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ALX-450-001
Revised 23-Jul-08
A23187 (free acid)
SYNONYMS
Calcium Ionophore A23187
Calcimycin
Antibiotic A23187
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Ionophores
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-450-001-M001
1 mg
28.00 USD
ALX-450-001-M005
5 mg
65.00 USD
ALX-450-001-5001
5x1 mg
80.00 USD
ALX-450-001-M010
10 mg
92.00 USD
ALX-450-001-M025
25 mg
195.00 USD
ALX-450-001-M050
50 mg
350.00 USD
Product Specification
FORMULA:
C
29
H
37
N
3
O
6
MW:
523.6
CAS NUMBER:
52665-69-7
MERCK INDEX:
14:
1639
RTECS:
DM4676000
SOURCE/HOST:
Isolated from
Streptomyces chartreusis
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO, 100% ethanol or methylene chloride; slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
In aqueous systems product may aggregate over time.
HANDLING:
Protect from light. In aqueous systems, the product aggregates over time.
HAZARD:
IRRITANT.
Product Description
Antibiotic possessing weak
in vitro
antimicrobial activity against gram positive bacteria and fungi. Divalent cation ionophore commonly used to increase intracellular Ca
2+
levels in intact cells.
Product Specific Literature References
A23187: a divalent cation ionophore:
P. W. Reed & H. A. Lardy; J. Biol. Chem.
247
, 6970 (1972)
Abstract
Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria:
D.T. Wong, et al.; Arch. Biochem. Biophys.
156
, 578 (1973)
Abstract
Biological applications of ionophores:
B.C. Pressman; Annu. Rev. Biochem.
45
, 501 (1976), (Review)
Abstract
Molecular mechanisms of endothelium-mediated vasodilation:
R.R. Fiscus; Semin. Thromb. Hemost.
14 Suppl
, 12 (1988), (Review)
Abstract
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: 1740, 481 (2005):
T. Przygodzki, et al.; Biochim. Biophys. Acta
1740
, 481 (2005)
Abstract
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
•
Respiratory Chain Other Products
•
Antibiotics - ATPase Inhibitors
ALX-380-075
Revised 03-Apr-08
Antimycin A
SYNONYMS
Antipiricullin
Virosin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-075-M005
5 mg
20.00 USD
ALX-380-075-M010
10 mg
33.00 USD
Product Specification
CAS NUMBER:
1397-94-0
MERCK INDEX:
14:
714 (A1) & 715 (A3)
RTECS:
CD0350000
SOURCE/HOST:
Isolated from
Streptomyces sp
. Mixture of antimycin A's.
APPEARANCE:
White to faint yellow powder.
SOLUBILITY:
Soluble in 100% ethanol (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Antibiotic. Induces apoptosis, which is not prevented by the presence of Bcl-2. Inhibits mitochondrial electron transport specifically between cytochromes b and c1.
Product Specific Literature References
The isolation and properties of antimycin A:
B. R. Dunshee, et al.; J. Am. Chem. Soc.
71
, 2436 (1949)
The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity:
M.L. Campo, et al.; J. Biol. Chem.
267
, 8123 (1992)
Abstract
;
Full Text
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3:
S.P. Tzung, et al.; Nat. Cell Biol.
3
, 183 (2001)
Abstract
Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A:
K.M. Kim, et al.; Biochemistry
40
, 4911 (2001)
Abstract
Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis
:
D. Liu & Z. Huang; Apoptosis
6
, 453 (2001)
Abstract
Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3:
S.P. Tzung, et al.; Nat. Cell. Biol.
3
, 183 (2001)
Abstract
Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage:
N. Dairaku, et al.; J. Lab. Clin. Med.
143
, 143 (2004)
Abstract
An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis:
W.H. Park, et al.; J. Cell. Biochem.
102
, 98 (2007)
Abstract
Further Categories Containing This Product:
Bcl-2 Family Modulators
•
Respiratory Chain Other Products
ALX-380-207
Revised 03-Apr-08
Apoptolidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Apoptosis Inducers & Inhibitors
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ALX-380-207-MC01
0.1 mg
290.00 USD
Product Specification
FORMULA:
C
58
H
96
O
21
MW:
1129.4
CAS NUMBER:
194874-06-1
SOURCE/HOST:
Isolated from
Amicolatopsis
sp. MST-AS5912.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Originally isolated from
Nocardiopsis
sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F
0
F
1
-ATPase inhibitor.
