ALEXIS Biochemicals: Arachidonic acid

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ALX-340-004

Revised 18-Aug-08

Arachidonic acid
SYNONYMS	5Z,8Z,11Z,14Z-Eicosatetraenoic acid
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Arachidonic Acid / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-004-M100		100 mg	147.00 USD

Product Specification

FORMULA:	C₂₀H₃₂O₂
MW:	304.5
CAS NUMBER:	506-32-1
MERCK INDEX:	14: 765
RTECS:	CE6675000
CONCENTRATION:	100mg/ml
PURITY:	≥98%
FORMULATION:	Liquid. Solution in ethanol containing 0.1% BHT.
SOLUBILITY:	100mg/ml soluble in DMSO or dimethyl formamide; sparingly soluble in basic aqueous buffers (1.7mg/ml). To prevent oxidation, the solvent should be purged with an inert gas.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C. Keep aqueous solutions on ice and use within 12 hours.
HANDLING:	Protect from light and oxygen.
HAZARD:	TOXIC.

Product Description

Precursor to a large family of eicosanoids. Activator for several protein kinase C (PKC) isotypes.

Product Specific Literature References

Arachidonic acid metabolism: P. Needleman, et al.; Ann. Rev. Biochem. 55, 69 (1986) Abstract
Kinetic analysis of the Ca2+-dependent, membrane-bound, macrophage phospholipase A2 and the effects of arachidonic acid: M.D. Lister, et al.; J. Biol. Chem. 263, 7506 (1988) Abstract; Full Text
Characterization of the L-arginine:nitric oxide pathway in human platelets: M.W. Radomski, et al.; Br. J. Pharmacol. 101, 325 (1990) Abstract
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor: A.J.R. Habenicht, et al.; Nature 345, 634 (1990) Abstract
The control of free arachidonic acid levels: R.D. Burgoyne & A. Morgan; TIBS 15, 365 (1990) Abstract
A unique pool of free arachidonate serves as substrate for both cyclooxygenase and lipoxygenase in platelets: F. Chevy, et al.; Lipids 26, 1080 (1991) Abstract
Regulation of Ras-GAP and the neurofibromatosis-1 gene product by eicosanoids: J.W. Han, et al.; Science 252, 576 (1991) Abstract
Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils: S.B. Abramson, et al.; J. Immunol. 147, 231 (1991) Abstract
The immediate activator of the NADPH oxidase is arachidonate not phosphorylation: Henderson, et al.; Eur. J. Biochem. 211, 157 (1993) Abstract
Nitric oxide and arachidonic acid modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia: G. Khurana & M.R. Bennett; Br. J. Pharmacol. 109, 480 (1993) Abstract
Arachidonic acid-induced Ca2+ release from isolated sarcoplasmic reticulum: C. Dettbarn & P. Palade; Biochem. Pharmacol. 45, 1301 (1993) Abstract
Covalent binding of arachidonate to G protein alpha subunits of human platelets: H. Hallak, et al.; J. Biol. Chem. 269, 4713 (1994) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION

To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.

Further Categories Containing This Product:

PKC Activators • Nitric Oxide Pathway Other Products • Fatty Acids

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