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Items 24 of 24
ALX-201-006
Revised 04-Sep-08
N-Acetyl-eglin C (recombinant)
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-201-006-MC01
0.1 mg
95.00 USD
ALX-201-006-MC05
0.5 mg
380.00 USD
ALX-201-006-M001
1 mg
670.00 USD
Product Specification
SEQUENCE:
Ac-Thr-Glu-Phe-Gly-Ser-Glu-Leu-Lys-Ser-Phe-Pro-Glu-Val-Val-Gly-Lys-Thr-Val-Asp-Gln-Ala-Arg-Glu-Tyr-Phe-Thr-Leu-His-Tyr-Pro-Gln-Tyr-Asn-Val-Tyr-Phe-Leu-Pro-Glu-Gly-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-Asp-Arg-Val-Arg-Val-Phe-Tyr-Asn-Pro-Gly-Thr-Asn-Val-Val-Asn-His-Val-Pro-His-Val-Gly-OH
FORMULA:
C
377
H
552
N
96
O
107
MW:
8141.1
CAS NUMBER:
96380-69-7
SOURCE/HOST:
Produced in
E. coli
.
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Product Description
Eglin C was originally isolated from the leech
Hirudo medicinalis
[1]. Recombinant N-acetyl-eglin C is a 70 amino acid peptide with identical biological activity to native eglin C. An effective inhibitor of chymotrypsin and subtilisin as well as of leukocyte elastase and cathepsin G.
Product Specific Literature References
[1]
Structure of the elastase-cathepsin G inhibitor of the leech Hirudo medicinalis:
U. Seemüller, et al.; Hoppe-Seyler's Z. Physiol. Chem.
361
, 1841 (1980)
Abstract
[2]
A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leech Hirudo medicinalis and its expression in E. coli:
H. Rink, et al.; Nucl. Acids Res.
12
, 6369 (1984)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link P01051:
Eglin C (Hirudo medicinalis)
Further Categories Containing This Product:
Proteases Other Products
•
Recombinant Proteins / Fusion Proteins
ALX-270-022
Revised 09-Jan-08
AEBSF . hydrochloride
SYNONYMS
4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc
®
SC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-022-M050
50 mg
40.00 USD
ALX-270-022-M250
250 mg
145.00 USD
ALX-270-022-G001
1 g
360.00 USD
Product Specification
FORMULA:
C
8
H
10
FNO
2
S . HCl
MW:
203.2 . 36.5
CAS NUMBER:
30827-99-7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No.
ALX-270-184
). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide:
B.R. Baker & H.J. Cory; J. Med. Chem.
14
, 119 (1971)
Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide:
P. Megyeri, et al.; Immunology
86
, 629 (1995)
Abstract
;
Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF:
M. Citron, et al.; Neuron
17
, 171 (1996)
Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor:
Y. Nakabo & M.J. Pabst; J. Leukoc. Biol.
60
, 328 (1996)
Abstract
;
Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds:
V. Diatchuk, et al.; J. Biol. Chem.
272
, 13292 (1997)
Abstract
;
Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening:
P. Megyeri, et al.; Eur. J. Pharmacol.
374
, 207 (1999)
Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis:
R. Buitrago-Rey, et al.; J. Antimicrob. Chemother.
49
, 871 (2002)
Abstract
;
Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes:
N. Wijayanti, et al.; J. Biol. Chem.
280
, 21820 (2005)
Abstract
;
Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression:
T. Hosoi, et al.; Eur. J. Pharmacol.
554
, 8 (2007)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
•
MAPK Pathway Activators
•
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-260-093
Revised 22-May-06
Antipain
SYNONYMS
[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
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ALX-260-093-M005
5 mg
35.00 USD
ALX-260-093-M025
25 mg
130.00 USD
Product Specification
SEQUENCE:
[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal
FORMULA:
C
27
H
44
N
10
O
6
. 2HCl
MW:
604.7 . 73.0
CAS NUMBER:
37682-72-7
SOURCE/HOST:
Synthetic.
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water, methanol, 100 % ethanol or acetonitrile.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Inhibits papain and trypsin and to a small extent plasmin. Antipain is more specific for papain and trypsin than is leupeptin (Prod. No.
ALX-260-009
). The inhibitory potency of antipain is 100-fold higher than that of elastatinal. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.
