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Phosphatases / Related Products
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ALX-430-031 Revised 11-Jan-07
Allethrin
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SYNONYMS (R,S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,S)-cis,trans-chrysanthemate
Allylcinerin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-031-M010   10 mg 30.00 USD Add To Cart
ALX-430-031-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 584-79-2
MERCK INDEX: 14: 260
RTECS: GZ1925000
PURITY: ≥95% (HPLC)
APPEARANCE: Clear or whitish film.
SOLUBILITY: Soluble in DMSO or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalis.
HAZARD: HARMFUL.

Product Description
Type I pyrethroid, useful as a very weakly active "negative" control for inhibition of calcineurin (protein phosphatase 2B) by type II pyrethroids.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol 43, 1777 (1992) Abstract
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; TIPS 13, 236 (1992), (Review) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-250-001 Revised 05-Sep-06
4-Aminophenylphosphate . sodium salt
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Phosphatases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-250-001-M010   10 mg 30.00 USD Add To Cart
ALX-250-001-M050   50 mg 120.00 USD Add To Cart
ALX-250-001-M100   100 mg 195.00 USD Add To Cart
Product Specification
FORMULA: 188.1 . 23.0 . 72.1
MW: C6H7NO4P . Na . 4.0H2O
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to light gray crystalline solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Substrate for the electrochemical measurement of alkaline phosphatase.
 
 
ALX-151-019 Revised 15-Dec-04
cAMP-dependent Protein Kinase Substrate
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SYNONYMS PKA Substrate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKA Substrates
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-151-019-MC05   0.5 mg 95.00 USD Add To Cart
ALX-151-019-M001   1 mg 165.00 USD Add To Cart
Product Specification
SEQUENCE: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
FORMULA: C92H150N28O29
MW: 2112.4
PURITY: ≥95%
APPEARANCE: White powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Derived from the RII subunit of cAMP-dependent protein kinase (PKA). Substrate for PKA. Has been used in a non-radioactive assay of calcineurin (protein phosphatase 2B) for screening purposes.
Product Specific Literature References
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity: D.K. Blumenthal, et al.; J. Biol. Chem. 261, 8140 (1986) Abstract; Full Text
Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate: A. Enz, et al.; Anal. Biochem. 216, 147 (1994) Abstract
Further Categories Containing This Product:
PP2B [Calcineurin] / Related Products • Peptides
 
 
ALX-380-005 Revised 03-Apr-08
Ascomycin
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SYNONYMS Immunomycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Immunomodulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-005-M001   1 mg 125.00 USD Add To Cart
ALX-380-005-M005   5 mg 540.00 USD Add To Cart
Product Specification
FORMULA: C43H69NO12
MW: 792.0
CAS NUMBER: 11011-38-4
RTECS: CI75700000
SOURCE/HOST: Isolated from Streptomyces sp.
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibiotic. Ethyl analog of FK506 (Prod. No. ALX-380-008) with similar immunosuppressant properties. Inhibits calcineurin phosphatase.
Product Specific Literature References
Ascomycin, an antifungal antibiotic: T. Arai, et al.; J. Antibiot. (Tokyo) 15, 23 (1962) Abstract
NMR studies of an FK-506 analog, [U-13C]ascomycin, bound to FK-506-binding protein: A.M. Petros, et al.; J. Med. Chem. 35, 2467 (1992) Abstract
Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues: M. Kawai, et al.; FEBS Lett. 316, 107 (1993) Abstract
Enzymatic synthesis and immunosuppressive activity of novel desmethylated immunomycins (ascomycins): A. Shafiee, et al.; J. Antibiot. (Tokyo) 46, 1397 (1993) Abstract
Further Categories Containing This Product:
Antibiotics - Other Signal Transduction Pathway Modulators • PP2B [Calcineurin] / Related Products
 
