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Stress & Heat Shock Proteins
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ALX-270-062 Revised 03-Feb-05
Cantharidic acid . disodium salt
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY PP2A / Related Products
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ALX-270-062-M010   10 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C10H12O5 . 2Na
MW: 212.2 . 46.0
CAS NUMBER: 28874-45-5
PURITY: ≥95%
APPEARANCE: White solid.
SOLUBILITY: Soluble in water; slightly soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent protein phosphatase 2A inhibitor.
Product Specific Literature References
M. Matsuzawa, et al.; J. Agric. Food Chem. 35, 823 (1987)
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1989) Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li & J.E. Casida; PNAS 89, 11867 (1992) Abstract
 
 
ALX-270-063 Revised 03-Apr-08
Cantharidin
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SYNONYMS Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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ALX-270-063-M025   25 mg 50.00 USD Add To Cart
ALX-270-063-M100   100 mg 160.00 USD Add To Cart
Product Specification
FORMULA: C10H12O4
MW: 196.2
CAS NUMBER: 56-25-7
MERCK INDEX: 14: 1752
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetone, DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).
Product Specific Literature References
Partial characterization of specific cantharidin binding sites in mouse tissues: M.J. Graziano, et al.; Mol. Pharmacol. 33, 706 (1988) Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A: Y.-M. Li and J.E. Casida; PNAS 89, 11867 (1992) Abstract
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues: Y.-M. Li, et al.; Biochem. Pharmacol. 46, 1435 (1993) Abstract
Further Categories Containing This Product:
PP2A / Related Products
 
 
ALX-350-052 Revised 17-Nov-08
Dihydrocapsaicin
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SYNONYMS 8-Methyl-N-vanillylnonanamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-350-052-M010   10 mg 28.00 USD Add To Cart
ALX-350-052-M050   50 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C18H29NO3
MW: 307.4
CAS NUMBER: 19408-84-5
RTECS: RA5998000
SOURCE/HOST: Isolated from Capsicum fruit.
PURITY: ≥85%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in chloroform, DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT. POTENT NEUROTOXIN.

Product Description
Dihydro-analog and congener of capsaicin (Prod. No. ALX-550-066) in chili peppers (Capsicum). Like capsaicin it is irritant. Dihydrocapsaicin accounts for about 22% of the total capsaicinoids mixture and has about the same pungency as capsaicin. Antioxidant. Reduces oxidation of serum lipids. Mutagenic.
Product Specific Literature References
The mutagenicity of capsaicin and dihydrocapsaicin in V79 cells: T. Lawson & P. Gannett; Cancer Lett. 48, 109 (1989) Abstract
Dihydrocapsaicin treatment depletes peptidergic nerve fibers of substance P and alters mast cell density in the respiratory tract of neonatal sheep: R. Ramirez-Romero, et al.; Regul. Pept. 91, 97 (2000) Abstract
Oxidative DNA damage by capsaicin and dihydrocapsaicin in the presence of Cu(II): S. Singh, et al.; Cancer Lett. 169, 139 (2001) Abstract
Determination of capsaicin and dihydrocapsaicin in capsicum fruits by liquid chromatography-electrospray/time-of-flight mass spectrometry: A. Garces-Claver, et al.; J. Agric. Food Chem. 54, 9303 (2006) Abstract
Effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids: K.D. Ahuja, et al.; J. Agric. Food Chem. 54, 6436 (2006) Abstract
General Literature References
Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin,induces autophagy in human cancer cells in a catalase-regulated manner: S.H. Oh, et al.; Autophagy 4, 1009 (2008) Abstract
Further Categories Containing This Product:
TRPV1 Agonists and Antagonists / Related Products • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables • Natural Products for Neurological Research • Alkaloids • Autophagy Other Products
 
 
ALX-550-084 Revised 13-Dec-04
Carbamazepine
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SYNONYMS 5H-Dibenz[b,f]azepine-5-carboxamide
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Benzodiazepines / Related Products
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ALX-550-084-G001   1 g 10.00 USD Add To Cart
ALX-550-084-G005   5 g 30.00 USD Add To Cart
Product Specification
FORMULA: C15H12N2O
MW: 236.3
CAS NUMBER: 298-46-4
MERCK INDEX: 14: 1781
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in ethanol. Insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Anticonvulsant and analgesic.
Further Categories Containing This Product:
Analgesic / Anti-nociceptive Agents / Related Products • Autophagy Other Products
 
