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ALX-101-003
Revised 07-May-03
β-Alanine
SYNONYMS
3-Aminopropionic acid
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-101-003-G001
1 g
15.00 USD
Product Specification
FORMULA:
C
3
H
7
NO
2
MW:
89.1
CAS NUMBER:
107-95-9
MERCK INDEX:
14:
205
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
ALX-105-005
Revised 20-May-08
N-Acetyl-L-cysteine
SYNONYMS
LNAL
N-Acetyl-3-mercaptoalanine
L-α-Acetamido-β-mercaptopropionic acid
NAC
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
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ALX-105-005-G001
1 g
16.00 USD
ALX-105-005-G005
5 g
27.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
3
S
MW:
163.2
CAS NUMBER:
616-91-1
MERCK INDEX:
14:
88
RTECS:
HA1660000
PURITY:
≥99%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in 5M hydrochloric acid (hot) (100mg/ml); also soluble in water or 100% ethanol; insoluble in chloroform or ether.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Specific Literature References
Modulation of platelet function by free radicals and free-radical scavengers:
D. Salvemini & R. Botting; TIPS
14
, 36 (1993), (Review)
Abstract
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells:
D. Salvemini, et al.; Br. J. Pharmacol.
108
, 162 (1993)
Abstract
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1:
H. Schenk, et al.; PNAS
91
, 1672 (1994)
Abstract
Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells:
J.C. Tsai, et al.; J. Biol. Chem.
271
, 3667 (1996)
Abstract
;
Full Text
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice:
E. Ho, et al.; Faseb. J.
13
, 1845 (1999)
Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells:
A. Iseki, et al.; Biochem. Biophys. Res. Commun.
276
, 88 (2000)
Abstract
Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells:
H. Kim, et al.; Free Radic. Biol. Med.
29
, 674 (2000)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-105-009
Revised 06-Jun-06
N-Methyl-D-aspartic acid
SYNONYMS
NMDA
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-009-M010
10 mg
23.00 USD
ALX-105-009-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
4
MW:
147.1
CAS NUMBER:
6384-92-5
MERCK INDEX:
14:
6662
RTECS:
CI9457000
PURITY:
≥98%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in dilute aqueous base; slightly soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Selective ionotropic NMDA receptor agonist.
Product Specific Literature References
Excitatory amino acid transmitters:
J.C. Watkins & R.H. Evans; Ann. Rev. Pharmacol. Toxicol.
21
, 165 (1981), (Review)
Abstract
NMDA receptors and ligands in the vertebrate CNS:
T.W. Stone & N.R. Burton; Progr. Neurobiol.
30
, 333 (1988), (Review)
Abstract
Further Categories Containing This Product:
Special Amino Acids
•
NMDA Receptors/Related Products
ALX-105-010
Revised 04-Dec-04
N-Methyl-L-aspartic acid
SYNONYMS
NMLA
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-105-010-M010
10 mg
20.00 USD
ALX-105-010-M050
50 mg
50.00 USD
Product Specification
FORMULA:
C
5
H
9
NO
4
MW:
147.1
CAS NUMBER:
4226-18-0
PURITY:
≥98%
APPEARANCE:
White crystalline powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Further Categories Containing This Product:
Special Amino Acids
ALX-106-012
Revised 02-Jun-06
S-Methyl-L-thiocitrulline . dihydrochloride
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-012-M010
10 mg
40.00 USD
ALX-106-012-M050
50 mg
150.00 USD
Product Specification
FORMULA:
C
7
H
15
N
3
O
2
S . 2HCl
MW:
205.3 . 73.0
CAS NUMBER:
209589-59-3
PURITY:
≥97%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and moisture. Hygroscopic. Packaged under inert gas.
Product Description
Inhibitor of neuronal nitric oxide synthase (nNOS; NOS I).
Product Specific Literature References
Potent and selective inhibition of human nitric oxide synthases. Selective inhibition of neuronal nitric oxide synthase by S-methyl-L- thiocitrulline and S-ethyl-L-thiocitrulline:
E.S. Furfine, et al.; J. Biol. Chem.
269
, 26677 (1994)
Abstract
;
Full Text
Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L- thiocitrulline: a new class of potent nitric oxide synthase inhibitors:
K. Narayanan & O.W. Griffith; J. Med. Chem.
37
, 885 (1994)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-106-013
Revised 04-Mar-05
L-Thiocitrulline . dihydrochloride
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-013-M010
10 mg
50.00 USD
ALX-106-013-M050
50 mg
145.00 USD
Product Specification
FORMULA:
C
6
H
13
N
3
O
2
S . 2HCl
MW:
191.3 . 73.0
CAS NUMBER:
212051-53-1
PURITY:
≥97%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Inhibitor of neuronal (nNOS; NOS I) and inducible (iNOS; NOS II) nitric oxide synthase.
