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ALX-550-007
Revised 26-Apr-07
(1S,3R)-homo-ACPD
SYNONYMS
(1S,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic)/Related Products
Ordering Information
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Unit Price:
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ALX-550-007-M005
5 mg
65.00 USD
Product Specification
FORMULA:
C
8
H
13
NO
4
MW:
187.2
PURITY:
≥97% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Active isomer of
trans
-1,2-
homo
-ACPD (Prod. No.
ALX-550-006
). Highly selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors:
H. Bräuner-Osborne, et al.; Eur. J. Pharmacol.
332
, 327 (1997)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
ALX-550-011
Revised 24-Nov-04
(1S,3S)-homo-ACPD
SYNONYMS
(1S,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Glutamate Receptors (Metabotropic)/Related Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
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ALX-550-011-M005
5 mg
95.00 USD
Product Specification
FORMULA:
C
8
H
13
NO
4
MW:
187.2
PURITY:
≥97%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in dilute aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
Product Description
Isomer of
cis
-1,3-
homo
-ACPD (Prod. No.
ALX-550-009
).
Partial agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors:
H. Bräuner-Osborne, et al.; Eur. J. Pharmacol.
332
, 327 (1997)
Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors
:
D.D. Schoepp, et al.; Neuropharmacology
38
, 1431 (1999), (Review)
Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
ALX-260-165
Revised 22-Oct-07
Ac-RCGVPD-NH2
SYNONYMS
MMP-3 Inhibitor
Stromelysin-1 Inhibitor
PRODUCT LINE
Cytoskeleton
PRODUCT CATEGORY
MMP Inhibitors
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ALX-260-165-M001
1 mg
45.00 USD
ALX-260-165-M005
5 mg
180.00 USD
Product Specification
SEQUENCE:
Ac-Arg-Cys-Gly-Val-Pro-Asp-NH
2
FORMULA:
C
27
H
46
N
10
O
9
S
MW:
686.8
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of matrix metalloproteinase 3 (MMP-3) (IC
50
=5µM).
Product Specific Literature References
Peptides based on the conserved predomain sequence of matrix metalloproteinases inhibit human stromelysin and collagenase:
A.C. Hanglow, et al.; Agents Actions
39
, C148 (1993)
Abstract
Potent peptide inhibitors of stromelysin based on the prodomain region of matrix metalloproteinases:
N. Fotouhi, et al.; J. Biol. Chem.
269
, 30227 (1994)
Abstract
ALX-260-128
Revised 03-Apr-08
Actinonin
SYNONYMS
3[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]-carbonyl]-2-methylpropyl]-carbamoyl]-octanohydroxamic acid
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antitumor Antibiotics
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Product Numbers:
Format:
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ALX-260-128-M005
5 mg
90.00 USD
Product Specification
FORMULA:
C
19
H
35
N
3
O
5
MW:
385.5
CAS NUMBER:
13434-13-4
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Inhibitor of aminopeptidase M, leucine aminopeptidase and deformylase. Shows antitumor activity. Apoptosis inducer.
Product Specific Literature References
Production of actinonin, an inhibitor of aminopeptidase M, by actinomycetes:
H. Umezawa, et al.; J. Antibiot. (Tokyo)
38
, 1629 (1985)
Abstract
Analgesic effect of actinonin, a new potent inhibitor of multiple enkephalin degrading enzymes:
M. Hachisu, et al.; Life Sci.
41
, 235 (1987)
Abstract
Effects of an antibiotic protease inhibitor, actinonin on the growth within collagen gels of non-metastatic and metastatic mouse mammary tumors of the same origin:
K. Sayama, et al.; Cancer Lett
94
, 171 (1995)
Abstract
Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299:
U. Lendeckel, et al.; BBRC
252
, 5 (1998)
Abstract
Antitumor activity of actinonin in vitro and in vivo:
Y. Xu, et al.; Clin. Cancer Res.
4
, 171 (1998)
Abstract
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor:
D.Z. Chen, et al.; Biochemistry
39
, 1256 (2000)
Abstract
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics:
M.D. Lee, et al.; J. Clin. Invest.
114
, 1107 (2004)
Abstract
Actinonin induces apoptosis in U937 leukemia cells:
M. Grujic, et al.; Cancer Lett.
223
, 211 (2005)
Abstract
Further Categories Containing This Product:
Aminopeptidases/Related Products
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Antitumor Agents (Enzyme Inhibitors)
ALX-480-011
Revised 17-Jan-05
Adenosine 3',5'-cyclic Monophosphate . sodium salt
SYNONYMS
Cyclic AMP . Na
cAMP . Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-480-011-M100
100 mg
38.00 USD
ALX-480-011-M250
250 mg
70.00 USD
ALX-480-011-G001
1 g
195.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
O
6
P . Na
MW:
328.2 . 23.0
CAS NUMBER:
37839-81-9
MERCK INDEX:
14:
2708
PURITY:
≥98%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Key regulator of many cellular reactions. Naturally occurring activator of cAMP-dependent protein kinase (PKA).
