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ALX-210-395 Revised 30-Oct-06
Polyclonal Antibody to Asb-11 (human)
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SYNONYMS anti-Ankyrin Repeat and SOCS Box Containing Protein 11 (human) PAb
PRODUCT LINE Other Products
PRODUCT CATEGORY Unidentified Gene Products & Proteins with Unknown Function / Related Products
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ALX-210-395-R200   200 µl 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide and 0.1mg/ml BSA.
IMMUNOGEN: Synthetic peptides corresponding to aa 40-51 and 250-265 of human Asb-11 (ankyrin repeat and SOCS box containing protein).
SPECIFICITY: Recognizes human Asb-11.
APPLICATION: Western Blot (1:500-1:1'000).
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
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General Information
The ankyrin repeat and SOCS box-containing (Asb) protein family is comprised of members which each contain “SOCS boxes” but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are C-terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-393 Revised 18-Sep-07
Polyclonal Antibody to Asb-3 (human)
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SYNONYMS anti-Ankyrin Repeat and SOCS Box Containing Protein 3 (human) PAb
PRODUCT LINE Other Products
PRODUCT CATEGORY Unidentified Gene Products & Proteins with Unknown Function / Related Products
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ALX-210-393-R200   200 µl 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide and 0.1mg/ml BSA.
IMMUNOGEN: Synthetic peptides corresponding to aa 63-75 and 166-180 of human Asb-3 (ankyrin repeat and SOCS box containing protein 3).
SPECIFICITY: Recognizes human Asb-3.  Does not cross-react with mouse or rat Asb-3.
APPLICATION: Western Blot (1:500-1:1'000).
Other applications not tested.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Images
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General Information
The ankyrin repeat and SOCS box-containing (Asb) protein family is comprised of members which each contain “SOCS boxes” but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are C-terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-922 Revised 26-Aug-05
Polyclonal Antibody to Cornulin (human) (SZ1229)
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SYNONYMS anti-Tumor Related Protein (human) PAb (SZ1229)
anti-C1orf10 Gene Product (human) PAb (SZ1229)
anti-Chromosome 1 Open Reading Frame 10 Gene Product (human) PAb (SZ1229)
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Differentiation
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ALX-210-922-C050   50 µg 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 0.5mg/ml
FORMULATION: Liquid. In PBS containing 1% BSA and 0.01% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 259-274 (E259ATNDQNRGTETHGQG274) of human cornulin.
SPECIFICITY: Recognizes human cornulin. Detects a band of ~70kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections (1:100))
Western Blot (1:2’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
[1] Cornulin, a new member of the "fused gene" family, is expressed during epidermal differentiation: R. Contzler, et al.; J. Invest. Dermatol. 124, 990 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Tissue Markers • Polyclonal Antibodies • Tumor Markers
 
 
ALX-210-925 Revised 12-Oct-05
Polyclonal Antibody to Repetin (AF646)
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PRODUCT LINE Cell Cycle
PRODUCT CATEGORY Cell Differentiation
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ALX-210-925-C050   50 µg 180.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In PBS containing 0.5% BSA and 0.005% sodium azide and 50% glycerol.
IMMUNOGEN: Synthetic peptide corresponding to aa 570-584 (H570YGQTDRQGQSSHYI584) of human repetin.
SPECIFICITY: Recognizes human and mouse repetin. Detects a band of ~100kDa by Western blot.
APPLICATION: Immunohistochemistry (frozen sections (1:250-1:500))
Western Blot (1:2’500-1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year after receipt when stored at -20°C.
HANDLING: Avoid freeze/thaw cycles.
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Product Specific Literature References
Isolation and characterization of human repetin, a member of the fused gene family of the epidermal differentiation complex: M. Huber, et al.; J. Invest. Dermatol. 124, 998 (2005) Abstract
General Information
MANUFACTURER Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Tissue Markers • Polyclonal Antibodies
 
