• Home
  • Sitemap
  • Help
  • Technical Support
  • Contact
Spin Traps, Spin Probes & Spin Labels
You are here: Product Lines > Oxidative Stress > Spin Traps, Spin Probes & Spin Labels
Toolbar - View Selection
 
 Items 1-20 of 33 Page 1 of 2 Select Page: 1 2  >>  
ALX-210-530 Revised 13-Oct-08
Polyclonal Antibody to DMPO
Add to Clipboard
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-210-530-R100   100 µl 290.00 USD Add To Cart
Product Specification
SOURCE/HOST: From rabbit.
FORMULATION: Liquid. Contains no stabilizers or preservatives.
IMMUNOGEN: DMPO-octanoic acid conjugated to ovalbumin.
SPECIFICITY: Recognizes DMPO (Prod. No. ALX-430-090), DMPO-octanoic acid and DMPO-protein adducts. Does not cross react with non-adducted proteins.
APPLICATION: ELISA: 1:5’000. Reactive against DMPO-protein adducts in dilutions of 1:100-10’000 followed by reaction with alkaline phosphatase conjugated, affinity purified anti-rabbit IgG (goat).
Immunocytochemistry
Western Blot:
 1:5’000.
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. Dilute only prior to immediate use.
Product Images
Please click on thumbnails to enlarge.
Product Specific Literature References
Immunological identification of the heart myoglobin radical formed by hydrogen peroxide: C.D. Detweiler, et al.; Free Radic. Biol. Med. 33, 364 (2002) Abstract
Immunochemical detection of hemoglobin-derived radicals formed by reaction with hydrogen peroxide: involvement of a protein-tyrosyl radical: D.C. Ramirez, et al.; Free Radic. Biol. Med. 34, 830 (2003) Abstract
UVA-ketoprofen-induced hemoglobin radicals detected by immuno-spin trapping: Y.Y. He, et al.; Photochem. Photobiol. 77, 585 (2003) Abstract
Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals: N. Romero, et al.; J. Biol. Chem. 278, 44049 (2003) Abstract
Identification of free radicals on hemoglobin from its self-peroxidation using mass spectrometry and immuno-spin trapping: observation of a histidinyl radical: L. Deterding; J. Biol. Chem. 279, 11600 (2004) Abstract
Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping: R.P. Mason; Free Radic. Biol. Med. 36, 1214 (2004) Abstract
Protein radical formation during lactoperoxidase-mediated oxidation of the suicide substrate glutathione: immunochemical detection of a lactoperoxidase radical-derived 5,5-dimethyl-1-pyrroline N-oxide nitrone adduct: Q. Guo, et al.; J. Biol. Chem. 279, 13272 (2004) Abstract
Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c: Y.R. Chen, et al.; Free Radic. Biol. Med. 37, 1591 (2004) Abstract
Novel identification of a sulfur-centered, radical-derived 5,5-dimethyl-1-pyrroline N-oxide nitrone adduct formed from the oxidation of DTT by LC/ELISA, LC/electrospray ionization-MS, and LC/tandem MS: Q. Guo, et al.; Chem. Res. Toxicol. 17, 1481 (2004) Abstract
Mechanism of hydrogen peroxide-induced Cu,Zn-superoxide dismutase-centered radical formation as explored by immuno-spin trapping: the role of copper- and carbonate radical anion-mediated oxidations: D.C. Ramirez, et al.; Free Radic. Biol. Med. 38, 201 (2005) Abstract
Copper-catalyzed protein oxidation and its modulation by carbon dioxide: enhancement of protein radicals in cells: D.C. Ramirez, et al.; J. Biol. Chem. 280, 27402 (2005) Abstract
Identification of the myoglobin tyrosyl radical by immuno-spin trapping and its dimerization: C.D. Detweiler, et al.; Free Radic. Biol. Med. 38, 969 (2005) Abstract
Immuno-spin trapping: detection of protein-centered radicals: D.C. Ramirez, et al.; Curr. Prot. in Toxicology 2, 17.7.1 (2005)
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors: V.E. Kagan, et al.; Nat. Chem. Biol. 1, 223 (2005) Abstract
Superoxide generation from mitochondrial NADH dehydrogenase induces self-inactivation with specific protein radical formation: Y.R. Chen, et al.; J. Biol. Chem. 280, 37339 (2005) Abstract; Full Text
Immunochemical detection of nitric oxide and nitrogen dioxide trapping of the tyrosyl radical and the resulting nitrotyrosine in sperm whale myoglobin: K. Nakai and R.P. Mason; Free Radic. Biol. Med. 39, 1050 (2005) Abstract
Immuno-spin trapping of DNA radicals: D.C. Ramirez, et al.; Nat. Methods 3, 123 (2006) Abstract
Immuno-spin trapping of hemoglobin and myoglobin radicals derived from nitrite-mediated oxidation: A. Keszler, et al.; Free Radic. Biol. Med. 40, 507 (2006) Abstract
Immuno-spin trapping: A breakthrough for sensitive detection of protein-derived radicals: R. Radi, et al.; Free Radic. Biol. Med. 41, 416 (2006)
Protein radical formation on thyroid peroxidase during turnover: M. Ehrenshaft, et al.; Free Radic. Biol. Med. 41, 422 (2006)
Immunolocalization of hypochlorite-induced, catalase-bound free radical formation in mouse hepatocytes: M.G. Bonini et al.; Free Rad. Biol. Med. 42, 530 (2007)
Mitochondrial Complex II in the Post-ischemic Heart: Oxidative injury and the role or protein S-Glutathionylation: Y.R. Chen, et al.; J. Biol. Chem. 282, 32640 (2007) Abstract; Full Text
Further Categories Containing This Product:
DNA Damage & Repair Other ProductsPolyclonal Antibodies
 
