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Oxidative Stress
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ALX-210-406 Revised 19-Jan-05
Polyclonal Antibody to ERp72 (human)
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SYNONYMS anti-PDIA4 (human) PAb
anti-Protein Disulfide Isomerase A4 (human) PAb
PRODUCT LINE Protein Synthesis, Modification & Degradation
PRODUCT CATEGORY Protein Synthesis, Modification & Degradation Other Products
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ALX-210-406-C100   100 µg 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. Epitope affinity purified antibody in PBS containing 1mg/ml BSA and 0.01% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 629-645 (K629FIEEHATKLSRTKEEL645) of human ERp72.
SPECIFICITY: Recognizes human ERp72. Detects a band of ~72kDa by Western blot.
APPLICATION: Western Blot (10µg/ml).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Endoplasmatic Reticulum Stress • Polyclonal Antibodies
 
 
ALX-210-882 Revised 04-Mar-05
Polyclonal Antibody to Formaldehyde
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-882-R100   100 µl 450.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST: From rat.
IMMUNOGEN: Formaldeyde conjuated to a carrier protein.
SPECIFICITY: Recognizes formaldehyde adducts.
APPLICATION: ELISA (1:2'000-1:5'000).
LONG TERM STORAGE: -20°C
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-209/1 Revised 07-Feb-08
Polyclonal Antibody to Glutathione S-transferase
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SYNONYMS anti-GST PAb
PRODUCT LINE Cancer
PRODUCT CATEGORY Glutathione S-Transferase
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ALX-210-209/1-C100   100 µg 234.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Others
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Epitope-affinity purified IgG.
FORMULATION: Liquid. In PBS containing 1mg/ml BSA and 0.05% sodium azide.
IMMUNOGEN: GST (glutathione S-transferase)-tagged fusion proteins.
SPECIFICITY: Recognizes GST and GST-tagged proteins.
CROSSREACTIVITY PROTEINS: GST and GST-tagged proteins.
APPLICATION: Western Blot (1:5’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Glutathione / Related Products • Polyclonal Antibodies
 
 
ALX-210-477 Revised 07-Jan-08
Polyclonal Antibody to GPX3
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SYNONYMS anti-Glutathione Peroxidase 3 PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-210-477-C100   100 µg 340.00 USD Add To Cart
ALX-210-477B-C050 Biotin 50 µg 340.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse GPX3 (glutathione peroxidase 3).
SPECIFICITY: Recognizes mouse GPX3. Weakly cross-reacts with human GPX3.
APPLICATION: ELISA (direct and indirect: 1:2’000-1:5’000)
Western Blot (1:2’000-1:5’000 using ECL. Suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk. Suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY:

