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Oxidative Stress
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ALX-850-033 Revised 17-Apr-08
Cu/Zn-Superoxide Dismutase ELISA Kit
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SYNONYMS SOD (Cu/Zn) ELISA Kit
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Superoxide Dismutases [SODs]/Related Products
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ALX-850-033-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.04ng/ml (range 0.08 to 5ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human Cu/Zn SOD in cell culture supernatants, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
Late stages of apoptosis are characterized by the loss of membrane integrity and a release of the intracellular Cu/Zn SOD.
Product Specific Literature References
A highly sensitive non-radioactive cytotoxicity assay for human target cells: L. Franke & T. Porstmann; J. Immunol. Methods 171, 259 (1994) Abstract
General Information
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
ELISA & EIA Kits
 
 
ALX-385-003 Revised 03-Apr-08
Cyanidin chloride
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SYNONYMS 3,3',4',5,7-Pentahydroxy-flavylium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-003-M010   10 mg 195.00 USD Add To Cart
ALX-385-003-M050   50 mg 780.00 USD Add To Cart
Product Specification
FORMULA: C15H11ClO6
MW: 322.7
CAS NUMBER: 528-58-5
MERCK INDEX: 14: 2687
RTECS: LK9824000
PURITY: ≥97%
APPEARANCE: Dark red to black solid.
SOLUBILITY: Soluble in methanol or 0.1% hydrochloric acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Antioxidant flavonoid. Nitric oxide (NO) scavenger.
Product Specific Literature References
Flavonoids as scavengers of nitric oxide radical: S.A.B.E. Acker, et al.; BBRC 214, 755 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Dietary flavonoids: bioavailability, metabolic effects, and safety: J.A. Ross & C.M. Kasum; Annu. Rev. Nutr. 22, 19 (2002), (Review) Abstract
Cyanidins: metabolism and biological properties: F. Galvano, et al.; J. Nutr. Biochem. 15, 2 (2004), (Review) Abstract
Further Categories Containing This Product:
Nitric Oxide Scavengers • Natural Products - Antioxidants • Natural Products - Nitric Oxide Pathway Modulators • Active Substances from Fruit and Vegetables
 
 
ALX-850-261 Revised 11-Apr-08
Cytochrome c (human) ELISA Kit
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cytochrome c
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ALX-850-261-KI01   1 Kit 619.00 USD Add To Cart
Product Specification
SENSITIVITY: 0.05ng/ml (range 0.08 to 5ng/ml)
QUANTITY: 96 wells (~80 tests).
APPLICATION: For the quantitative determination of human cytochrome c in cell culture lysates, serum and other body fluids.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
Measurement of cytochrome c release from the mitochondria is a tool to detect the first early steps of apoptosis initiation in cells. Cytochrome c release in the cytosol occurs prior to the activation of caspases and DNA fragmentation which is considered the hallmark of apoptosis.
General Information
Measurement of cytochrome c release from the mitochondria is a tool to detect the first early steps for initiating apoptosis in cells. Cytochrome c release in the cytosol occurs prior to the activation of caspases and DNA fragmentation which is considered the hallmark of apoptosis.
MANUFACTURER Manufactured by Bender MedSystems.
Further Categories Containing This Product:
Mitochondria-based Apoptosis Detection • ELISA & EIA Kits
 
 
ALX-850-277 Revised 03-Feb-05
Cytochrome c Releasing Apoptosis Assay Kit
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Cytochrome c
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ALX-850-277-KI01   1 Kit 539.00 USD Add To Cart
Product Specification
QUANTITY: 100 tests.
KIT/SET CONTAINS: 10ml Mitochondria Extraction Buffer, 20ml 5X Cytosol Extraction Buffer, 110µl DTT (1M), 1 vial 500X Protease Inhibitor Cocktail, 0.5ml Cytochrome c Antibody (0.2mg/ml).
APPLICATION: For the detection of cytochrome c translocation from mitochondria into cytosol during apoptosis.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
Product Description
The kit provides an easy-to-use procedure and reagents for separating a mitochondria-enriched fraction from cytosol. Cytochrome c released from mitochondria into cytosol is determined by Western blot using the cytochrome c antibody provided in the kit. The procedure is simple, straightforward and requires no ultracentrifugation.
General Information
MANUFACTURER

Manufactured by BioVision.
Further Categories Containing This Product:
Mitochondria-based Apoptosis Detection • Detection Kits
 