 
ALX-400-003 Revised 25-May-07
Diethyldithiocarbamic acid . sodium salt . trihydrate (high purity)
Add to Clipboard
SYNONYMS DETC . 3H2O (high purity)
Diethyldithiocarbamate . 3H2O (high purity)
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-400-003-G005   5 g 17.00 USD Add To Cart
ALX-400-003-G025   25 g 27.00 USD Add To Cart
Product Specification
FORMULA: C5H10NS2 . Na . 3H2O
MW: 148.3 . 23.0 . 54.0
CAS NUMBER: 20624-25-3
MERCK INDEX: 14: 3378
RTECS: EZ6550000
PURITY: ≥99%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: HARMFUL.

Product Description
Nitric oxide (NO) spin-trapping reagent. Thiol and iron chelator. Inhibits induction of macrophage nitric oxide synthase (NOS). Has been shown to be an inhibitor of the nuclear transcription factor κB (NF-κB).
Product Specific Literature References
On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy: P. Mordvintcev, et al.; Anal. Biochem. 199, 142 (1991) Abstract
NO accounts completely for the oxygenated nitrogen species generated by enzymic L-arginine oxygenation: A. Mülsch, et al.; Biochem. J. 288, 597 (1992) Abstract
Iron diethyldithiocarbamate as spin trap for nitric oxide detection: A.F. Vanin; Methods Enzymol. 301, 269 (1999), Review Abstract
Diethyldithiocarbamate inhibits induction of macrophage NO synthase: A. Mülsch, et al.; FEBS Lett. 321, 215 (1993) Abstract
The relationship between L-arginine-dependent nitric oxide synthesis, nitrite release and dinitrosyl-iron complex formation by activated macrophages: A. Vanin, et al.; Biochim. Biophys. Acta 1177, 37 (1993) Abstract
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells: R. Schreck, et al.; J. Exp. Med. 175, 1181 (1992) Abstract
In vivo spin trapping of nitric oxide generated in the small intestine, liver, and kidney during the development of endotoxemia: a time-course study: G. Wallis, et al.; Shock 6, 274 (1996) Abstract
Epr evidence of nitric oxide production by the regenerating rat liver: M. Obolenskaya, et al.; BBRC 202, 571 (1994) Abstract
EPR and laser flash photolysis studies of the reaction of nitric oxide with water soluble NO trap Fe(II)-proline-dithiocarbamate complex: S.V. Paschenko, et al.; BBRC 225, 577 (1996) Abstract
Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997) Abstract
NO-dependent mechanisms of adaptation to hypoxia: I.Y. Malyshev, et al.; Nitric Oxide 3, 105 (1999) Abstract
Ex vivo EPR detection of nitric oxide in brain tissue: H. Fujii & L.J. Berliner; Magn. Reson. Med. 42, 599 (1999) Abstract
EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell Mol. Biol. Lett. 7, 142 (2002) Abstract
EPR quantification of vascular nitric oxide production in genetically modified mouse models: J.P. Khoo, et al.; Nitric Oxide 10, 156 (2004) Abstract
Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006) Abstract
Further Categories Containing This Product:
NF-kB Pathway InhibitorsNOS Inhibitors (NOS Induction & Enzyme Activity)
 
