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Lipid Peroxidation
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ALX-210-881 Revised 04-Mar-05
Polyclonal Antibody to Acrolein
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-881-C100   100 µg 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
IMMUNOGEN: Acrolein conjugated to a carrier protein.
SPECIFICITY: Recognizes acrolein adducts. Slightly cross-reacts with malondialdehyde-BSA (cross-reactivity ratio=1:55 as determined with competitive ELISA test).
APPLICATION: ELISA (1:2'000-1:5'000).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Lyophilized powder is stable at least 2 years if stored at -20°C. Reconstitute with 100µl of distilled water if solution will be used entirely within 8 hours.
If stored at +4°C (stable for 2 months) reconstitute with 100µl distilled water containing 0.1% merthiolate.
If stored at -20°C (stable for at least 1 year) reconstitute with a mixture of distilled water/glycerol (v/v).
Antibody can be prediluted 10x in PBS containing 0.1% merthiolate.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-882 Revised 04-Mar-05
Polyclonal Antibody to Formaldehyde
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-882-R100   100 µl 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST: From rat.
IMMUNOGEN: Formaldeyde conjuated to a carrier protein.
SPECIFICITY: Recognizes formaldehyde adducts.
APPLICATION: ELISA (1:2'000-1:5'000).
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-767 Revised 13-Aug-08
Polyclonal Antibody to (E)-4-Hydroxynonenal
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SYNONYMS anti-HNE PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents/Related Products
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ALX-210-767-R100   100 µl 495.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized. Neat serum containing 0.05% sodium azide.
RECONSTITUTION: Reconstitute with 100µl PBS.
IMMUNOGEN: Free HNE (E)-4-hydroxynonenal.
SPECIFICITY: Recognizes HNE-adducts.
APPLICATION: ELISA (1:1'000-1:10'000)
Immunohistochemistry (1:500-1:1'000)
Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes: K. Uchida, et al.; PNAS 90, 8742 (1993) Abstract
Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma: K. Okamoto, et al.; Int. J. Cancer 58, 825 (1994) Abstract
Immunocytochemical detection of lipid peroxidation in phagosomes of human neutrophils: correlation with expression of flavocytochrome b: M.T. Quinn, et al.; J. Leukoc. Biol. 57, 415 (1995) Abstract
Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies: K. Uchida, et al.; Arch. Biochem. Biophys. 324, 241 (1995) Abstract
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease: A. Yoritaka, et al.; PNAS 93, 2696 (1996) Abstract
alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain: S. Lin, et al.; Brain Res. 1007, 132 (2004) Abstract
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes: K. Stadler, et al.; Free Radic. Biol. Med. Epub ahead of print, (2008) Abstract
Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes: L.M. Aleksunes, et al.; Toxicol. Sci. 104, 261 (2008) Abstract
Related Products
Further Categories Containing This Product:
Lipid Peroxidation • Polyclonal Antibodies
 
 
ALX-210-879 Revised 18-Jul-07
Polyclonal Antibody to Malondialdehyde
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SYNONYMS anti-MDA PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-879-R100   100 µl 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
IMMUNOGEN: Malondialdehyde (MDA) conjugated to a carrier protein.
SPECIFICITY: Recognizes MDA adducts.
APPLICATION: ELISA (1:1’000-1:10’000)
Immunohistochemistry (1:500-1:1’000)
Western blot (1:500-1:1’000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Do not freeze, thaw or store diluted working solutions.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-350-252 Revised 02-Oct-07
Pyrrolostatin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-252-C100   100 µg 45.00 USD Add To Cart
ALX-350-252-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C15H21NO2
MW: 247.2
CAS NUMBER: 144314-68-1
SOURCE/HOST: Isolated from Streptomyces chrestomyceticus.
PURITY: ≥99%
APPEARANCE: Yellowish powder.
SOLUBILITY: Soluble in methanol, abs. ethanol or DMSO. Insoluble in water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Protect from light. Keep under inert gas.

