ALEXIS Biochemicals: Metallothionein-1 (rabbit liver)

You are here: Product Lines > Oxidative Stress > Antioxidants, Flavonoids & Free Radical Scavengers > Antioxidants, Flavonoids & Free Radical Scavengers Other Products

ALX-105-005

Revised 20-May-08

N-Acetyl-L-cysteine
SYNONYMS	LNAL N-Acetyl-3-mercaptoalanine L-α-Acetamido-β-mercaptopropionic acid NAC
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Antioxidants, Flavonoids & Free Radical Scavengers Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-105-005-G001		1 g	16.00 USD
ALX-105-005-G005		5 g	27.00 USD

Product Specification

FORMULA:	C₅H₉NO₃S
MW:	163.2
CAS NUMBER:	616-91-1
MERCK INDEX:	14: 88
RTECS:	HA1660000
PURITY:	≥99%
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in 5M hydrochloric acid (hot) (100mg/ml); also soluble in water or 100% ethanol; insoluble in chloroform or ether.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Specific Literature References

Modulation of platelet function by free radicals and free-radical scavengers: D. Salvemini & R. Botting; TIPS 14, 36 (1993), (Review) Abstract
Conversion of glyceryl trinitrate to nitric oxide in tolerant and non- tolerant smooth muscle and endothelial cells: D. Salvemini, et al.; Br. J. Pharmacol. 108, 162 (1993) Abstract
Distinct effects of thioredoxin and antioxidants on the activation of transcription factors NF-kappa B and AP-1: H. Schenk, et al.; PNAS 91, 1672 (1994) Abstract
Induction of apoptosis by pyrrolidinedithiocarbamate and N- acetylcysteine in vascular smooth muscle cells: J.C. Tsai, et al.; J. Biol. Chem. 271, 3667 (1996) Abstract; Full Text
Supplementation of N-acetylcysteine inhibits NFkappaB activation and protects against alloxan-induced diabetes in CD-1 mice: E. Ho, et al.; Faseb. J. 13, 1845 (1999) Abstract
Pyrrolidine dithiocarbamate inhibits TNF-alpha-dependent activation of NF-kappaB by increasing intracellular copper level in human aortic smooth muscle cells: A. Iseki, et al.; Biochem. Biophys. Res. Commun. 276, 88 (2000) Abstract
Suppression of NF-kappaB activation and cytokine production by N- acetylcysteine in pancreatic acinar cells: H. Kim, et al.; Free Radic. Biol. Med. 29, 674 (2000) Abstract

Further Categories Containing This Product:

Special Amino Acids

ALX-153-055

Revised 25-May-07

Carnosine
SYNONYMS	β-Alanyl-L-histidine
PRODUCT LINE	Nitric Oxide Pathway
PRODUCT CATEGORY	Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-153-055-G001		1 g	55.00 USD

Product Specification

SEQUENCE:	H-β-Ala-His-OH
FORMULA:	C₉H₁₄N₄O₃
MW:	226.2
CAS NUMBER:	305-84-0
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 80% acetic acid (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Antioxidant. Inhibits soluble guanylyl cyclase (sGC) by interacting with the heme iron to form a chelate complex.

Product Specific Literature References

Carnosine as a regulator of soluble guanylate cyclase: I.S. Severina, et al.; Biochemistry (Mosc) 65, 783 (2000) Abstract; Full Text

Further Categories Containing This Product:

Antioxidants, Flavonoids & Free Radical Scavengers Other Products

ALX-270-097

Revised 07-Sep-06

Ebselen
SYNONYMS	2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Peroxynitrite / Scavengers / Detection

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-097-M001		1 mg	12.00 USD
ALX-270-097-M005		5 mg	20.00 USD
ALX-270-097-M025		25 mg	60.00 USD

Product Specification

FORMULA:	C₁₃H₉NOSe
MW:	274.2
CAS NUMBER:	60940-34-3
PURITY:	≥98% (NMR)
APPEARANCE:	White to off-white crystalline solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Selenium-based inhibitor of protein kinase C, NADPH, 5-lipoxygenase, cyclooxygenase (COX) and NADPH oxidase. Anti-inflammatory antioxidant. Mimics glutathione peroxidase. Inhibits oxidative modifications of low density lipoproteins (LDL).

