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ALX-270-022
Revised 09-Jan-08
AEBSF . hydrochloride
SYNONYMS
4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc
®
SC
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Proteases Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-270-022-M050
50 mg
40.00 USD
ALX-270-022-M250
250 mg
145.00 USD
ALX-270-022-G001
1 g
360.00 USD
Product Specification
FORMULA:
C
8
H
10
FNO
2
S . HCl
MW:
203.2 . 36.5
CAS NUMBER:
30827-99-7
PURITY:
≥98% (HPLC)
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from moisture.
Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No.
ALX-270-184
). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide:
B.R. Baker & H.J. Cory; J. Med. Chem.
14
, 119 (1971)
Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide:
P. Megyeri, et al.; Immunology
86
, 629 (1995)
Abstract
;
Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF:
M. Citron, et al.; Neuron
17
, 171 (1996)
Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor:
Y. Nakabo & M.J. Pabst; J. Leukoc. Biol.
60
, 328 (1996)
Abstract
;
Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds:
V. Diatchuk, et al.; J. Biol. Chem.
272
, 13292 (1997)
Abstract
;
Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening:
P. Megyeri, et al.; Eur. J. Pharmacol.
374
, 207 (1999)
Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis:
R. Buitrago-Rey, et al.; J. Antimicrob. Chemother.
49
, 871 (2002)
Abstract
;
Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes:
N. Wijayanti, et al.; J. Biol. Chem.
280
, 21820 (2005)
Abstract
;
Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression:
T. Hosoi, et al.; Eur. J. Pharmacol.
554
, 8 (2007)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
•
MAPK Pathway Activators
•
Cell Stress, Oxidative Stress & Redox Signalling Other Products
•
Fatty Acid Amide Hydrolase [FAAH] / Related Products
ALX-340-029
Revised 08-Jul-08
Anandamide
SYNONYMS
AEA
N-Arachidonoylethanolamine
(all-Z)-N-(2-Hydroxyethyl)-5,8,11,14-eicosatetraenamide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Anandamide & Anandamide Analogs
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ALX-340-029-M005
5 mg
51.00 USD
Product Specification
FORMULA:
C
22
H
37
NO
2
MW:
347.5
CAS NUMBER:
94421-68-8
MERCK INDEX:
14:
624
RTECS:
JX3842500
CONCENTRATION:
50mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
10mg/ml soluble in DMSO or dimethyl formamide.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months in other organic solvents when stored at -20°C.
HANDLING:
Protect from light and oxygen.
Product Description
Endogenous [1] ligand for the CB
1
receptor (CB
1
: K
i
=52nm; CB
2
: K
i
=1930nm [2]) and TRPV1 (K
i
=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].
Product Specific Literature References
[1]
Isolation and structure of a brain constituent that binds to the cannabinoid receptor:
W.A. Devane, et al.; Science
258
, 1946 (1992)
Abstract
[2]
Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability
:
S. Lin, et al.; J. Med. Chem.
41
, 5353 (1998)
Abstract
[3]
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
:
P.M. Zygmunt, et al.; Nature
400
, 452 (1999)
Abstract
[4]
Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
:
R.A. Ross, et al.; Br. J. Pharmacol.
132
, 631 (2001)
Abstract
[5]
Anandamide inhibits nuclear factor-kappaB activation through a cannabinoid receptor-independent pathway
:
R. Sancho, et al.; Mol. Pharmacol.
63
, 429 (2003)
Abstract
[6]
Anandamide induces cell death independently of cannabinoid receptors or vanilloid receptor 1: possible involvement of lipid rafts
:
K.P. Sarker, et al.; Cell Mol. Life Sci.
60
, 1200 (2003)
Abstract
[7]
The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide
:
M. Wartmann, et al.; FEBS Lett.
359
, 133 (1995)
Abstract
Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid:
C.J. Hillard & W.B. Campbell; J. Lipid Res.
38
, 2383 (1997), (Review)
Abstract
The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
:
L. De Petrocellis, et al.; PNAS
95
, 8375 (1998)
Abstract
Cannabinoid receptors and their endogenous agonist, anandamide:
J. Axelrod & C.C. Felder; Neurochem. Res.
23
, 575 (1998), (Review)
Abstract
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action:
V. Di Marzo, et al.; TINS
21
, 521 (1998), (Review)
Abstract
Endocannabinoids: a new class of vasoactive substances:
M.D. Randall & D.A. Kendall; TIPS
19
, 55 (1998), (Review)
Abstract
Metabolism of anandamide and 2-arachidonoylglycerol: an historical overview and some recent developments:
V. Di Marzo, et al.; Lipids
34
, S319 (1999), (Review)
Abstract
Anandamide: a candidate neurotransmitter heads for the big leagues:
D.W. Self; Nat. Neurosci.
2
, 303 (1999), (Review)
Abstract
New perspectives on enigmatic vanilloid receptors
:
A. Szallasi & V. Di Marzo; TINS
23
, 491 (2000), (Review)
Abstract
Anandamide: some like it hot
:
V. Di Marzo, et al.; TIPS
22
, 346 (2001), (Review)
Abstract
Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes:
J. Joseph, et al.; Cancer Immunol. Immunother.
53
, 723 (2004)
Abstract
Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways:
V.A. Movsesyan, et al.; Cell Death Differ.
11
, 1121 (2004)
Abstract
Arachidonylethanolamide induces apoptosis of human glioma cells through vanilloid receptor-1:
E. Contassot, et al.; J. Neuropathol. Exp. Neurol.
63
, 956 (2004)
Abstract
Preferred conformations of endogenous cannabinoid ligand anandamide:
J.Z. Chen, et al.; Life Sci.
76
, 2053 (2005)
Abstract
The cardiovascular actions of anandamide: more targets?:
M.D. Randall; Br. J. Pharmacol.
145
, 565 (2005)
Abstract
;
Full Text
Accumulation of anandamide: Evidence for cellular diversity:
C.J. Hillard and A. Jarrahian; