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ALX-480-099 Revised 25-Mar-08
5-Fluorouracil
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SYNONYMS 5-FU
2,4-Dioxo-5-fluoropyrimidine
5-Fluoro-2,4(1H,3H)-pyrimidinedione
PRODUCT LINE Cancer
PRODUCT CATEGORY Antitumor Agents (Apoptosis Inducers)
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-099-G001   1 g 15.00 USD Add To Cart
ALX-480-099-G005   5 g 60.00 USD Add To Cart
Product Specification
FORMULA: C4H3FN2O2
MW: 130.1
CAS NUMBER: 51-21-8
MERCK INDEX: 14: 4181
RTECS: YR0350000
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline powder.
SOLUBILITY: Soluble in DMSO (5mg/ml), dimethyl formamide (5mg/ml), methanol (1mg/ml) or hot water (1mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.
IDENTITY: Determined by IR and UV.

Product Description

Potent antitumor agent. Inhibits thymidylate synthetase. Induces p53-dependent apoptosis.
Product Specific Literature References
Apoptosis of human primary and metastatic colon adenocarcinoma cell lines in vitro induced by 5-fluorouracil, verapamil, and hyperthermia: I.B. Shchepotin, et al.; Anticancer Res. 14, 1027 (1994) Abstract
Modulation of the equilibrative nucleoside transporter by inhibitors of DNA synthesis: J. Pressacco, et al.; Br. J. Cancer 72, 939 (1995) Abstract
Nucleoside-mediated mitigation of 5-fluorouracil-induced toxicity in synchronized murine erythroleukemic cells: K.H. Elstein, et al.; Toxicol. Appl. Pharmacol. 146, 29 (1997) Abstract
Effects of perturbations of pools of deoxyribonucleoside triphosphates on expression of ribonucleotide reductase, a G1/S transition state enzyme, in p53-mutated cells: S. Wadler, et al.; Biochem. Pharmacol. 55, 1353 (1998) Abstract
Chemically-induced apoptosis: p21 and p53 as determinants of enterotoxin activity: D.M. Pritchard, et al.; Toxicol. Lett. 102, 19 (1998) Abstract
Effect of 5-fluorouracil on cell cycle regulatory proteins in human colon cancer cell line: H. Takeda, et al.; Jpn. J. Cancer Res. 90, 677 (1999) Abstract
5-fluorouracil sensitivity and dihydropyrimidine dehydrogenase activity in advanced gastric cancer: T. Inada, et al.; Anticancer Res. 20, 2457 (2000) Abstract
Further Categories Containing This Product:
DNA Replication Other Products
 
 
ALX-460-006 Revised 08-Oct-07
Folic acid
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SYNONYMS Pteroylglutamic acid
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Folic Acid & Folate Receptors / Related Products
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ALX-460-006-G010   10 g 28.00 USD Add To Cart
Product Specification
FORMULA: C19H19N7O6
MW: 441.4
CAS NUMBER: 59-30-3
MERCK INDEX: 14: 4221
PURITY: ≥97%
APPEARANCE: Yellow to orange powder.
SOLUBILITY: Soluble in diluted acids or alkaline solutions; slightly soluble in water or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Alkaline solutions are reasonably stable. Other solutions may be light and heat sensitive.

Further Categories Containing This Product:
Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Vitamins
 
 
ALX-380-065 Revised 24-Sep-08
Fostriecin
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SYNONYMS Phosphotrienin
CI-920
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Topoisomerase Inhibitors
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ALX-380-065-C010   10 µg 150.00 USD Add To Cart
Product Specification
FORMULA: C19H26O9PNa
MW: 452.4
CAS NUMBER: 87860-39-7
RTECS: UQ0600000
SOURCE/HOST: Isolated from Streptomyces pulveraceous subsp. fostreus.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless solid.
SOLUBILITY: Soluble in water (50mg/ml), methanol (10mg/ml) or 100% ethanol (10mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at -20°C. Use fresh solution.
HANDLING: Protect from light. Packaged under inert gas. Hygroscopic.