HANDLING: Avoid freeze/thaw cycles.
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General Information
MANUFACTURER Manufactured by AdipoGen, Inc.
Related Products
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-116 Revised 29-Sep-08
Polyclonal Antibody to Heme Oxygenase-1
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SYNONYMS anti-HO-1 PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Heme Oxygenase / Related Products
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ALX-210-116-R100   100 µl 379.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
Others
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Neat serum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 1-30 (M1ERPQLDSMSQDL
SEALKEATKEVHIRAEN30) of N-terminal rat HO-1 (heme oxygenase-1).
SPECIFICITY: Recognizes human, mouse, rat, monkey and bovine HO-1. Detects a band of ~32kDa by Western blot. Does not cross-react with HO-2.
APPLICATION: Immunocytochemistry
Immunohistochemistry (paraffin sections (1:100))
Western Blot (1:1’000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease: M.A. Smith, et al.; Am. J. Pathol. 145, 42 (1994) Abstract
RT-PCR assay for heme oxygenase-1 and heme oxygenase-2: a sensitive method to estimate cellular oxidative damage: R.K. Kutty, et al.; Ann. N. Y. Acad. Sci. 738, 427 (1994) Abstract
Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta: R.K. Kutty, et al.; J. Cell. Physiol. 159, 371 (1994) Abstract
Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea: R.K. Kutty, et al.; PNAS 92, 1177 (1995) Abstract
Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion: A.C. Zenclussen, et al.; Scand. J. Immunol. 55, 560 (2002) Abstract
Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface: A. Sollwedel, et al.; J. Immunol. 175, 4875 (2005) Abstract
Heme oxygenase as a therapeutic target in immunological pregnancy complications: A.C. Zenclussen, et al.; Int. Immunopharmacol. 5, 41 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Immunohistochemical staining of HO-1 in Alzheimer's diseased human brain with Prod. No. ALX-210-116 results in staining of the neurofibrillary tangles, senile plaque neurites and neurophil threads.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-069 Revised 16-Jul-08
Polyclonal Antibody to HIF-1α
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SYNONYMS anti-Hypoxia-inducible Factor 1α PAb
anti-ARNT-interacting Protein PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hypoxia-inducible Factor [HIF] / Related Products
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ALX-210-069-C050   50 µg 220.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 2.8mg/ml
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
IMMUNOGEN: Recombinant HIF-1α (hypoxia-inducible factor-1a) (aa 609-826).
SPECIFICITY: Recognizes human and mouse HIF-1α.
APPLICATION: Immunohistochemistry (1:200)
Immunoprecipitation (1-5µg)
Western Blot (1µg/ml)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis: N. Tang, et al.; Cancer Cell 6, 485 (2004) Abstract
Epidermal sensing of oxygen is essential for systemic hypoxic response: A.T. Boutin, et al.; Cell 133, 206 (2008) Abstract
Critical Role of HIF-1alpha in Keratinocyte Defense against Bacterial Infection: C. Peyssonnaux, et al.; J. Invest. Dermatol. 128, 1964 (2008) Abstract
General Literature References
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin: C. C. Hudson, et al.; Mol. Cell Biol. 22, 7004 (2002) Abstract; Full Text
Further Categories Containing This Product:
Aryl Hydrocarbon Receptor / Related Products • Polyclonal Antibodies
 
 
ALX-215-058 Revised 12-Sep-07
Polyclonal Antibody to HIF-2α (human)
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SYNONYMS anti-Hypoxia-inducible Factor 2α (human) PAb
anti-EPAS-1 (human) PAb
anti-Endothelial PAS Domain-containing Protein 1 (human) PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Hypoxia-inducible Factor [HIF] / Related Products
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ALX-215-058-R200   200 µl 267.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST: From rabbit.
PURITY DETAIL: Protein G-affinity purified.
FORMULATION: Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN: Synthetic peptide corresponding to aa 426-443 of human HIF-2α (hypoxia-inducible factor 2α).
SPECIFICITY: Recognizes human HIF-2α. Detects a band of ~90kDa.
APPLICATION: Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -4°C.
HANDLING: Avoid freeze/thaw cycles.
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Further Categories Containing This Product:
Aryl Hydrocarbon Receptor / Related Products • Polyclonal Antibodies
 
 
ALX-210-802 Revised 06-Dec-06
Polyclonal Antibody to 8-Hydroxyguanosine
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-210-802-R100   100 µl 210.00 USD Add To Cart
Product Specification
SOURCE/HOST: From goat.
FORMULATION: Liquid. Neat serum containing 0.1% sodium azide.
IMMUNOGEN: Synthetic 8-hydroxyguanosine-conjugate.
SPECIFICITY: Recognizes 8-hydroxyguanosine and 8-hydroxy-2'-deoxyguanosine. Partially cross-reacts with 8-mercaptoguanosine and slightly with 8-bromoguanosine. Does not cross-react with other naturally occuring nucleotides.
APPLICATION: ELISA (1:250'000)
Immunohistochemistry (frozen sections, paraffin sections (1:200))
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: Avoid freeze/thaw cycles.
General Information
8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging and neurodegenerative conditions, such as Alzheimer's disease. 8OHdG has become increasing popular as a sensitive, stable and integral marker of oxidative damage in cellular DNA. Biomonitoring in humans has demonstrated that 8OHdG can be excreted in the urine and that a significant increase is caused by exposure to tobacco smoke and ionizing radiation. Because 8OHdG is so well correlated with oxidative stress and damage to DNA, which leads to degenerative disease states, the development of an antibody that can be used to study DNA damage has numerous applications. In addition to the direct study of DNA damage within cells, this antibody has applications in the development of immunoassays that can monitor 8OHdG excretion in the urine and serve as a biomarker of oxidative stress. Industrial uses may extend to the dietary supplement manufacturers, who could benefit from an immunoassay that could be used to test the effectiveness of antioxidants and other nutraceuticals.
Further Categories Containing This Product:
Nucleic Acid Oxidation & Alkylation / Related Products • Polyclonal Antibodies
 
