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Natural Products - Antitumor Reagents
•
Natural Products - Antioxidants
ALX-350-365
Revised 07-Oct-08
Cinnamtannin B-1
SYNONYMS
Epicatechin-(4β→8,2β→O→7)-epicatechin-(4α→8)-epicatechin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Apoptosis Inducers & Inhibitors
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ALX-350-365-M005
5 mg
230.00 USD
Product Specification
FORMULA:
C
45
H
36
O
18
MW:
864.7
CAS NUMBER:
88082-60-4
SOURCE/HOST:
Isolated from
Laurus nobilis
L.
PURITY:
≥90% (
1
H-NMR)
APPEARANCE:
Brown solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol or in a mixture of DMSO and water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas.
Product Description
A-type proanthocyanidin contained in several plant species such as
Laurus nobilis L.
,
Vaccinium vitis-idaea
,
Parameria laevigata
,
Cinnamomum zeylanicum
and
Lindera umbellata
. Potent antioxidant. Protective agent against oxidative stress and apoptosis in human platelets.
Product Specific Literature References
Pharmacological Studies on Linderae umbellatae Ramus, IV*. Effects of condensed tannin related compounds on peptic activity and stress-induced gastric lesions in mice:
N. Ezaki, et al.; Planta Med.
51
, 34 (1985)
Abstract
Antitumor agents, 129. Tannins and related compounds as selective cytotoxic agents
:
Y. Kashiwada, et al.; J. Nat. Prod.
55
, 1033 (1992)
Abstract
Antioxidant activity of tannin components from Vaccinium vitis-idaea L:
K.Y. Ho, et al.; J. Pharm. Pharmacol.
51
, 1075 (1999)
Abstract
Studies on the constituents of bark of Parameria laevigata Moldenke:
K. Kamiya, et al.; Chem. Pharm. Bull.
49
, 551 (2001)
Abstract
;
Full Text
Cinnamtannin B1 activity on adipocytes formation
:
M. Taher, et al.; Med. J. Malaysia
59
, 97 (2004)
Abstract
Phenolic constituents in the fruits of Cinnamomum zeylanicum and their antioxidant activity:
G.K. Jayaprakasha, et al.; J. Agric. Food Chem.
54
, 1672 (2006)
Abstract
Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets:
N. Ben Amor, et al.; J. Med. Chem.
50
, 3937 (2007)
Abstract
Cinnamtannin B-1 from bay wood exhibits antiapoptotic effects in human platelets:
A. Bouaziz, et al.; Apoptosis
12
, 489 (2007)
Abstract
Cinnamtannin B-1 from bay wood reduces abnormal intracellular Ca2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients:
A. Bouaziz, et al.; Arch. Biochem. Biophys.
457
, 235 (2007)
Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables
•
Flavanols
•
Natural Products - Antioxidants
ALX-380-058
Revised 09-Oct-08
Citrinin
SYNONYMS
Antimycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
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ALX-380-058-M001
1 mg
15.00 USD
ALX-380-058-M005
5 mg
60.00 USD
ALX-380-058-M010
10 mg
105.00 USD
ALX-380-058-M025
25 mg
210.00 USD
Product Specification
FORMULA:
C
13
H
14
O
5
MW:
250.3
CAS NUMBER:
518-75-2
MERCK INDEX:
14:
2327
RTECS:
DJ2275000
PURITY:
≥97% (HPLC)
APPEARANCE:
Yellow crystalline solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dioxane, pyridine or dichlormethane; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
HAZARD:
TOXIC.
MELTINGPOINT:
110-112°C
Product Description
Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.
Product Specific Literature References
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling:
G.M. Chagas, et al.; J. Appl. Toxicol.
15
, 91 (1995)
Abstract
Mycotoxins:
J.W. Bennett & M. Klich; Clin. Microbiol. Rev.
16
, 497 (2003)
Abstract
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway:
F.Y. Yu, et al.; Toxicol. Lett.
161
, 143 (2006)
Abstract
Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts:
W.H. Chan; Biochem. J.
404
, 317 (2007)
Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
•
Mycotoxins
ALX-430-117
Revised 16-May-08
CMH . hydrochloride
SYNONYMS
1-Hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Spin Traps, Spin Probes & Spin Labels
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ALX-430-117-M010
10 mg
65.00 USD
ALX-430-117-M050
50 mg
195.00 USD
ALX-430-117-M250
250 mg
450.00 USD
Product Specification
FORMULA:
C
10
H
19
NO
3
. HCl
MW:
201.3 . 36.5
PURITY:
≥99% (EPR)
APPEARANCE:
White to off-white crystalline powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Analog of CPH (Prod. No.
ALX-430-078
) with higher cell permeability and 3-fold better reactivity with superoxide. Has been used to study intracellular production of superoxide radicals in plasma, endothelial cells and isolated hearts.