Product Specific Literature References
Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp:
J.W. Kim, et al.; J. Antibiot. (Tokyo)
50
, 6628 (1997)
Abstract
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase:
A.R. Salomon, et al.; PNAS
97
, 14766 (2000)
Abstract
;
Full Text
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase:
A.R. Salomon, et al.; Chem. Biol.
8
, 71 (2001)
Abstract
;
Full Text
Apoptolidin: induction of apoptosis by a natural product:
P.T. Daniel, et al.; Angew. Chem. Int. Ed. Engl.
45
, 872 (2006)
Abstract
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues:
P.A. Wender, et al.; Org. Lett.
8
, 589 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - ATPase Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Antitumor Antibiotics
•
Respiratory Chain Other Products
ALX-380-108
Revised 03-Apr-08
Atpenin A5
SYNONYMS
3-[(2
S
,4
S
,5
R
)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1
H
)-pyridinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
Product Numbers:
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ALX-380-108-C250
250 µg
90.00 USD
Product Specification
FORMULA:
C
15
H
21
Cl
2
NO
5
MW:
366.2
CAS NUMBER:
119509-24-9
RTECS:
CJ8800000
SOURCE/HOST:
Produced by
Penicillium
sp.
PURITY:
≥85% (HPLC)
APPEARANCE:
Colorless oil.
SOLUBILITY:
Soluble in DMSO, methanol or 100% ethanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antibiotic. Potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase).
Product Specific Literature References
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties:
S. Omura, et al.; J. Antibiot.
41
, 1769 (1988)
Abstract
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp:
H. Kumagai, et al.; J. Antibiot.
43
, 1553 (1990)
Abstract
Mechanism of action of atpenin B on Raji cells:
K. Oshino, et al.; J. Antibiot.
43
, 1064 (1990)
Abstract
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase):
H. Miyadera, et al.; PNAS
100
, 473 (2003)
Abstract
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction:
R. Horsefield, et al.; J. Biol. Chem.
281
, 7309 (2006)
Abstract
;
Full Text
General Information
MANUFACTURER
Fungal strain courtesy of the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Respiratory Chain Other Products
ALX-385-029
Revised 07-Oct-08
4’-Bromoflavone
SYNONYMS
4’-Bromo-2-phenylbenzopyran
4’-Bromo-2-phenyl-4
H
-1-benzopyran-4-one
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Flavonoids / Related Products
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ALX-385-029-G001
1 g
90.00 USD
Product Specification
FORMULA:
C
15
H
9
BrO
2
MW:
301.1
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
IRRITANT.
Product Description
Chemopreventive compound. Potent inducer of phase II detoxifying enzymes. Quininone reductase and glutathione S-transferase in cell culture and different tissues of rats. Aryl hydrocarbon hydroxylase inducer.
Product Specific Literature References
Simple vs. complex inheritance of inducible aryl hydrocarbon hydroxylase in mouse tissues:
K. Burki, et al.; Biochem. Genet.
13
, 417 (1975)
Abstract
Cancer chemopreventive activity mediated by 4’-bromoflavone, a potent inducer of phase II detoxification enzymes:
L.L. Song, et al.; Cancer Res.
59
, 578 (1999)
Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
•
Natural Products - Chemopreventive Agents
ALX-380-058
Revised 07-Oct-08
Citrinin
SYNONYMS
Antimycin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-380-058-M001
1 mg
15.00 USD
ALX-380-058-M005
5 mg
60.00 USD
ALX-380-058-M010
10 mg
105.00 USD
ALX-380-058-M025
25 mg
210.00 USD
Product Specification
FORMULA:
C
13
H
14
O
5
MW:
250.3
CAS NUMBER:
518-75-2
MERCK INDEX:
14:
2327
SOURCE/HOST:
Isolated from
Penicillium citrinum
.
PURITY:
≥98%
APPEARANCE:
Yellow crystals.