Product Description
Antitumor antibiotic. Catalytic inhibitor of topoisomerase II. Strong protein phosphatase 2A (PP2A) inhibitor (IC50=3.2nM). Weak inhibitor for PP1 (IC50=131µM). No apparent effect on PP2B. The binding site for fostriecin on PP2A is different from that of okadaic acid (see Prod. No. ALX-350-003).
Product Specific Literature References
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization: S.S. Stampwala, et al.; J. Antibiot. (Tokyo) 36, 1601 (1983) Abstract
Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties: J.B. Tunac, et al.; J. Antibiot. (Tokyo) 36, 1595 (1983) Abstract
Studies on the biochemical mechanism of the novel antitumor agent, CI- 920: D.W. Fry, et al.; Cancer Chemother. Pharmacol. 13, 171 (1984) Abstract
Anticancer activity of the structurally novel antibiotic Cl-920 and its analogues: W.R. Leopold, et al.; Cancer Res. 44, 1928 (1984) Abstract
Inhibition of type II topoisomerase by fostriecin: T.J. Boritzki, et al.; Biochem. Pharmacol. 37, 4063 (1988) Abstract
Comparison of effects of fostriecin, novobiocin, and camptothecin, inhibitors of DNA topoisomerases, on DNA replication and repair in human cells: C.M. Gedik & A.R. Collins; Nucl. Acids Res. 18, 1007 (1990) Abstract
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents: W. Gorczyca, et al.; Cancer Res. 53, 3186 (1993) Abstract
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias: W. Gorczyca, et al.; Leukemia 7, 659 (1993) Abstract
Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A: M. Roberge, et al.; Cancer Res. 54, 6115 (1994) Abstract
Fostriecin: a review of the preclinical data: R.S. de Jong, et al.; Anticancer Drugs 8, 413 (1997) Abstract
Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A: A.H. Walsh, et al.; FEBS Lett. 416, 230 (1997) Abstract
Fostriecin, an inhibitor of protein phosphatase 2A, limits myocardial infarct size even when administered after onset of ischemia: C. Weinbrenner, et al.; Circulation 98, 899 (1998) Abstract
Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin: R.S. de Jong, et al.; Br. J. Cancer 79, 882 (1999) Abstract
Fostriecin: chemistry and biology: D.S. Lewy, et al.; Curr. Med. Chem. 9, 2005 (2002) Abstract
Further Categories Containing This Product:
Antibiotics - Other Signal Transduction Pathway Modulators • PP2A / Related Products • Antitumor Agents (Enzyme Inhibitors) • Antitumor Antibiotics
 
 
ALX-350-119 Revised 20-Feb-08
Fumagillin
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SYNONYMS Fumidil B
Fumadil B
TNP-470
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Angiogenesis Research
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ALX-350-119-MC05   0.5 mg 65.00 USD Add To Cart
ALX-350-119-M001   1 mg 105.00 USD Add To Cart
Product Specification
FORMULA: C26H34O7
MW: 458.6
CAS NUMBER: 23110-15-8
MERCK INDEX: 14: 4286
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥95%
APPEARANCE: Light yellow solid
SOLUBILITY: Soluble in chloroform or diluted aqueous bases. Slightly soluble in methanol and other alcoholic solvents. Insoluble in water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Unstable in aqueous solutions with pH >9.0 or pH <5.0.
HANDLING: Packaged under inert gas. Protect from light.
HAZARD: HARMFUL.

Product Description
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II). Antineoplastic. Anti-infective.
Product Specific Literature References
Fumagillin (H-3), a new antibiotic with amebicidal properties: C.M. Mc, et al.; Science 113, 202 (1951) Abstract
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth: D. Ingber, et al.; Nature 348, 555 (1990) Abstract
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase: W.T. Lowther, et al.; PNAS 95, 12153 (1998) Abstract; Full Text
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2: E.C. Griffith, et al.; PNAS 95, 15183 (1998) Abstract
Fumagillin treatment of intestinal microsporidiosis: J.M. Molina, et al.; N. Engl. J. Med. 346, 1963 (2002) Abstract
Whirling disease of salmonid fish: life cycle, biology, and disease: M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol. 89, 658 (2003) Abstract
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis: I.S. Sheen, et al.; World J. Gastroenterol. 11, 771 (2005) Abstract
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors: B. Lefkove, et al.; Expert Rev. Anti Infect. Ther. 5, 573 (2007), Review Abstract
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470): G.J. Chen, et al.; J. Cell Biochem. 101, 1492 (2007) Abstract
Further Categories Containing This Product:
Aminopeptidases / Related Products • Fibroblast Growth Factors [FGFs] & Receptors / Related Products • Natural Products - Other Anti-infective Agents • Antitumor Antibiotics • Antitumor Agents (Anti-proliferative)
 
