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Lipid Peroxidation
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ALX-350-144 Revised 03-Apr-08
Bakuchiol
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SYNONYMS 4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Other Signal Transduction Pathway Modulators
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-144-M001   1 mg 170.00 USD Add To Cart
Product Specification
FORMULA: C18H24O
MW: 256.4
CAS NUMBER: 10309-37-2
SOURCE/HOST: Isolated from plant Psoralea corylifolia.
PURITY: ≥97% (HPLC)
APPEARANCE: Yellow to brownish oil.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Determined by 1H-NMR, 13C-NMR and MS.

Product Description
Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.
Product Specific Literature References
Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod. 51, 1084 (1988) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000) Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol. 78, 27 (2001) Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001) Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001) Abstract; Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol. 79, 57 (2002) Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol. 16, 1062 (2003) Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005) Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med. 71, 508 (2005) Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007) Abstract
Further Categories Containing This Product:
Natural Products - DNA Replication Inhibitors • NOS Inhibitors (NOS Induction & Enzyme Activity) • Lipid Peroxidation • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Topoisomerase Inhibitors • Natural Products with Antibiotic Activity • Protein Tyrosine Phosphatases Other Products • Natural Products - Antioxidants
 
 
ALX-350-253 Revised 28-Sep-07
Carazostatin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-350-253-C100   100 µg 45.00 USD Add To Cart
ALX-350-253-M001   1 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C20H25NO
MW: 295.4
CAS NUMBER: 126168-32-9
SOURCE/HOST: Isolated from Streptomyces chrestomyceticus.
APPEARANCE: Pale yellow solid.
SOLUBILITY: Soluble in methanol, abs. ethanol or DMSO. Insoluble in water.
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and air. Keep under inert gas

Product Description
Antioxidant. Free radical scavenger. Potent inhibitor of lipid peroxidation.
Product Specific Literature References
Studies on free radical scavenging substances from microorganisms. I. Carazostatin, a new free radical scavenger produced by Streptomyces chromofuscus DC 118: S. Kato, et al.; J. Antibiot. (Tokyo) 42, 1879 (1989) Abstract
Antioxidant activities of natural and synthetic carbazoles: M. Iwatsuki, et al.; Biofactors 4, 123 (1993) Abstract
In vitro and ex vivo free radical scavenging activities of carazostatin, carbazomycin B and their derivatives: S. Kato, et al.; J. Antibiot. (Tokyo) 46, 1859 (1993) Abstract
Total Syntheses of Carazostatin, Hyellazole, and Carbazoquinocins B-F: T. Choshi, et al.; J. Org. Chem. 62, 2535 (1997) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Free Radical Scavengers
 
 
ALX-270-264 Revised 17-Apr-08
Carnosic acid
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-264-M010   10 mg 45.00 USD Add To Cart
ALX-270-264-M050   50 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C20H28O4
MW: 332.4
CAS NUMBER: 3650-09-7
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥95%
APPEARANCE: Yellow powder.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description
Naturally occurring phenolic compound with antioxidant properties. Inhibits lipid peroxidation induced by NADH or NADPH oxidation. Peroxisome proliferator-activated receptor γ (PPARγ) activator. Anti-inflammatory. Antimicrobial.
Product Specific Literature References
Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis. II. Isolation of carnosic acid and formation of other phenolic diterpenes: K. Schwarz & W. Ternes; Z. Lebensm. Unters. Forsch. 195, 99 (1992) Abstract
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Radical intermediates and antioxidants: an ESR study of radicals formed on carnosic acid in the presence of oxidized lipids: M. Geoffroy, et al.; Free Radic. Res. 21, 247 (1994) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells: E.A. Offord, et al.; Carcinogenesis 16, 2057 (1995) Abstract
Chemiluminescence determination of the in vivo and in vitro antioxidant activity of RoseOx and carnosic acid: A.I. Kuzmenko, et al.; J. Photochem. Photobiol. B 48, 63 (1999) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract
Further Categories Containing This Product:
Lipid Peroxidation • Active Substances from Fruit and Vegetables • PPAR Agonists • Natural Products with Antibiotic Activity • Natural Products - Anti-inflammatory Agents
 
 
ALX-270-254 Revised 03-Apr-08
Carnosol
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SYNONYMS 1,3,4,9,10,10aS-Hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antioxidants
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ALX-270-254-M001   1 mg 60.00 USD Add To Cart
ALX-270-254-M005   5 mg 269.00 USD Add To Cart
Product Specification
FORMULA: C20H26O4
MW: 330.4
CAS NUMBER: 5957-80-2
SOURCE/HOST: Isolated from Rosmarinus officinalis.
PURITY: ≥96%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol, DMSO or dimethyl formamide; sparingly soluble in aqueous buffers (e. g. PBS).
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 1 year when stored at –20°C.
HANDLING: Protect from light.