SOLUBILITY:
Soluble in 100% ethanol or dioxane. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
USE/STABILITY:
Solutions change color with changes in pH from yellow (pH 4.6) to red (pH 9.9).
HAZARD:
TOXIC.
Product Description
Antibiotic. Induces mitochondrial permeability pore opening and inhibits respiration by interfering with complex I of the respiratory chain. Mycotoxin. Acts as nephrotoxin in all species in which it has been tested. Has been implicated as a cause of Balkan nephropathy and yellow rice fever in humans. Induces apoptosis.
Product Specific Literature References
Mechanism of citrinin-induced dysfunction of mitochondria. III. Effects on renal cortical and liver mitochondrial swelling:
G.M. Chagas, et al.; J. Appl. Toxicol.
15
, 91 (1995)
Abstract
Mycotoxins:
J.W. Bennett & M. Klich; Clin. Microbiol. Rev.
16
, 497 (2003)
Abstract
Citrinin induces apoptosis in HL-60 cells via activation of the mitochondrial pathway:
F.Y. Yu, et al.; Toxicol. Lett.
161
, 143 (2006)
Abstract
Citrinin induces apoptosis via a mitochondria-dependent pathway and inhibition of survival signals in embryonic stem cells, and causes developmental injury in blastocysts:
W.H. Chan; Biochem. J.
404
, 317 (2007)
Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
•
Antibiotics - Apoptosis Inducers & Inhibitors
•
Mycotoxins
ALX-350-028
Revised 12-Sep-08
Curcumin (high purity)
SYNONYMS
1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
Diferuloylmethane
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Natural Products for Inflammation Research
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-350-028-M010
10 mg
15.00 USD
ALX-350-028-M050
50 mg
60.00 USD
ALX-350-028-M250
250 mg
240.00 USD
Product Specification
FORMULA:
C
21
H
20
O
6
MW:
368.4
CAS NUMBER:
458-37-7
MERCK INDEX:
14:
2673
SOURCE/HOST:
Isolated from turmeric (
Curcuma longa
).
PURITY:
≥98.5% (Note: This highly purified product is free of demethoxy- and bis-demethoxycurcumin and does not contain 30-40% bioactive impurities)
APPEARANCE:
Orange-yellow crystalline powder.
SOLUBILITY:
Soluble in acetic acid or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
Product Description
Dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase. Also inhibits glutathione S-transferase, induction of nitric oxide (NO) in activated macrophages and inhibits EGF-induced tyrosine phosphorylation of EGF receptors. Antioxidant. Inhibitor of NAD(P)H:quinone oxidoreductase 1 (NQO1), disrupting the binding of NQO1 to wild type p53 inducing ubiquitin-independent degradation of p53 and inhibits p53-mediated apoptosis in normal thymocytes and myeloid leukemic cells.
Product Specific Literature References
Modification of certain inflammation-induced biochemical changes by curcumin:
R. Srivastava & R.C. Srimal; Indian J. Med. Res.
81
, 215 (1985)
Abstract
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones:
D.L. Flynn, et al.; Prostagl. Leukotr. Med.
22
, 357 (1986)
Abstract
Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells:
L. Korutla & R. Kumar; Biochim. Biophys. Acta
1224
, 597 (1994)
Abstract
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages:
I. Brouet & H. Okshima; BBRC
206
, 533 (1995)
Abstract
Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin:
J.N. Commandeur & N.P. Vermeulen; Xenobiotica
26
, 667 (1996)
Abstract
Nitric oxide scavenging by curcuminoids:
Sreejayan & M.N. Rao; J. Pharm. Pharmacol.
49
, 105 (1997)
Abstract
Inhibitory effects of curcumin on tumorigenesis in mice:
M.T. Huang, et al.; J. Cell. Biochem. (Suppl.)
27
, 26 (1997)
Abstract
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties:
M.M. Chan, et al.; Biochem. Pharmacol.
