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Cell Stress, Oxidative Stress & Redox Signalling Other Products
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Items 13 of 13
ALX-270-022 Revised 09-Jan-08
AEBSF . hydrochloride
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SYNONYMS 4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc®SC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-022-M050   50 mg 40.00 USD Add To Cart
ALX-270-022-M250   250 mg 145.00 USD Add To Cart
ALX-270-022-G001   1 g 360.00 USD Add To Cart
Product Specification
FORMULA: C8H10FNO2S . HCl
MW: 203.2 . 36.5
CAS NUMBER: 30827-99-7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.

Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No. ALX-270-184). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide: B.R. Baker & H.J. Cory; J. Med. Chem. 14, 119 (1971) Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide: P. Megyeri, et al.; Immunology 86, 629 (1995) Abstract; Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF: M. Citron, et al.; Neuron 17, 171 (1996) Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor: Y. Nakabo & M.J. Pabst; J. Leukoc. Biol. 60, 328 (1996) Abstract; Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997) Abstract; Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999) Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis: R. Buitrago-Rey, et al.; J. Antimicrob. Chemother. 49, 871 (2002) Abstract; Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes: N. Wijayanti, et al.; J. Biol. Chem. 280, 21820 (2005) Abstract; Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression: T. Hosoi, et al.; Eur. J. Pharmacol. 554, 8 (2007) Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products • MAPK Pathway Activators • Cell Stress, Oxidative Stress & Redox Signalling Other Products • Fatty Acid Amide Hydrolase [FAAH] / Related Products
 
 
ALX-152-006 Revised 23-Jan-07
Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-152-006-M005   5 mg 22.00 USD Add To Cart
ALX-152-006-M025   25 mg 86.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C50H73N15O11
MW: 1060.3
CAS NUMBER: 5979-11-3
MERCK INDEX: 14: 1359
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
Product Description
Activator of eNOS (NOS III).
Product Specific Literature References
Different activation of L-arginine pathway by bradykinin, serotonin, and clonidine in coronary arteries: V. Richard, et al.; Am. J. Physiol. 259, H1433 (1990) Abstract
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cells: R.G. Bogle, et al.; BBRC 180, 926 (1991) Abstract
Activation of a small-conductance Ca(2+)-dependent K+ channel contributes to bradykinin-induced stimulation of nitric oxide synthesis in pig aortic endothelial cells: K. Groschner, et al.; Biochim. Biophys. Acta 1137, 162 (1992) Abstract
G proteins in aortic endothelial cells and bradykinin-induced formation of nitric oxide: J. Gil-Longo, et al.; Eur. J. Pharmacol. 247, 119 (1993) Abstract
Simultaneous measurements of Ca2+ and nitric oxide in bradykinin-stimulated vascular endothelial cells: L.A. Blatter, et al.; Circ. Res. 76, 922 (1995) Abstract; Full Text
Biosynthesis of endothelium-derived nitric oxide by bradykinin as endogenous precursor: A.R. Volpe, et al.; Immunopharmacology 33, 287 (1996) Abstract
Nitric oxide as mediator of bradykinin-induced pancreatic circulatory and metabolic responses: W.W. Pawlik, et al.; J. Physiol. Pharmacol. 48, 751 (1997) Abstract
Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase: S.G. Bernier, et al.; J. Biol. Chem. 275, 30707 (2000) Abstract; Full Text
Reciprocal phosphorylation and regulation of endothelial nitric-oxide synthase in response to bradykinin stimulation: M.B. Harris, et al.; J. Biol. Chem. 276, 16587 (2001) Abstract; Full Text
Bradykinin down-regulates, whereas arginine analogs up-regulates, endothelial nitric-oxide synthase expression in coronary endothelial cells: N.D. Vaziri, et al.; J. Pharmacol. Exp. Ther. 313, 121 (2005) Abstract; Full Text
Bradykinin mediates phosphorylation of eNOS in odontoblasts: Y. Korkmaz, et al.; J. Dent. Res. 85, 536 (2006) Abstract
Further Categories Containing This Product:
NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products • Peptides
 
