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ALX-151-019
Revised 15-Dec-04
cAMP-dependent Protein Kinase Substrate
SYNONYMS
PKA Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKA Substrates
Ordering Information
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ALX-151-019-MC05
0.5 mg
95.00 USD
ALX-151-019-M001
1 mg
165.00 USD
Product Specification
SEQUENCE:
H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH
FORMULA:
C
92
H
150
N
28
O
29
MW:
2112.4
PURITY:
≥95%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Derived from the RII subunit of cAMP-dependent protein kinase (PKA). Substrate for PKA. Has been used in a non-radioactive assay of calcineurin (protein phosphatase 2B) for screening purposes.
Product Specific Literature References
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity:
D.K. Blumenthal, et al.; J. Biol. Chem.
261
, 8140 (1986)
Abstract
;
Full Text
Nonradioactive assay for protein phosphatase 2B (calcineurin) activity using a partial sequence of the subunit of cAMP-dependent protein kinase as substrate:
A. Enz, et al.; Anal. Biochem.
216
, 147 (1994)
Abstract
Further Categories Containing This Product:
PP2B [Calcineurin] / Related Products
•
Peptides
ALX-165-020
Revised 21-Feb-03
Protein Tyrosine Phosphatase Substrate
SYNONYMS
Tyrosine Phosphatase Substrate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Protein Tyrosine Phosphatases Other Products
Ordering Information
Product Numbers:
Format:
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ALX-165-020-M001
1 mg
140.00 USD
ALX-165-020-M005
5 mg
560.00 USD
Product Specification
SEQUENCE:
H-Thr-Glu-Pro-Glu-Tyr(PO
3
H
2
)-Gln-Pro-Gly-Glu-NH
2
FORMULA:
C
45
H
66
N
11
O
21
P
MW:
1128.1
PURITY:
≥97%
APPEARANCE:
White lyophilized powder.
SOLUBILITY:
Soluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for protein tyrosine phosphatases, suitable for continuous fluorimetric assays, based on the effect of phosphate substitution on the intrinsic fluorescence of the dephosphorylated peptide.
Product Specific Literature References
Synthesis and fluorescence properties of a substrate for a continuous fluorimetric assay of protein tyrosine phosphatases
:
C. Garcia-Echeverria & D.H. Rich; Bioorg. Med. Chem. Lett.
3
, 1601 (1993)
Further Categories Containing This Product:
Peptides
ALX-202-034
Revised 13-Dec-04
Calcineurin (bovine brain)
SYNONYMS
Calmodulin Binding Protein (bovine brain)
Protein Phosphatase 2B (bovine brain)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2B [Calcineurin] / Related Products
Ordering Information
Product Numbers:
Format:
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ALX-202-034-U100
100 U
590.00 USD
Product Specification
CAS NUMBER:
9025-75-6
EC:
3.1.3.16
MERCK INDEX:
14:
1640
SOURCE/HOST:
Isolated from bovine brain.
FORMULATION:
Lyophilized powder containing ~1% protein (Lowry) and 0.5% EGTA, buffer salts and stabilizers.
SPECIFIC ACTIVITY:
~2'500-5'000U/mg protein. One unit causes a 50% inhibition of the activated phosphodiesterase activity when assayed with 2 units of activator and 0.1mM Ca
2+
in an enzyme coupled system at 30°C, pH 7.5.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
Further Categories Containing This Product:
Enzymes
•
Natural Proteins
•
Nitric Oxide Pathway Other Products
ALX-210-020
Revised 24-Mar-05
Polyclonal Antibody to FAP-1 (human) (1730)
SYNONYMS
anti-PTND (human) PAb (1730)
anti-Fas-associated Protein-tyrosine Phosphatase 1 (human) PAb (1730)
anti-PTP-E1 (human) PAb (1730)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Protein Tyrosine Phosphatases Other Products
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Format:
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ALX-210-020-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Serum containing PBS and 0.05% sodium azide.
