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ALX-380-011

Revised 01-Oct-07

Fusidic acid . sodium salt
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Nitric Oxide Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-011-M050		50 mg	15.00 USD

Product Specification

FORMULA:	C₃₁H₄₇O₆ . Na
MW:	515.7 . 23.0
CAS NUMBER:	751-94-0
MERCK INDEX:	14: 4317
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.

Product Description

Antibiotic which suppresses nitric oxide (NO) toxicity in pancreatic islet cells. Inhibits protein synthesis by inhibition of elongation factor G at the level of the ribosome.

Product Specific Literature References

Fusidic acid: a new antibiotic: W.O. Godtfredsen, et al.; Nature 193, 987 (1962) Abstract
Mechanism of protein synthesis inhibition by fusidic acid and related antibiotics: N. Tanaka, et al.; BBRC 30, 278 (1968) Abstract
On the Mode of Action of Fusidic Acid: C.L. Harvey, et al.; Biochemistry 5, 3320 (1969)
Fusidic acid suppresses nitric oxide toxicity in pancreatic islet cells: V. Burkart, et al.; Biochem. Pharmacol. 48, 1379 (1994) Abstract
Fusidic acid in vitro activity: P. Collignon and J. Turnidge; Int. J. Antimicrob. Agents 12, S45 (1999), Review Abstract
Fusidic acid non-antibacterial activity: K. Christiansen; Int J Antimicrob Agents 12, S73 (1999), Review Abstract
Dumb and dumber--the potential waste of a useful antistaphylococcal agent: emerging fusidic acid resistance in Staphylococcus aureus
: B.P. Howden & M.L. Grayson; Clin. Infect. Dis. 42, 394 (2006), Review Abstract

Further Categories Containing This Product:

Protein Synthesis Other Products

ALX-380-013

Revised 12-Jun-08

G418 . sulfate
SYNONYMS	Geneticin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics for Molecular Biology Application

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-013-M100		100 mg	20.00 USD
ALX-380-013-M500		500 mg	39.00 USD
ALX-380-013-G001		1 g	48.00 USD
ALX-380-013-G005		5 g	160.00 USD

Product Specification

FORMULA:	C₂₀H₄₀N₄O₁₀ . 2H₂SO₄
MW:	496.6 . 196.1
CAS NUMBER:	108321-42-2
RTECS:	CB9378500
PURITY:	~98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water.
ACTIVITY:	Potency: ≥650µg/mg.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solutions are stable for 3 to 6 months when stored at -20 °C.
HANDLING:	Avoid freeze/thaw cycles.

Product Description

Gentamycin-class aminoglycoside antibiotic. Cytotoxic to prokaryotic and eukaryotic cells. Induces apoptosis. Widely employed in the selection of eukaryotic expression vectors, in combination with either aminoglycoside phosphotransferase 3’ or APH II.

Product Specific Literature References

Antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminths: fermentation, isolation, and preliminary characterization: G.H. Wagman, et al.; Antimicrob. Agents Chemother. 6, 144 (1974) Abstract
Phosphatidylinositol phospholipase C is activated allosterically by the aminoglycoside G418. 2-deoxy-2-fluoro-scyllo-inositol-1-O-dodecylphosphonate and its analogs inhibit glycosylphosphatidylinositol phospholipase C: J.C. Morris, et al.; J. Biol. Chem. 271, 15468 (1996) Abstract
Addition of G418 and other aminoglycoside antibiotics to mammalian cells results in the release of GPI-anchored proteins: M. Kung, et al.; FEBS Lett. 409, 333 (1997) Abstract
Cytochrome c release and endoplasmic reticulum stress are involved in caspase-dependent apoptosis induced by G418: Q.H. Jin, et al.; Cell. Mol. Life Sci. 61, 1816 (2004) Abstract
Expression and distribution of HSP27 in response to G418 in different human breast cancer cell lines: L. Qian, et al.; Histochem. Cell Biol. 126, 593 (2006) Abstract

Further Categories Containing This Product:

Carbohydrates • Antibiotics - Apoptosis Inducers & Inhibitors

ALX-550-336

Revised 18-Sep-07

Galanthamine . hydrobromide
SYNONYMS	Galantamine Nivalin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products for Neurological Research

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ALX-550-336-M050		50 mg	120.00 USD

Product Specification

FORMULA:	C₁₇H₂₁NO₃ . HBr
MW:	287.4 . 80.9
CAS NUMBER:	1953-04-4
MERCK INDEX:	14: 4340
RTECS:	DF8075000
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol; sparingly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	Protect from moisture.
HAZARD:	TOXIC.