Product Specific Literature References
TGF-beta 1 and cyclic AMP promote apoptosis in resting human B lymphocytes:
J. Lomo, et al.; J. Immunol.
154
, 1634 (1995)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-085
Revised 05-Sep-07
Adenosine-3’,5’-cyclic Monophosphothioate, Rp-Isomer . sodium salt
SYNONYMS
Rp-cAMPS . Na
cAMPS . Na, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
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ALX-480-085-M001
1 mg
120.00 USD
ALX-480-085-M005
5 mg
490.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
MW:
367.3
CAS NUMBER:
73208-40-9
PURITY:
≥99% (low adenosine, cAMP and Sp-cAMPS content)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
For application and literature references see the triethylammonium salt (Prod. No.
ALX-480-012
).
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-012
Revised 27-Apr-06
Adenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt
SYNONYMS
Rp-cAMPS . TEA
cAMPS . TEA, Rp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
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ALX-480-012-M001
1 mg
110.00 USD
ALX-480-012-M005
5 mg
460.00 USD
Product Specification
FORMULA:
C
10
H
12
N
5
O
5
PS . C
6
H
16
N
MW:
345.5 . 101.0
CAS NUMBER:
151837-09-1
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Competitive inhibitor of protein cAMP-dependent protein kinase type I and II (cAMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic as compared to cAMP and thus membrane permeable in many biological systems.
Product Specific Literature References
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase:
J.D. Rothermel; Biochem. J.
251
, 757 (1988)
Abstract
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates:
E. Butt, et al.; FEBS Lett.
263
, 47 (1990)
Abstract
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases
:
L.Y. Wang, et al.; Science
253
, 1132 (1991)
Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells:
T. Bouschet, et al.; J. Biol. Chem.
278
, 4778 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
PKA Inhibitors
ALX-480-086
Revised 30-Aug-06
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . sodium salt
SYNONYMS
Sp-cAMPS . Na
cAMPS . Na, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
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ALX-480-086-M001
1 mg
75.00 USD
ALX-480-086-M005
5 mg
300.00 USD
Product Specification
FORMULA:
C
10
H
11
N
5
NaO
5
PS
MW:
367.3
CAS NUMBER:
717794-13-5
PURITY:
≥99% (low adenosine, cAMP and Rp-cAMPS content)
APPEARANCE:
White to off-white lyophilized powder.
SOLUBILITY:
Soluble in water or aqueous buffers.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
For application and literature references see the triethylammonium salt (Prod. No.
ALX-480-013
).
Further Categories Containing This Product:
PKA Activators
ALX-480-013
Revised 10-Feb-05
Adenosine 3',5'-cyclic Monophosphothioate, Sp-Isomer . triethylammonium salt
SYNONYMS
Sp-cAMPS . TEA
cAMPS . TEA, Sp-Isomer
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
cAMP Derivatives
Ordering Information
Product Numbers:
Format:
Size:
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ALX-480-013-M001
1 mg
75.00 USD
ALX-480-013-M005
5 mg
298.00 USD
ALX-480-013-M010
10 mg
580.00 USD
Product Specification
FORMULA:
C
16
H
27
N
6
O
5
PS
MW:
446.5
CAS NUMBER:
93602-66-5
PURITY:
≥99%
APPEARANCE:
White lyophilized solid.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Activator of cAMP-dependent protein kinase (PKA) (cAMP agonist). Considerably higher resistance against cyclic nucleotide-dependent phosphodiesterases as compared to N
6
,O
2'
-dibutyryladenosine 3',5'-cyclic monophosphate (dibutyryl-cAMP) (Prod. No.
ALX-480-045
) or 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) (Prod. No.
ALX-480-007
). No metabolic side effects. Membrane permeable in many biological systems.
Product Specific Literature References
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates:
W.R.G. Dostmann, et al.; J. Biol. Chem.
265
, 10484 (1990)
Abstract
;
Full Text
Cyclic AMP antagonist Rp-cAMPS inhibits amylase exocytosis from saponin- permeabilized parotid acini:
T. Takuma & T. Ichida; J. Biochem.
110
, 292 (1991)
Abstract
Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange:
T. Sugimoto, et al.; J. Cell Physiol.
152
, 28 (1992)
Abstract
The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone:
H. Kaji, et al.; BBRC
182
, 1356 (1992)
Abstract
Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging:
P.J. Sammak, et al.; J. Cell. Biol.
117
, 57 (1992)
Abstract
Effects of activators and inhibitors of protein kinase A on increases in quantal size at the frog neuromuscular junction:
W. Van Der Kloot & D.D. Branisteanu; Pfluegers Arch.
420
, 336 (1992)
Abstract
Further Categories Containing This Product:
PKA Activators
ALX-480-001
Revised 13-Jul-06
Adenosine 5'-diphosphate . disodium salt
SYNONYMS
ADP . 2Na
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Adenosine Derivatives Other Products
Ordering Information
Product Numbers:
Format:
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Unit Price:
Quantity:
Add To Cart
ALX-480-001-G001
1 g
45.00 USD
ALX-480-001-G005
5 g
160.00 USD
Product Specification
FORMULA:
C
10
H
13
N
5
O
10
P
2
. 2Na
MW:
471.2 . 46.0
CAS NUMBER:
16178-48-6
MERCK INDEX:
14:
154
SOURCE/HOST:
Isolated from yeast.
PURITY:
≥
95%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Slight degradation to AMP may occur during storage.
HANDLING:
Protect from moisture.
Further Categories Containing This Product:
Nitric Oxide Pathway Other Products
ALX-480-002
Revised 12-Apr-07
Adenosine 5'-diphosphate . potassium salt
