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ALX-350-335
Revised 14-Nov-07
Cochlioquinone A
SYNONYMS
Luteoleersin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-335-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
30
H
44
O
8
MW:
532.7
CAS NUMBER:
32450-25-2
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Shows antiangiogenic and nematocidal activities. Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of diacylglycerol acyltransferase, diacylglycerol kinase and NADH-ubiquinone reductase.
Product Specific Literature References
Cochlioquinone A, a nematocidal agent which competes for specific [3H]ivermectin binding sites:
J.M. Schaeffer, et al.; J. Antibiot. (Tokyo)
43
, 1179 (1990)
Abstract
Epi-cochlioquinone A, a novel acyl-CoA : cholesterol acyltransferase inhibitor produced by Stachybotrys bisbyi:
T. Fujioka, et al.; J. Antibiot. (Tokyo)
49
, 409 (1996)
Abstract
Cochlioquinone A1, a new anti-angiogenic agent from Bipolaris zeicola:
H.J. Jung, et al.; Bioorg. Med. Chem.
11
, 4743 (2003)
Abstract
Inhibitory activity of diacylglycerol acyltransferase by cochlioquinones A and A1:
H.B. Lee, et al.; J. Antibiot. (Tokyo)
56
, 967 (2003)
Abstract
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
Vitamins
•
NAD+ Metabolism / Related Products
ALX-350-341
Revised 14-Nov-07
Cochlioquinone B
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products for Angiogenesis Research
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ALX-350-341-MC05
0.5 mg
260.00 USD
Product Specification
FORMULA:
C
28
H
40
O
6
MW:
472.6
CAS NUMBER:
32450-26-3
SOURCE/HOST:
Isolated from
Bipolaris leersia
MST-FP107.
PURITY:
≥99% (HPLC)
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antagonist of the human chemokine receptor CCR5 in human immunodeficiency virus type 1 (HIV-1). Inhibitor of NADH-ubiquinone reductase. Phytotoxic agent inhibiting root growth.
Product Specific Literature References
Cochlioquinones and epi-cochlioquinones: antagonists of the human chemokine receptor CCR5 from Bipolaris brizae and Stachybotrys chartarum:
K. Yoganathan, et al.; J. Antibiot. (Tokyo)
57
, 59 (2004)
Abstract
Further Categories Containing This Product:
CC Chemokines & Receptors / Related Products
•
Vitamins
•
NAD+ Metabolism / Related Products
ALX-804-489
Revised 02-Jun-05
Monoclonal Antibody to CCL1 (human) (8P16-N4-L21)
SYNONYMS
anti-I-309 (human) MAb (8P16-N4-L21)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
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ALX-804-489-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
8P16-N4-L21
ISOTYPE:
Mouse IgM
CONCENTRATION:
1mg/ml
PURITY DETAIL:
DEAE purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
Recombinant human CCL1 (I-309).
SPECIFICITY:
Recognizes human CCL1.
APPLICATION:
Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-594
Revised 10-Jun-05
Monoclonal Antibody to CCL2 (human) (5J.1)
SYNONYMS
anti-MCP-1 (human) MAb (5J.1)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5J.1)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
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ALX-804-594-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5J.1
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
Immunohistochemistry (frozen sections (5µg/ml))
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-465
Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (5D3-F7)
SYNONYMS
anti-MCP-1 (human) MAb (5D3-F7)
anti-Monocyte Chemotactic Protein-1 (human) MAb (5D3-F7)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
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ALX-804-465-C100
100 µg
350.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5D3-F7
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Purified antibody in PBS containing 0.1% sodium azide.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
ELISA (capture)
Immunocytochemistry (1:1'000)
Immunohistochemistry (frozen sections, paraffin sections (1:250-1:500))
Immunoprecipitation
Western Blot (1:1'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
A new monoclonal antibody (5D3-F7) which recognizes human monocyte chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells
:
G. Peri, et al.; J. Immunol. Methods
174
, 249 (1994)
Abstract
Analysis of the Gene Expression Profile Activated by the CC Chemokine Ligand 5/RANTES and by Lipopolysaccharide in Human Monocytes:
M. Locati, et al.; J. Immunol.
168
, 3557 (2002)
Full Text
Human Pancreatic Islets Produce and Secrete MCP-1/CCL2: Relevance in Human Islet Transplantation:
L. Piemonti, et al.; Diabetes
51
, 55 (2002)
Full Text
Further Categories Containing This Product:
Osteocalcin & Matrix Gla-protein [MGP] Family / Related Products
•
Monoclonal Antibodies
ALX-804-549
Revised 29-Feb-08
Monoclonal Antibody to CCL2 (human) (D9)
SYNONYMS
anti-MCP-1 (human) MAb (D9)
anti-Monocyte Chemotactic Protein-1 (human) MAb (D9)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
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ALX-804-549-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
D9
ISOTYPE:
Mouse IgG1
CONCENTRATION:
1mg/ml
FORMULATION:
Liquid. Protein G purified antibody in PBS.
IMMUNOGEN:
Recombinant human CCL2 (monocyte chemotactic protein-1; MCP-1).
SPECIFICITY:
Recognizes human CCL2.
APPLICATION:
Immunoprecipitation
Western Blot (5µg/ml)
Functional Application (blocks CCL2 [MCP-1]; 2µg/ml)
Not recommended for immunohistochemistry.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-470
Revised 10-May-06
Monoclonal Antibody to CCL22 (human) (152/11)
SYNONYMS
anti-MDC (human) MAb (152/11)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
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ALX-804-470-C250
250 µg
540.00 USD
ALX-804-470E-C250
Peroxidase
250 µg
580.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
152/11
ISOTYPE:
Rat IgG
CONCENTRATION:
ALX-804-470
: 2.3mg/ml
ALX-804-470E
: 0.36mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
ALX-804-470
: Liquid. In PBS, pH 7.4.