Product Description
Potent inhibitor of lipid peroxidation (IC50=49µM; inhibition of lipid peroxidation in rat brain homogenate). Free radical scavenger. Improves angiogenesis.
Product Specific Literature References
Pyrrolostatin, a novel lipid peroxidation inhibitor from Streptomyces chrestomyceticus. Taxonomy, fermentation, isolation, structure elucidation and biological properties: S. Kato, et al.; J. Antibiot. (Tokyo) 46, 892 (1993) Abstract
Biodesign of a skeletal muscle flap as a model for cardiac assistance: V.V. Nikolaychik, et al.; Artif. Organs 24, 137 (2000) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Natural Products for Angiogenesis Research
 
 
ALX-270-253 Revised 18-Mar-08
Rosmarinic acid
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SYNONYMS (R)-α-[[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy-benzenepropanoic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-253-M010   10 mg 20.00 USD Add To Cart
ALX-270-253-M050   50 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C18H16O8
MW: 360.3
CAS NUMBER: 537-15-5, 20283-92-5
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥98% (HPLC)
APPEARANCE: White to brown solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; also soluble in PBS.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Naturally occurring polyphenolic compound with antioxidant and anti-inflammatory properties. Anticarcinogenic. Inhibitor of lipid peroxidation, TCR-induced T cell activation and proliferation.
Product Specific Literature References
Modification of endotoxin-induced haemodynamic and haematological changes in the rabbit by methylprednisolone, F(ab')2 fragments and rosmarinic acid: H. Bult, et al.; Br. J. Pharmacol. 84, 317 (1985) Abstract
Complement-dependent stimulation of prostacyclin biosynthesis: inhibition by rosmarinic acid: M. Rampart, et al.; Biochem. Pharmacol. 35, 1397 (1986) Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes: Y. Kimura, et al.; J. Nat. Prod. 50, 392 (1987) Abstract
Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes: G.T. Liu, et al.; Biochem. Pharmacol. 43, 147 (1992) Abstract
Metabolism of rosmarinic acid in rats: T. Nakazawa & K. Ohsawa; J. Nat. Prod. 61, 993 (1998) Abstract
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner: J. Won, et al.; Eur. J. Immunol. 33, 870 (2003) Abstract
Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity: M.A. Kang, et al.; Blood 101, 3534 (2003) Abstract
Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model: N. Osakabe, et al.; Carcinogenesis 25, 549 (2004) Abstract
Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2): C. Renzulli, et al.; J. Appl. Toxicol. 24, 289 (2004) Abstract
Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro: S.S. Huang & R.L. Zheng; Cancer Lett. 239, 271 (2006) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Active Substances from Fruit and Vegetables • T Cell Regulation Other Products • Natural Products - Antitumor Reagents • Antitumor Agents (Anti-proliferative) • Natural Products - Anti-inflammatory Agents
 
 
ALX-350-324 Revised 30-May-07
Rubellin D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Plant Research Reagents
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ALX-350-324-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C30H22O10
MW: 542.5
SOURCE/HOST: Isolated from fungus Ramularia collo-cygni.
PURITY: ≥98% (HPLC)
APPEARANCE: Red powder.
SOLUBILITY: Soluble in tetrahydrofuran, n-propanol, methanol, ethyl acetate, DMSO or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Phytotoxin. Triggers the light-dependent production of reactive oxygen species and α-linolenic acid peroxidation.
Product Specific Literature References
Secondary mould metabolites. XX. The structure of rubellins C and D, two novel anthraquinone metabolites from Mycosphae-rella rubella: A. Arnone et al.; Gazz. Chim. Ital. 119, 35 (1989)
Photodynamic oxygen activation by rubellin D, a phytotoxin produced by Ramularia collo-cygni (Sutton et Waller): I. Heiser et al.; Physiol. Mol. Plant Pathol. 62, 29 (2003)
The phytopathogenic fungus Ramularia collo-cygni produces biologically active rubellins on infected barley leaves: S. Miethbauer et al.; J. Phytopathol. 151, 665 (2003)
Fatty acid peroxidation by rubellin B, C, and D, phytotoxins produced by Ramularia collo-cygni (Sutton et Waller): I. Heiser et al.; Physiol. Mol. Plant Pathol. 64, 135 (2004)
Biosynthesis of photodynamically active rubellins and structure elucidation of new anthraquinone derivatives produced by Ramularia collo-cygni: S. Miethbauer, et al.; Phytochemistry 67, 1206 (2006) Abstract
Further Categories Containing This Product:
Other Toxins • Lipid Peroxidation • Lipid Peroxidation • Plant Research Reagents/Related Products
 
 
ALX-550-361 Revised 18-Dec-07
(Z)-4-Hydroxytamoxifen
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SYNONYMS (Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Hormone-related)
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ALX-550-361-M001   1 mg 40.00 USD Add To Cart
ALX-550-361-M005   5 mg 145.00 USD Add To Cart
Product Specification
FORMULA: C26H29NO2
MW: 387.5
CAS NUMBER: 68047-06-3, 65213-48-1
PURITY: ≥98% (Z-isomer)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol (20mg/ml) or methanol (10mg/ml); insoluble water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: MAY BE CARCINOGENIC. TOXIC.

