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Superoxide Dismutases [SODs] / Related Products
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ALX-430-069 Revised 25-Jan-08
MnTBAP chloride
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SYNONYMS Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-069-M010   10 mg 20.00 USD Add To Cart
ALX-430-069-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C48H28MnN4O8Cl
MW: 879.2
PURITY: ≥97%
APPEARANCE: Black crystalline powder.
SOLUBILITY: Dissolve at 0.1M in aqueous base, then buffer to pH 7.0 or higher as needed.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.

Product Description
Cell permeable SOD mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO).
Product Specific Literature References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994) Abstract; Full Text
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275, 1227 (1995) Abstract
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett. 381, 82 (1996) Abstract
Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation: P. Ghafourifar, et al.; J. Biol. Chem. 274, 31185 (1999) Abstract; Full Text
Reactive oxygen species regulate activation-induced T cell apoptosis:: D.A. Hildeman, et al.; Immunity 10, 735 (1999) Abstract
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen.: S. Kotamraju, et al.; J. Biol. Chem. 275, 33585 (2000) Abstract; Full Text
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols: R. Motterlini, et al.; J. Biol. Chem. 275, 13613 (2000) Abstract; Full Text
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis: H. Dussmann, et al.; J. Biol. Chem. 278, 12645 (2003) Abstract; Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Superoxide Dismutases [SODs] / Related Products
 
 
ALX-430-070 Revised 05-Mar-08
MnTMPyP . pentachloride
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SYNONYMS Manganese (III) tetrakis (1-methyl-4-pyridyl)porphyrin . 5Cl-
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Porphyrins
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-070-M010   10 mg 20.00 USD Add To Cart
ALX-430-070-M050   50 mg 50.00 USD Add To Cart
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Product Specification
FORMULA: C44H36MnN8Cl5
MW: 909.0
PURITY: ≥95%
APPEARANCE: Black crystalline powder.
SOLUBILITY: Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY:

Prepare solutions immediately before experiments. We recommend using fresh preparations each day.

Product Description
Cell permeable SOD mimetic. Catalyzes the dismutation of O2- even in the presence of excess EDTA.
Product Specific Literature References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994) Abstract; Full Text
A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli: S.I. Liochev & I. Fridovich; Arch. Biochem. Biophys. 321, 271 (1995) Abstract
Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys. 325, 20 (1996) Abstract
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem. 273, 24521 (1998) Abstract; Full Text
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol. 53, 795 (1998) Abstract
SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells: R. Morandini, et al.; Cell. Mol. Biol. (Noisy-le-grand) 45, 1053 (1999) Abstract
Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta: A. MacKenzie, et al.; Br. J. Pharmacol. 127, 1159 (1999) Abstract
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure: A.A. Miller, et al.; Br. J. Pharmacol. 131, 29 (2000) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • NOS Inhibitors (NOS Induction & Enzyme Activity) • Superoxide Dismutases [SODs] / Related Products
 
 
ALX-202-022 Revised 01-Oct-07
Cu/Zn-Superoxide Dismutase (bovine liver)
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SYNONYMS SOD (Cu/Zn) (bovine liver)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Superoxide Dismutases [SODs] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-202-022-UT50   5 KU 40.00 USD Add To Cart
ALX-202-022-5T50   5x5 KU 160.00 USD Add To Cart
ALX-202-022-UZ50   50 KU 170.00 USD Add To Cart
ALX-202-022-5Z50   5x50 KU 660.00 USD Add To Cart
Product Specification
MW: ~31kDa.
CAS NUMBER: 9054-89-11
EC: 1.15.1.1
SOURCE/HOST: Isolated from bovine liver.
FORMULATION: Lyophilized. Essentially salt free.
RECONSTITUTION: Reconstitute with distilled water, saline or neutral buffer to give a clear slightly blue solution.
SPECIFIC ACTIVITY: ~4'600U/mg protein. One unit is defined as the amount of enzyme that inhibits the rate of reduction of ferricytochrome c by 50% at 25°C, pH 7.8 (J.M. McCord & I. Fridovich; J. Biol. Chem. 244, 6049 (1969)).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY:

Reconstituted product should be stored at +4° and is stable for up to 2 days.
HANDLING: Avoid freeze/thaw cycles.
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P00442: Cu/Zn Superoxide Dismutase (bovine)
Further Categories Containing This Product:
Enzymes • Natural Proteins
 
 
ALX-804-265 Revised 11-Mar-08
Monoclonal Antibody to MnSOD (human) (MnS-1)
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SYNONYMS anti-Manganese Superoxide Dismutase (human) MAb (MnS-1)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Superoxide Dismutases [SODs] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-265-C100   100 µg 259.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: MnS-1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Liquid. In PBS.
IMMUNOGEN: Human MnSOD (manganese superoxide dismutase).
SPECIFICITY: Recognizes human MnSOD.
APPLICATION: Immunohistochemistry (frozen sections): 0.5-10µg/ml. Use to stain both indirectly or directly acetone-fixed cryostat sections or cell smears; recommended is the alkaline phosphatase-anti-alkaline-phosphatase (APAAP) or peroxidase anti-peroxidase (PAP) procedure or the three stage immunoperoxidase technique on acetone-fixed cryostat sections.
Western Blot.
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
ALX-850-033 Revised 17-Apr-08
Cu/Zn-Superoxide Dismutase ELISA Kit
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SYNONYMS SOD (Cu/Zn) ELISA Kit
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Superoxide Dismutases [SODs] / Related Products
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ALX-850-033-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.04ng/ml (range 0.08 to 5ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human Cu/Zn SOD in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
Late stages of apoptosis are characterized by the loss of membrane integrity and a release of the intracellular Cu/Zn SOD.
Product Specific Literature References
A highly sensitive non-radioactive cytotoxicity assay for human target cells: L. Franke & T. Porstmann; J. Immunol. Methods 171, 259 (1994) Abstract
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
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