Product Specific Literature References
Antipain, a new protease inhibitor isolated from actinomycetes:
H. Suda, et al.; J. Antibiot.
25
, 263 (1972)
Abstract
Structures and activities of protease inhibitors of microbial origin
:
H. Umezawa; Meth. Enzymol.
45
, 678 (1976)
Abstract
ALX-620-080
Revised 23-May-06
bADA
SYNONYMS
Dibenzyl-1-[(R)-biotin-6-aminohexanoyl-aziridine]-2,3-(S,S+R,R)-dicarboxylate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
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ALX-620-080-M002
2 mg
540.00 USD
Product Specification
FORMULA:
C
34
H
42
N
4
O
7
S
MW:
650.8
CAS NUMBER:
744207-03-02
PURITY:
≥98% (HPLC)
APPEARANCE:
White to yellow solid.
SOLUBILITY:
Soluble in DMSO (50mg/ml), 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Irreversible, cell permeable, biotin-labelled inhibitor of cysteine proteases.
Product Specific Literature References
Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate:
C. Gelhaus, et al.; Biol. Chem.
385
, 435 (2004)
Abstract
Blocking effect of a biotinylated protease inhibitor on the egress of Plasmodium falciparum merozoites from infected red blood cells:
C. Gelhaus, et al.; Biol. Chem.
386
, 499 (2005)
Abstract
Further Categories Containing This Product:
Cathepsin Inhibitors
ALX-260-037
Revised 30-May-07
Calpain Inhibitor I
SYNONYMS
Ac-LL-Norleucinal
Ac-Leu-Leu-Nle-CHO
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calpains / Related Products
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ALX-260-037-M010
10 mg
80.00 USD
ALX-260-037-M050
50 mg
310.00 USD
Product Specification
FORMULA:
C
20
H
37
N
3
O
4
MW:
383.5
CAS NUMBER:
110044-82-1
SOURCE/HOST:
Synthetic.
PURITY:
≥96% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and moisture.
Product Description
Inhibits calpain I (K
i
=190nM), calpain II (K
i
=220nM), cathepsin B (K
i
=150nM) and cathepsin L (K
i
=0.5nM). Inhibits neutral cysteine proteases and the proteasome. Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with the transcription of inducible nitric oxide synthase (iNOS; NOS II). Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex.
Product Specific Literature References
Serine and cysteine proteinase inhibitors prevent nitric oxide production by activated macrophages by interfering with transcription of the inducible NO synthase gene:
J.M. Griscavage, et al.; BBRC
215
, 721 (1995)
Abstract
Further Categories Containing This Product:
Proteasome / Related Products
•
Cathepsin Inhibitors
•
Proteases Other Products
ALX-260-006
Revised 14-Jul-03
Chloroacetyl-HOLeu-Ala-Gly-NH2
SYNONYMS
N-Chloroacetyl-N-hydroxy-L-leucyl-L-alanyl-glycine amide
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
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ALX-260-006-M001
1 mg
62.00 USD
ALX-260-006-M005
5 mg
245.00 USD
Product Specification
FORMULA:
C
13
H
23
N
4
O
5
Cl
MW:
350.8
SOURCE/HOST:
Synthetic.
PURITY:
≥99%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of
P. aeruginosa
elastase.
Product Specific Literature References
Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand:
N. Nishino & J.C. Powers; J. Biol. Chem.
255
, 3482 (1980)
Abstract
;
Full Text
ALX-260-005
Revised 03-Mar-05
Chymostatin
SYNONYMS
(S)-1-Carboxy-2-phenylethyl)-carbamoyl-α-[2-iminohexahydro-4(S)-pyrimidyl]-(S)-glycyl-X-phenylalaninal
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
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ALX-260-005-M001
1 mg
22.00 USD
ALX-260-005-M005
5 mg
75.00 USD
Product Specification
FORMULA:
C
21
H
38
N
4
O
8
MW:
605.0 (average)
CAS NUMBER:
9076-44-2
SOURCE/HOST:
Microbial.
SOLUBILITY:
Soluble in DMSO (20 mg/ml) or glacial acetic acid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of serine proteinases having a chymotrypsin-like specificity like α-, β-, δ- and γ-chymotrypsin, chymases, cathepsin G, and most cysteine proteinases including papain and cathepsin A, B, H, and L. Mixture of type A (R=L-Leu), type B (R=L-Val), type C (R=L-Ile).
Product Specific Literature References
Chymostatin, a new chymotrypsin inhibitor produced by actinomycetes:
H. Umezawa, et al.; J. Antibiot.
23
, 425 (1970)
Abstract
Further Categories Containing This Product:
Proteases Other Products
ALX-260-007
Revised 16-Feb-05
E-64
SYNONYMS
N-[N-(L-3-
trans
-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine
L-
trans
-Epoxysuccinyl-leucylamide-(4-guanido)-butane
PRODUCT LINE
Cancer
PRODUCT CATEGORY
Cathepsin Inhibitors
Ordering Information
Product Numbers:
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ALX-260-007-M005
5 mg
55.00 USD
ALX-260-007-M025
25 mg
195.00 USD
Product Specification
FORMULA:
C
15
H
27
N
5
O
5
MW:
357.4
CAS NUMBER:
66701-25-5
SOURCE/HOST:
Synthetic.