Product Description

Specific, competitive and reversible acetylcholinesterase inhibitor. Alzheimer's disease therapeutic.

Product Specific Literature References

Galanthamine treatment in Alzheimer's disease: P. Dal-Bianco, et al.; J. Neural. Transm. Suppl. 33, 59 (1991) Abstract
Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats: P. Chopin & M. Briley; Psychopharmacology 106, 26 (1992) Abstract
Galanthamine from snowdrop-the development of a modern drug against Alzheimer's disease from local Caucasian knowledge.: M. Heinrich & H. Lee Teoh; J. Ethnopharmacol 92, 147 (2004) Abstract
Acetylcholinesterase inhibitors: novel activities of old molecules.: M. Racchi, et al.; Pharmacol. Res. 50, 441 (2004) Abstract

Further Categories Containing This Product:

Acetylcholine Esterase / Related Products • Alkaloids

ALX-350-336

Revised 05-Apr-08

Galiellalactone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation / Transcription

Ordering Information

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ALX-350-336-MC05		0.5 mg	320.00 USD

Product Specification

FORMULA:	C₁₁H₁₄O₃
MW:	194.2
CAS NUMBER:	133613-71-5
SOURCE/HOST:	Isolated from an unidentified fungus, MST-FP1889.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to light tan solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Originally isolated from Galiella rufa as a plant growth regulator. Inhibits IL-6 mediated signal transduction by blocking the binding of the activated STAT3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation site of the STAT3 transcription factor.

Product Specific Literature References

Screening of basidiomycetes and ascomycetes for plant regulating substances: R. Hautzel and H. Anke; Z. Naturforsch. 45c, 1094 (1990)
Inhibition of interleukin-6 signaling by galiellalactone: M. Weidler, et al.; FEBS Lett. 484, 1 (2000) Abstract
Synthesis of (-)-galiellalactone: M. Johansson and O. Sterner; J. Antibiot. (Tokyo) 55, 663 (2002) Abstract
Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities: B. Kopcke, et al.; J. Antibiot. (Tokyo) 55, 36 (2002) Abstract
Galiellalactone and its biogenetic precursors as chemotaxonomic markers of the Sarcosomataceae (Ascomycota): B. Kopcke, et al.; Phytochemistry 60, 709 (2002) Abstract

ALX-380-072

Revised 05-Apr-08

Gallidermin
SYNONYMS	6L-Epidermin
PRODUCT LINE	Immunology
PRODUCT CATEGORY	Antimicrobial Peptides & Proteins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-072-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₉₈H₁₄₁N₂₅O₂₃S₄
MW:	2069.4
CAS NUMBER:	117978-77-5
SOURCE/HOST:	Isolated from Staphylococcus gallinarum Tü3928.
PURITY:	≥90% (HPLC)
APPEARANCE:	Lyophilized.
SOLUBILITY:	Soluble in water, 100% ethanol or methanol (1mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	TOXIC.

Product Description

Antibiotic peptide. Interferes with bacterial cell wall biosynthesis.

Product Specific Literature References

Gallidermin: a new lanthionine-containing polypeptide antibiotic: R. Kellner, et al.; Eur. J. Biochem. 177, 53 (1988) Abstract
Isolation and characterization of genetically engineered gallidermin and epidermin analogs: B. Ottenwalder, et al.; Appl. Environ. Microbiol. 61, 3894 (1995) Abstract; Full Text
Secretion of the lantibiotics epidermin and gallidermin: sequence analysis of the genes gdmT and gdmH, their influence on epidermin production and their regulation by EpiQ: A. Peschel, et al.; Mol. Gen. Genet. 254, 312 (1997) Abstract
Identification of unusual amino acids in peptides using automated sequential Edman degradation coupled to direct detection by electrospray-ionization mass spectrometry: T.B. Walk, et al.; Biopolymers 49, 329 (1999) Abstract
Dual role of GdmH in producer immunity and secretion of the Staphylococcal lantibiotics gallidermin and epidermin: M. Hille, et al.; Appl. Environ. Microbiol. 67, 1380 (2001) Abstract; Full Text
Circumventing the effect of product toxicity: development of a novel two-stage production process for the lantibiotic gallidermin: G. Valsesia, et al.; Appl. Environ. Microbiol. 73, 1635 (2007) Abstract; Full Text

ALX-270-418

Revised 16-Jun-08

Gallotannin
SYNONYMS	Tannic acid
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Natural Products - DNA Regulation / Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-418-G001		1 g	10.00 USD