 
ALX-400-043 Revised 09-May-07
Propidium Iodide
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PRODUCT LINE Other Products
PRODUCT CATEGORY Dyes / Stains / Fluorescent Probes / Fluorescent Labels
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ALX-400-043-M001   1 mg 77.00 USD Add To Cart
Product Specification
FORMULA: C27H34N4I2
MW: 668.4
CAS NUMBER: 25535-16-4
RTECS: SF7949600
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Solution in PBS.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
DNA intercalator. Useful for differentiation between apoptotic cell death if used in combination with annexin V conjugates by flow cytometry. Ex(max): 536nm; Em(max): 617nm.
Product Specific Literature References
Propidium iodide staining correlates with the extent of DNA degradation in isolated nuclei: T. Crompton, et al.; BBRC 183, 532 (1992) Abstract
A flow cytometric method using Hoechst 33342 and propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells: F. Belloc, et al.; Cytometry 17, 59 (1994) Abstract
Assessment of secondary necrosis of Jurkat cells using a new microscopic system and double staining method with annexin V and propidium iodide: O. Honda, et al.; Int. J. Oncol. 16, 283 (2000) Abstract
Flow cytometric analysis of apoptotic subpopulations with a combination of annexin V-FITC, propidium iodide, and SYTO 17: M. Eray, et al.; Cytometry 43, 134 (2001) Abstract
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V: I. Vermes, et al.; J. Immunol. Meth. 184, 39 (1995) Abstract
Distribution of the human intracellular serpin protease inhibitor 8 in human tissues: M.C. Strik, et al.; J. Histochem. Cytochem. 50, 1443 (2002) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Dilute to 250µg/ml in PBS before use. Add 1µl per annexin V assay.
Related Products
Further Categories Containing This Product:
DNA Intercalators & Crosslinkers
 
 
ALX-350-300 Revised 14-Dec-07
Pseurotin A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-350-300-M001   1 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO8
MW: 431.5
CAS NUMBER: 58523-30-1
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in methanol or ethyl acetate; poorly soluble in water.
SHIPPING: AMBIENT
SHORT TERM STORAGE: -20°C
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Inhibitor of chitin synthase. Cytotoxic. Has nematicidal activity.
Product Specific Literature References
Novel neuritogenic activities of pseurotin A and penicillic acid: D. Komagata, et al.; J. Antibiot. 49, 958 (1996) Abstract
Directed biosynthesis of fluorinated pseurotin A, synerazol and gliotoxin: Y. Igarashi, et al.; J. Antibiot. 57, 748 (2004) Abstract
Fumiquinones A and B, nematicidal quinones produced by Aspergillus fumigatus: A. Hayashi, et al.; Biosci. Biotechnol. Biochem. 71, 1697 (2007) Abstract
Identification of a hybrid PKS/NRPS required for pseurotin A biosynthesis in the human pathogen Aspergillus fumigatus: S. Maiya, et al.; Chembiochem 8, 1736 (2007) Abstract
Further Categories Containing This Product:
Pesticides / Related Products
 
 
ALX-350-364 Revised 08-Apr-08
Psoralen
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SYNONYMS Ficusin
7H-Furo[3,2-g]benzopyran-7-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-364-M025   25 mg 95.00 USD Add To Cart
ALX-350-364-M100   100 mg 285.00 USD Add To Cart
Product Specification
FORMULA: C11H6O3
MW: 186.2
CAS NUMBER: 66-97-7
MERCK INDEX: 14: 7928
RTECS: LV0944000
SOURCE/HOST: Isolated from Psoralea corylifolia.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in ethyl acetate or acetone; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE MUTAGENIC. HARMFUL.

Product Description
Shows antiviral, antibacterial, antifungal and insecticidal properties. Binds DNA through single and double-stranded cross-linking after photoactivation. Used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human.
Product Specific Literature References
Psoralen phototoxicity: correlation with serum and epidermal 8-methoxypsoralen and 5-methoxypsoralen in the guinea pig: A. Kornhauser, et al.; Science 217, 733 (1982) Abstract
Psoralens as photoactive probes of nucleic acid structure and function: organic chemistry, photochemistry, and biochemistry: G.D. Cimino, et al.; Annu. Rev. Biochem. 54, 1151 (1985), (Review) Abstract
Electron microscopic identification of supercoiled regions in complex DNA structures: R.B. Inman & M. Schnos; J. Mol. Biol. 193, 377 (1987) Abstract
Probing DNA structure with psoralen in vitro: D.W. Ussery, et al.; Meth. Enzymol. 212, 242 (1992) Abstract
DNA interstrand cross-links induced by psoralen are not repaired in mammalian mitochondria: C. Cullinane & V.A. Bohr; Cancer Res. 58, 1400 (1998) Abstract; Full Text
Psoralen photocrosslinking, a tool to study the chromatin structure of RNA polymerase I--transcribed ribosomal genes: M. Toussaint, et al.; Biochem. Cell Biol. 83, 449 (2005) Abstract
Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells: S. Couve-Privat, et al.; Nucl. Acids Res. 35, 5672 (2007) Abstract; Full Text
Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids: K.H. Kim, et al.; Nucl. Acids Res. 35, 7604 (2007) Abstract; Full Text
Further Categories Containing This Product:
Natural Products - Antiviral / anti-HIV Agents • Natural Products - Antifungal Agents • DNA Intercalators & Crosslinkers • Pesticides / Related Products
 