Product Specific Literature References
Detection of superoxide with new cyclic hydroxylamine CMH in plasma, cells and isolated heart
:
B. Fink & S. Dikalov; Free Radical Biol. Med.
33
, S366 (2002)
Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion
:
J. Hwang, et al.; J. Biol. Chem.
278
, 47291 (2003)
Abstract
;
Full Text
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase:
N. Kuzkaya, et al.; Biochem. Pharmacol.
70
, 343 (2005)
Abstract
Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases:
S.C. Dudley, Jr., et al.; Circulation
112
, 1266 (2005)
Abstract
Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice:
A. Dikalova, et al.; Circulation
112
, 2668 (2005)
Abstract
Measurement of reactive oxygen species in cardiovascular studies:
S. Dikalov, et al.; Hypertension
49
, 717 (2007)
Abstract
Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay:
S.I. Dikalov, et al.; Biochem. Pharmacol.
73
, 972 (2007)
Abstract
;
Full Text
Related Products
ALX-430-078
CPH . hydrochloride
ALX-430-076
Revised 03-Oct-08
Cobalt (III) Protoporphyrin IX chloride
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
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ALX-430-076-M025
25 mg
80.00 USD
Product Specification
FORMULA:
C
34
H
32
CoN
4
O
4
. Cl
MW:
654.5
PURITY:
≥95% (TLC)
APPEARANCE:
Dark purple solid.
SOLUBILITY:
Soluble in acidic or basic aqueous solutions at pH between 8.5-9.0. Once in solution pH can be adjusted to physiological pH.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
Vitamins
•
NAD+ Metabolism / Related Products
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
Vitamins
•
NAD+ Metabolism / Related Products
ALX-620-063
Revised 03-Feb-05
Coelenterazine
SYNONYMS
2-[(4-Hydroxyphenyl)methyl]-6-(4-hydroxyphenyl)-8-(phenylmethyl)-imidazo [1,2-a] pyrazin-3-(
7H
)-one
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Peroxynitrite / Scavengers / Detection
Ordering Information
Product Numbers:
Format:
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ALX-620-063-C050
50 µg
110.00 USD
Product Specification
FORMULA:
C
26
H
21
N
3
O
3
MW:
423.5
CAS NUMBER:
55779-48-1
PURITY:
≥95%
APPEARANCE:
Brown solid.
SOLUBILITY:
Slightly soluble in methanol or ethanol. Avoid DMSO.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Keep under inert gas. Keep calcium free when stored in solution.
Product Description
Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. When oxidized by oxygen it emits blue light at 446nm when Ca
2+
binds to the complex. Powerful antioxidant. See also 2-(4-Dehydroxy)coelenterazine (Prod. No.
ALX-620-062
).
Product Specific Literature References
Use of calcium-regulated photoproteins as intracellular Ca2+ indicators:
J.R. Blinks; Meth. Enzymol.
172
, 164 (1989)
Abstract
Slow calcium waves accompany cytokinesis in medaka fish eggs:
R.A. Fluck, et al.; J. Cell Biol.
115
, 1259 (1991)
Abstract
Coelenterazine is a superoxide anion-sensitive chemiluminescent probe: its usefulness in the assay of respiratory burst in neutrophils:
M. Lucas & F. Solano; Anal. Biochem.
206
, 273 (1992)
Abstract
Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization:
D. Button & M. Brownstein; Cell Calcium
14
, 663 (1993)
Abstract
Imaging [Ca2+]i with aequorin using a photon imaging detector:
A.L. Miller, et al.; Meth. Cell Biol.
40
, 305 (1994)
Abstract
Intracellular free calcium level and its response to cAMP stimulation in developing Dictyostelium cells transformed with jellyfish apoaequorin cDNA:
S. Saran, et al.; FEBS Lett.
337
, 43 (1994)
Abstract
The origins of marine bioluminescence: turning oxygen defence mechanisms into deep-sea communication tools:
J.F. Rees, et al.; J. Exp. Biol.
201
, 1211 (1998)
Abstract
;
Full Text
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation:
M.M. Tarpey, et al.; Circ. Res.
84
, 1203 (1999)
Abstract
Further Categories Containing This Product:
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
•
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
Luciferin & Luciferase / Related Products
•
Calcium Indicators / Probes
•
Oxidative Stress Markers & Reagents / Related Products
ALX-430-048
Revised 03-Oct-08
Copper(II) Protoporphyrin IX (free acid)
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
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ALX-430-048-M025
25 mg
75.00 USD
Product Specification
FORMULA:
C
34
H
32
CuN
4
O
4
MW:
624.2
PURITY:
≥95%
APPEARANCE:
Red to brown solid.
SOLUBILITY:
Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING:
Protect from light and moisture.
Product Description
Negative control for the heme oxygenase inhibitor zinc protoporphyrin IX (Prod. No.
ALX-430-049
).
Product Specific Literature References
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin:
R.J. Chernick, et al.; Hepatology
10
, 365 (1989)
Abstract
Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii:
S.R. Glaum & R.J. Miller; Mol. Pharmacol.
43
, 965 (1993)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
ALX-430-078
Revised 10-Nov-06
CPH . hydrochloride
SYNONYMS
1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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