ALEXIS Biochemicals: Ceruloplasmin (human)

Advanced Search

You are here: Product Lines > Immunology > Serum Proteins / Related Products > Serum Proteins Other Products

ALX-200-089

Revised 18-Mar-08

Ceruloplasmin (human)
SYNONYMS	Ferroxidase (human)
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Nitric Oxide Pathway Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-200-089-M001		1 mg	210.00 USD

Product Specification

MW:	~134kDa
CAS NUMBER:	9031-37-2
EC:	1.16.3.1
MERCK INDEX:	14: 2006
SOURCE/HOST:	Isolated from human plasma.
CONCENTRATION:	1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
PURITY DETAIL:	Plasma has been tested negative for HBsAg and for antibodies to HIV and HCV.
FORMULATION:	Lyophilized from 50mM potassium phosphate, pH 6.8, containing 100mM potassium chloride, 20mM ε-aminocaproic acid and 5mM EDTA.
RECONSTITUTION:	Reconstitute with water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Serum copper transport and iron-oxidizing protein. Expressed in plasma at concentrations of 1-5µM. Contains six copper centers and is known to oxidize amines in a process coupled to the reduction of molecular oxygen. Has ferroxidase activity that is responsible for the oxidation of ferrous iron to its ferric form, which is necessary for efficient iron efflux from the cell (e.g. during hypoxia). Has previously been considered a target for nitric oxide (NO) and an inhibitor of endothelial nitric oxide synthase (eNOS/NOS III). Catalyzes S-nitrosothiol formation in cell culture media. Is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis.

Product Specific Literature References

The reaction of nitric oxide with ceruloplasmin: R. Wever, et al.; Biochim. Biophys. Acta 302, 236 (1973) Abstract
Copper transport: an overview: E.D. Harris; Proc. Soc. Exp. Biol. Med. 196, 130 (1991) Abstract
Ceruloplasmin inhibits carbonyl formation in endogenous cell proteins: J.A. Krsek-Staples & R.O. Webster; Free Radic. Biol. Med. 14, 115 (1993) Abstract
Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins: J.M. Gutteridge & G.J. Quinlan; Biochim. Biophys. Acta 1156, 144 (1993) Abstract
Inhibition of endothelial nitric-oxide synthase by ceruloplasmin: A. Bianchini, et al.; J. Biol. Chem. 274, 20265 (1999) Abstract; Full Text
The reactions of copper proteins with nitric oxide: J. Torres and M.T. Wilson; Biochim. Biophys. Acta 1411, 310 (1999) Abstract
Role of ceruloplasmin in macrophage iron efflux during hypoxia: J. Sarkar, et al.; J. Biol. Chem. 278, 44018 (2003) Abstract; Full Text
Does oxidative stress change ceruloplasmin from a protective to a vasculopathic factor?: N. Shukla, et al.; Atherosclerosis 187, 238 (2006) Abstract
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis: S. Shiva, et al.; Nat. Chem. Biol. 2, 486 (2006) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link P00450: Ceruloplasmin (human) [Precursor]

Further Categories Containing This Product:

Natural Proteins • Serum Proteins Other Products

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.