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Antioxidants, Flavonoids & Free Radical Scavengers
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ALX-385-025 Revised 07-Apr-08
8-Isopentenylnaringenin
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SYNONYMS 8-Prenylnaringenin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavanones
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ALX-385-025-M005   5 mg 155.00 USD Add To Cart
Product Specification
FORMULA: C20H20O5
MW: 340.4
SOURCE/HOST: Isolated from hops (Humulus lupulus L.).
PURITY: ≥97% (HPLC)
APPEARANCE: Light yellow powder
SOLUBILITY: Soluble in methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Prenyl flavonoid. Phytoestrogen. Selective, non-steroidal estrogen receptor α (ERα) ligand. Potent inhibitor of angiogenesis in vitro and in vivo. Chemopreventive agent against cancer induced by heterocyclic amines.
Product Specific Literature References
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship: M. Kitaoka, et al.; Planta Med. 64, 511 (1998) Abstract
Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 2). Estrogenic effects of 8-isopentenylnaringenin on bone metabolism: M. Miyamoto, et al.; Planta Med. 64, 516 (1998) Abstract
Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer: S.R. Milligan, et al.; J. Clin. Endocrinol. Metab. 84, 2249 (1999) Abstract
Prenylflavonoids from hops inhibit the metabolic activation of the carcinogenic heterocyclic amine 2-amino-3-methylimidazo[4, 5-f]quinoline, mediated by cDNA-expressed human CYP1A2: C.L. Miranda, et al.; Drug Metab. Dispos. 28, 1297 (2000) Abstract; Full Text
The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids: S.R. Milligan, et al.; J. Clin. Endocrinol. Metab. 85, 4912 (2000) Abstract; Full Text
8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo: M.S. Pepper, et al.; J. Cell Physiol. 199, 98 (2004) Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types: T.F. Bovee, et al.; J. Steroid Biochem. Mol. Biol. 91, 99 (2004) Abstract
8-Prenylnaringenin, inhibits estrogen receptor-alpha mediated cell growth and induces apoptosis in MCF-7 breast cancer cells: E. Brunelli, et al.; J. Steroid Biochem. Mol. Biol. 107, 140 (2007) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Estrogen & Estrogen Receptors / Related Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Other Natural Products - DNA Regulation / Transcription
 
 
ALX-385-024 Revised 06-Oct-08
Isorhamnetin
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SYNONYMS 3-Methylquercetin
3'-Methoxy-3,4',5,7-tetrahydroxyflavone
3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-024-M005   5 mg 90.00 USD Add To Cart
ALX-385-024-M010   10 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C16H12O7
MW: 316.3
CAS NUMBER: 480-19-3
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in acetone, methanol, ethylacetate or DMSO. Only sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: MAY BE CARCINOGENIC. HARMFUL.

Product Description
Antiviral agent. Antioxidant. Antitumor compound. Apoptosis inducer.
Product Specific Literature References
Anti-tumor promoting activity of polyphenols from Cowania mexicana and Coleogyne ramosissima: H. Ito, et al.; Cancer Lett. 143, 5 (1999) Abstract
Inhibition of xanthine oxidase by flavonoids: A. Nagao, et al.; Biosci. Biotechnol. Biochem. 63, 1787 (1999) Abstract
Effects of intrinsic fluorescence and quenching on fluorescence-based screening of natural products: L. Zou, et al.; Phytomedicine 9, 263 (2002) Abstract
Antioxidant effects of isorhamnetin 3,7-di-O-beta-D-glucopyranoside isolated from mustard leaf (Brassica juncea) in rats with streptozotocin-induced diabetes: T. Yokozawa, et al.; J. Agric. Food Chem. 50, 5490 (2002) Abstract
Effect of five flavonoid compounds isolated from leaves of Diospyros kaki on stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils: G. Chen, et al.; Clin. Chim. Acta 326, 169 (2002) Abstract
Isorhamnetin prevent endothelial cell injuries from oxidized LDL via activation of p38MAPK: M. Bao & Y. Lou; Eur. J. Pharmacol. 547, 22 (2006) Abstract
The flavonoid component isorhamnetin in vitro inhibits proliferation and induces apoptosis in Eca-109 cells: G. Ma, et al.; Chem. Biol. Interact. 167, 153 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Antitumor Reagents • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants • Natural Products - Antiviral / anti-HIV Agents
 