IMMUNOGEN:
Recombinant human FAP-1 (Fas-associated protein-tyrosine phosphatase 1) (aa 1279-1883).
SPECIFICITY:
Recognizes human FAP-1.
APPLICATION:
Immunohistochemistry (paraffin sections (1:2'000))
Western Blot (1:3'000)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-80°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer
:
I. Meinhold-Heerlein, et al.; Am. J. Pathol.
158
, 1335 (2001)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Fas Signalling Other Products
•
Polyclonal Antibodies
ALX-210-021
Revised 29-Jun-05
Polyclonal Antibody to FAP-1 (human) (1729)
SYNONYMS
anti-PTND (human) PAb (1729)
anti-Fas-associated Protein-tyrosine Phosphatase 1 (human) PAb (1729)
anti-PTP-E1 (human) PAb (1729)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Protein Tyrosine Phosphatases Other Products
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ALX-210-021-R050
50 µl
190.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. In PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 438-453 (E
438
PTRQENWTPLKNDLE
453
) of human FAP-1 (Fas-associated protein-tyrosine phosphatase 1).
SPECIFICITY:
Recognizes human FAP-1.
APPLICATION:
Western Blot
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-80°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -80°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Expression and potential role of Fas-associated phosphatase-1 in ovarian cancer
:
I. Meinhold-Heerlein, et al.; Am. J. Pathol.
158
, 1335 (2001)
Abstract
;
Full Text
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Fas Signalling Other Products
•
Polyclonal Antibodies
ALX-210-119
Revised 30-Oct-06
Polyclonal Antibody to Calcineurin B
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2B [Calcineurin] / Related Products
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Product Numbers:
Format:
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Unit Price:
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ALX-210-119-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Antiserum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Recombinant mouse calcineurin B.
SPECIFICITY:
Recognizes human, mouse and bovine calcineurin B. Does not cross-react with calcineurin A.
APPLICATION:
Immunoprecipitation
Western Blot (1:2'000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-575
Revised 10-Apr-08
Polyclonal Antibody to DUSP27
SYNONYMS
anti-Dual Specificity Phosphatase 27 PAb
anti-DUPD1 PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphatases Other Products
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Format:
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ALX-210-575-R100
100 µl
270.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Contains sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to human DUSP27 (dual specificity phosphatase 27).
SPECIFICITY:
Recognizes human and mouse DUSP27.
APPLICATION:
Western Blot (1:1’000)
Optimal conditions must be determined individually for each application.
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Identification and characterization of DUSP27, a novel dual-specific protein phosphatase:
I. Friedberg; et al.; FEBS Lett.
581
, 2527 (2007)
Abstract
General Information
DUSP27 is a cytosolic enzyme, expressed in skeletal muscle, liver and adipose tissue, suggesting its possible role in energy metabolism.
Further Categories Containing This Product:
Polyclonal Antibodies
ALX-210-917
Revised 02-Nov-06
Polyclonal Antibody to SET (human)
SYNONYMS
anti-PHAPII (human) PAb
anti-I
2
α
PP2A
(human) PAb
anti-Phosphatase 2A Inhibitor Protein 2α (human) PAb
anti-HLA-DR-associated Protein 2 (human) PAb
anti-IGAAD (human) PAb
anti-Inhibitor of Granzyme-activated DNase (human) PAb
anti-TAF-Iβ (human) PAb
anti-Template-activating Factor Iβ (human) PAb
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2A / Related Products
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ALX-210-917-C050
50 µg
194.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
SOURCE/HOST:
From rabbit.
CONCENTRATION:
1mg/ml
PURITY DETAIL:
Protein A affinity-purified.
FORMULATION:
Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 3-16 (A
3
PAAKVSKKELNSN
16
) of human SETβ.
SPECIFICITY:
Recognizes human SETβ. Detects endogenous protein by IP and WB.
APPLICATION:
Flow cytometry (1:100-1:200);
Immunocytochemistry;
Immunoprecipitation;
Western blot (1:1'000).