 
ALX-307-001 Revised 18-Feb-08
L-Quebrachitol
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SYNONYMS 1L-2-O-Methyl-chiro-inositol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-307-001-G001   1 g 40.00 USD Add To Cart
Product Specification
FORMULA: C7H14O6
MW: 194.2
CAS NUMBER: 642-38-6
SOURCE/HOST: Isolated from rubber tree.
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, dimethyl formamide or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Key starting material for the synthesis of optically active inositol phosphates.
Product Specific Literature References
Synthesis of 1D-3-deoxy-, 1D-2,3-dideoxy-, and 1D-2,3,6-trideoxy-myo-inositol 1,4,5-trisphosphate from quebrachitol, their binding affinities, and calcium release activity: A.P. Kozikowski, et al.; JACS 115, 4429 (1993)
Synthesis and Biological Activity of the D-3-Deoxy-3-fluoro and D-3-Chloro-3-deoxy Analogs of Phosphatidylinositol: A.P. Kozikowski, et al.; J. Org. Chem. 59, 963 (1994)
Quebrachitol: A Versatile Building Block in the Construction of Naturally
Occurring Bioactive Materials: J.J. Kiddle; Chem. Rev. 95, 2189 (1995), (Review) Abstract
A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-quebrachitol: L. Qiao, et al.; Org. Lett. 2, 115 (2000) Abstract
Further Categories Containing This Product:
Chiral Compounds (Organic) • Chemical Synthesis - Reagents & Intermediates • Inositols & Inositolphosphates / Related Products
 
 
ALX-620-006 Revised 04-Mar-05
QUIN 2 . tetrapotassium salt
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SYNONYMS 2-[(2-bis-[Carboxymethyl]amino-5-methylphenoxy)-methyl]-6-methoxy-8-bis[carboxymethyl]aminoquinoline . 4K
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calcium Chelators / Caged Calcium Chelators
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ALX-620-006-M005   5 mg 35.00 USD Add To Cart
Product Specification
FORMULA: C26H23N3O10 . 4K
MW: 537.5 . 156.4
CAS NUMBER: 73630-23-6
MERCK INDEX: 14: 8042
PURITY: ≥95% (contains 11-13% water)
APPEARANCE: Yellow powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Calcium specific chelator and indicator. Upon binding calcium there is a shift in the UV spectrum and an enhancement of fluorescence. QUIN 2 was a member of the first generation of Ca2+ chelators introduced by Tsien in 1980. These chelators have backbones similar to that of EGTA (ethylenglycol-bis(β-aminoethyl)-N,N,N',N'-tetraacetic acid) and, like EGTA, they are able to chelate Ca2+ with high affinity and specifity. Moreover, these molecules contain aromatic rings that interact electronically and sterically with the chelating backbone. Thus chelation results in changes in the UV-absorbing and fluorescing properties of the molecules. The resulting spectral changes allow these substances to be used as very sensitive probes for Ca2+ ions, Ca2+ concentrations in single cells of various types can be measured for the first time! TPEN (Prod. No. ALX-450-011) can be used in conjunction with QUIN 2 to reduce heavy-metal quenching of QUIN 2 fluorescence in cells.
Product Specific Literature References
Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator: R.Y. Tsien, et al.; J. Cell. Biol. 94, 325 (1982) Abstract
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+: P. Arslan, et al.; J. Biol. Chem. 260, 2719 (1985) Abstract; Full Text
Calcium transients in human platelets monitored by aequorin, fura-2 and quin-2: effects of protein kinase C activation and inhibition: P. Erne, et al.; BBRC 145, 66 (1987) Abstract
Effect of DFP on loading of fura 2/AM and quin 2/AM into single smooth muscle cells prepared from guinea pig taenia coli: I. Maruyama, et al.; FEBS Lett. 220, 89 (1987) Abstract
Effects of interferon on natural killer (NK) cells assessed by fluorescent probes and flow cytometry: K. McGinnes, et al.; J. Immunol. Meth. 107, 129 (1988) Abstract
Measurement and manipulation of cytoplasmic free calcium of ram and boar spermatozoa using quin 2: A.M. Simpson & I.G. White; Cell Calcium 9, 45 (1988) Abstract
Measurement of the cytosolic free calcium ion concentration of individual lymphocytes by microfluorometry using quin 2 or fura-2: H. Komada, et al.; Cell Struct. Funct. 14, 141 (1989) Abstract
Quantitation of bovine sperm cytoplasmic calcium with Quin-2 and Fura- 2: evidence that external calcium does not have direct access to the sperm cytoplasm: S. Vijayaraghavan & D. Hoskins; Cell Calcium 10, 241 (1989) Abstract
Further Categories Containing This Product:
MDR Other Products • Calcium Indicators / Probes • Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-550-293 Revised 19-Mar-08
Reactive Blue 2
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SYNONYMS Basilen Blue E-3G
PRODUCT LINE Neurobiology
PRODUCT CATEGORY P2Y Purinergic Receptors / Related Products
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