 
ALX-350-279 Revised 02-Jun-08
Isoxanthohumol
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Natural Products - DNA Regulation / Transcription
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ALX-350-279-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C21H22O5
MW: 354.4
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO (50mg/ml) or methanol (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.
Product Specific Literature References
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review) Abstract
Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents: E. Bertl, et al.; BBRC 325, 287 (2004) Abstract
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes: D. Nikolic, et al.; J. Mass Spectrom. 40, 289 (2005) Abstract
The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine: S. Possemiers, et al.; J. Nutr. 136, 1862 (2006) Abstract
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.): J. Guo, et al.; Drug Metab. Dispos. 34, 1152 (2006)
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007) Abstract
Further Categories Containing This Product:
Flavanones • Estrogen & Estrogen Receptors / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Lipid Metabolism Other Products • Active Substances from Fruit and Vegetables • Natural Products - Other Signal Transduction Pathway Modulators
 
 
ALX-385-005 Revised 21-May-08
Kaempferol
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SYNONYMS 3,4',5,7-Tetrahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-385-005-M010   10 mg 40.00 USD Add To Cart
ALX-385-005-M050   50 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C15H10O6
MW: 286.2
CAS NUMBER: 520-18-3
MERCK INDEX: 14: 5274
RTECS: LK9275200
PURITY: ≥90%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in ether or 100% ethanol (hot); slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: IRRITANT. MAY BE MUTAGENIC.

Product Description
Antioxidant flavonoid. Apoptosis inducer. Reversible inhibitor of fatty acid synthase (FAS).
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Presence of fatty acid synthase inhibitors in the rhizome of Alpinia officinarum hance: B.H. Li & W.X. Tian; J. Enzyme Inhib. Med. Chem. 18, 349 (2003) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Fatty Acid Synthase [FAS] / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants
 
 
ALX-430-124 Revised 23-Feb-05
Licochalcone A (synthetic)
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SYNONYMS (E)-3-[5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hydroxyphenyl)-2-propen-1-one
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Bcl-2 Family Modulators
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ALX-430-124-M005   5 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C21H22O4
MW: 338.4
CAS NUMBER: 58749-22-7
PURITY: ≥96% (HPLC)
APPEARANCE: Yellow crystalline solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for up to 6 months when stored at –20°C. Dilute stock solution 1:10 with aqueous buffer or medium just prior to use.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Packaged under inert gas. Protect from light.
HAZARD: HARMFUL.

Product Description
Reduces Bcl-2 protein expression.
Further Categories Containing This Product:
Chalcones
 
 
ALX-270-266 Revised 19-May-03
DL-α-Lipoic acid
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SYNONYMS DL-6,8-Thioctic acid
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Antioxidants, Flavonoids & Free Radical Scavengers Other Products
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ALX-270-266-G001   1 g 20.00 USD Add To Cart
ALX-270-266-G005   5 g 60.00 USD Add To Cart
Product Specification
FORMULA: C8H14O2S2
MW: 206.3
CAS NUMBER: 1077-28-7
MERCK INDEX: 14: 9326
PURITY: ≥97%
APPEARANCE: Solid.
SOLUBILITY: Soluble in 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Antioxidant.
 