55
, 1955 (1998)
Abstract
Effect of curcumin on the production of nitric oxide by cultured rat mammary gland:
M. Onoda & H. Inano; Nitric Oxide
4
, 505 (2000)
Abstract
Suppression of nitric oxide oxidation to nitrite by curcumin is due to the sequestration of the reaction intermediate nitrogen dioxide, not nitric oxide:
B.D. Johnston & E.G. DeMaster; Nitric Oxide
8
, 231 (2003)
Abstract
Biological properties of curcumin-cellular and molecular mechanisms of action:
B. Joe, et al.; Crit. Rev. Food Sci. Nutr.
44
, 97 (2004), (Review)
Abstract
Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects:
M.E. Egan, et al.; Science
304
, 600 (2004)
Abstract
Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin:
P. Tsvetkov, et al.; PNAS
102
, 5535 (2005)
Abstract
Immunomodulatory effects of curcumin:
V.S. Yadav, et al.; Immunopharmacol. Immunotoxicol.
27
, 485 (2005)
Abstract
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases:
S. Bengmark; JPEN J. Parenter. Enteral. Nutr.
30
, 45 (2006), (Review)
Abstract
Curcumin is an inhibitor of p300 histone acetylatransferase:
M.G. Marcu, et al.; Med. Chem.
2
, 169 (2006)
Abstract
Multiple biological activities of curcumin: a short review:
R.K. Maheshwari, et al.; Life Sci.
78
, 2081 (2006), (Review)
Abstract
Curcumin inhibits hypoxia-induced angiogenesis via down-regulation of HIF-1:
M.K. Bae, et al.; Oncol. Rep.
15
, 1557 (2006)
Abstract
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells:
Z. Wang, et al.; Cancer
106
, 2503 (2006)
Abstract
Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species:
M. Panchatcharam, et al.; Mol. Cell Biochem.
290
, 87 (2006)
Abstract
Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia:
K.K. Jung, et al.; Life Sci.
79
, 2022 (2006)
Abstract
The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats:
T. Morimoto, et al.; J. Clin. Invest.
118
, 868 (2008)
Abstract
;
Full Text
Further Categories Containing This Product:
Other Natural Products for Cancer Research
•
Natural Products - Protein Kinase Inhibitors
•
EGFR Kinase Inhibitors
•
Respiratory Chain Other Products
•
Natural Products - Nitric Oxide Pathway Modulators
•
Natural Products - Antioxidants
•
Lipoxygenases / Related Products
•
Glutathione S-Transferase
•
Active Substances from Fruit and Vegetables
•
Natural Products - Apoptosis Inducers & Inhibitors
•
COX Inhibitors
ALX-610-021
Revised 04-Nov-05
Dihydrorhodamine 123
SYNONYMS
DHR
PRODUCT LINE
Other Products
PRODUCT CATEGORY
Dyes / Stains / Fluorescent Probes / Fluorescent Labels
Ordering Information
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Format:
Size:
Unit Price:
Quantity:
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ALX-610-021-M005
5 mg
153.00 USD
ALX-610-021-M010
10 mg
272.00 USD
Product Specification
FORMULA:
C
21
H
18
N
2
O
3
MW:
346.4
CAS NUMBER:
109244-58-8
PURITY:
≥98%
APPEARANCE:
Pink crystalline solid.
SOLUBILITY:
Soluble in organic solvents such as ethanol, DMSO or dimethyl formamide.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for at least 6 months when stored at -20°C.
Product Description
Sensitive indicator of peroxynitrite formation. DHR is oxidized by peroxynitrite to the highly fluorescent product rhodamine. Formation of rhodamine can be monitored by fluorescence spectroscopy (Ex(max): 500nm, Em(max): 536nm), or by absorbance spectroscopy at 500nm (ε=78'800M
-1
cm
-1
). Neither nitric oxide, superoxide, nor hydrogen peroxide alone appear to oxidize DHR.
Product Specific Literature References
Peroxynitrite-mediated oxidation of dihydrorhodamine 123:
N.W. Kooy, et al.; Free Radic. Biol. Med.