 
ALX-400-014 Revised 29-Jul-08
MGD . sodium salt . monohydrate
Add to Clipboard
SYNONYMS N-(Dithiocarbamoyl)-N-methyl-D-glucamine . Na . H20
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-400-014-M050   50 mg 50.00 USD Add To Cart
ALX-400-014-M250   250 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C8H16NO5S2Na . H2O
MW: 293.3 . 18.0
PURITY: ≥99% (1H-NMR)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Together with FeSO4 MGD is a useful component for the formation of the MGD2-Fe2+complex, which is an excellent nitric oxide (NO) spin-trapping reagent. The MGD2-Fe2+complex is quite unstable, especially in the presence of dissolved oxygen. Thus, the complex should be used immediately after being made. An excess (usually 5-fold excess), of MGD to Fe2+ is used for making the complex with FeSO4 to give a more stable complex solution. Acidic conditions should be avoided because dithiocarbamate tends to decompose forming toxic carbon disulfide. It was reported that MGD and Fe(MGD)2 do not exhibit toxicity up to 8mmol/kg and 0.3mmol/kg, respectively.
Product Specific Literature References
Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication: L.A. Shinobu, et al.; Acta Pharmacol. Toxicol. 54, 189 (1984) Abstract
In vivo spin trapping of nitric oxide in mice: A. Komarov, et al.; BBRC 195, 1191 (1993) Abstract
Spin trapping of nitric oxide produced in vivo in septic-shock mice: C.-S. Lei & A.M. Komarov; FEBS Lett. 345, 120 (1994) Abstract
Spin trapping isotopically-labelled nitric oxide produced from [15N]L- arginine and [17O]dioxygen by activated macrophages using a water soluble Fe(++)-dithiocarbamate spin trap: Y. Kotake, et al.; Free Rad. Res. 23, 287 (1995) Abstract
Continuous and quantitative monitoring of rate of cellular nitric oxide generation: Y. Kotake; Methods Enzymol. 268, 222 (1996) Abstract
Continuous monitoring of cellular nitric oxide generation by spin trapping with an iron-dithiocarbamate complex: Y. Kotake, et al.; Biochim. Biophys. Acta 1289, 362 (1996) Abstract
Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997) Abstract
Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems: A.F. Vanin, et al.; Biochim. Biophys. Acta 1474, 365 (2000) Abstract
Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase: A.M. Komarov, et al.; Free Radic. Biol. Med. 28, 793 (2000) Abstract
Detailed methods for the quantification of nitric oxide in aqueous solutions using either an oxygen monitor or EPR: S. Venkataraman, et al.; Free Radic. Biol. Med. 29, 580 (2000) Abstract
EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell. Mol. Biol. Lett. 7, 142 (2002) Abstract
Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate: C. Lu & W.H. Koppenol; Free Radic. Biol. Med. 39, 1581 (2005) Abstract
Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006) Abstract
 
 
ALX-430-071 Revised 19-Sep-06
TEMPONE-H . hydrochloride
Add to Clipboard
SYNONYMS 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine . HCl
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-071-M010   10 mg 65.00 USD Add To Cart
ALX-430-071-M050   50 mg 195.00 USD Add To Cart
ALX-430-071-M250   250 mg 490.00 USD Add To Cart
Product Specification
FORMULA: C9H17NO2 . HCl
MW: 171.2 . 36.5
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in DMSO, water, methanol or 100% ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY:

Stable for at least two years when stored at -20 °C.


