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PKC Activators
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ALX-420-014 Revised 29-Jan-05
SC-9
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SYNONYMS 5-Chloro-N-(6-phenylhexyl)-1-naphthalenesulfonamide
N-(6-Phenylhexyl)-5-chloro-1-naphthalenesulfonamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Activators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-014-M001   1 mg 25.00 USD Add To Cart
ALX-420-014-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C22H24ClNO2S
MW: 402.0
CAS NUMBER: 102649-78-05
PURITY: ≥98%
APPEARANCE: Off-white solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Protein kinase C (PKC) activator in the presence of Ca2+.
Product Specific Literature References
N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C: M. Ito, et al.; Biochemistry 25, 4179 (1986) Abstract
N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase: H. Nishino, et al.; Biochim. Biophys. Acta. 889, 236 (1986) Abstract
Manipulation of phototransductive membrane turnover by crab photoreceptors in vitro: effects of two protein kinase activators, SC-9 and phorbol ester in the presence of a protein phosphatase inhibitor, okadaic acid: A.D. Blest, et al.; J. Comp. Physiol. 170, 189 (1992) Abstract
Neurokinin3 receptor regulation of acetylcholine release from myenteric plexus: W.M. Yau, et al.; Am. J. Physiol. 263, G659 (1992) Abstract
 
 
ALX-420-015 Revised 04-Mar-05
SC-10
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SYNONYMS 5-Chloro-N-heptylnaphthalene-1-sulfonamide
N-Heptyl-5-chloro-1-naphthalene-sulfonamide
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PKC Activators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-420-015-M001   1 mg 25.00 USD Add To Cart
ALX-420-015-M005   5 mg 90.00 USD Add To Cart
Product Specification
FORMULA: C17H22ClNO2S
MW: 339.9
CAS NUMBER: 102649-79-6
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Protein kinase C (PKC) activator. Stimulates PKC mediated myosin light chain phosphorylation without activating myosin light chain kinase.
Product Specific Literature References
N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide, a novel activator of protein kinase C: M. Ito, et al.; Biochemistry 25, 4179 (1986) Abstract
N-(6-phenylhexyl)-5-chloro-1-naphthalenesulfonamide is one of a new class of activators for Ca2+-activated, phospholipid-dependent protein kinase: H. Nishino, et al.; Biochim. Biophys. Acta 889, 236 (1986) Abstract
Contribution of protein kinase C to central sensitization and persistent pain following tissue injury: T.J. Coderre; Neurosci. Lett. 140, 181 (1992) Abstract
 
 
ALX-300-135 Revised 24-Jul-08
1-Stearoyl-2-arachidonoyl-sn-glycerol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-300-135-M010   10 mg 85.00 USD Add To Cart
Product Specification
FORMULA: C41H72O5
MW: 645.0
CAS NUMBER: 65914-84-3
PURITY: ≥96%
APPEARANCE: Colorless oil to waxy solid.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Avoid contact with acids or bases. Compound may isomerize over time. Solutions are stable for up to 2 months when stored at -20°C. Product is not sterile.

Product Description
Endogenous protein kinase C (PKC) activator, formed during receptor-mediated hydrolysis of inositol phospholipids.
Product Specific Literature References
Further studies on the specificity of diacylglycerol for protein kinase C activation: M. Go, et al.; BBRC 144, 598 (1987) Abstract
Further Categories Containing This Product:
PKC Activators
 
 
ALX-300-136 Revised 18-Nov-05
1-Stearoyl-2-linoleoyl-sn-glycerol
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Mono- & Diacylglycerols
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ALX-300-136-M010   10 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C39H72O5
MW: 621.0
PURITY: ≥98%
APPEARANCE: Clear oil.
SOLUBILITY: Soluble in 100% ethanol or DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Avoid acidic or basic conditions. In solution product may isomerize to the 1,3-isomer over time.