16
, 149 (1994)
Abstract
Attenuation of oxidation and nitration reactions of peroxynitrite by selenomethionine, selenocystine and ebselen:
K. Briviba, et al.; Biochem. J.
319
, 13 (1996)
Abstract
Dichlorodihydrofluorescein and dihydrorhodamine 123 are sensitive indicators of peroxynitrite in vitro: implications for intracellular measurement of reactive nitrogen and oxygen species:
J.P. Crow; Nitric Oxide
1
, 145 (1997)
Abstract
Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase:
H. Sies, et al.; J. Biol. Chem.
272
, 27812 (1997)
Abstract
;
Full Text
Dihydrofluorescein diacetate is superior for detecting intracellular oxidants: comparison with 2',7'-dichlorodihydrofluorescein diacetate, 5(and 6)-carboxy-2',7'-dichlorodihydrofluorescein diacetate:
S.L. Hempel, et al.; Free Radic. Biol. Med.
27
, 146 (1999)
Abstract
Detection of reactive nitrogen species using 2,7-dichlorodihydrofluorescein and dihydrorhodamine 123:
H. Ischiropoulos, et al.; Meth. Enzymol.
301
, 367 (1999)
Abstract
Further Categories Containing This Product:
Respiratory Chain Other Products
•
Peroxynitrite / Scavengers / Detection
ALX-270-003
Revised 08-Aug-08
Diphenyleneiodonium chloride
SYNONYMS
Dibenziodolium chloride
PRODUCT LINE
Nitric Oxide Pathway
PRODUCT CATEGORY
NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-003-M025
25 mg
85.00 USD
ALX-270-003-M100
100 mg
255.00 USD
Product Specification
FORMULA:
C
12
H
8
ICl
MW:
314.5
CAS NUMBER:
4673-26-1
PURITY:
≥98% (TLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
10mg/ml soluble in DMSO (warm).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
HARMFUL.
Product Description
Binds strongly to flavoproteins and is thus a powerful and specific inhibitor of several important enzymes, including nitric oxide synthase (NOS), NADPH-ubiquinone oxidoreductase, NADPH oxidases and NADPH cytochrome P450 oxidoreductase. Nitric oxide synthase, which shows significant homology with cytochrome P450 reductase, has shown to be irreversibly inhibited by this compound.
Product Specific Literature References
Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium:
C.I. Ragan & D.P. Bloxham; Biochem. J.
163
, 605 (1977)
Abstract
The inhibition by diphenyleneiodonium and its analogues of superoxide generation by macrophages:
J.T. Hancock & O.T.G. Jones; Biochem. J.
242
, 103 (1987)
Abstract
Indications to an NADPH oxidase as a possible pO2 sensor in the rat carotid body:
H. Acker, et al.; FEBS Lett.
256
, 75 (1989)
Abstract
Purification and some properties of the 45 kDa diphenylene iodonium- binding flavoprotein of neutrophil NADPH oxidase:
C.M. Yea, et al.; Biochem. J.
265
, 95 (1990)
Abstract
Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs:
D.J. Stuehr, et al.; FASEB J.
5
, 98 (1991)
Abstract
Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications:
D.G. Tew; Biochemistry
32
, 10209 (1993)
Abstract
Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat:
H. Kono, et al.; Am. J. Physiol. Gastrointest. Liver Physiol.
280
, G1005 (2001)
Abstract
Diphenyleneiodonium inhibits NF-kappaB activation and iNOS expression induced by IL-1beta: involvement of reactive oxygen species:
A.F. Mendes, et al.; Mediators Inflamm.
10
, 209 (2001)
Abstract
Preferential inhibition of the plasma membrane NADH oxidase (NOX) activity by diphenyleneiodonium chloride with NADPH as donor:
D.J. Morre; Antioxid. Redox Signal
4
, 207 (2002)
Abstract
G2 cell cycle arrest, down-regulation of cyclin B, and induction of mitotic catastrophe by the flavoprotein inhibitor diphenyleneiodonium:
R.M. Scaife; Mol. Cancer Ther.
3
, 1229 (2004)
Abstract
Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium:
A. Balcerczyk, et al.; Biochem. Pharmacol.
69
, 1263 (2005)
Abstract
Selective and irreversible cell cycle inhibition by diphenyleneiodonium:
R.M. Scaife; Mol. Cancer Ther.
4
, 876 (2005)
Abstract
Further Categories Containing This Product:
Oxygenases Other Products
•
Cytochrome P450 [CYP450] / Related Products
•
Respiratory Chain Other Products
ALX-480-084
Revised 14-Sep-06
Flavin Adenine Dinucleotide . disodium salt . hydrate