PURITY:
≥99%
SOLUBILITY:
Soluble in DMSO or water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Irreversible inhibitor of cysteine proteinases like papain, cathepsin B and L. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases.
Product Specific Literature References
K. Hanada, et al.; Agric. Biol. Chem.
42
, 529 (1978)
K. Hanada, et al.; Agric. Biol. Chem.
42
, 523 (1978)
Further Categories Containing This Product:
Proteases Other Products
ALX-270-014
Revised 17-Jul-06
Ebelactone B
SYNONYMS
2-Ethyl-3,11-dihydroxy-4,6,8,10,12-pentamethyl-9-oxo-6-tetradecenoic 1,3-lactone
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Aminopeptidases / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-270-014-M001
1 mg
95.00 USD
ALX-270-014-M005
5 mg
380.00 USD
Product Specification
FORMULA:
C
21
H
36
O
4
MW:
352.5
CAS NUMBER:
76808-15-6
SOURCE/HOST:
Microbial.
PURITY:
≥99%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of esterases, lipases, N-formylmethionine aminopeptidase and carboxypeptidase Y-like kinase (CPY).
Product Specific Literature References
Ebelactone, an inhibitor of esterase, produced by actinomycetes:
H. Umezawa, et al.; J. Antibiot. (Tokyo)
33
, 1594 (1980)
Abstract
Identification of an isoprenylated cysteine methyl ester hydrolase activity in bovine rod outer segment membranes:
E.W. Tan & R.R. Rando; Biochemistry
31
, 5572 (1992)
Abstract
Structural studies on ebelactone A and B, esterase inhibitors produced by actinomycetes:
K. Uotani, et al.; J. Antibiot. (Tokyo)
35
, 1495 (1982)
Abstract
Biosynthetic studies of ebelactone A and B by 13C NMR spectrometry:
K. Uotani, et al.; J. Antibiot. (Tokyo)
35
, 1670 (1982)
Abstract
Diuretic and natriuretic effect of ebelactone B in anesthetized rats by inhibition of a urinary carboxypeptidase Y-like kininase:
M. Majima, et al.; Jpn. J. Pharmacol.
65
, 79 (1994)
Abstract
Inhibition of kinin degradation on the luminal side of renal tubules reduces high blood pressure in deoxycorticosterone acetate salt-treated rats:
S. Nakajima, et al.; Clin. Exp. Pharmacol. Physiol.
27
, 80 (2000)
Abstract
Further Categories Containing This Product:
Proteases Other Products
ALX-201-240
Revised 25-Jan-07
Elafin (human) (recombinant)
SYNONYMS
ESI (human) (recombinant)
Elastase-specific Inhibitor (human) (recombinant)
SKALP (human) (recombinant)
Skin-derived Antileukoproteinase (human) (recombinant)
Protease Inhibitor WAP3 (human) (recombinant)
PRODUCT LINE
Immunology
PRODUCT CATEGORY
Antimicrobial Peptides & Proteins / Related Products
Ordering Information
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Format:
Size:
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ALX-201-240-C100
100 µg
275.00 USD
Product Specification
MW:
~6kDa
SOURCE/HOST:
Produced in yeast.
PURITY:
≥90% (HPLC, SDS-PAGE)
FORMULATION:
Lyophilized.
RECONSTITUTION:
Reconstitute in sterile distilled water. Further dilutions should be made in aqueous buffers, pH 4.0-8.0.
BIOLOGICAL ACTIVITY:
Inhibits human leukocyte elastase (K
i
=0.17nM) and human proteinase 3 (K
i
=0.42nM) .
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
HAZARD:
HARMFUL.
Product Description
Belongs to the chelonianin family of protease inhibitors and is involved in the physiological control of neutrophil serine proteinases, where it targets NE and proteinase 3. Shows antiprotease, antibacterial and antiinflammatory activity and primes innate immunity.
Product Specific Literature References
[1]
Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence:
O. Wiedow, et al.; J. Biol. Chem.
265
, 14791 (1990)
Abstract
;
Full Text
[2]
Skin-derived antileucoproteases (SKALPs): characterization of two new elastase inhibitors from psoriatic epidermis:
J. Schalkwijk, et al.; Br. J. Dermatol.
122
, 631 (1990)
Abstract
[3]
Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor:
J.M. Sallenave and A.P. Ryle; Biol. Chem. Hoppe Seyler
372
, 13 (1991)
Abstract
[4]
Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment:
Saheki, et al.; Biochem
