• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
You are here: Product Lines > Oxidative Stress > Antioxidants, Flavonoids & Free Radical Scavengers Other Products
Toolbar - View Selection
 
Items 22 of 22
ALX-105-005 Revised 20-May-08
N-Acetyl-L-cysteine
Add to Clipboard
SYNONYMS LNAL
N-Acetyl-3-mercaptoalanine
L-α-Acetamido-β-mercaptopropionic acid
NAC
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Antioxidants, Flavonoids & Free Radical Scavengers Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-105-005-G001   1 g 16.00 USD Add To Cart
ALX-105-005-G005   5 g 27.00 USD Add To Cart
Product Specification
FORMULA: C5H9NO3S
MW: 163.2
CAS NUMBER: 616-91-1
MERCK INDEX: 14: 88
RTECS: HA1660000
PURITY: ≥99%
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in 5M hydrochloric acid (hot) (100mg/ml); also soluble in water or 100% ethanol; insoluble in chloroform or ether.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Specific Literature References
Modulation of platelet function by free radicals and free-radical scavengers: D. Salvemini & R. Botting; TIPS 14, 36 (1993), (Review) Abstract
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells: D. Salvemini, et al.; Br. J. Pharmacol. 108, 162 (1993) Abstract
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1: H. Schenk, et al.; PNAS 91, 1672 (1994) Abstract
Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells: J.C. Tsai, et al.; J. Biol. Chem. 271, 3667 (1996) Abstract; Full Text
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice: E. Ho, et al.; Faseb. J. 13, 1845 (1999) Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun. 276, 88 (2000) Abstract
Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells: H. Kim, et al.; Free Radic. Biol. Med. 29, 674 (2000) Abstract
Further Categories Containing This Product:
Special Amino Acids
 
 
ALX-850-318 Revised 14-Feb-07
Antioxidant Assay Kit
Add to Clipboard
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-318-KI01   1 Kit 349.00 USD Add To Cart
Product Specification
QUANTITY: 96 wells (~80 tests)
APPLICATION: For the rapid measurement of antioxidant capacity in a variety of sample types, including plasma, serum, urine, saliva, and cell lysates.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
Product Description
This antioxidant assay is designed to measure the overall antioxidant capacity within a given sample. The assay relies on the ability of antioxidants in the sample to inhibit the oxidation of ABTS in comparison to trolox, a water-soluble tocopherol analog. By quantifying the cumulative effect of all antioxidants present, more relevant biological information is acquired compared with the measurement of individual components alone. The assay relies on the ability of antioxidants in the sample to inhibit the oxidation of ABTS® (2,2’-azino-di-[3-ethylbenzthiazoline sulphonate]) to ABTS®·+ by metmyoglobin.
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Quantification Kits
 
 
ALX-153-055 Revised 25-May-07
Carnosine
Add to Clipboard
SYNONYMS β-Alanyl-L-histidine
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-153-055-G001   1 g 55.00 USD Add To Cart
Product Specification
SEQUENCE: H-β-Ala-His-OH
FORMULA: C9H14N4O3
MW: 226.2
CAS NUMBER: 305-84-0
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 80% acetic acid (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antioxidant. Inhibits soluble guanylyl cyclase (sGC) by interacting with the heme iron to form a chelate complex.
Product Specific Literature References
Carnosine as a regulator of soluble guanylate cyclase: I.S. Severina, et al.; Biochemistry (Mosc) 65, 783 (2000) Abstract; Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
 
 
ALX-620-063 Revised 03-Feb-05
Coelenterazine
Add to Clipboard
SYNONYMS 2-[(4-Hydroxyphenyl)methyl]-6-(4-hydroxyphenyl)-8-(phenylmethyl)-imidazo [1,2-a] pyrazin-3-(7H)-one
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-063-C050   50 µg 110.00 USD Add To Cart
Product Specification
FORMULA: C26H21N3O3
MW: 423.5
CAS NUMBER: 55779-48-1
PURITY: ≥95%
APPEARANCE: Brown solid.
SOLUBILITY: Slightly soluble in methanol or ethanol. Avoid DMSO.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas. Keep calcium free when stored in solution.