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least one year after receipt if stored at -20°C.
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks
:
P.J. Beresford, et al.; J. Biol. Chem.
276
, 43285 (2001)
Abstract
;
Full Text
HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
:
Z. Fan, et al.; Mol. Cell. Biol.
22
, 2810 (2002)
Abstract
;
Full Text
Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A
:
Z. Fan, et al.; Nat. Immunol.
4
, 145 (2003)
Abstract
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor
:
Z. Fan, et al.; Cell
112
, 659 (2003)
Abstract
Granzyme a induces caspase-independent mitochondrial damage, a required first step for apoptosis:
D. Martinvalet, et al.; Immunity
22
, 355 (2005)
Abstract
General Information
MANUFACTURER
Manufactured by Apotech Corporation.
Further Categories Containing This Product:
Granzymes Other Products
•
Polyclonal Antibodies
ALX-250-001
Revised 05-Sep-06
4-Aminophenylphosphate . sodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Phosphatases Other Products
Ordering Information
Product Numbers:
Format:
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ALX-250-001-M010
10 mg
30.00 USD
ALX-250-001-M050
50 mg
120.00 USD
ALX-250-001-M100
100 mg
195.00 USD
Product Specification
FORMULA:
188.1 . 23.0 . 72.1
MW:
C
6
H
7
NO
4
P . Na . 4.0H
2
O
PURITY:
≥97% (HPLC)
APPEARANCE:
Off-white to light gray crystalline solid.
SOLUBILITY:
Soluble in methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Substrate for the electrochemical measurement of alkaline phosphatase.
ALX-270-062
Revised 03-Feb-05
Cantharidic acid . disodium salt
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PP2A / Related Products
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ALX-270-062-M010
10 mg
110.00 USD
Product Specification
FORMULA:
C
10
H
12
O
5
. 2Na
MW:
212.2 . 46.0
CAS NUMBER:
28874-45-5
PURITY:
≥95%
APPEARANCE:
White solid.
SOLUBILITY:
Soluble in water; slightly soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
Product Description
Potent protein phosphatase 2A inhibitor.
Product Specific Literature References
M. Matsuzawa, et al.; J. Agric. Food Chem.
35
, 823 (1987)
Partial characterization of specific cantharidin binding sites in mouse tissues
:
M.J. Graziano, et al.; Mol. Pharmacol.
33
, 706 (1989)
Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A:
Y.-M. Li & J.E. Casida; PNAS
89
, 11867 (1992)
Abstract
ALX-270-063
Revised 03-Apr-08
Cantharidin
SYNONYMS
Hexahydro-3a,7a-dimethyl-4,7-epoxyisobenzo-furan-1,3-dione
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Natural Products - Other Signal Transduction Pathway Modulators
Ordering Information
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ALX-270-063-M025
25 mg
50.00 USD
ALX-270-063-M100
100 mg
160.00 USD
Product Specification
FORMULA:
C
10
H
12
O
4
MW:
196.2
CAS NUMBER:
56-25-7
MERCK INDEX:
14:
1752
PURITY:
≥98%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in acetone, DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
HANDLING:
Protect from light.
HAZARD:
TOXIC.
Product Description
Potent protein phosphatase 2A (PP2A) inhibitor. At higher concentrations, also inhibits protein phosphatase 1 (PP1).
Product Specific Literature References
Partial characterization of specific cantharidin binding sites in mouse tissues
:
M.J. Graziano, et al.; Mol. Pharmacol.
33
, 706 (1988)
Abstract
Cantharidin-binding protein: identification as protein phosphatase 2A:
Y.-M. Li and J.E. Casida; PNAS
89
, 11867 (1992)
Abstract
Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues:
Y.-M. Li, et al.; Biochem. Pharmacol.
46
, 1435 (1993)
Abstract
Further Categories Containing This Product:
PP2A / Related Products
ALX-270-169
Revised 07-Dec-04
Dephostatin