Product Specific Literature References
L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric- oxide synthases:
C. Frey, et al.; J. Biol. Chem.
269
, 26083 (1994)
Abstract
;
Full Text
Synthesis of L-thiocitrulline, L-homothiocitrulline, and S-methyl-L- thiocitrulline: a new class of potent nitric oxide synthase inhibitors:
K. Narayanan & O.W. Griffith; J. Med. Chem.
37
, 885 (1994)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-106-015
Revised 07-Dec-04
L-allo-Isoleucine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-015-G001
1 g
110.00 USD
Product Specification
FORMULA:
C
6
H
13
NO
2
MW:
131.2
CAS NUMBER:
1509-34-8
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Keep cool and dry.
Further Categories Containing This Product:
Special Amino Acids
ALX-106-016
Revised 06-Jun-06
D-allo-Isoleucine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
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ALX-106-016-G001
1 g
80.00 USD
Product Specification
FORMULA:
C
6
H
13
NO
2
MW:
131.2
CAS NUMBER:
1509-35-9
RTECS:
BA2930000
PURITY:
≥98%
APPEARANCE:
White to off-white crystalline solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Further Categories Containing This Product:
Special Amino Acids
ALX-106-017
Revised 04-Mar-05
L-Pipecolic acid . hydrochloride
SYNONYMS
L-(-)-Pipecolinic acid . HCl
PRODUCT LINE
Combinatorial Chemistry
PRODUCT CATEGORY
Special Amino Acids
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ALX-106-017-M050
50 mg
30.00 USD
Product Specification
FORMULA:
C
6
H
11
NO
2
. HCl
MW:
129.2 . 36.5
CAS NUMBER:
3105-95-1
PURITY:
≥98%
APPEARANCE:
White powder.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Lysine metabolite. Defect in its catabolism is involved in hyperpipecolic acidemia, cerebro-hepato-renal syndrome, neonatal onset adrenoleukodystrophy, and infantile Refsum disease. Apoptosis inducer in neuronal cells.
Product Specific Literature References
L-pipecolic acid oxidation in the rabbit and cynomolgus monkey. Evidence for differing organellar locations and cofactor requirements in each species:
S.J. Mihalik & W.J. Rhead; J. Biol. Chem.
264
, 2509 (1989)
Abstract
;
Full Text
Pipecolic acid induces apoptosis in neuronal cells
:
S. Matsumoto, et al.; Brain Res.
980
, 179 (2003)
Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products
ALX-106-020
Revised 28-Jan-05
3-Nitro-L-tyrosine
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
Nitrotyrosine/Related Products
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ALX-106-020-G001
1 g
25.00 USD
ALX-106-020-G005
5 g
90.00 USD
Product Specification
FORMULA:
C
9
H
10
N
2
O
5
MW:
226.2
CAS NUMBER:
621-44-3
PURITY:
≥98%
APPEARANCE:
Yellow to yellow-green powder.
SOLUBILITY:
Soluble in acidic aqueous solution (e. g. 1N hydrochloric acid).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Nitrotyrosine is the major product from the spontaneous reaction of peroxynitrite with tyrosine. Formation of nitrotyrosine
in vivo
can indicate the formation of peroxynitrite by a nitric oxide (NO)-dependent oxidative damage.
Product Specific Literature References
Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase:
H. Ischiropoulos, et al.; Arch. Biochem. Biophys.
298
, 431 (1992)
Abstract
Extensive nitration of protein tyrosines in human atherosclerosis detected by immunohistochemistry:
J.S. Beckman, et al.; Biol. Chem. Hoppe-Seyler
375
, 81 (1994)
Abstract
Peroxynitrite-mediated oxidative protein modifications:
H. Ischiropoulos & A.B. Al-Mehdi; FEBS Lett.
364
, 279 (1995)
Abstract
Detection and quantitation of nitrotyrosine residues in proteins: in vivo marker of peroxynitrite:
J.P. Crow, et al.; Meth. Enzymol.
269
, 185 (1996)
Abstract
Antibodies that recognize nitrotyrosine:
Y.Z. Ye, et al.; Meth. Enzymol.
269
, 201 (1996)
Abstract
Further Categories Containing This Product:
Special Amino Acids
ALX-106-023
Revised 13-Dec-02
5-Hydroxy-L-tryptophan
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Serotonergics & Serotonin Receptors/Related Products
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ALX-106-023-M500
500 mg
20.00 USD
Product Specification
FORMULA:
C
11
H
12
N
2
O
3
MW:
220.2
CAS NUMBER:
56-69-9
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Serotonin precursor.
Further Categories Containing This Product:
Special Amino Acids
•
Glutamate Receptors (Metabotropic)/Related Products
ALX-106-024
Revised 06-Jun-06
O-Phospho-L-serine
SYNONYMS
L-Phosphoserine
L-Serine-O-phosphate
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
NMDA Receptors/Related Products
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ALX-106-024-G001