 
ALX-350-127 Revised 07-May-08
Fumitremorgin C
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SYNONYMS FTC
SM-Q
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Mycotoxins
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ALX-350-127-C250   250 µg 130.00 USD Add To Cart
Product Specification
FORMULA: C22H25N3O3
MW: 379.5
CAS NUMBER: 118974-02-0
SOURCE/HOST: Isolated from Aspergillus fumigatus.
PURITY: ≥96% (HPLC)
APPEARANCE: Off-white to light brown powder.
SOLUBILITY: Soluble in DMSO, methanol or chloroform.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: TOXIC.

Product Description
Mycotoxin. Tremorgenic. Potent and specific inhibitor of the breast cancer resistance protein (BCRP; ABCG2). Reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.
Product Specific Literature References
Mycotoxins produced by Aspergillus fumigatus species isolated from molded silage: R.J. Cole, et al.; J. Agric. Food Chem. 25, 826 (1977) Abstract
Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties: C.B. Cui, et al.; J. Antibiot. 49, 527 (1996) Abstract
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin: S.K. Rabindran, et al.; Cancer Res. 58, 5850 (1998) Abstract
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein.: S.K. Rabindran, et al.; Cancer Res. 60, 47 (2000) Abstract
Characterization of drug transport, ATP hydrolysis, and nucleotide trapping by the human ABCG2 multidrug transporter. Modulation of substrate specificity by a point mutation.: Ozvegy, et al.; J. Biol. Chem. 277, 47980 (2002) Abstract
The role of breast cancer resistance protein in acute lymphoblastic leukemia.: S.L. Plasschaert, et al.; Clin. Cancer Res. 9, 5171 (2003) Abstract
Plasma pharmacokinetics and tissue distribution of the breast cancer resistance protein (BCRP/ABCG2) inhibitor fumitremorgin C in SCID mice bearing T8 tumors: T.S. Garimella, et al.; Cancer Chemother. Pharmacol. 55, 101 (2005) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Optical Rotation: [α]D= +19° ±1° (c=1.0 in methanol).
Further Categories Containing This Product:
Other Natural Products for Cancer Research • Breast Cancer Resistance Protein [BCRP / MXR] / Related Products • MDR Inhibitors
 
 
ALX-350-017 Revised 18-Nov-08
Fumonisin B1
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Tumor Promoters
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ALX-350-017-M001   1 mg 60.00 USD Add To Cart
ALX-350-017-M005   5 mg 245.00 USD Add To Cart
Product Specification
FORMULA: C34H59NO15
MW: 721.8
CAS NUMBER: 116355-83-0
MERCK INDEX: 14: 4289
RTECS: TZ8350000
SOURCE/HOST: Isolated from Fusarium moniliforme.
PURITY: ~98% (TLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water, methanol, DMSO or acetonitrile.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC. MAY BE MUTAGENIC. MAY BE TERATOGENIC. HARMFUL.

Product Description
Mycotoxin. Induces DNA damage in the liver and cancer. Inhibitor of sphingosine biosynthesis. Induces apoptosis. Activates Akt (protein kinase B; PKB), which leads to increased survival, inhibition of GSK-3β activity and post-translational stabilization of cyclin D1.
Product Specific Literature References
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem. 266, 14486 (1991) Abstract; Full Text
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ: A.H. Merrill Jr., et al.; J. Biol. Chem. 268, 27299 (1993) Abstract; Full Text
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993) Abstract
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996) Abstract
A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity: D. Ramljak, et al.; Carcinogenesis 21, 1537 (2000) Abstract
Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example: Y.P. Dragan, et al.; Toxicol. Sci. 61, 6 (2001), Review Abstract
Fumonisin B(1): oxidative status and DNA damage in rats: A.M. Domijan, et al.; Toxicology 232, 163 (2007) Abstract
Further Categories Containing This Product:
Akt [PKB] / Related Products • Sphingolipids & Glycosphingolipids Other Products • Carcinogens & Tumor Promoters Other Products • Mycotoxins • DNA Damage & Repair Other Products • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-350-237 Revised 21-Apr-08
Fumonisin B2
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Tumor Promoters
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ALX-350-237-M001   1 mg 155.00 USD Add To Cart
Product Specification
FORMULA: C34H59NO14
MW: 705.8
CAS NUMBER: 116355-84-1
MERCK INDEX: 14: 4289 (Fumonisin B1)
RTECS: TZ8335000
SOURCE/HOST: Isolated from Fusarium moniliforme.
PURITY: ≥96%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: MAY BE CARCINOGENIC. VERY TOXIC.