Product Description
Cell permeable, very sensitive and specific chemiluminescence probe of the superoxide anion and peroxynitrite. When oxidized by oxygen it emits blue light at 446nm when Ca2+ binds to the complex. Powerful antioxidant. See also 2-(4-Dehydroxy)coelenterazine (Prod. No. ALX-620-062).
Product Specific Literature References
Use of calcium-regulated photoproteins as intracellular Ca2+ indicators: J.R. Blinks; Meth. Enzymol. 172, 164 (1989) Abstract
Slow calcium waves accompany cytokinesis in medaka fish eggs: R.A. Fluck, et al.; J. Cell Biol. 115, 1259 (1991) Abstract
Coelenterazine is a superoxide anion-sensitive chemiluminescent probe: its usefulness in the assay of respiratory burst in neutrophils: M. Lucas & F. Solano; Anal. Biochem. 206, 273 (1992) Abstract
Aequorin-expressing mammalian cell lines used to report Ca2+ mobilization: D. Button & M. Brownstein; Cell Calcium 14, 663 (1993) Abstract
Imaging [Ca2+]i with aequorin using a photon imaging detector: A.L. Miller, et al.; Meth. Cell Biol. 40, 305 (1994) Abstract
Intracellular free calcium level and its response to cAMP stimulation in developing Dictyostelium cells transformed with jellyfish apoaequorin cDNA: S. Saran, et al.; FEBS Lett. 337, 43 (1994) Abstract
The origins of marine bioluminescence: turning oxygen defence mechanisms into deep-sea communication tools: J.F. Rees, et al.; J. Exp. Biol. 201, 1211 (1998) Abstract; Full Text
Chemiluminescent detection of oxidants in vascular tissue. Lucigenin but not coelenterazine enhances superoxide formation: M.M. Tarpey, et al.; Circ. Res. 84, 1203 (1999) Abstract
Further Categories Containing This Product:
Calcium Indicators / Probes • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Luciferin & Luciferase / Related Products • Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-270-281 Revised 28-Sep-06
Daphnetin
Add to Clipboard
SYNONYMS 7,8-Dihydroxycoumarin
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY EGFR Kinase Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-281-M005   5 mg 25.00 USD Add To Cart
ALX-270-281-M025   25 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C9H6O4
MW: 178.1
CAS NUMBER: 486-35-1
RTECS: GN6382600
PURITY: ≥97%
APPEARANCE: White to rose powder.
SOLUBILITY: Soluble in 100% ethanol, methanol or dimethyl formamide.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C

Product Description
Inhibitor of protein kinases. EGF receptor tyrosine kinase (IC50=7.87µM), PKA (IC50=9.33µM), PKC (IC50=25.01µM). Antioxidant. Antimalarial agent.
Product Specific Literature References
Daphnetin: a novel antimalarial agent with in vitro and in vivo activity: Y.Z. Yang, et al.; Am. J. Trop. Med. Hyg. 46, 15 (1992) Abstract
Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor: E.B. Yang, et al.; BBRC 260, 682 (1999) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • PKA Inhibitors • Malaria / Related Products • Tyrosine Kinase Inhibitors
 
 
ALX-620-062 Revised 01-Jun-06
2-(4-Dehydroxy)coelenterazine
Add to Clipboard
SYNONYMS Coelenterazine h
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-620-062-C050   50 µg 110.00 USD Add To Cart
Product Specification
FORMULA: C26H21N3O2
MW: 407.5
PURITY: ≥95%
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in 100% ethanol or methanol; slightly soluble in water. Avoid DMSO as product is unstable in this solvent.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light. Keep under inert gas. Keep calcium free when stored in solution.
HAZARD: IRRITANT.

Product Description
Derivative of coelenterazine (Prod. No. ALX-620-063) with ~20 times higher luminescence intensity.
Product Specific Literature References
Semi-synthetic aequorins with improved sensitivity to Ca2+ ions: O. Shimomura, et al.; Biochem. J. 261, 913 (1989) Abstract
Preparation and handling of aequorin solutions for the measurement of cellular Ca2+: O. Shimomura; Cell Calcium 12, 635 (1991) Abstract
Imaging calcium dynamics in living plants using semi-synthetic recombinant aequorins: M.R. Knight, et al.; J. Cell. Biol. 121, 83 (1993) Abstract
Intracellular Ca2+ signals in Dictyostelium chemotaxis are mediated exclusively by Ca2+ influx: T. Nebl & P.R. Fisher; J. Cell Sci. 110, 2845 (1997) Abstract
Further Categories Containing This Product:
Calcium Indicators / Probes • Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Dyes / Stains / Fluorescent Probes / Fluorescent Labels • Oxidative Stress Markers & Reagents / Related Products
 
