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Oxidative Stress
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ALX-430-152 Revised 03-Apr-08
Cannabidiol
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SYNONYMS CBD
2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-152-M001   1 mg Inquire
ALX-430-152-M005   5 mg Inquire
Product Specification
FORMULA: C21H30O2
MW: 314.5
CAS NUMBER: 13956-29-1
MERCK INDEX: 14: 1747
RTECS: VH1600000
SOURCE/HOST: Natural product.
PURITY: ≥98% (HPLC)
APPEARANCE: White to pale yellow powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol or methanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Non-psychotropic, anticonvulsive and neuroprotective in vivo. Shown to be a weak CB1 receptor antagonist and inhibitor of anandamide uptake (IC50=3.35mM and 27.5mM, respectively). Weak agonist of TRPV1 (EC50=3.5mM).
Product Specific Literature References
Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants: A.J. Hampson, et al.; PNAS 95, 8268 (1998) Abstract; Full Text
The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis: A.M. Malfait, et al.; PNAS 97, 9561 (2000) Abstract; Full Text
Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite: A.B. El-Remessy, et al.; Am. J. Pathol. 163, 1997 (2003) Abstract; Full Text
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines: P. Massi, et al.; J. Pharmacol. Exp. Ther. 308, 838 (2004) Abstract; Full Text
Effects of cannabidiol (CBD) on regional cerebral blood flow: J.A. Crippa, et al.; Neuropsychopharmacology 29, 417 (2004) Abstract; Full Text
Inhibition of an equilibrative nucleoside transporter by cannabidiol: a mechanism of cannabinoid immunosuppression: E.J. Carrier, et al.; PNAS 103, 7895 (2006) Abstract; Full Text
Cannabidiol, unlike synthetic cannabinoids, triggers activation of RBL-2H3 mast cells: E. Del Giudice, et al.; J. Leukoc. Biol. 81, 1512 (2007) Abstract; Full Text
Further Categories Containing This Product:
Anandamide Uptake Inhibitors • Cannabinoid Receptor Agonists & Antagonists / Related Products • TRPV1 Agonists and Antagonists / Related Products • Natural Products - Antioxidants
 
 
ALX-430-154 Revised 03-Apr-08
Cannabigerol
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SYNONYMS CBG
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
Ordering Information
not sold in USA
Product Specification
FORMULA: C21H32O2
MW: 316.5
SOURCE/HOST: Natural product.
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Analog of cannabidiol (Prod. No. ALX-430-152) with similar pharmacological properties.
Product Specific Literature References
Cannabigerol monomethyl ether, a new component of hemp: T. Yamauchi, et al.; Chem. Pharm. Bull 16, 1164 (1968) Abstract
In vitro metabolism of cannabigerol in several mammalian species: D.J. Harvey and N.K. Brown; Biomed. Environ. Mass Spectrom. 19, 545 (1990) Abstract
Further Categories Containing This Product:
Cannabinoid Receptor Agonists & Antagonists / Related Products • Natural Products - Antioxidants
 
 
ALX-460-001 Revised 13-Mar-06
L-(+)-Ascorbic acid
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SYNONYMS Vitamin C
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-001-G010   10 g 20.00 USD Add To Cart
Product Specification
FORMULA: C6H8O6
MW: 176.1
CAS NUMBER: 50-81-7
MERCK INDEX: 14: 830
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
USE/STABILITY: Aqueous solutions are easily oxidized. Stable at pH 5.0-6.0.

Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables
 
 
ALX-460-004 Revised 11-Jul-07
β-Carotene
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SYNONYMS Provitamin A
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Retinol [Vitamin A] & Retinol Derivatives / Related Products
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ALX-460-004-G005   5 g 65.00 USD Add To Cart
Product Specification
FORMULA: C40H56
MW: 536.9
CAS NUMBER: 7235-40-7
MERCK INDEX: 14: 1853
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Red powder.
SOLUBILITY: Soluble in DMSO, n-hexane, carbon disulfide, benzene or vegetable oils; slightly soluble in ether, petroleum ether or oils; almost insoluble in 100% ethanol, methanol, water, diluted acidic or alkaline solutions.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Absorbs oxygen from air. Keep under inert gas.

Further Categories Containing This Product:
Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Vitamins
 
 
ALX-460-018 Revised 08-Apr-08
DL-α-Tocopherol (high purity)
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SYNONYMS Vitamin E (high purity)
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-018-G001   1 g 38.00 USD Add To Cart
Product Specification
FORMULA: C29H50O2
MW: 430.7
CAS NUMBER: 10191-41-0
MERCK INDEX: 14: 9495
SOURCE/HOST: Synthetic.
PURITY: ≥98%
APPEARANCE: Slightly yellow viscous oil.
SOLUBILITY: Soluble in 100% ethanol, ether, chloroform, acetone or vegetable oils.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable to heat and alkalis.
HANDLING: Protect from light.

Product Specific Literature References
Suppression of nitric oxide toxicity in islet cells by alpha-tocopherol: V. Burkart, et al.; FEBS Lett. 364, 259 (1995) Abstract
Further Categories Containing This Product:
Natural Products - Antioxidants
 
 
ALX-460-019 Revised 24-Oct-07
DL-α-Tocopherol . acetate
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SYNONYMS Vitamin E . acetate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Vitamins
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ALX-460-019-G005   5 g 23.00 USD Add To Cart
Product Specification
FORMULA: C31H52O3
MW: 472.8
CAS NUMBER: 7695-91-2
MERCK INDEX: 14: 9495
RTECS: GA8747000
SOURCE/HOST: Synthetic.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow-greenish liquid.
SOLUBILITY: Soluble in methanol or 96% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Further Categories Containing This Product:
Natural Products - Antioxidants
 
 
ALX-460-028 Revised 24-Oct-07
Rutin . trihydrate
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SYNONYMS Quercetin-3-rutinoside . 3H2O
Vitamin P
3,3',4',5,7-Pentahydroxyflavone-3-rutinoside . 3H2O
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonols
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ALX-460-028-G005   5 g 15.00 USD Add To Cart
Product Specification
FORMULA: C27H30O16 . 3H2O
MW: 610.5 . 54.0
CAS NUMBER: 153-18-4
MERCK INDEX: 14: 8304
PURITY: ≥99% (Assay)
APPEARANCE: Off-white to yellow powder.
SOLUBILITY: Soluble in pyridine or alkaline solutions; slightly soluble in 100% ethanol; very slightly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: IRRITANT.

