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Heme Oxygenase / Related Products
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ALX-270-022 Revised 09-Jan-08
AEBSF . hydrochloride
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SYNONYMS 4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc®SC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-022-M050   50 mg 40.00 USD Add To Cart
ALX-270-022-M250   250 mg 145.00 USD Add To Cart
ALX-270-022-G001   1 g 360.00 USD Add To Cart
Product Specification
FORMULA: C8H10FNO2S . HCl
MW: 203.2 . 36.5
CAS NUMBER: 30827-99-7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.

Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No. ALX-270-184). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide: B.R. Baker & H.J. Cory; J. Med. Chem. 14, 119 (1971) Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide: P. Megyeri, et al.; Immunology 86, 629 (1995) Abstract; Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF: M. Citron, et al.; Neuron 17, 171 (1996) Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor: Y. Nakabo & M.J. Pabst; J. Leukoc. Biol. 60, 328 (1996) Abstract; Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997) Abstract; Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999) Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis: R. Buitrago-Rey, et al.; J. Antimicrob. Chemother. 49, 871 (2002) Abstract; Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes: N. Wijayanti, et al.; J. Biol. Chem. 280, 21820 (2005) Abstract; Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression: T. Hosoi, et al.; Eur. J. Pharmacol. 554, 8 (2007) Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products • Cell Stress, Oxidative Stress & Redox Signalling Other Products • MAPK Pathway Activators • Fatty Acid Amide Hydrolase [FAAH] / Related Products
 
 
ALX-430-048 Revised 09-Nov-06
Copper(II) Protoporphyrin IX (free acid)
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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ALX-430-048-M025   25 mg 75.00 USD Add To Cart
Product Specification
FORMULA: C34H32CuN4O4
MW: 624.2
PURITY: ≥95%
APPEARANCE: Red to brown solid.
SOLUBILITY: Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base;  slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING: Protect from light and moisture.

Product Description
Negative control for the heme oxygenase inhibitor zinc protoporphyrin IX (Prod. No. ALX-430-049).
Product Specific Literature References
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin: R.J. Chernick, et al.; Hepatology 10, 365 (1989) Abstract
Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii: S.R. Glaum & R.J. Miller; Mol. Pharmacol. 43, 965 (1993) Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
 
 
ALX-430-049 Revised 25-May-07
Zinc(II) Protoporphyrin IX
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-049-M005   5 mg 20.00 USD Add To Cart
ALX-430-049-M025   25 mg 60.00 USD Add To Cart
ALX-430-049-M100   100 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C34H32N4O4Zn
MW: 626.0
CAS NUMBER: 15442-64-5
PURITY: ≥95% (TLC)
APPEARANCE: Dark red solid.
SOLUBILITY: Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base;  slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING: Protect from light and moisture.

Product Description
Potent and selective inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC50=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier.
Product Specific Literature References
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase: B. Brune & V. Ullrich; Mol. Pharmacol. 32, 497 (1987) Abstract
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function: G.S. Marks, et al.; Can. J. Physiol.Pharmacol. 71, 753 (1993) Abstract
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus: M. Zhuo, et al; Science 260, 1946 (1993) Abstract
Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats: C. Kadoya, et al.; Stroke 26, 1035 (1995) Abstract; Full Text
Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase: L. Ny, et al.; Br. J. Pharmacol. 115, 186 (1995) Abstract
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter: S. Chakder, et al.; J. Pharmacol. Exp. Ther. 277, 1376 (1996) Abstract
Inhibition of nitric oxide synthase isoforms by porphyrins: D.J. Wolff, et al.; Arch. Biochem. Biophys. 333, 27 (1996) Abstract
Pitfalls using metalloporphyrins in carbon monoxide research: L. Grundemar and L. Ny; TIPS 18, 193 (1997), (Review) Abstract
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock: S.F. Yet, et al.; J. Biol. Chem. 272, 4295 (1997) Abstract; Full Text
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity: L. Serfass and J.N. Burstyn; Arch. Biochem. Biophys. 359, 8 (1998) Abstract
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX: S. Rattan, et al.; Am. J. Physiol. 276, G138 (1999) Abstract; Full Text
Further Categories Containing This Product:
Heme Oxygenase / Related Products • Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products • NOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
ALX-430-050 Revised 13-Jun-03
Zinc(II) Deuteroporphyrin IX-2,4-bisethyleneglycol
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-050-M001   1 mg 30.00 USD Add To Cart
ALX-430-050-M005   5 mg 90.00 USD Add To Cart
ALX-430-050-M010   10 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C34H36N4O8Zn
MW: 694.1
PURITY: ≥85%
APPEARANCE: Dark purple solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Extremely potent inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO).
Product Specific Literature References
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin: R.J. Chernick, et al.; Hepatology 10, 365 (1989) Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
 
 
ALX-430-051 Revised 01-Jun-07
Tin Protoporphyrin IX . dichloride
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-051-M005   5 mg 45.00 USD Add To Cart
ALX-430-051-M025   25 mg 180.00 USD Add To Cart
Product Specification
FORMULA: C34H32N4O4SnCl2
MW: 750.3
PURITY: ≥95% (TLC)
APPEARANCE: Dark red solid.
SOLUBILITY: Soluble in aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Potent inhibitor of heme oxygenase.
Product Specific Literature References
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation: G.S. Drummond & A. Kappas; PNAS 78, 6466 (1981) Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
 
 
ALX-210-116 Revised 15-May-06
Polyclonal Antibody to Heme Oxygenase-1
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SYNONYMS anti-HO-1 PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Heme Oxygenase / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-116-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-30 (M1ERPQLDSMSQDL
SEALKEATKEVHIRAEN30) of N-terminal rat HO-1 (heme oxygenase-1).
SPECIFICITY: Recognizes human, mouse, rat, monkey and bovine HO-1. Detects a band of ~32kDa by Western blot. Does not cross-react with HO-2.
APPLICATION: Immunohistochemistry (paraffin sections (1:100))
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease: M.A. Smith, et al.; Am. J. Pathol. 145, 42 (1994) Abstract
RT-PCR assay for heme oxygenase-1 and heme oxygenase-2: a sensitive method to estimate cellular oxidative damage: R.K. Kutty, et al.; Ann. N. Y. Acad. Sci. 738, 427 (1994) Abstract
Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta: R.K. Kutty, et al.; J. Cell. Physiol. 159, 371 (1994) Abstract
Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea: R.K. Kutty, et al.; PNAS 92, 1177 (1995) Abstract
Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion: A.C. Zenclussen, et al.; Scand. J. Immunol. 55, 560 (2002) Abstract
Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface: A. Sollwedel, et al.; J. Immunol. 175, 4875 (2005) Abstract
Heme oxygenase as a therapeutic target in immunological pregnancy complications: A.C. Zenclussen, et al.; Int. Immunopharmacol. 5, 41 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Immunohistochemical staining of HO-1 in Alzheimer's diseased human brain with Prod. No. ALX-210-116 results in staining of the neurofibrillary tangles, senile plaque neurites and neurophil threads.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-523 Revised 30-Oct-06
Polyclonal Antibody to Biliverdin-IX α-Reductase (human)
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SYNONYMS anti-BLVRA (human) PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Heme Oxygenase / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-523-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From chicken.
PURITY DETAIL: Epitope-affinity purified IgY.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: Recombinant human BLVRA (biliverdin-IX α-reductase).
SPECIFICITY: Recognizes human BLVRA. Detects a band of ~40kDa by Western blot.
APPLICATION: Western Blot (0.1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
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