 
ALX-152-031 Revised 24-Nov-06
(Des-Arg1)-Bradykinin
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SYNONYMS Bradykinin (2-9)
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-031-M001   1 mg 15.00 USD Add To Cart
ALX-152-031-M005   5 mg 50.00 USD Add To Cart
Product Specification
SEQUENCE: H-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 16875-11-9
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products • Peptides
 
 
ALX-152-032 Revised 08-Dec-06
(Des-Arg9)-Bradykinin
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-152-032-M005   5 mg 75.00 USD Add To Cart
ALX-152-032-M025   25 mg 300.00 USD Add To Cart
Product Specification
SEQUENCE: H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-OH
FORMULA: C44H61N11O10
MW: 904.0
CAS NUMBER: 15958-92-6
PURITY: ≥99%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
NOS Regulation • Cell Stress, Oxidative Stress & Redox Signalling Other Products • Peptides
 
 
ALX-430-137 Revised 17-Apr-07
IM-54
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SYNONYMS 2-(1H-Indol-3-yl)-3-pentylamino-maleimide
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Non-apoptotic Cell Death / Necrosis
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ALX-430-137-M001   1 mg 30.00 USD Add To Cart
ALX-430-137-M025   25 mg 420.00 USD Add To Cart
Product Specification
FORMULA: C19H23N3O2
MW: 325.4
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO (100mg/ml), dichloomethane, 100% ethanol or methanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100µM H2O2). Does not protect etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50µM.
Product Specific Literature References
Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives: K. Dodo, et al.; Bioorg. Med. Chem. Lett. 15, 3114 (2005) Abstract
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-460-007 Revised 02-Feb-07
Menadione
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SYNONYMS Vitamin K3
2-Methyl-1,4-naphthoquinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-007-G010   10 g 10.00 USD Add To Cart
Product Specification
FORMULA: C11H8O2
MW: 172.2
CAS NUMBER: 58-27-5
MERCK INDEX: 14: 5831
RTECS: QL9100000
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow crystals.
SOLUBILITY: Soluble in 96% ethanol (16mg/ml) or DMSO (1mg/ml); almost insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.

Product Description
Cytotoxic in various cell lines. Induces apoptosis via elevation of peroxide and superoxide radical levels. Affects gap-junctional intercellular communication by mediation of tyrosine phosphorylation.
Product Specific Literature References
Vitamin K3 induces cell cycle arrest and cell death by inhibiting Cdc25 phosphatase: F.Y. Wu and T.P.; Eur. J. Cancer 35, 1388 (1999) Abstract
Apoptosis-inducing activity of vitamin C and vitamin K: H. Sakagami, et al.; Cell Mol. Biol. 46, 129 (2000) Abstract
Cytotoxic effect through fas/APO-1 expression due to vitamin K in human glioma cells: L.K. Sun, et al.; J. Neurooncol. 47, 31 (2000) Abstract
Cytotoxic activity of vitamins K1, K2 and K3 against human oral tumor cell lines: H. Okayasu, et al.; Anticancer Res. 21, 2387 (2001) Abstract
2-Methyl-1,4-naphthoquinone, vitamin K(3), decreases gap-junctional intercellular communication via activation of the epidermal growth factor receptor/extracellular signal-regulated kinase cascade: L.O. Klotz, et al.; Cancer Res. 62, 4922 (2002) Abstract; Full Text
Menadione metabolism to thiodione in hepatoblastoma by scanning electrochemical microscopy: J. Mauzeroll, et al.; PNAS 101, 17582 (2004) Abstract; Full Text
Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells: D.N. Criddle, et al.; J. Biol. Chem. 281, 40485 (2006) Abstract; Full Text
Further Categories Containing This Product:
Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Agents (Apoptosis Inducers) • Cell Stress, Oxidative Stress & Redox Signalling Other Products
 