 
ALX-350-009 Revised 03-Apr-08
Daidzein
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SYNONYMS 4',7-Dihydroxyisoflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-350-009-M010   10 mg 20.00 USD Add To Cart
ALX-350-009-M025   25 mg 40.00 USD Add To Cart
ALX-350-009-M050   50 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C15H10O4
MW: 254.2
CAS NUMBER: 486-66-8
MERCK INDEX: 14: 2801
RTECS: DJ3100040
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO; slightly soluble in 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
Inactive analog of the tyrosine kinase inhibitor genistein (Prod. No. ALX-350-006). Shows anti-inflammatory effect.
Product Specific Literature References
Genistein, a specific inhibitor of tyrosine-specific protein kinases: T. Akiyama, et al.; J. Biol. Chem. 262, 5592 (1987) Abstract; Full Text
Role of tyrosine kinases in IgE-mediated signal transduction in human lung mast cells and basophils: S.E. Lavens, et al.; Am. J. Respir. Cell. Mol. Biol. 7, 637 (1992) Abstract
Tyrosine kinase inhibitors block calcium channel currents in vascular smooth muscle cells: S. Wijetunge, et al.; BBRC 189, 1620 (1992) Abstract
Genistein and daidzein, and their ß-glycoside conjugates: anti-tumor isoflavones in soybean foods from American and Asian diets: L. Coward, et al.; J. Agric. Food Chem. 41, 1961 (1993)
Stimulation of pS2 expression by diet-derived compounds: N. Sathyamoorthy, et al.; Cancer Res. 54, 957 (1994) Abstract
Daidzein inhibits insulin- or insulin-like growth factor-1-mediated signaling in cell cycle progression of Swiss 3T3 cells: K. Higashi and H. Ogawara; Biochim. Biophys. Acta 1221, 29 (1994) Abstract
Decreased circulating levels of tumor necrosis factor-alpha in postmenopausal women during consumption of soy-containing isoflavones: Y. Huang, et al.; J. Clin. Endocrinol. Metab. 90, 3956 (2005) Abstract
Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health: C. Atkinson, et al.; Exp. Biol. Med. (Maywood) 230, 155 (2005), Review Abstract
Clinical review: a critical evaluation of the role of soy protein and isoflavone supplementation in the control of plasma cholesterol concentrations: A. Dewell, et al.; J. Clin. Endocrinol. Metab. 91, 772 (2006), Review Abstract
Phytoestrogens and lipoproteins in women: C.N. Bairey Merz, et al.; J. Clin. Endocrinol. Metab. 91, 2209 (2006) Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents • Tyrosine Kinase Inhibitors • Active Substances from Fruit and Vegetables • Flavonoids/Related Products
 
 
ALX-350-248 Revised 23-Jun-05
Daidzin
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SYNONYMS Daidzein-7-O-glucoside
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-248-M002   2 mg 75.00 USD Add To Cart
ALX-350-248-M010   10 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C21H20O9
MW: 416.4
CAS NUMBER: 552-66-9
MERCK INDEX: 14: 2801
PURITY: ≥98%
APPEARANCE: White to beige powder.
SOLUBILITY: Soluble in DMSO or dilute aqueous base; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Glucoside of the isoflavone daidzein (Prod. No. ALX-350-009) found in soy beans.
Product Specific Literature References
Metabolism of puerarin and daidzin by human intestinal bacteria and their relation to in vitro cytotoxicity: D.H. Kim, et al.; Biol. Pharm. Bull. 21, 628 (1998) Abstract
Daidzin and its antidipsotropic analogs inhibit serotonin and dopamine metabolism in isolated mitochondria: W.M. Keung & B.L. Vallee; PNAS 95, 2198 (1998) Abstract
Daidzein and genistein but not their glucosides are absorbed from the rat stomach: M.K. Piskula, et al.; FEBS Lett. 447, 287 (1999) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Flavonoids/Related Products
 
 
ALX-270-281 Revised 28-Sep-06
Daphnetin
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SYNONYMS 7,8-Dihydroxycoumarin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
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ALX-270-281-M005   5 mg 25.00 USD Add To Cart
ALX-270-281-M025   25 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C9H6O4
MW: 178.1
CAS NUMBER: 486-35-1
RTECS: GN6382600
PURITY: ≥97%
APPEARANCE: White to rose powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Inhibitor of protein kinases. EGF receptor tyrosine kinase (IC50=7.87µM), PKA (IC50=9.33µM), PKC (IC50=25.01µM). Antioxidant. Antimalarial agent.
Product Specific Literature References
Daphnetin: a novel antimalarial agent with in vitro and in vivo activity: Y.Z. Yang, et al.; Am. J. Trop. Med. Hyg. 46, 15 (1992) Abstract
Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor: E.B. Yang, et al.; BBRC 260, 682 (1999) Abstract
Further Categories Containing This Product:
PKA Inhibitors • Malaria/Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Tyrosine Kinase Inhibitors
 