Product Specific Literature References

A novel biologically active seleno-organic compound--III. Effects of PZ 51 (Ebselen) on glutathione peroxidase and secretory activities of mouse macrophages: M.J. Parnham & S. Kindt; Biochem. Pharmacol. 33, 3247 (1984) Abstract
Seleno-organic compounds and the therapy of hydroperoxide-linked pathological conditions: M.J. Parnham & E. Graf; Biochem. Pharmacol. 36, 3095 (1987) Abstract
Kinetic mechanism and substrate specificity of glutathione peroxidase activity of ebselen (PZ51): M. Maiorino, et al.; Biochem. Pharmacol. 37, 2267 (1988) Abstract
Studies on the anti-inflammatory activity of ebselen. Ebselen interferes with granulocyte oxidative burst by dual inhibition of NADPH oxidase and protein kinase C?: I.A. Cotgreave, et al.; Biochem. Pharmacol. 38, 649 (1989) Abstract
T. Nikawa, et al.; Biochem. Pharmacol. 47, 1007 (1994) Abstract
Effects of ebselen and probucol on oxidative modifications of lipid and protein of low density lipoprotein induced by free radicals: N. Noguchi, et al.; Biochim. Biophys. Acta 1213, 176 (1994) Abstract
Strong inhibition of mammalian lipoxygenases by the antiinflammatory seleno-organic compound ebselen in the absence of glutathione: C. Schewe, et al.; Biochem. Pharmacol. 48, 65 (1994) Abstract
Ebselen: a glutathione peroxidase mimic: H. Sies; Meth. Enzymol. 234, 476 (1994) Abstract
Molecular actions of ebselen-an antiinflammatory antioxidant: T. Schewe; Gen. Pharmacol. 26, 1153 (1995) Abstract
Ebselen: H. Sies; Meth. Enzymol. 252, 341 (1995) Abstract
Ebselen as a glutathione peroxidase mimic and as a scavenger of peroxynitrite: H. Sies & H. Masumoto; Adv. Pharmacol. 38, 229 (1997) Abstract
Free radical generation by selenium compounds and their prooxidant toxicity: J.E. Spallholz; Biomed. Environ. Sci. 10, 260 (1997) Abstract
Protection against peroxynitrite by selenoproteins: H. Sies, et al.; Z. Naturforsch. [C] 53, 228 (1998) Abstract
Ebselen protects mice against T cell-dependent, TNF-mediated apoptotic liver injury: G. Tiegs, et al.; J. Pharmacol. Exp. Ther. 287, 1098 (1998) Abstract; Full Text

Further Categories Containing This Product:

Antioxidants, Flavonoids & Free Radical Scavengers Other Products • PKC Inhibitors • Malaria / Related Products • Lipoxygenases / Related Products • Anti-inflammatory Agents Other Products • COX Inhibitors

ALX-270-262

Revised 13-Feb-08

Ellagic acid . dihydrate
SYNONYMS	4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone . 2H₂O
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-262-M100		100 mg	12.00 USD

Product Specification

FORMULA:	C₁₄H₆O₈. 2H₂O
MW:	302.2 . 36.0
CAS NUMBER:	476-66-4
MERCK INDEX:	14: 3547
RTECS:	DJ2620000
SOURCE/HOST:	Isolated from chestnut bark.
PURITY:	≥97%
APPEARANCE:	Grey to green solid.
SOLUBILITY:	Soluble in 1M sodium hydroxide (10mg/ml) or pyridine.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Keep under inert gas. Protect from light.
HAZARD:	IRRITANT.
IDENTITY:	Determined by MS and NMR.

Product Description

Polyphenol antioxidant with antitumor properties. Inhibitor of topoisomerases. Inhibits VEGF-induced phosphorylation of VEGFR-2 and PDGF-induced phosphorylation of PDGFR. Induces apoptosis.