Product Description
Mycotoxin, structurally similar to fumonisin B1 (Prod. No. ALX-350-017). Found as contaminant mostly in corn silage; was detected recently for the first time in the industrially important Aspergillus niger. Induces cancer. Inducer of apoptosis.
Product Specific Literature References
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993) Abstract
Liquid chromatographic determination of the mycotoxin fumonisin B2 in physiological samples: G.S. Shephard, et al.; J. Chromatogr. A 692, 39 (1995) Abstract
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996) Abstract
Liquid chromatographic determination of fumonisins B1, B2, and B3 in corn silage: E.K. Kim, et al.; J. Agric. Food Chem. 52, 196 (2004) Abstract
Fumonisin B2 Production by Aspergillus niger: J.C. Frisvad, et al.; J. Agric. Food Chem. 55, 9727 (2007) Abstract
Further Categories Containing This Product:
Carcinogens & Tumor Promoters Other Products • Mycotoxins • Natural Products - Apoptosis Inducers & Inhibitors
 
 
ALX-620-004 Revised 21-May-08
FURA 2 . pentapotassium salt
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SYNONYMS 1-[2-(5-Carboxyoxazol-2-yl)-6-aminobenzofuran-5-oxy]-2-(2'-amino-5'-methyl-phenoxy)ethane-N,N,N',N'-tetraacetic acid . 5K
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calcium Chelators / Caged Calcium Chelators
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ALX-620-004-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C29H22N3O14 . 5K
MW: 636.5 . 195.5
CAS NUMBER: 113694-64-7
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to orange solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.
IDENTITY:

Identity determined by NMR and fluorescence.

Product Description
Ca2+ chelator that offers more than 30-fold greater fluorescence intensity than QUIN 2, (Prod. No. ALX-620-006), allowing much smaller amounts to be used and minimizes toxic effects and other artifacts. Shows a strong shift in UV absorption maxima on chelation of Ca2+. Ca2+ concentration has been shown to be closely correlated to the ratios of fluorescence, measured at ~510nm, when excitated at 340nm and at 380nm. This ratioing method allows estimation of Ca2+ concentration independent of the dye concentration. Used in many cellular systems, including cardiac myocytes, vascular smooth muscle cells and medullary collecting tubules.
Product Specific Literature References
Spontaneous and experimentally evoked [Ca2+]i-transients in cardiac myocytes measured by means of a fast Fura-2 technique: S. Bals, et al.; Cell Calcium 11, 385 (1990) Abstract
Measurement of intracellular Ca2+ in cultured arterial smooth muscle cells using Fura-2 and digital imaging microscopy: W.F. Goldman, et al.; Cell Calcium 11, 221 (1990) Abstract
Ryanodine reveals multiple contractile and relaxant mechanisms in vascular smooth muscle: simultaneous measurements of mechanical activity and of cytoplasmic free Ca2+ level with fura-2: T. Hisayama, et al.; Br. J. Pharmacol. 100, 677 (1990) Abstract
Cholinergic agonists increase cell calcium in rat medullary collecting tubules. A fura-2 study: J. Marchetti, et al.; Pfluegers Arch. 416, 561 (1990) Abstract
Estimation of intracellular calcium activity in confluent monolayers of primary cultures of quail medullary bone osteoclasts: S. Arkle, et al.; Exp. Physiol. 79, 975 (1994) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION FURA 2 pentapotassium salt is not cell-permeable. Cells need to be loaded by pressure microinjection or permeabilized prior to use this compound. These approaches are only suggestions as optimal conditions should be determined by individual users.
Further Categories Containing This Product:
MDR Other Products • Calcium Indicators / Probes • Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
ALX-620-005 Revised 22-Feb-08
FURA 2/AM
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