Product Specification

FORMULA:	C₇₆H₅₂O₄₆
MW:	1701.2
CAS NUMBER:	1401-55-4
MERCK INDEX:	14: 9052
RTECS:	WW5075000
SOURCE/HOST:	Occurs in the bark and fruit of many plants, notably in the bark of the oak species, in sumac and myrobalan.
PURITY:	>95%
APPEARANCE:	Beige to light brown powder.
SOLUBILITY:	Soluble in water, 100% ethanol, acetone or warm glycerol.
SHIPPING:	AMBIENT
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Inhibitor of poly(ADP-ribose) glycohydrolase (PARG). Cytoprotective in oxidatively stressed cells. Inhibitor of endothelial nitric oxide synthase (eNOS; NOS III) and weak inhibitor of inducible (iNOS; NOS II) and neuronal nitric oxide synthase (nNOS; NOS I). Induces cyclooxygenase-2 (COX-2) expression. Free radical scavenger.

Product Specific Literature References

Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin: M. Chiesi & R. Schwaller; Biochem. Pharmacol. 49, 495 (1995) Abstract
The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death: W. Ying, et al.; Neuroreport 11, 1385 (2000) Abstract
Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties: R.C. Srivastava, et al.; Cancer Lett. 153, 1 (2000) Abstract
Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes: E. Rapizzi, et al.; Mol. Pharmacol. 66, 890 (2004) Abstract
Tannic acid in plant dust causes airway obstruction: D. Taubert, et al.; Thorax 60, 789 (2005) Abstract
Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice: I.H. El-Sayed, et al.; Toxicol. Ind. Health 22, 157 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • PARG / Related Products • DNA Repair Other Products • Free Radical Scavengers • Natural Products - Nitric Oxide Pathway Modulators • Phenolic Acids

ALX-380-291

Revised 15-Apr-08

Gatifloxacin
SYNONYMS	AM-1155 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-291-G001		1 g	60.00 USD
ALX-380-291-G005		5 g	240.00 USD

Product Specification

FORMULA:	C₁₉H₂₂FN₃O₄
MW:	375.4
CAS NUMBER:	112811-59-3
MERCK INDEX:	14: 4376
PURITY:	≥98% (Assay)
APPEARANCE:	White to yellow crystalline powder.
SOLUBILITY:	Soluble in water at pH 2-5 (40-60mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Fluoroquinolone with broad spectrum activity against Gram-negative and Gram-positive bacteria. Inhibits bacterial DNA-gyrase and topoisomerase IV. May cause dysglycemia.

Product Specific Literature References

Comparison of the antibacterial activities of the quinolones Bay 12-8039, gatifloxacin (AM 1155), trovafloxacin, clinafloxacin, levofloxacin and ciprofloxacin: A. Bauernfeind; J. Antimicrob. Chemother. 40, 639 (1997) Abstract; Full Text
Activities of gatifloxacin compared to those of seven other agents against anaerobic organisms: L.M. Ednie, et al.; Antimicrob. Agents Chemother. 42, 2459 (1998) Abstract; Full Text
Inhibitory activities of gatifloxacin (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases: M. Takei, et al.; Antimicrob. Agents Chemother. 42, 2678 (1998) Abstract; Full Text
Primary targets of fluoroquinolones in Streptococcus pneumoniae: H. Fukuda & K. Hiramatsu; Antimicrob. Agents Chemother. 43, 410 (1999) Abstract; Full Text
Gatifloxacin: C.M. Perry, et al.; Drugs 58, 683 (1999), (Review) Abstract
Contributions of the 8-methoxy group of gatifloxacin to resistance selectivity, target preference, and antibacterial activity against Streptococcus pneumoniae: H. Fukuda, et al.; Antimicrob. Agents Chemother. 45, 1649 (2001) Abstract; Full Text
Gatifloxacin affects GLUT1 gene expression and disturbs glucose homeostasis in vitro: T.F. Ge, et al.; Eur. J. Pharmacol. 573, 70 (2007) Abstract
Gatifloxacin-associated hypoglycemia: T. Ali, et al.; J. Okla. State Med. Assoc. 100, 425 (2007) Abstract
Gatifloxacin produces both hypoglycemia and hyperglycemia: a retrospective study: H. Haerian, et al.; Am. J. Med. Sci. 335, 95 (2008) Abstract

Further Categories Containing This Product:

Antibiotics - DNA Replication Inhibitors • Antibiotics - Topoisomerase Inhibitors

ALX-380-054

Revised 18-Jun-08

Geldanamycin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-054-C100		100 µg	28.00 USD
ALX-380-054-C500		500 µg	50.00 USD
ALX-380-054-M001		1 mg	75.00 USD
ALX-380-054-M005		5 mg	300.00 USD