 
ALX-201-093 Revised 15-Apr-08
Caspase-4 (active) (human) (recombinant)
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PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspases
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ALX-201-093-U025   25 U 203.00 USD Add To Cart
ALX-201-093-U100   100 U 371.00 USD Add To Cart
Product Specification
EC: 3.4.22.57
SOURCE/HOST: Produced in E. coli.
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute with PBS containing 15% glycerol to 1U/µl.
SPECIFIC ACTIVITY: ~5'000U/mg protein. One unit is defined as the amount of enzyme that cleaves 1nmol of the caspase substrate WEHD-pNA per hour at 37°C in reaction solution containing 50mM HEPES, pH 7.2, 50mM NaCl, 0.1% CHAPS, 10mM EDTA, 5% glycerol and 10mM DTT.
APPLICATION: Useful in screening caspase inhibitors, studying enzyme regulation and kinetics, determining target substrate or as a positive control in caspase activity assays. We recommend using 1 unit per assay for analyzing caspase activity.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
General Information
Caspase-4 is a member of the caspase family of cysteine proteases. It exists in cells as an inactive pro-enzyme. The pro-enzyme is matured by proteolysis to yield large and small subunits. The active enzyme is a heterotetramer consisting of two large and two small subunits. The expressed caspase-4 spontaneously undergoes auto-processing to yield subunits characteristic of the native enzyme. The active caspase-4 is routinely tested for its ability to enzymatically cleave the substrate WEHD-AFC or WEHD-pNA.
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P49662: Caspase-4 (human) (precursor)
AfCS Signalling Gateway link A000499: Caspase-4 (mouse)
Further Categories Containing This Product:
Enzymes • Endoplasmatic Reticulum Stress • Recombinant Proteins / Fusion Proteins
 
 
ALX-201-148 Revised 16-Feb-05
Cdc37 (yeast) (recombinant)
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SYNONYMS Cell Division Control Protein 37 (yeast) (recombinant)
HSP90 Co-chaperone Cdc37 (yeast) (recombinant)
HSP90 Chaperone Protein Kinase-targeting Subunit (yeast) (recombinant)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Co-Chaperones & HSP-interacting Proteins / Related Products
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ALX-201-148-C025   25 µg 155.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1.7mg/ml
PURITY: ≥99%
FORMULATION: Liquid. In 50mM TRIS/HCl, pH 7.5, containing 50mM NaCl, 5mM EDTA and 1mM DTT.
SHIPPING: SHIPPED ON DRY ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -80°C
HANDLING: For maximum product recovery after thawing, centrifuge the vial before opening the cap. Avoid freeze/thaw cycles.
Product Specific Literature References
Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37: G. Siligardi, et al.; J. Biol. Chem. 277, 20151 (2002) Abstract; Full Text
General Information
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link P06101: HSP90 Co-chaperone Cdc73 (Saccharomyces cerevisiae (Baker's yeast))
General Literature References
Heat-shock protein 90, a chaperone for folding and regulation: D. Picard; Cell. Mol. Life Sci. 59, 1640 (2002), (Review) Abstract
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins
 
 
ALX-350-332 Revised 20-Oct-08
Celastrol
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SYNONYMS Tripterine
3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic acid
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Anti-inflammatory Agents
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ALX-350-332-M005   5 mg 65.00 USD Add To Cart
ALX-350-332-M025   25 mg 260.00 USD Add To Cart
Product Specification
FORMULA: C29H38O4
MW: 450.6
CAS NUMBER: 34157-83-0
SOURCE/HOST: Isolated from the root of Tripterygium sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Red cubic crystals.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Cell permeable triterpenoid; anti-inflammatory and immunosuppressive compound. Antioxidant. Suppresses LPS-induced cytokine release in macrophages and monocytes (IC50=40nM for IL-1β and IL-1α, 80nM for IL-6, 110nM for prostaglandin E2 and 210nM for IL-8 and TNF-α). Suppresses nitric oxide (NO) production (IC50=230nM) and LPS-induced NF-κB activation (IC50=270nM). Inhibits chymotrypsin-like activity of 20S proteasome (IC50=2.5µM). Inhibits lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50=7µM). Induces expression of a wider set of heat shock proteins. Inhibits topoisomerse II.
Product Specific Literature References
The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria: H. Sassa, et al.; BBRC 172, 890 (1990) Abstract
Structural basis of potent antiperoxidation activity of the triterpene celastrol in mitochondria: effect of negative membrane surface charge on lipid peroxidation: H. Sassa, et al.; Free Radic. Biol. Med. 17, 201 (1994) Abstract
Novel cytokine release inhibitors. Part III: Truncated analogs of tripterine: W. He, et al.; Bioorg. Med. Chem. Lett. 8, 3659 (1998) Abstract
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer’s disease: A.C. Allison, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341 (2001) Abstract
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production: H.Z. Jin, et al.; J. Nat. Prod. 65, 89 (2002) Abstract
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol: M. Nagase, et al.; Biosci. Biotechnol. Biochem. 67, 1883 (2003) Abstract; Full Text
Celastrol inhibits pro-inflammatory cytokine secretion in Crohn’s disease biopsies: G.F. Pinna, et al.; BBRC 322, 778 (2004) Abstract
Celastrols as inducers of the heat shock response and cytoprotection: S.D. Westerheide, et al.; J. Biol. Chem. 279, 56053 (2004) Abstract; Full Text
Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity: C. Cleren, et al.; J. Neurochem. 94, 995 (2005) Abstract
Celastrol blocks neuronal cell death and extends life in transgenic mouse model of amyotrophic lateral sclerosis: M. Kiaei, et al.; Neurodegener. Dis. 2, 246 (2005) Abstract
Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice: H. Yang, et al.; Cancer Res. 66, 4758 (2006) Abstract; Full Text
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-kappaB-regulated gene products and TAK1-mediated NF-kappaB activation: G. Sethi, et al.; Blood 109, 2727 (2007) Abstract
Induction of heat shock proteins in differentiated human and rodent neurons by celastrol: A.M. Chow & I.R. Brown; Cell Stress Chaperones 12, 237 (2007) Abstract
Further Categories Containing This Product:
Stress & Heat Shock Proteins Other Products • NF-kB Pathway Inhibitors • Natural Products - Topoisomerase Inhibitors • Natural Products - Antioxidants • Ubiquitin & Proteasome Other Products • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Immunomodulators
 