Product Description
Antioxidant flavonoid. Nitric oxide (NO) scavenger.
Product Specific Literature References
Flavonoids as scavengers of nitric oxide radical: S.A.B.E. Acker, et al.; BBRC 214, 755 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Antioxidant and chelating properties of flavonoids
: L.G. Korkina and I.B. Afanas´ev; Adv. Pharmacol. 38, 151 (1997) Abstract
Antimicrobial activity of flavonoids: T. P. Cushnie & A. J. Lamb; Int. J. Antimicrob. Agents 26, 343 (2005) Abstract
Further Categories Containing This Product:
Natural Products - Nitric Oxide Pathway Modulators • Nitric Oxide Scavengers • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables
 
 
ALX-460-031 Revised 24-Oct-07
Astaxanthin (crystalline)
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SYNONYMS 3,3'-Dihydroxy-β,β-carotene-4,4'-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-460-031-M050   50 mg 40.00 USD Add To Cart
ALX-460-031-M250   250 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C40H52O4
MW: 596.8
CAS NUMBER: 472-61-7
MERCK INDEX: 14: 855
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: Dark violet powder.
SOLUBILITY: Soluble in chloroform (0.05%). Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Material oxidizes at temperatures above 60°C. Decomposes slowly when exposed to light and high temperatures. Material reacts with acids and may corrode steel. Use stainless steel or polylethylene equipment for mixing purposes.
HANDLING: Protect from light.

Product Description
Extremely potent antioxidant. Shows anti-inflammatory properties. Has effects on cancer, cardiovascular disease, and diabetes.
Product Specific Literature References
Antioxidant activity of beta-carotene-related carotenoids in solution: J. Terao; Lipids 24, 659 (1989) Abstract
Astaxanthin and canthaxanthin are potent antioxidants in a membrane model: P. Palozza & N.I. Krinsky; Arch. Biochem. Biophys. 297, 291 (1992) Abstract
Antioxidant effects of carotenoids in vivo and in vitro: an overview: P. Palozza & N.I. Krinsky; Meth. Enzymol. 213, 403 (1992) Abstract
Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma: W.A. Schroeder & E.A. Johnson; J. Biol. Chem. 270, 18374 (1995) Abstract; Full Text
Haematococcus astaxanthin: applications for human health and nutrition: M. Guerin, et al.; Trends Biotechnol. 21, 210 (2003), (Review) Abstract
Astaxanthin, a carotenoid with potential in human health and nutrition: G. Hussein, et al.; J. Nat. Prod. 69, 443 (2006), (Review) Abstract
Further Categories Containing This Product:
Natural Products - Anti-inflammatory Agents
 
 
ALX-105-005 Revised 20-May-08
N-Acetyl-L-cysteine
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SYNONYMS LNAL
N-Acetyl-3-mercaptoalanine
L-α-Acetamido-β-mercaptopropionic acid
NAC
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Antioxidants, Flavonoids & Free Radical Scavengers Other Products
Ordering Information
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ALX-105-005-G001   1 g 16.00 USD Add To Cart
ALX-105-005-G005   5 g 27.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO3S
MW: 163.2
CAS NUMBER: 616-91-1
MERCK INDEX: 14: 88
RTECS: HA1660000
PURITY: ≥99%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 5M hydrochloric acid (hot) (100mg/ml); also soluble in water or 100% ethanol; insoluble in chloroform or ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Specific Literature References
Modulation of platelet function by free radicals and free-radical scavengers: D. Salvemini & R. Botting; TIPS 14, 36 (1993), (Review) Abstract
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells: D. Salvemini, et al.; Br. J. Pharmacol. 108, 162 (1993) Abstract
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1: H. Schenk, et al.; PNAS 91, 1672 (1994) Abstract
Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells: J.C. Tsai, et al.; J. Biol. Chem. 271, 3667 (1996) Abstract; Full Text
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice: E. Ho, et al.; Faseb. J. 13, 1845 (1999) Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun. 276, 88 (2000) Abstract
Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells: H. Kim, et al.; Free Radic. Biol. Med. 29, 674 (2000) Abstract
Further Categories Containing This Product:
Special Amino Acids
 
 
ALX-153-055 Revised 25-May-07
Carnosine
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SYNONYMS β-Alanyl-L-histidine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
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ALX-153-055-G001   1 g 55.00 USD Add To Cart
Product Specification
SEQUENCE: H-β-Ala-His-OH
FORMULA: C9H14N4O3
MW: 226.2
CAS NUMBER: 305-84-0
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 80% acetic acid (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antioxidant. Inhibits soluble guanylyl cyclase (sGC) by interacting with the heme iron to form a chelate complex.
Product Specific Literature References
Carnosine as a regulator of soluble guanylate cyclase: I.S. Severina, et al.; Biochemistry (Mosc) 65, 783 (2000) Abstract; Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-270-266 Revised 19-May-03
DL-α-Lipoic acid
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