Product Description
Very effective, cell permeable and non-toxic spin trap for the detection of superoxide radical and peroxynitrite.
Product Specific Literature References
Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance: S. Dikalov, et al.; Nitric Oxide Biol. Chem. 1, 423 (1997) Abstract
Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine: S. Dikalov, et al.; BBRC 230, 54 (1997) Abstract
Spin trapping of superoxide radicals and peroxynitrite by 1-Hydroxy-3-carboxy-pyrrolidine and 1-Hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants: S. Dikalov, et al.; BBRC 231, 701 (1997) Abstract
 
 
ALX-430-073 Revised 19-Sep-06
TMIO
Add to Clipboard
SYNONYMS 2,2,4-Trimethyl-2H-imidazole-1-oxide
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-073-M050   50 mg 45.00 USD Add To Cart
ALX-430-073-M250   250 mg 180.00 USD Add To Cart
ALX-430-073-G001   1 g 470.00 USD Add To Cart
Product Specification
FORMULA: C6H10N2O
MW: 126.2
PURITY: ≥98%
APPEARANCE: Light yellow crystalline solid.
SOLUBILITY: Soluble in DMSO, water, methanol or 100% ethanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic. Protect from light and moisture.

Product Description
Selective, cell permeable and non-toxic spin trap for peroxynitrite and secondary O-, C-, S-, and N- centered free radicals.
Product Specific Literature References
Spin trapping of O-, C-, and S-centered radicals and peroxynitrite by 2H-imidazole-1-oxides: S.I. Dikalov, et al.; BBRC 218, 616 (1996) Abstract
Determination of rate constants of the reactions of thiols with superoxide radical by electron paramagnetic resonance: critical remarks on spectrophotometric approaches: S. Dikalov, et al.; Arch. Biochem. Biophys. 326, 207 (1996) Abstract
Oxygen-centered spin adducts of 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and 2H-imidazole 1-oxides: A.G. Krainev, et al.; J. Magn. Reson. B. 111, 272 (1996) Abstract
Quantification of peroxynitrite, superoxide, and peroxyl radicals by a new spin trap hydroxylamine 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine: S. Dikalov, et al.; BBRC 230, 54 (1997) Abstract
Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3-carboxy-pyrrolidine and 1-hydroxy-2,2,6,6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants: S. Dikalov, et al.; BBRC 231, 701 (1997) Abstract
Formation of reactive oxygen species in various vascular cells during glyceryltrinitrate metabolism: S. Dikalov, et al.; J. Cardiovasc. Pharmacol. Ther. 3, 51 (1998) Abstract
Reassignment of organic peroxyl radical adducts: S.I. Dikalov & R.P. Mason; Free Radic. Biol. Med. 27, 864 (1999) Abstract
 
 
ALX-430-078 Revised 10-Nov-06
CPH . hydrochloride
Add to Clipboard
SYNONYMS 1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine . HCl
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-078-M010   10 mg 65.00 USD Add To Cart
ALX-430-078-M050   50 mg 195.00 USD Add To Cart
ALX-430-078-M250   250 mg 450.00 USD Add To Cart
Product Specification
FORMULA: C9H17NO3 . HCl
MW: 187.2 . 36.5
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Effective, cell permeable and non-toxic spin trap for the detection of superoxide radical and peroxynitrite, both in vitro and in vivo. Resistant to reduction by vitamin C and thiols.
Product Specific Literature References
Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3- carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants: S. Dikalov, et al.; BBRC 231, 701 (1997) Abstract
Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance: S. Dikalov, et al.; Nitric Oxide 1, 423 (1997) Abstract
Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C: S. Dikalov, et al.; Free Radic. Biol. Med. 27, 170 (1999) Abstract
A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo: B. Fink, et al.; Free Radic. Biol. Med. 28, 121 (2000) Abstract
Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine: S.I. Dikalov, et al.; Arch. Biochem. Biophys. 402, 218 (2002) Abstract
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase: N. Kuzkaya, et al.; J. Biol. Chem. 278, 22546 (2003) Abstract; Full Text
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005) Abstract
Indoxyl sulfate induces complex redox alterations in mesangial cells: A.K. Gelasco & J.R. Raymond; Am. J. Physiol. Renal Physiol. 290, F1551 (2006) Abstract
 