Product Description
Naturally occurring phenolic compound with antioxidant and anti-inflammatory properties. Suppresses nitric oxide (NO) production and inducible nitric oxide synthase (iNOS; NOS II) gene expression by inhibiting NF-κB activation. Inhibits lipid peroxidation. Antimicrobial. Anticarcinogenic. Inhibits cyclooxygenase-2 (COX-2).
Product Specific Literature References
Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid: O.I. Aruoma, et al.; Xenobiotica 22, 257 (1992) Abstract
Effects of three dietary phytochemicals from tea, rosemary and turmeric on inflammation-induced nitrite production: M.M. Chan, et al.; Cancer Lett. 96, 23 (1995) Abstract
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis: H. Haraguchi, et al.; Planta Med. 61, 333 (1995) Abstract
Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation: K. Singletary, et al.; Cancer Lett. 104, 43 (1996) Abstract
Development of in vitro models for cellular and molecular studies in toxicology and chemoprevention: K. Macé, et al.; Arch. Toxicol. Suppl. 20, 227 (1998) Abstract
Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse macrophages: A.H. Lo, et al.; Carcinogenesis 23, 983 (2002) Abstract
Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma: O. Rau, et al.; Planta Med. 72, 881 (2006) Abstract
Potentiation of antimicrobial activity of aminoglycosides by carnosol from Salvia officinalis: K. Horiuchi, et al.; Biol. Pharm. Bull. 30, 287 (2007) Abstract
Further Categories Containing This Product:
NOS Inhibitors (NOS Induction & Enzyme Activity) • Lipid Peroxidation • Natural Products - Chemopreventive Agents • Active Substances from Fruit and Vegetables • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - NF-kB Pathway Inhibitors • COX Inhibitors • Natural Products - Anti-inflammatory Agents
 
 
ALX-385-028 Revised 03-Apr-08
Delphinidin chloride (high purity)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Flavonoids/Related Products
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ALX-385-028-M010   10 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C15H11ClO7
MW: 338.7
CAS NUMBER: 528-53-0
RTECS: DK1310000
PURITY: ≥97% (HPLC)
APPEARANCE: Red to dark brown powder.
SOLUBILITY: Soluble in water or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.

Product Description

Anthocyanidin with antioxidant effect found in pigmented fruits and vegetables. Shown to inhibit angiogenesis and endothelial cell apoptosis by stimulating nitric oxide (NO) production. Inhibits solar radiation (UVB)-mediated oxidative stress, reducing DNA damage.
Product Specific Literature References
Delphinidin, an active compound of red wine, inhibits endothelial cell apoptosis via nitric oxide pathway and regulation of calcium homeostasis: S. Martin, et al.; Br. J. Pharmacol. 139, 1095 (2003) Abstract; Full Text
Anthocyanins induce cell cycle perturbations and apoptosis in different human cell lines: M.C. Lazzè; Carcinogenesis 25, 1427 (2004) Abstract; Full Text
DNA interaction with naturally occurring antioxidant flavonoids quercetin, kaempferol, and delphinidin: C.D. Kanakis, et al.; J. Biomol. Struct. Dyn. 22, 719 (2005) Abstract
Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK: M.H. Oak, et al.; Br. J. Pharmacol. 149, 283 (2006) Abstract; Full Text
Delphinidin, a dietary anthocyanidin, inhibits vascular endothelial growth factor receptor-2 phosphorylation: S. Lamy, et al.; Carcinogenesis 27, 989 (2006) Abstract; Full Text
Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis: F. Afaq, et al.; J. Invest. Dermatol. 127, 222 (2007) Abstract; Full Text
Further Categories Containing This Product:
Natural Products for Angiogenesis Research • Lipid Peroxidation • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables
 
 
ALX-850-320 Revised 03-Jul-08
HNE-histidine FINE ELISA Kit
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents/Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-320-KI01   1 Kit 750.00 USD Add To Cart
Product Specification
SENSITIVITY: 8.1nmol/mg (7.1 to 143pmol/mg)
QUANTITY: 2x96 wells
APPLICATION: For the quantitative determination of HNE-histidine conjugates in human cell lysates induced by mild oxidative stress.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store standards at -80°C. Store rest of the kit at +4°C.
Product Description

- Quantitative determination of HNE-histidine in human cell lysates
- Indirect enzyme immunoassay
- Based on a well described monoclonal antibody used in ICC, IHC & WB
- Range of detection between 7.1pmol/mg and 143pmol/mg
- Human plasma spiking tested
- Tissue homogenates have not been tested yet