 
ALX-804-647 Revised 13-Oct-06
Monoclonal Antibody to Bradykinin (MBK3)
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PRODUCT LINE Neurobiology
PRODUCT CATEGORY Bradykinin Receptor / Related Products
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ALX-804-647-R100   100 µl 210.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
CLONE: MBK3
ISOTYPE: Mouse IgG1
FORMULATION: Liquid. Undiluted ascites.
IMMUNOGEN: Bradykinin (H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH).
SPECIFICITY: Recognizes bradykinin from various species.
APPLICATION: Western Blot (1:1’000-1:4’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Anti-idiotypic antibodies bearing the internal image of a bradykinin epitope. Production, characterization, and interaction with the kinin receptor: M. Haasemann, et al.; J. Immunol. 147, 3882 (1991) Abstract
Related Products
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products • NOS Regulation • Monoclonal Antibodies
 
 
ALX-803-302 Revised 06-Aug-07
Monoclonal Antibody to CHP1 (5E9G5)
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SYNONYMS anti-CHORD Containing Protein-1 MAb (5E9G5)
anti-CHORDC1 MAb (5E9G5)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Cell Stress, Oxidative Stress & Redox Signalling Other Products
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ALX-803-302-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: 5E9G5
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml
PURITY: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
PURITY DETAIL: Protein A-affinity purified.
IMMUNOGEN: Recombinant mouse CHP1 (CHORD containing protein-1).
SPECIFICITY: Recognizes human and mouse CHP1.
APPLICATION: ELISA
Immunocytochemistry (5µg/ml)
Immunohistochemistry (5µg/ml)
Immunoprecipitation (5µg per 5x106 cells)
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
General Literature References
Chp-1 and melusin, two CHORD containing proteins in vertebrates: M. Brancaccio, et al.; FEBS Lett. 551, 47 (2003) Abstract; Full Text
Further Categories Containing This Product:
Co-Chaperones & HSP-interacting Proteins / Related Products • Nod-complex / Related Products • Monoclonal Antibodies
 
 
ALX-803-301 Revised 31-Oct-06
Monoclonal Antibody to Melusin (human) (5E1)
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SYNONYMS anti-Integrin β1-binding Protein 2 (human) MAb (5E1)
anti-ITGB1BP2 (human) MAb (5E1)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Cell Stress, Oxidative Stress & Redox Signalling Other Products
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ALX-803-301-C100   100 µg 240.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: 5E1
ISOTYPE: Mouse IgG1
CONCENTRATION: 0.2mg/ml
PURITY: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
PURITY DETAIL: Protein A-affinity purified.
IMMUNOGEN: Recombinant human melusin (integrin β1-binding protein 2).
SPECIFICITY: Recognizes human melusin. Cross-reacts weakly with mouse melusin.
APPLICATION: ELISA
Immunocytochemistry (5µg/ml)
Immunohistochemistry (5µg/ml)
Immunoprecipitation
Western Blot (2µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
GSK-3 Other Products • Monoclonal Antibodies
 
 
ALX-804-872 Revised 30-Sep-08 New product
Monoclonal Antibody to TIGAR (human) (Woody-1)
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SYNONYMS anti-TP53-induced Glycolysis and Apoptosis Regulator (human) MAb (Woody-1)
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Glycobiology Other Products
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ALX-804-872-C100   100 µg 380.00 USD Add To Cart
Product Specification
CLONE: Woody-1
ISOTYPE: Mouse IgG2b
SOURCE/HOST: Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human TIGAR (aa 1-270).
SPECIFICITY: Recognizes human TIGAR.
APPLICATION: Immunoprecipitation (1:200)
Western Blot (1:1‘000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Related Products
Further Categories Containing This Product:
Cell Stress, Oxidative Stress & Redox Signalling Other Products • Cell Death / Apoptosis / Autophagy Other Products • Monoclonal Antibodies
 
 
ALX-210-872 Revised 11-Nov-05
Polyclonal Antibody to Bradykinin B2 Receptor