 
ALX-550-350 Revised 26-Mar-05
tris(Dicarboxymethylene)fullerene-C3 - Discontinued Due to Patent Restrictions
Add to Clipboard
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Antioxidants, Flavonoids & Free Radical Scavengers Other Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-350-MC05   0.5 mg Inquire
ALX-550-350-M001   1 mg Inquire
Product Specification
FORMULA: C63((COOH)2)3
MW: 1026.8
APPEARANCE: Red to brown powder.
SOLUBILITY: Soluble in methanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Water soluble neuroprotective antioxidant, both in vitro and in vivo.
Product Specific Literature References
Carboxyfullerenes as neuroprotective agents [published erratum appears in PNAS 94, 12241 (1997)]: L.L. Dugan, et al.; PNAS 94, 9434 (1997) Abstract
Blockage of apoptotic signaling of transforming growth factor-beta in human hepatoma cells by carboxyfullerene: Y.L. Huang, et al.; Eur. J. Biochem. 254, 38 (1998) Abstract
Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons: J. Lotharius, et al.; J. Neurosci. 19, 1284 (1999) Abstract; Full Text
C60 and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation: I.C. Wang, et al.; J. Med. Chem. 42, 4614 (1999) Abstract
C3-fullero-tris-methanodicarboxylic acid protects epithelial cells from radiation-induced anoikia by influencing cell adhesion ability: E. Straface, et al.; FEBS Lett. 454, 335 (1999) Abstract
Carboxyfullerene prevents iron-induced oxidative stress in rat brain: A.M. Lin, et al.; J. Neurochem. 72, 1634 (1999) Abstract
Further Categories Containing This Product:
Fullerenes
 
 
ALX-270-097 Revised 07-Sep-06
Ebselen
Add to Clipboard
SYNONYMS 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Peroxynitrite / Scavengers / Detection
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-097-M001   1 mg 12.00 USD Add To Cart
ALX-270-097-M005   5 mg 20.00 USD Add To Cart
ALX-270-097-M025   25 mg 60.00 USD Add To Cart
Product Specification
FORMULA: C13H9NOSe
MW: 274.2
CAS NUMBER: 60940-34-3
PURITY: ≥98% (NMR)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL).
Product Specific Literature References
A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984) Abstract
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987) Abstract
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988) Abstract
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989) Abstract
T. Nikawa, et al.; Biochem. Pharmacol. 47, 1007 (1994) Abstract
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta 1213, 176 (1994) Abstract
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994) Abstract
Ebselen: a glutathione peroxidase mimic: H. Sies; Meth. Enzymol. 234, 476 (1994) Abstract
Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995) Abstract
Ebselen: H. Sies; Meth. Enzymol. 252, 341 (1995) Abstract
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol. 38, 229 (1997) Abstract
Free radical generation by selenium compounds and their prooxidant toxicity: J.E. Spallholz; Biomed. Environ. Sci. 10, 260 (1997) Abstract
Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C] 53, 228 (1998) Abstract
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther. 287, 1098 (1998) Abstract; Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • PKC Inhibitors • Malaria / Related Products • Lipoxygenases / Related Products • Anti-inflammatory Agents Other Products • COX Inhibitors
 
 
ALX-270-262 Revised 13-Feb-08
Ellagic acid . dihydrate
Add to Clipboard
SYNONYMS 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone . 2H2O
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-262-M100   100 mg 12.00 USD Add To Cart
Product Specification
FORMULA: C14H6O8 . 2H2O
MW: 302.2 . 36.0
CAS NUMBER: 476-66-4
MERCK INDEX: 14: 3547
RTECS: DJ2620000
SOURCE/HOST: Isolated from chestnut bark.
PURITY: ≥97%
APPEARANCE: Grey to green solid.
SOLUBILITY: Soluble in 1M sodium hydroxide (10mg/ml) or pyridine.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep under inert gas. Protect from light.
HAZARD: IRRITANT.
IDENTITY: Determined by MS and NMR.

Product Description
Polyphenol antioxidant with antitumor properties. Inhibitor of topoisomerases. Inhibits VEGF-induced phosphorylation of VEGFR-2 and PDGF-induced phosphorylation of PDGFR. Induces apoptosis.
Product Specific Literature References
The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro: A. Constantinou, et al.; Nutr. Cancer 23, 121 (1995) Abstract
Novel inhibitors of 3-phosphoglycerate kinase: M.J. Hickey, et al.; Biochem. Soc. Trans. 23, 607S (1995) Abstract
Inhibitory actions of ellagic acid on growth and arylamide N-acetyltransferase activity in strains of Heliobacter pylori from peptic ulcer patients: J.G. Chung; Microbios 93, 115 (1998) Abstract
Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals: A. Kaul & K.L. Khanduja; Nutr. Cancer 32, 81 (1998) Abstract
Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol: B.H. Wang, et al.; Planta Med. 64, 195 (1998) Abstract
p53/p21 (WAF1CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells: B.A. Narayanan, et al.; Cancer Lett. 136, 215 (1999) Abstract
Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound: L. Labrecque, et al.; Carcinogenesis 26, 821 (2005) Abstract
Antioxidant and apoptosis-inducing activities of ellagic acid: D.H. Han, et al.; Anticancer Res. 26, 3601 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine: A.R. Sudheer, et al.; Toxicology 230, 11 (2007) Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Antitumor Agents (Enzyme Activators & Inducers) • Natural Products - Topoisomerase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Antitumor Reagents • Polyphenols Other Products • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-270-466 Revised 14-Sep-07
Fluvastatin . sodium salt
Add to Clipboard
PRODUCT LINE