 
ALX-350-355 Revised 26-Mar-08
Lupeol
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SYNONYMS Fagarasterol
20(29)-Lupen-3β-ol
3β-Hydroxy-20(29)-lupene
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
Ordering Information
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ALX-350-355-M010   10 mg 35.00 USD Add To Cart
ALX-350-355-M050   50 mg 105.00 USD Add To Cart
ALX-350-355-G001   1 g 990.00 USD Add To Cart
Product Specification
FORMULA: C30H50O
MW: 426.7
CAS NUMBER: 545-47-1
MERCK INDEX: 14: 5608
RTECS: OK5763000
SOURCE/HOST: Isolated from Lupinus polyphyllus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in ether or warm 100% ethanol; insoluble in water
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Anti-inflammatory, antioxidant and antimutagenic compound. Shows preventive effects on DMBA induced DNA alkylation damage in mouse skin. Modulator of NF-κB and PI(3)K/Akt (protein kinase B; PKB) pathways. Induces Fas-mediated apoptosis via inhibition of Ras signalling. Inhibits tumor growth in mouse in vivo.
Product Specific Literature References
Anti-inflammatory activity of lupeol and lupeol linoleate in rats: T. Geetha & P. Varalakshmi; J. Ethnopharmacol. 76, 77 (2001) Abstract
Lupeol, a triterpene, inhibits early responses of tumor promotion induced by benzoyl peroxide in murine skin: M. Saleem, et al.; Pharmacol. Res. 43, 127 (2001) Abstract
Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice: M. Saleem, et al.; Oncogene 23, 5203 (2004) Abstract
Induction of antifertility with lupeol acetate in male albino rats: R.S. Gupta, et al.; Pharmacology 75, 57 (2005) Abstract
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model: M. Saleem, et al.; Cancer Res. 65, 11203 (2005) Abstract; Full Text
Lupeol, a fruit and vegetable based triterpene, induces apoptotic death of human pancreatic adenocarcinoma cells via inhibition of Ras signaling pathway: M. Saleem, et al.; Carcinogenesis 26, 1956 (2005) Abstract; Full Text
Lupeol long-chain fatty acid esters with antimalarial activity from Holarrhena floribunda: J. Fotie, et al.; J. Nat. Prod. 69, 62 (2006) Abstract
Lupeol ameliorates aflatoxin B1-induced peroxidative hepatic damage in rats: S.P. Preetha, et al.; Comp. Biochem. Physiol C. Toxicol. Pharmacol. 143, 333 (2006) Abstract
Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia: V. Sudhahar, et al.; Life Sci. 78, 1329 (2006) Abstract
Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin: N. Nigam, et al.; Food Chem. Toxicol. 45, 2331 (2007) Abstract
Lupeol suppresses cisplatin-induced nuclear factor-kappaB activation in head and neck squamous cell carcinoma and inhibits local invasion and nodal metastasis in an orthotopic nude mouse model: T.K. Lee, et al.; Cancer Res. 67, 8800 (2007) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants
 
 
ALX-385-007 Revised 07-Oct-08
Luteolin
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SYNONYMS 3',4',5,7-Tetrahydroxyflavone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavones
Ordering Information
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ALX-385-007-M010   10 mg 15.00 USD Add To Cart
ALX-385-007-M050   50 mg 45.00 USD Add To Cart
Product Specification
FORMULA: C15H10O6
MW: 286.2
CAS NUMBER: 491-70-3
MERCK INDEX: 14: 5614
RTECS: LK9275210
PURITY: ≥90%
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in methanol, alkaline solutions; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Antioxidant flavonoid. Inhibits VEGF-induced angiogenesis. Inhibitor of phosphoinositide 3-kinase (PI(3)K). Inhibitor of fatty acid synthase (FAS). Apoptosis inducer.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity: E. Bagli, et al.; Cancer Res. 64, 7936 (2004)
Dietary flavonoids: bioavailability, metabolic effects, and safety: J.A. Ross & C.M. Kasum; Annu. Rev. Nutr. 221, 19 (2002), (Review) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract
Further Categories Containing This Product:
Natural Products - Other Signal Transduction Pathway Modulators • Fatty Acid Synthase [FAS] / Related Products • Free Radical Scavengers • Phosphoinositide 3-kinase [PI(3)K] / Related Products • Natural Products for Angiogenesis Research • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants
 
 
ALX-385-013 Revised 16-Jun-08
Malvidin chloride
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SYNONYMS 3,4',5,7-Tetrahydroxy-3',5'-dimethoxyflavylium chloride
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Anthocyanidins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-385-013-M010   10 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C17H15O7Cl
MW: 366.8
CAS NUMBER: 643-84-5
MERCK INDEX: 14: 5715
RTECS: LK9900000
PURITY: ≥97%
APPEARANCE: Reddish brown to black powder.
SOLUBILITY: Soluble in 100% ethanol; slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light. Hygroscopic.

Product Description
Antioxidant flavonoid. Antitumor compound. Induces cell cycle arrest in the G2/M-phase.
Product Specific Literature References
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Biological activities of malvidin, a red wine anthocyanidin: J. Fritz, et al.; Mol. Nutr. Food Res. 50, 390 (2006) Abstract
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products - Antitumor Reagents • Natural Products - Antioxidants • Natural Products for Cell Cycle Research
 
 
ALX-202-070 Revised 10-Jun-05
Metallothionein-1 (rabbit liver)