Product Description
Metabolite of tamoxifen (Prod. No. ALX-550-095). Exhibits a more potent estrogen agonist/antagonist activity than the parent drug. Has antioxidant properties. Intramembranous inhibitor of lipid peroxidation.
Product Specific Literature References
The antioxidant action of tamoxifen and its metabolites. Inhibition of lipid peroxidation: H. Wiseman, et al.; FEBS Lett. 263, 192 (1990) Abstract
Mechanism of inhibition of lipid peroxidation by tamoxifen and 4-hydroxytamoxifen introduced into liposomes. Similarity to cholesterol and ergosterol: H. Wiseman, et al.; FEBS Lett. 274, 107 (1990) Abstract
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?: H. Wiseman, et al.; Biochem. J. 292, 635 (1993) Abstract
Tamoxifen and hydroxytamoxifen as intramembraneous inhibitors of lipid peroxidation. Evidence for peroxyl radical scavenging activity: J.B. Custódio, et al.; Biochem. Pharmacol. 47, 1989 (1994) Abstract
Peroxidase-catalyzed pro- versus antioxidant effects of 4-hydroxytamoxifen: enzyme specificity and biochemical sequelae: B.W. Day, et al.; Chem. Res. Toxicol. 12, 28 (1999) Abstract
Estrogen and tamoxifen metabolites protect smooth muscle cell membrane phospholipids against peroxidation and inhibit cell growth: R.K. Dubey, et al.; Circ. Res. 84, 229 (1999) Abstract
Further Categories Containing This Product:
Estrogen & Estrogen Receptors/Related Products • Lipid Peroxidation • Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-400-046 Revised 01-Dec-06
Taurine
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SYNONYMS 2-Aminoethanesulfonic acid
PRODUCT LINE Cancer
PRODUCT CATEGORY Chemopreventive Agents Other Products
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ALX-400-046-G010   10 g 25.00 USD Add To Cart
Product Specification
FORMULA: C2H7NO3S
MW: 125.2
CAS NUMBER: 107-35-7
MERCK INDEX: 14: 9074
RTECS: WX0175000
PURITY: ≥99%
SOLUBILITY: 50mg/ml soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Inhibitor of lipid peroxidation. Inhibits diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis.
Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-270-265 Revised 29-Jan-05
U-74389G
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SYNONYMS 21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-270-265-M010   10 mg 15.00 USD Add To Cart
ALX-270-265-M050   50 mg 63.00 USD Add To Cart
Product Specification
FORMULA: C37H50N6O2 . C4H4O4
MW: 610.8 . 116.1
CAS NUMBER: 153190-29-5
PURITY: ≥98%
APPEARANCE: Crystalline solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol. Insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Store solutions of U-74389G on ice and use within 6 hours of preparation. We strongly recommend using fresh solution for each experiment. 
HANDLING: Hygroscopic.

Product Description
Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant.
Product Specific Literature References
Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995) Abstract
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers: F. Shi, et al.; Free Radic. Biol. Med. 19, 349 (1995) Abstract
Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation: G.M. Campo, et al.; J. Pharmacol. Exp. Ther. 277, 333 (1996) Abstract
Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G: A.M. Perna, et al.; Pharmacol. Res. 34, 25 (1996) Abstract
Comparison of various lazaroid compounds for protection against ischemic liver injury: N. Ishizaki, et al.; Transplantation 63, 202 (1997) Abstract
Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389: S. Awasthi, et al.; Toxicol. Lett. 95, 47 (1998) Abstract
The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain: R.H. Fabian, et al.; J. Neurotrauma 15, 433 (1998) Abstract
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals: A. Khalil, et al.; Life Sci. 63, 769 (1998) Abstract
Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats: D. Melchiorri, et al.; Life Sci. 62, 1927 (1998) Abstract
The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock:: D. Altavilla, et al.; Eur. J. Pharmacol. 369, 49 (1999) Abstract
Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice: K. Fukuma, et al.; Surgery 125, 421 (1999) Abstract
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia: R. Schmid-Elsaesser, et al.; Brain Res. 816, 471 (1999) Abstract; Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
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