ALX-804-470E
: Liquid. In PBS, pH 7.4, containing 0.2% bronidox and 0.05% phenol.
IMMUNOGEN:
Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY:
Recognizes human CCL22.
APPLICATION:
ALX-804-470
: Western Blot (2-4µg/ml)
Detection Limit: 0.2µg/lane.
ALX-804-470E
: ELISA (detection (1-2µ/ml))
Use microtiter plates coated with primary antibody (Prod. No.
ALX-804-469
, MAb to CCL22 (human) (349/6) at 20µg/ml in 0.05M carbonate/bicarbonate buffer, pH 9.6) to detect human fractalkine.
Detection Limit: ~60pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
SHIPPING:
SHIPPED ON BLUE ICE
USE/STABILITY:
ALX-804-470
: Short Term Storage: +4°C. Long Term Storage: After opening, prepare aliquots and store at -20°C.
ALX-804-470E
: Long Term Storage: +4°C.
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-469
Revised 07-May-08
Monoclonal Antibody to CCL22 (human) (349/6)
SYNONYMS
anti-MDC (human) MAb (349/6)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
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ALX-804-469-C250
250 µg
540.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
349/6
ISOTYPE:
Rat IgG
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN:
Recombinant human CCL22 (macrophage-derived chemokine; MDC).
SPECIFICITY:
Recognizes human CCL22.
APPLICATION:
ELISA
(capture (20µg/ml))
Use microtiter plates coated with this antibody in 0.05M carbonate/bicarbonate buffer, pH 9.6, in combination with secondary antibody (Prod. No.
ALX-804-470
, MAb to CCL22 (human) (152/11)) at 1-2µg/ml to detect human MDC.
Detection Limit: ~40pg/ml.
Substrate: 0.26mg/ml tetramethyl benzydine and 0.01% hydrogen peroxide stabilized in 0.05M citrate buffer, pH 3.8.
Western Blot
(1-2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Preservative may be added for storage at +4°C.
HANDLING:
For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-804-591
Revised 20-Nov-06
Monoclonal Antibody to CCR3 (human) (5E8)
SYNONYMS
anti-C-C Chemokine Receptor 3 (human) MAb (5E8)
anti-Eotaxin Receptor (human) MAb (5E8)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
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Unit Price:
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ALX-804-591-C100
100 µg
220.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE:
5E8
ISOTYPE:
Mouse IgG2a
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS.
IMMUNOGEN:
L1.2 cells expressing human CCR3 (C-C Chemokine Receptor 3).
SPECIFICITY:
Recognizes human CCR3.
APPLICATION:
Flow Cytometry
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Monoclonal Antibodies
ALX-210-641
Revised 25-Sep-07
Polyclonal Antibody to CCR3 (mouse)
SYNONYMS
anti-C-C Chemokine Receptor 3 (mouse) PAb
anti-Eotaxin Receptor (mouse) PAb
anti-CD193 (mouse) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
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ALX-210-641-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST:
From goat.
CONCENTRATION:
2mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 5-29 (T
5
DEIKTVVESFETTPYEYEWAPPC
28
) of the N-terminal extracellular domain of mouse CCR3 (C-C Chemokine Receptor 3).
SPECIFICITY:
Recognizes mouse CCR3.
APPLICATION:
Immunocytochemistry (>1:400)
Immunohistochemistry (paraffin sections (>1:250))
Western Blot (>1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-066
.
Product Images
Please click on thumbnails to enlarge.
Related Products
ALX-153-066
Blocking Peptide for PAb to CCR3 (mouse) (Prod. No.
ALX-210-641
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-620
Revised 25-Jan-07
Polyclonal Antibody to CCR1 (human)
SYNONYMS
anti-C-C Chemokine Receptor 1 (human) PAb
anti-CD191 (human) PAb
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
CC Chemokines & Receptors / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-210-620-C200
200 µg
340.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From goat.
CONCENTRATION:
1mg/ml.
PURITY DETAIL:
Epitope-affinity purified IgG.
FORMULATION:
Liquid. In PBS containing 1mg/ml BSA and 0.1% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 7-24 (T
7
EDYDTTTEFDY
GDATPC
24
) of the N-terminal extracellular domain of human CCR1 (C-C chemokine receptor 1).
SPECIFICITY:
Recognizes human CCR1. Does not cross-react with mouse CCR1.
APPLICATION:
Immunocytochemistry (1:400)
Western Blot (1:1’000)
QUALITY CONTROL:
Immunocytochemistry on human peripheral blood leukocytes.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap.
BLOCKING PEPTIDE:
For Blocking Peptide see Prod. No.
ALX-153-019
.
Product Description
CCR1 is a receptor for macrophage inflammatory protein-1α (MIP-1α) and RANTES, expressed in peripheral blood lymphocytes and monocytes (but not neutrophils). The antibody is useful in determining the number of CCR1 positive cells and in detecting any changes in the level of CCR1 expression in cells present at the site of inflammation.
General Literature References
Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor
:
K. Neote, et al.; Cell
72
, 415 (1993)
Abstract
Related Products
ALX-153-019
Blocking Peptide for PAb to CCR1 (human) (Prod. No.
ALX-210-620
and
ALX-210-741
)
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-741
Revised 25-Jan-07
Polyclonal Antibody to CCR1 (human)