 
ALX-430-079 Revised 19-Sep-06
TEMPONE
Add to Clipboard
SYNONYMS 4-Oxo-2,2,6,6-tetramethylpiperidine-1-oxyl
4-Oxo-TEMPO
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-079-M250   250 mg 15.00 USD Add To Cart
ALX-430-079-M500   500 mg 25.00 USD Add To Cart
ALX-430-079-G001   1 g 40.00 USD Add To Cart
Product Specification
FORMULA: C9H16NO2
MW: 170.2
CAS NUMBER: 2896-70-0
PURITY: ≥98%
APPEARANCE: Orange crystalline powder.
SOLUBILITY: Soluble in acetone, DMSO, diethylether, 100% ethanol or water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Spin trap, useful for both in vitro and in vivo experiments.
Product Specific Literature References
Cytotoxicity of commonly used nitroxide radical spin probes: E.G. Ankel, et al.; Life Sci. 40, 495 (1987) Abstract
Biologically active metal-independent superoxide dismutase mimics: J.B. Mitchell, et al.; Biochemistry 29, 2802 (1990) Abstract
Superoxide reaction with nitroxides: A. Samuni, et al.; Free Rad. Res. Commun. 9, 241 (1990) Abstract
Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol: J.B. Mitchell, et al.; Arch. Biochem. Biophys. 289, 62 (1991) Abstract
Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis: A.F. Slater, et al.; Biochem. J. 306, 771 (1995) Abstract
Cytotoxicity of spin trapping compounds: R.F. Haseloff, et al.; FEBS Lett. 418, 73 (1997) Abstract
Characterization of the 4-oxo-2,2,6,6-tetramethylpiperidinooxy dosimeter for in situ radiolysis electron spin resonance studies: K.P. Madden; Radiat. Res. 147, 335 (1997) Abstract
Metabolism of the stable nitroxyl radical 4-oxo-2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPONE): C. Kroll & H.H. Borchert; Eur. J. Pharm. Sci. 8, 5 (1999) Abstract
Related Products
 
 
ALX-430-080 Revised 31-Mar-08
PPH . hydrochloride
Add to Clipboard
SYNONYMS 1-Hydroxy-4-phosphono-oxy-2,2,6,6-tetramethylpiperidine . HCl
PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Spin Traps, Spin Probes & Spin Labels
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-430-080-M010   10 mg 90.00 USD Add To Cart
ALX-430-080-M050   50 mg 315.00 USD Add To Cart
Product Specification
FORMULA: C9H20NO5P . HCl
MW: 253.2 . 36.5
PURITY: ≥99% (EPR)
APPEARANCE: White to off-white solid.
PURITY DETAIL: ≤0.1% paramagnetic impurities (EPR)
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C

Product Description
Effective, non-cell permeable and non-toxic analog of CPH for the detection of superoxide radicals. Resistant against reduction of vitamin C. For cell permeable analog see CPH (Prod. No. ALX-430-078).
Product Specific Literature References
Detection of superoxide radicals and peroxynitrite by 1-hydroxy-4- phosphonooxy-2,2,6,6-tetramethylpiperidine: quantification of extracellular superoxide radicals formation: S. Dikalov, et al.; BBRC 248, 211 (1998) Abstract
A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo: B. Fink, et al.; Free Radic. Biol. Med. 28, 121 (2000) Abstract
Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine: S.I. Dikalov, et al.; Arch. Biochem. Biophys. 402, 218 (2002) Abstract
Rotenone model of Parkinson disease: multiple brain mitochondria dysfunctions after short term systemic rotenone intoxication: A. Panov, et al.; J. Biol. Chem. 280, 42026 (2005) Abstract
Molecular Mechanisms of Angiotensin II Mediated Mitochondrial Dysfunct