Product Specification

FORMULA:	C₂₉H₄₀N₂O₉
MW:	560.6
CAS NUMBER:	30562-34-6
RTECS:	LX8920000
SOURCE/HOST:	Isolated from Streptomyces hygroscopicus.
PURITY:	≥96%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Slightly soluble in methanol, chloroform or DMSO; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Potent antitumor antibiotic. Inhibitor of pp60^src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src, and yes. Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Capable of destabilizing several oncogene and proto-oncogene products. Potent inhibitor of the nuclear hormone receptor family. Protects against α-synuclein toxicity to dopaminergic neurons in Drosophila. Destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits basal and hypoxia-induced expression of c-Jun (IC₅₀=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells. ~10-fold more potent than herbimycin A (Prod. No. ALX-350-029)

Product Specific Literature References

Geldanamycin, a new antibiotic: C. DeBoer, et al.; J. Antibiot. 23, 442 (1970) Abstract
Phenotypic change from transformed to normal induced by benzoquinonoid ansamycins accompanies inactivation of p60src in rat kidney cells infected with Rous sarcoma virus: Y. Uehara, et al.; Mol. Cell. Biol. 6, 2198 (1986) Abstract
Inhibition of c-myc gene expression in murine lymphoblastoma cells by geldanamycin and herbimycin, antibiotics of benzoquinoid ansamycin group: H. Yamaki, et al.; J.Antibiot. 42, 604 (1989) Abstract
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation: L. Whitesell, et al.; PNAS 91, 8324 (1994) Abstract
Geldanamycin selectively destabilizes and conformationally alters mutated p53: M.V. Blagosklonny, et al.; Oncogene 11, 933 (1995) Abstract
Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives: R.C. Schnur, et al.; J. Med. Chem. 38, 3806 (1995) Abstract
p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2: C. Chavany, et al.; J. Biol. Chem. 271, 4974 (1996) Abstract; Full Text
Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells: L. Whitesell & P. Cook; Mol. Endocrinol. 10, 705 (1996) Abstract
Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity: L. Neckers, et al.; Invest. New Drugs 17, 361 (1999), (Review) Abstract
Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs: M.V. Blagosklonny; Leukemia 16, 455 (2002), (Review) Abstract
Pharmacological prevention of Parkinson disease in Drosophila: P.K. Auluck & N.M. Bonini; Nat. Med. 8, 1185 (2002) Abstract
Effects of geldanamycin on signaling through activator-protein 1 in hypoxic HT29 human colon adenocarcinoma cells: I.A. Vasilevskaya and P.J. O'Dwyer; Cancer Res. 59, 3935 (1999) Abstract
Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells: R. Villa, et al.; Carcinogenesis 24, 851 (2003) Abstract
Chaperoning oncogenes: HSP90 as a target of geldanamycin: L. Neckers; Handb. Exp. Pharmacol. 259 (2006), (Review) Abstract
Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages: H.Y. Hsu, et al.; Mol. Pharmacol. 71, 344 (2007) Abstract; Full Text
Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol: P. Thepchatri, et al.; JACS 129, 3127 (2007) Abstract
Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo: S.A. Lang, et al.; Mol. Cancer Ther. 6, 1123 (2007) Abstract; Full Text
Geldanamycin, a heat-shock protein 90-binding agent, induces thymocyte apoptosis through destabilization of Lck in presence of 12-O-tetradecanoylphorbol 13-acetate: K. Ohta, et al.; Biomed. Res. 28, 33 (2007) Abstract; Full Text
Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells: F. Koga, et al.; Cell Cycle 6, 1393 (2007) Abstract
The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation: Y.K. Jeon, et al.; J. Pathol. 213, 170 (2007) Abstract
Geldanamycin, a HSP90 inhibitor, attenuates the hypoxia-induced vascular endothelial growth factor expression in retinal pigment epithelium cells in vitro: W.C. Wu, et al.; Exp. Eye Res. 85, 721 (2007) Abstract
HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo: E. Lesko, et al.; Anticancer Drugs 18, 1173 (2007) Abstract
Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cells: K. Makondo, et al.; Eur. J. Pharmacol. 582, 110 (2007) Abstract
Hsp90-inhibitor geldanamycin abrogates G(2) arrest in p53-negative leukemia cell lines through the depletion of Chk1: K. Sugimoto, et al.; Oncogene 27, 3091 (2008) Abstract

Further Categories Containing This Product:

Tyrosine Kinase Inhibitors • Chaperone-mediated Autophagy [CMA] • Antitumor Antibiotics • HSP90 / HtpG / Related Products • Antitumor Agents (DNA Interaction & Gene Regulation)

ALX-350-150

Revised 16-Jun-08

Gelonin