Product Description
Endogenous protein kinase C (PKC) activator, formed during receptor-mediated hydrolysis of inositol phospholipids.
Product Specific Literature References
Further studies on the specificity of diacylglycerol for protein kinase C activation: M. Go, et al.; BBRC 144, 598 (1987) Abstract
Further Categories Containing This Product:
PKC Activators
 
 
ALX-380-068 Revised 09-Apr-08
Trichostatin A
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SYNONYMS TSA
[R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide]
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Antibiotics - DNA Regulation / Transcription
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-068-M001   1 mg 115.00 USD Add To Cart
ALX-380-068-M005   5 mg 385.00 USD Add To Cart
Product Specification
FORMULA: C17H22N2O3
MW: 302.4
CAS NUMBER: 58880-19-6
MERCK INDEX: 14: 9649
SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
PURITY: ≥98% (HPLC)
APPEARANCE: Whitish film adhered to inside of vial.
SOLUBILITY: Soluble in DMSO, dimethyl formamide, acetonitrile, methanol or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.

Product Description
Potent, reversible inhibitor of histone deacetylase (HDAC). Mediates the activation of O6-methylguanine-DNA methyltransferase (MGMT). May be involved in cell cycle progression of several cell types. Induces cell growth arrest at both G1 and G2/M phases. May induce apoptosis in some cases. Induces acetylation of histone-3/4 and expression of p300.
Product Specific Literature References
A new antifungal antibiotic, trichostatin: N. Tsuji, et al.; J. Antibiot. 29, 1 (1976) Abstract
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A: M. Yoshida, et al.; J. Biol. Chem. 265, 17174 (1990) Abstract; Full Text
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines: Y. Hoshikawa, et al.; Exp. Cell Res. 214, 189 (1994) Abstract
Trichostatin A inhibits both ras-induced neurite outgrowth of PC12 cells and morphological transformation of NIH3T3 cells: M. Futamura, et al.; Oncogene 10, 1119 (1995) Abstract
Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function: M. Yoshida, et al.; Bioessays 17, 423 (1995) Abstract
Selective inhibition of IL-2 gene expression by trichostatin A, a potent inhibitor of mammalian histone deacetylase: I. Takahashi, et al.; J. Antibiot. 49, 453 (1996) Abstract
A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p: J. Taunton, et al.; Science 272, 408 (1996) Abstract
Transcriptional activation and chromatin remodeling of the HIV-1 promoter in response to histone acetylation: C. Van Lint, et al.; EMBO J. 15, 1112 (1996) Abstract
Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c- dependent pathway:: V. Medina, et al.; Cancer Res. 57, 3697 (1997) Abstract
A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells: S. Minucci, et al.; PNAS 94, 11295 (1997) Abstract; Full Text
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites: Y. Sowa, et al.; BBRC 241, 142 (1997) Abstract
Retinoblastoma protein recruits histone deacetylase to repress transcription: A. Brehm, et al.; Nature 391, 597 (1998) Abstract
Effects of cell density and trichostatin A on the expression of HDAC1 and p57Kip2 in Hep 3B cells: S.G. Gray & T.J. Ekstrom; BBRC 245, 423 (1998) Abstract
Regulation of the human O6-methylguanine-DNA methyltransferase gene by transcriptional coactivators cAMP response element-binding protein- binding protein and p300: K.K. Bhakat & S. Mitra; J. Biol. Chem. 275, 34197 (2000) Abstract; Full Text
Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells: P.A. Marks, et al.; J. Natl. Cancer Inst. 92, 1210 (2000) Abstract
Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo: D.M. Vigushin, et al.; Clin. Cancer Res. 7, 971 (2001) Abstract
Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow: S. Snykers, et al.; BMC Dev. Biol. 7, 24 (2007) Abstract
Trichostatin A induces myocardial differentiation of monkey ES cells: M. Hosseinkhani, et al.; BBRC 356, 386 (2007) Abstract
 
 

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