 
ALX-430-120 Revised 02-Nov-07
DEDPI
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SYNONYMS 4-(Dimethylamino)-2-ethyl-5,5-dimethyl-2-pyridine-4-yl-2,5-dihydro-1H-imidazol-1-oxyl
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
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ALX-430-120-M010   10 mg 60.00 USD Add To Cart
ALX-430-120-M050   50 mg 210.00 USD Add To Cart
Product Specification
FORMULA: C14H21N4O
MW: 261.3
PURITY: ≥99% (HPLC; EPR)
APPEARANCE: Orange crystalline solid.
SOLUBILITY: Highly soluble in DMSO, methanol or 100% ethanol; moderately soluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
pH-sensitive nitroxide for in vivo studies. The presence of two ionizable groups in the side-chains extends the range of pH sensitivity. The relatively high solubility in water and broad range of pH-sensitivity makes the probe particularly suitable for pH monitoring in stomach using non-invasive low-field EPR techniques.
Product Specific Literature References
Grignard reagent addition to 5-alkylamino-4H-imidazole 3-oxides: synthesis of new pH-sensitive spin probes : T.G. Shevelev, et al.; Synthesis 2003, 871
Synthesis of the tetraethyl substituted pH-sensitive nitroxides of imidazole series with enhanced stability towards reduction: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 2, 1025 (2004) Abstract
In vitro and in vivo measurement of pH and thiols by EPR-based techniques: V.V. Khramtsov, et al.; Antioxid. Redox Signal. 6, 667 (2004) Abstract
Nitroxides with two pK values--useful spin probes for pH monitoring within a broad range: I.A. Kirilyuk, et al.; Org. Biomol. Chem. 3, 1269 (2005) Abstract
Real-time monitoring of drug-induced changes in the stomach acidity of living rats using improved pH-sensitive nitroxides and low-field EPR techniques: D.I. Potapenko, et al.; J. Magn. Reson. 182, 1 (2006) Abstract
 
 
ALX-620-062 Revised 01-Jun-06
2-(4-Dehydroxy)coelenterazine
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SYNONYMS Coelenterazine h
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite/Scavengers/Detection
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ALX-620-062-C050   50 µg 110.00 USD Add To Cart
Product Specification
FORMULA: C26H21N3O2
MW: 407.5
PURITY: ≥95%
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in 100% ethanol or methanol; slightly soluble in water. Avoid DMSO as product is unstable in this solvent.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas. Keep calcium free when stored in solution.
HAZARD: IRRITANT.

Product Description
Derivative of coelenterazine (Prod. No. ALX-620-063) with ~20 times higher luminescence intensity.
Product Specific Literature References
Semi-synthetic aequorins with improved sensitivity to Ca2+ ions: O. Shimomura, et al.; Biochem. J. 261, 913 (1989) Abstract
Preparation and handling of aequorin solutions for the measurement of cellular Ca2+: O. Shimomura; Cell Calcium 12, 635 (1991) Abstract
Imaging calcium dynamics in living plants using semi-synthetic recombinant aequorins: M.R. Knight, et al.; J. Cell. Biol. 121, 83 (1993) Abstract
Intracellular Ca2+ signals in Dictyostelium chemotaxis are mediated exclusively by Ca2+ influx: T. Nebl & P.R. Fisher; J. Cell Sci. 110, 2845 (1997) Abstract
Further Categories Containing This Product:
Dyes/Stains/Fluorescent Probes/Fluorescent Labels • Oxidative Stress Markers & Reagents/Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Calcium Indicators/Probes
 
 
ALX-385-028 Revised 03-Apr-08 New product
Delphinidin chloride (high purity)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-028-M010   10 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C15H11ClO7
MW: 338.7
CAS NUMBER: 528-53-0
RTECS: DK1310000
PURITY: ≥97% (HPLC)
APPEARANCE: Red to dark brown powder.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.

Product Description

Anthocyanidin with antioxidant effect found in pigmented fruits and vegetables. Shown to inhibit angiogenesis and endothelial cell apoptosis by stimulating nitric oxide (NO) production. Inhibits solar radiation (UVB)-mediated oxidative stress, reducing DNA damage.
Product Specific Literature References
Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis: S. Martin, et al.; Br. J. Pharmacol. 139, 1095 (2003) Abstract;