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Natural Products / Antibiotics
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ALX-350-272 Revised 17-Dec-07
γ-Amanitin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-272-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C39H54N10O13S
MW: 903.0
CAS NUMBER: 13567-11-8; 21150-23-2
MERCK INDEX: 14: 373
SOURCE/HOST: Isolated from Amanita phalloides mushrooms.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Dilute with buffer immediately prior to use. Product is destroyed by concentrated acid or base.
HANDLING: Protect from light.
HAZARD: VERY TOXIC.

Product Description
Biological activity like α-amanitin (Prod. No. ALX-350-270).
Further Categories Containing This Product:
Amanitins & Phalloidins / Related Products • Protein Synthesis Other Products • RNA Polymerases / Related Products
 
 
ALX-380-262 Revised 09-Apr-08
Amidepsine A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-262-M001   1 mg 230.00 USD Add To Cart
ALX-380-262-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C29H29NO11
MW: 567.6
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: Pale white to pale yellow powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=10.2µM) and Raji cells (IC50=15.5µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-380-263 Revised 09-Apr-08
Amidepsine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products
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ALX-380-263-M001   1 mg 230.00 USD Add To Cart
ALX-380-263-MM25   2.5 mg 470.00 USD Add To Cart
Product Specification
FORMULA: C26H24O10
MW: 496.5
SOURCE/HOST: Isolated from fungal strain FO-2943.
PURITY: ≥95% (HPLC)
APPEARANCE: White to light pink powder.
SOLUBILITY: Soluble in methanol (1mg/ml); insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Inhibitor of diacylglycerol acyltransferase (DGAT). Shows inhibitory effect in rat liver microsomes (IC50=17.5µM) and Raji cells (IC50=2.8µM). Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product Specific Literature References
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995) Abstract
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995) Abstract
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Related Products
Further Categories Containing This Product:
Lipid Metabolism Other Products
 
 
ALX-380-266 Revised 03-Apr-08
Amikacin . disulfate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-266-M250   250 mg 30.00 USD Add To Cart
ALX-380-266-G001   1 g 70.00 USD Add To Cart
Product Specification
FORMULA: C22H43N5O13 . 2H2SO4
MW: 585.6 . 196.2
CAS NUMBER: 39831-55-5
MERCK INDEX: 14: 405
RTECS: WK1961200
SOURCE/HOST: Semisynthetic from kanamycin A (Prod. No. ALX-380-275).
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml).
ACTIVITY: Potency is 647-786µg/ml (on dry basis).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Aminoglycoside antibiotic. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
BB-K 8, a new semisynthetic aminoglycoside antibiotic: H. Kawaguchi, et al.; J. Antibiot. 25, 695 (1972) Abstract
Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans: B.E. Cabana & J.G. Taggart; Antimicrob. Agents Chemother. 3, 478 (1973) Abstract
Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin: P.K. Yu & J.A. Washington; Antimicrob. Agents Chemother. 4, 133 (1973) Abstract
Pharmacology of amikacin in humans: G.P. Bodey, et al.; Antimicrob. Agents Chemother. 5, 508 (1974) Abstract
Aminoglycoside antibiotics. VII. Acute toxicity of aminoglycoside antibiotics: K. Fujisawa, et al.; J. Antibiot. 27, 677 (1974) Abstract
Ototoxicity and pharmacokinetically determined dosages of amikacin in granulocytopenic cancer patients: F.J. Danhauer, et al.; Clin. Pharm. 1, 539 (1982) Abstract
Biological transformation of kanamycin A to amikacin (BBK-8): L.M. Cappelletti & R. Spagnoli; J. Antibiot. 36, 328 (1983) Abstract
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ALX-380-045 Revised 03-Apr-08
Amikacin (free base)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-045-G001   1 g 60.00 USD Add To Cart
Product Specification
FORMULA: C22H43N5O13
MW: 585.6
CAS NUMBER: 37517-28-5
MERCK INDEX: 14: 405
SOURCE/HOST: Semisynthetic from kanamycin A (Prod. No. ALX-380-275).
PURITY: ≥98% (contains ≤5% water)
APPEARANCE: White solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HAZARD: TOXIC.