Product Specific Literature References

The dietary anticancer agent ellagic acid is a potent inhibitor of DNA topoisomerases in vitro: A. Constantinou, et al.; Nutr. Cancer 23, 121 (1995) Abstract
Novel inhibitors of 3-phosphoglycerate kinase: M.J. Hickey, et al.; Biochem. Soc. Trans. 23, 607S (1995) Abstract
Inhibitory actions of ellagic acid on growth and arylamide N-acetyltransferase activity in strains of Heliobacter pylori from peptic ulcer patients: J.G. Chung; Microbios 93, 115 (1998) Abstract
Polyphenols inhibit promotional phase of tumorigenesis: relevance of superoxide radicals: A. Kaul & K.L. Khanduja; Nutr. Cancer 32, 81 (1998) Abstract
Inhibition of eukaryote serine/threonine-specific protein kinases by piceatannol: B.H. Wang, et al.; Planta Med. 64, 195 (1998) Abstract
p53/p21 (WAF1CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells: B.A. Narayanan, et al.; Cancer Lett. 136, 215 (1999) Abstract
Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound: L. Labrecque, et al.; Carcinogenesis 26, 821 (2005) Abstract
Antioxidant and apoptosis-inducing activities of ellagic acid: D.H. Han, et al.; Anticancer Res. 26, 3601 (2006) Abstract
The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells: C.H. Chen, et al.; Mol. Nutr. Food Res. 51, 962 (2007) Abstract
Ellagic acid, a natural polyphenol protects rat peripheral blood lymphocytes against nicotine-induced cellular and DNA damage in vitro: with the comparison of N-acetylcysteine: A.R. Sudheer, et al.; Toxicology 230, 11 (2007) Abstract

Further Categories Containing This Product:

Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Antitumor Agents (Enzyme Activators & Inducers) • Natural Products - Topoisomerase Inhibitors • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Antitumor Reagents • Polyphenols Other Products • Natural Products - Apoptosis Inducers & Inhibitors

ALX-270-265

Revised 29-Jan-05

U-74389G
SYNONYMS	21-(4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-pregna-1,4,9(11)-triene-3,20-dione . (Z)-2-butenedioate
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Lipid Peroxidation

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-265-M010		10 mg	15.00 USD
ALX-270-265-M050		50 mg	63.00 USD

Product Specification

FORMULA:	C₃₇H₅₀N₆O₂. C₄H₄O₄
MW:	610.8 . 116.1
CAS NUMBER:	153190-29-5
PURITY:	≥98%
APPEARANCE:	Crystalline solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol. Insoluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Store solutions of U-74389G on ice and use within 6 hours of preparation. We strongly recommend using fresh solution for each experiment.
HANDLING:	Hygroscopic.

Product Description

Lazaroid inhibitor of iron-dependent lipid peroxidation. Antioxidant.

Product Specific Literature References

Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells: A. Salahudeen, et al.; J. Am. Soc. Nephrol. 6, 1300 (1995) Abstract
21-aminosteroid and 2-(aminomethyl)chromans inhibition of arachidonic acid-induced lipid peroxidation and permeability enhancement in bovine brain microvessel endothelial cell monolayers: F. Shi, et al.; Free Radic. Biol. Med. 19, 349 (1995) Abstract
Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation: G.M. Campo, et al.; J. Pharmacol. Exp. Ther. 277, 333 (1996) Abstract
Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G: A.M. Perna, et al.; Pharmacol. Res. 34, 25 (1996) Abstract
Comparison of various lazaroid compounds for protection against ischemic liver injury: N. Ishizaki, et al.; Transplantation 63, 202 (1997) Abstract
Protein oxidation biomarkers in hyperoxic lung injury in rats: effects of U-74389: S. Awasthi, et al.; Toxicol. Lett. 95, 47 (1998) Abstract
The 21-aminosteroid U-74389G reduces cerebral superoxide anion concentration following fluid percussion injury of the brain: R.H. Fabian, et al.; J. Neurotrauma 15, 433 (1998) Abstract
Novel 21-aminosteroid U-74389G inhibits low-density lipoprotein peroxidation induced by .OH and O2-. free radicals: A. Khalil, et al.; Life Sci. 63, 769 (1998) Abstract
Intrahippocampal injection of paraquat produces apoptotic cell death which is prevented by the lazaroid U74389G, in rats: D. Melchiorri, et al.; Life Sci. 62, 1927 (1998) Abstract
The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock:: D. Altavilla, et al.; Eur. J. Pharmacol. 369, 49 (1999) Abstract
Effect of lazaroid U-74389G and methylprednisolone on endotoxin-induced shock in mice: K. Fukuma, et al.; Surgery 125, 421 (1999) Abstract
Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia: R. Schmid-Elsaesser, et al.; Brain Res. 816, 471 (1999) Abstract; Full Text