(E)-4-Hydroxynonenal (HNE) is one of the most important breakdown products and reliable marker of lipid peroxidation (LPO). This indirect enzyme immunoassay (EIA) allows for the first time the quantitative determination of HNE-histidine conjugates from lysates of human cells which were exposed to mild oxidative stress.
Product Specific Literature References
Enzyme-linked immunosorbent assay for 4-hydroxynonenal-histidine conjugates: S. Borovic, et al.; Free Radic. Res. 40, 809 (2006) Abstract
Differential sensitivity to 4-hydroxynonenal for normal and malignant mesenchymal cells: S. Borovic, et al.; Redox Rep. 12, 50 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Do not use serum free cell culture supernatants. Running duplicate wells for samples and standards is recommended.
Related Products
Further Categories Containing This Product:
Lipid Peroxidation • ELISA & EIA Kits
 
 
ALX-840-041 Revised 03-Jul-08
HNE-histidine FINE Standard
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-840-041-1   1 Vial 110.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: 8 vials with ELISA FINE standard (F1-F8), 200μl each. Standards contain 35mg/ml BSA and variable amounts of HNE:
F1:     0 pmol/mg HNE
F2:     7 pmol/mg HNE
F3:   14 pmol/mg HNE
F4:   29 pmol/mg HNE
F5:   57 pmol/mg HNE
F6:   86 pmol/mg HNE
F7: 114 pmol/mg HNE
F8: 143 pmol/mg HNE
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After thawing, keep standards for 30 min. at +4°C before further use. Vortex and mix vigorously before use.
Product Images
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Product Description
Standard for the HNE-histidine FINE ELISA Kit (Prod. No. ALX-850-320).
Related Products
Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-850-322 Revised 03-Jul-08
HNE-histidine STRESS ELISA Kit
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-850-322-KI01   1 Kit 750.00 USD Add To Cart
Product Specification
SENSITIVITY: 8.1nmol/mg (0.143-1.714nmol/mg)
QUANTITY: 2x96 wells
APPLICATION: For the quantitative determination of HNE-histidine conjugates in human cell lysates induced by strong oxidative stress.
SHIPPING: SHIPPED ON BLUE ICE
HANDLING: Store standards at -80°C. Store rest of the kit at +4°C.
Product Description

- Quantitative determination of HNE-histidine in human cell lysates
- Indirect enzyme immunoassay
- Based on a well described monoclonal antibody used in ICC, IHC & WB
- Range of detection between 71pmol/mg and 857pmol/mg
- Human plasma spiking tested
- Tissue homogenates have not been tested yet

(E)-4-Hydroxynonenal (HNE) is one of the most important breakdown products and reliable marker of lipid peroxidation (LPO). This indirect enzyme immunoassay (EIA) allows for the first time the quantitative determination of HNE-histidine conjugates from lysates of human cells which were exposed to strong oxidative stress.
Product Specific Literature References
Enzyme-linked immunosorbent assay for 4-hydroxynonenal-histidine conjugates: S. Borovic, et al.; Free Radic. Res. 40, 809 (2006) Abstract
Differential sensitivity to 4-hydroxynonenal for normal and malignant mesenchymal cells: S. Borovic, et al.; Redox Rep. 12, 50 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Do not use serum free cell culture supernatants. Running duplicate wells for samples and standards is recommended.
Related Products
Further Categories Containing This Product:
Lipid Peroxidation • ELISA & EIA Kits
 
 
ALX-840-042 Revised 03-Jul-08
HNE-histidine STRESS Standard
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PRODUCT LINE Oxidative Stress
PRODUCT CATEGORY Oxidative Stress Markers & Reagents/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-840-042-1   1 Vial 110.00 USD Add To Cart
Product Specification
KIT/SET CONTAINS: 8 vials with ELISA STRESS standard (S1-S8), 200μl each. Standards contain 35mg/ml BSA and variable amounts of HNE:
S1: 0.000 nmol/mg HNE
S2: 0.143 nmol/mg HNE
S3: 0.286 nmol/mg HNE
S4: 0.571 nmol/mg HNE
S5: 0.857 nmol/mg HNE
S6: 1.143 nmol/mg HNE
S7: 1.429 nmol/mg HNE
S8: 1.714 nmol/mg HNE
SHIPPING: SHIPPED ON DRY ICE
LONG TERM STORAGE: -80°C
HANDLING: Avoid freeze/thaw cycles. After thawing, keep standards for 30 min. at +4°C before further use. Vortex and mix vigorously before use.
Product Images
Please click on thumbnails to enlarge.
Product Description
Standard for the HNE-histidine STRESS ELISA Kit (Prod. No. ALX-850-322).
Related Products
Further Categories Containing This Product:
Lipid Peroxidation
 
 
ALX-270-447 Revised 11-Jul-08
4-Hydroperoxy-2-nonenal
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