 
ALX-210-767 Revised 30-Sep-08
Polyclonal Antibody to (E)-4-Hydroxynonenal
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SYNONYMS anti-HNE PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
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ALX-210-767-R100   100 µl 495.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized. Neat serum containing 0.05% sodium azide.
RECONSTITUTION: Reconstitute with 100µl PBS.
IMMUNOGEN: Free recombinant HNE (E)-4-hydroxynonenal.
SPECIFICITY: Recognizes HNE-adducts.
APPLICATION: ELISA (1:1'000-1:10'000)
Immunohistochemistry (1:500-1:1'000)
Western Blot (1:500-1:1'000)
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Product Specific Literature References
Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes: K. Uchida, et al.; PNAS 90, 8742 (1993) Abstract
Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma: K. Okamoto, et al.; Int. J. Cancer 58, 825 (1994) Abstract
Immunocytochemical detection of lipid peroxidation in phagosomes of human neutrophils: correlation with expression of flavocytochrome b: M.T. Quinn, et al.; J. Leukoc. Biol. 57, 415 (1995) Abstract
Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies: K. Uchida, et al.; Arch. Biochem. Biophys. 324, 241 (1995) Abstract
Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease: A. Yoritaka, et al.; PNAS 93, 2696 (1996) Abstract
alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain: S. Lin, et al.; Brain Res. 1007, 132 (2004) Abstract
Acquired Resistance to Acetaminophen Hepatotoxicity is Associated with Induction of Multidrug Resistance-Associated Protein 4 (Mrp4) in Proliferating Hepatocytes: L.M. Aleksunes, et al.; Toxicol. Sci. 104, 261 (2008) Abstract
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes: K. Stadler, et al.; Free Radic. Biol. Med. Epub ahead of print, (2008) Abstract
Related Products
Further Categories Containing This Product:
Lipid Peroxidation • Polyclonal Antibodies
 
 
ALX-210-879 Revised 18-Jul-07
Polyclonal Antibody to Malondialdehyde
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SYNONYMS anti-MDA PAb
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Lipid Peroxidation
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ALX-210-879-R100   100 µl 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
FORMULATION: Lyophilized.
IMMUNOGEN: Malondialdehyde (MDA) conjugated to a carrier protein.
SPECIFICITY: Recognizes MDA adducts.
APPLICATION: ELISA (1:1’000-1:10’000)
Immunohistochemistry (1:500-1:1’000)
Western blot (1:500-1:1’000)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Do not freeze, thaw or store diluted working solutions.
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C.
Further Categories Containing This Product:
Polyclonal Antibodies
 
 
ALX-210-428 Revised 23-Oct-08
Polyclonal Antibody to Nampt/Visfatin (mouse)
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SYNONYMS anti-Nicotinamide Phosphoribosyltransferase (mouse) PAb
anti-PBEF1 (mouse) PAb
anti-Pre-B-Cell Colony Enhancing Factor 1 (mouse) PAb
PRODUCT LINE Obesity & Adipokines
PRODUCT CATEGORY Visfatin / Nampt / PBEF / Related Products
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ALX-210-428-C100   100 µg 310.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
SOURCE/HOST: From rabbit.
CONCENTRATION: 1mg/ml.
PURITY DETAIL: Purified IgG.
FORMULATION: Liquid. In PBS, pH 7.4. Contains no preservatives.
IMMUNOGEN: Recombinant mouse Nampt/visfatin.
SPECIFICITY: Recognizes mouse Nampt/visfatin. Weakly cross-reacts with human Nampt/visfatin.
APPLICATION: ELISA (direct and indirect: 1:2'000-1:5'000).
Western Blot (1:2'000-1:5'000 using ECL; suggested blocking and dilution buffer is PBST containing 0.05% Tween 20 and 5% skim milk; suggested incubation time is 1 hour at room temperature).
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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