 
ALX-350-144 Revised 03-Apr-08
Bakuchiol
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SYNONYMS 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-350-144-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C18H24O
MW: 256.4
CAS NUMBER: 10309-37-2
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brownish oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Specific Literature References
Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod. 51, 1084 (1988) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000) Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol. 78, 27 (2001) Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001) Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001) Abstract; Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol. 79, 57 (2002) Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol. 16, 1062 (2003) Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005) Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med. 71, 508 (2005) Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - DNA Replication Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Topoisomerase Inhibitors • Natural Products with Antibiotic Activity • Protein Tyrosine Phosphatases Other Products • Lipid Peroxidation • Natural Products - Antioxidants
 
 
ALX-430-032 Revised 24-Feb-05
Bioallethrin
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SYNONYMS D-trans-Allethrin
(S)-3-Allyl-2-methyl-4-oxocyclopent-2-enyl-(1R,3R)-2,2-dimethyl-3-(2-methyl-prop-1-enyl)cyclopropancarboxylate
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-032-M025   25 mg 90.00 USD Add To Cart
ALX-430-032-M100   100 mg 270.00 USD Add To Cart
Product Specification
FORMULA: C19H26O3
MW: 302.4
CAS NUMBER: 22431-63-6
PURITY: ≥97%
SOLUBILITY: Soluble in hot water, diluted acids or alkaline solutions; hardly soluble in cold water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Avoid alkalies.
HAZARD: HARMFUL.

Product Description
Although bioallethrin is a type I pyrethroid, its effects on calcineurin (protein phosphatase 2B) resembles those of type II pyrethrins. Unlike most type I pyrethrins, which are very weak, bioallethrin is a potent calcineurin inhibitor.
Product Specific Literature References
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol. 43, 1777 (1992) Abstract
Further Categories Containing This Product:
Pyrethroids
 
 
ALX-270-207 Revised 24-Jun-05
bpV(bipy)
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SYNONYMS Potassium bisperoxo (bipyridine) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-207-M005   5 mg 65.00 USD Add To Cart
ALX-270-207-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C10H8N2]
MW: 326.2
PURITY: ≥95%
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-270-204 Revised 24-Jun-08
bpV(phen)
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SYNONYMS Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
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ALX-270-204-M005   5 mg 53.00 USD Add To Cart
ALX-270-204-M025   25 mg 195.00 USD Add To Cart
Product Specification
FORMULA: K[VO(O2)2C12H8N2] . 3H2O
MW: 350.3 . 54.0
PURITY: ≥98% (51V-NMR)
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
IDENTITY: Identity determined by MS and 51V-NMR (D2O)

Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic in vitro and in vivo.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling: A.P. Bevan, et al.; J. Biol. Chem. 270, 10784 (1995) Abstract; Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency: A.P. Bevan, et al.; Am. J. Physiol. 268, E60 (1995) Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats: J.F. Yale, et al.; Diabetes 44, 1274 (1995) Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo: P.G. Drake, et al.; Endocrinology 137, 4960 (1996) Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ: C.J. Band & B.I. Posner; J. Biol. Chem. 272, 138 (1997) Abstract; Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1: K.J. Serio, et al.; J. Immunol. 170, 2121 (2003) Abstract; Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
 
 
ALX-270-205 Revised 12-Sep-08
bpV(pic)
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SYNONYMS Dipotassium bisperoxo (picolinato) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
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ALX-270-205-M005   5 mg 75.00 USD Add To Cart
ALX-270-205-M025   25 mg 275.00 USD Add To Cart
Product Specification
FORMULA: K2 [VO(O2)2C6H4NO2] . 2 H2O
MW: 331.2 . 36.0
PURITY: ≥95% (51V-NMR)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water (10mM).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Unstable in solution; reconstitute just prior to use.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H- and 51V-NMR.

Product Description
Potent protein phosphotyrosine phosphatase inhibitor.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics: B.I. Posner, et al.; J. Biol. Chem. 269, 4596 (1994) Abstract; Full Text
 
 
ALX-270-206 Revised 07-Dec-04
bpV(HOpic)
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SYNONYMS Dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V)
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Oxovanadates
Ordering Information
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ALX-270-206-M005   5 mg 75.00 USD Add To Cart
Product Specification
FORMULA: K2[VO(O2)2C6H4NO3]
MW: 347.2
PURITY: ≥90%
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Protein phosphotyrosine phosphatase inhibitor.