 
ALX-850-307 Revised 29-Apr-05
Chaperone Cocktail
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PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Stress & Heat Shock Proteins Other Products
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ALX-850-307-KI01   1 Kit 590.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
QUANTITY: 85µl
CONCENTRATION: 2.4mg/ml total protein.
KIT/SET CONTAINS: Contains the following recombinant E. coli proteins:
ClpB (10µM)
DnaK (10µM)
DnaJ (2µM)
GrpE (1µM)
GroEL (10µM)
GroES (10µM)
PURITY: ≥95%
FORMULATION: Liquid. In 50mM TRIS-HCl, pH 7.5, containing 50mM sodium chloride, 5mM magnesium dichloride and 5% (v/v) glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Description
High power chaperone mix which mediates the ATP-dependent refolding of aggregated proteins (i.e. inclusion bodies).
Product Specific Literature References
Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network: P. Goloubinoff, et al.; PNAS 96, 13732 (1999) Abstract; Full Text
Further Categories Containing This Product:
Panels / Sets
 
 
ALX-201-215 Revised 02-Apr-08
CHIP (human) (recombinant)
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SYNONYMS C-terminus of HSC70 Interacting Protein
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Co-Chaperones & HSP-interacting Proteins / Related Products
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ALX-201-215-C025   25 µg 160.00 USD Add To Cart
Product Specification
SOURCE/HOST: Produced in E. coli.
CONCENTRATION: 1mg/ml
PURITY: ≥99%
FORMULATION: Liquid. In 50mM HEPES/KOH, pH 7.0, containing 50mM potassium chloride, 5mM DTT and 10% (v/v) glycerol.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles.
Product Specific Literature References
Dimerization of the human E3 ligase CHIP via a coiled-coil domain is essential for its activity: R. Nikolay, et al.; J. Biol. Chem. 279, 2673 (2004) Abstract; Full Text
Further Categories Containing This Product:
Recombinant Proteins / Fusion Proteins • Chaperone-mediated Autophagy [CMA] • Ubiquitin Ligases [E3]
 
 
ALX-270-437 Revised 07-Oct-08
6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY Sirtuins / Related Products
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ALX-270-437-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C13H13ClN2O
MW: 248.7
CAS NUMBER: 49843-98-3
PURITY: ≥95%
APPEARANCE: White to beige powder.
SOLUBILITY: Soluble in DMSO (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months when stored at -20°C in the dark.
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Potent cell permeable and metabolically stable specific inhibitor of hSIRT1 (IC50=98nM in vivo / IC50=38nM in vitro; compared to hSIRT2: IC50=19µM and hSIRT3: IC50=48µM) with no effect on human histone deacetylases (HDACs) class I and class II, nor NAD glycohydrolase (IC50>100µg). Inhibits the deacetylation of p53 (IC50=1µM).
Product Specific Literature References
Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1: A.D. Napper, et al.; J. Med. Chem. 48, 8045 (2005) Abstract
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes: J.C. Milne, et al.; Nature 450, 712 (2007) Abstract