Product Description
Aminoglycoside antibiotic derived from kanamycin A. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
Antimicrobial activity of amikacin combinations against Enterobacteriaceae moderately susceptible to third-generation cephalosporins: R.N. Jones, et al.; Antimicrob. Agents Chemother. 22, 985 (1982) Abstract
BB-K 8, a new semisynthetic aminoglycoside antibiotic: H. Kawaguchi, et al.; J Antibiot (Tokyo) 25, 695 (1972) Abstract
An overview of amikacin: A. M. Ristuccia & B. A. Cunha; Ther. Drug Monit. 7, 12 (1985), Review Abstract
New uses for older antibiotics: nitrofurantoin, amikacin, colistin, polymyxin B, doxycycline, and minocycline revisited: B.A. Cunha; Med. Clin. North Am. 90, 1089 (2006), Review Abstract
 
 
ALX-380-283 Revised 21-May-08
7-Amino-actinomycin D
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SYNONYMS 7-AAD
7-Aminoactinomycin C1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antitumor Antibiotics
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ALX-380-283-M001   1 mg 90.00 USD Add To Cart
ALX-380-283-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C62H87N13O16
MW: 1270.4
CAS NUMBER: 7240-37-1
RTECS: AU1579000
SOURCE/HOST: Semisynthetic from actinomycin D (Prod. No. ALX-380-009).
PURITY: ≥96% (HPLC)
APPEARANCE: Red to dark purple powder.
SOLUBILITY: Soluble in DMSO (20mg/ml), methanol or 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Hygroscopic.
HAZARD: VERY TOXIC.

Product Description
Membrane impermeable fluorescent DNA intercalator. Used as a fluorescent DNA stain. Inhibitor of DNA-primed RNA polymerase and DNA polymerase. Induces apoptosis and is used as a tool to identify apoptotic cells. Cytochemical probe. Exhibits growth-inhibitory activity against certain leukemias and sarcomas. Has antibacterial properties.
Product Specific Literature References
7-Amino-actinomycin D as a cytochemical probe. I. Spectral properties: J.E. Gill, et al.; J. Histochem. Cytochem. 23, 793 (1975) Abstract; Full Text
7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies: S.K. Sengupta, et al.; J. Med. Chem. 18, 1175 (1975) Abstract
Simultaneous cell cycle analysis and two-color surface immunofluorescence using 7-amino-actinomycin D and single laser excitation: applications to study of cell activation and the cell cycle of murine Ly-1 B cells: P.S. Rabinovitch, et al.; J. Immunol. 136, 2769 (1986) Abstract
Binding specificities of actinomycin D to non-self-complementary -XGCY-tetranucleotide sequences: F.M. Chen; Biochemistry 31, 6223 (1992) Abstract
Dead cell discrimination with 7-amino-actinomycin D in combination with dual color immunofluorescence in single laser flow cytometry: I. Schmid, et al.; Cytometry 13, 204 (1992) Abstract
Improved staining method for the simultaneous flow cytofluorometric analysis of DNA content, S-phase fraction, and surface phenotype using single laser instrumentation: K. Toba, et al.; Cytometry 13, 60 (1992) Abstract
Flow cytometric immunofluorescence assay for quantification of cyclobutyldithymine dimers in separate phases of the cell cycle: R.J. Berg, et al.; Carcinogenesis 14, 103 (1993) Abstract
Simultaneous three-color analysis of the surface phenotype and DNA-RNA quantitation using 7-amino-actinomycin D and pyronin Y: K. Toba, et al.; J. Immunol. Methods 182, 193 (1995) Abstract
Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect: X. Su, et al.; J. Immunol. 156, 4198 (1996) Abstract
The use of 7-amino actinomycin D in identifying apoptosis: simplicity of use and broad spectrum of application compared with other techniques: N.J. Philpott, et al.; Blood 87, 2244 (1996) Abstract; Full Text
A rapid method for measuring apoptosis and dual-color immunofluorescence by single laser flow cytometry: I. Schmid, et al.; J. Immunol. Methods 170, 145 (1996) Abstract
Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods: H. Lecoeur, et al.; J. Immunol. Methods 209, 111 (1997) Abstract
Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY: K. Toba, et al.; Eur. J. Haematol. 64, 10 (2000) Abstract
Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D: I. Schmid, et al.; Nat. Protoc. 2, 187 (2007) Abstract
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Further Categories Containing This Product:
Antibiotics - Apoptosis Inducers & Inhibitors • Antitumor Agents (Apoptosis Inducers) • DNA Intercalators & Crosslinkers • Apoptosis & Necrosis Detection Other Products • Transcription Inhibitors / Related Products
 
