ALEXIS Biochemicals: U-74389G

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ALX-270-267

Revised 11-Nov-08

Trolox®
SYNONYMS	6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Antioxidants, Flavonoids & Free Radical Scavengers Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-267-M100		100 mg	15.00 USD

Product Specification

FORMULA:	C₁₄H₁₈O₄
MW:	250.3
CAS NUMBER:	53188-07-1; 56305-04-5
RTECS:	DJ2273000
PURITY:	≥97%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by IR.

Product Description

Cell permeable derivative of vitamin E. Antioxidant. Prevents peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.

Product Specific Literature References

Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected]: M.G. Salgo, et al.; Arch. Biochem. Biophys. 322, 500 (1995) Abstract
Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes: M.G. Salgo & W.A. Pryor; Arch. Biochem. Biophys. 333, 482 (1996) Abstract

ALX-270-265

Revised 29-Jan-05

U-74389G
SYNONYMS	21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Lipid Peroxidation

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-265-M010		10 mg	15.00 USD
ALX-270-265-M050		50 mg	63.00 USD

Product Specification

FORMULA:	C₃₇H₅₀N₆O₂. C₄H₄O₄
MW:	610.8 . 116.1
CAS NUMBER:	153190-29-5
PURITY:	≥98%
APPEARANCE:	Crystalline solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol. Insoluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Store solutions of U-74389G on ice and use within 6 hours of preparation. We strongly recommend using fresh solution for each experiment.
HANDLING:	Hygroscopic.

Product Description

Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant.

Product Specific Literature References

Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995) Abstract
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers: F. Shi, et al.; Free Radic. Biol. Med. 19, 349 (1995) Abstract
Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation: G.M. Campo, et al.; J. Pharmacol. Exp. Ther. 277, 333 (1996) Abstract
Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G: A.M. Perna, et al.; Pharmacol. Res. 34, 25 (1996) Abstract
Comparison of various lazaroid compounds for protection against ischemic liver injury: N. Ishizaki, et al.; Transplantation 63, 202 (1997) Abstract
Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389: S. Awasthi, et al.; Toxicol. Lett. 95, 47 (1998) Abstract
The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain: R.H. Fabian, et al.; J. Neurotrauma 15, 433 (1998) Abstract
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals: A. Khalil, et al.; Life Sci. 63, 769 (1998) Abstract
Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats: D. Melchiorri, et al.; Life Sci. 62, 1927 (1998) Abstract
The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock:: D. Altavilla, et al.; Eur. J. Pharmacol. 369, 49 (1999) Abstract
Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice: K. Fukuma, et al.; Surgery 125, 421 (1999) Abstract
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia: R. Schmid-Elsaesser, et al.; Brain Res. 816, 471 (1999) Abstract; Full Text

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