Further Categories Containing This Product:

Antioxidants, Flavonoids & Free Radical Scavengers Other Products

ALX-270-266

Revised 19-May-03

DL-α-Lipoic acid
SYNONYMS	DL-6,8-Thioctic acid
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Antioxidants, Flavonoids & Free Radical Scavengers Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-266-G001		1 g	20.00 USD
ALX-270-266-G005		5 g	60.00 USD

Product Specification

FORMULA:	C₈H₁₄O₂S₂
MW:	206.3
CAS NUMBER:	1077-28-7
MERCK INDEX:	14: 9326
PURITY:	≥97%
APPEARANCE:	Solid.
SOLUBILITY:	Soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Antioxidant.

ALX-270-267

Revised 11-Nov-08

Trolox®
SYNONYMS	6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Antioxidants, Flavonoids & Free Radical Scavengers Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-267-M100		100 mg	15.00 USD

Product Specification

FORMULA:	C₁₄H₁₈O₄
MW:	250.3
CAS NUMBER:	53188-07-1; 56305-04-5
RTECS:	DJ2273000
PURITY:	≥97%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.
IDENTITY:	Identity determined by IR.

Product Description

Cell permeable derivative of vitamin E. Antioxidant. Prevents peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes.

Product Specific Literature References

Peroxynitrite causes DNA damage and oxidation of thiols in rat thymocytes [corrected]: M.G. Salgo, et al.; Arch. Biochem. Biophys. 322, 500 (1995) Abstract
Trolox inhibits peroxynitrite-mediated oxidative stress and apoptosis in rat thymocytes: M.G. Salgo & W.A. Pryor; Arch. Biochem. Biophys. 333, 482 (1996) Abstract

ALX-270-281

Revised 28-Sep-06

Daphnetin
SYNONYMS	7,8-Dihydroxycoumarin
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	EGFR Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-281-M005		5 mg	25.00 USD
ALX-270-281-M025		25 mg	95.00 USD

Product Specification

FORMULA:	C₉H₆O₄
MW:	178.1
CAS NUMBER:	486-35-1
RTECS:	GN6382600
PURITY:	≥97%
APPEARANCE:	White to rose powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Inhibitor of protein kinases. EGF receptor tyrosine kinase (IC₅₀=7.87µM), PKA (IC₅₀=9.33µM), PKC (IC₅₀=25.01µM). Antioxidant. Antimalarial agent.

Product Specific Literature References

Daphnetin: a novel antimalarial agent with in vitro and in vivo activity: Y.Z. Yang, et al.; Am. J. Trop. Med. Hyg. 46, 15 (1992) Abstract
Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor: E.B. Yang, et al.; BBRC 260, 682 (1999) Abstract

Further Categories Containing This Product:

Antioxidants, Flavonoids & Free Radical Scavengers Other Products • PKA Inhibitors • Malaria / Related Products • Tyrosine Kinase Inhibitors

ALX-270-466

Revised 14-Sep-07

Fluvastatin . sodium salt
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Statins / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-466-M010		10 mg	48.00 USD
ALX-270-466-M050		50 mg	190.00 USD

Product Specification

FORMULA:	C₂₄H₂₅FNO₄ . Na
MW:	410.5 . 23.0
CAS NUMBER:	93957-54-1
MERCK INDEX:	14: 4218
RTECS:	MJ9675050
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Off-white to light yellow solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:	Protect from light.
HAZARD:	TOXIC. MAY BE TERATOGENIC.

Product Description

Anticholesterol agent. HMG-CoA reductase inhibitor and antioxidant.

Product Specific Literature References

Folate and carcinogenesis: an integrated scheme: S.W. Choi and J.B. Mason; J. Nutr. 130, 129 (2000) Abstract; Full Text
Effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on nitric oxide-induced hydroxyl radical generation in the rat heart: T. Obata, et al.; Biochim. Biophys. Acta 1536, 55 (2001) Abstract
Antioxidative effect of fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, on peroxidation of phospholipid liposomes: A. Yamamoto, et al.; J. Pharm. Pharmacol. 53, 227 (2001) Abstract

Further Categories Containing This Product:

Antioxidants, Flavonoids & Free Radical Scavengers Other Products • Obesity & Diabetes Other Products