 
ALX-385-021 Revised 23-Oct-07
4'-Amino-6-hydroxyflavone
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SYNONYMS Aminogenistein
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
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ALX-385-021-M001   1 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C15H11NO3
MW: 253.3
PURITY: ≥95%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Inhibitor of the p56lck protein-tyrosine kinase.
Product Specific Literature References
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues: M. Cushman, et al.; J. Med. Chem. 34, 798 (1991) Abstract
Expression of p56lck in B-cell neoplasias: A. Von Knethen, et al.; Leuk. Lymphoma 26, 551 (1997) Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors • Src Family Kinases / Related Products • Kinases in T Cell Signal Transduction / Related Products
 
 
ALX-380-280 Revised 08-Apr-08
Amphotericin B
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SYNONYMS Fungizone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-280-M250   250 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C47H73NO17
MW: 924.1
CAS NUMBER: 1397-89-3
MERCK INDEX: 14: 585
RTECS: BU2625000
SOURCE/HOST: Isolated from Streptomyces sp.
APPEARANCE: Yellow to orange powder.
PURITY DETAIL: Contains 50% sodium deoxycholate for solubilization.
SOLUBILITY: Soluble in water (20mg/ml), DMSO or dimethyl formamide (30mg/ml).
ACTIVITY: Potency is 1017µg/mg.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Antibiotic. Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out. Effective against yeasts and molds.
Product Specific Literature References
Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells: J. Medoff, et al.; Cancer Res. 35, 2548 (1975) Abstract; Full Text
Effects of amphotericin B with combination chemotherapy on response rates and on survival in non-small cell carcinoma of the lung: C.A. Presant, et al.; Cancer Treat. Rep. 68, 651 (1984) Abstract
Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior: Biophys. J.; C. Barth, et al. 64, 92 (1993) Abstract
Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro: B.S. Charak, et al.; Br. J. Haematol. 88, 693 (1994) Abstract
Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study: J. Tollemar, et al.; Transplantation 59, 45 (1995) Abstract
 
 
ALX-380-268 Revised 21-May-08
Ampicillin . sodium salt
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SYNONYMS D-(−)-α-Aminobenzylpenicillin . Na
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-268-G005   5 g 45.00 USD Add To Cart
Product Specification
FORMULA: C16H18N3O4S . Na
MW: 348.4 . 23.0
CAS NUMBER: 69-52-3
MERCK INDEX: 14: 586
RTECS: XH8400000
SOURCE/HOST: Semisynthetic from penicillin.
PURITY: ≥95% (Assay)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
β-Lactam antibiotic. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking). Inactivates transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-negative and Gram-positive bacteria. Is inactivated by β-lactamase.
Product Specific Literature References
7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies: J. Med. Chem.; S.K. Sengupta, et al. 18, 1175 (1975) Abstract
N7-Substituted 7-aminoactinomycin D analogues. Synthesis and biological properties: M.S. Madhavarao, et al.; J. Med. Chem. 21, 958 (1978) Abstract
Sulbactam/ampicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use: D.M. Campoli-Richards & R.N. Brogden; Drugs 33, 577 (1987) Abstract
Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis: S.J. Martin, et al.; J. Immunol. 145, 1859 (1990) Abstract
Short exposure to actinomycin D induces "reversible" translocation of protein B23 as well as "reversible" inhibition of cell growth and RNA synthesis in HeLa cells: B.Y. Yung, et al.; Cancer Res. 50, 5987 (1990) Abstract
Schedule-dependent effects of two consecutive, divided, low doses of actinomycin D on translocation of protein B23, inhibition of cell growth and RNA synthesis in HeLa cells: B.Y. Yung, et al.; Int. J. Cancer 52, 317 (1992) Abstract
Nerve growth factor and epidermal growth factor rescue PC12 cells from programmed cell death induced by etoposide: distinct modes of protection against cell death by growth factors and a protein-synthesis inhibitor: M. Nakajima, et al.; Neurosci. Lett. 176, 161 (1994) Abstract
 
 
ALX-350-106 Revised 29-Nov-07
Ampullosporin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Other Signal Transduction Pathway Modulators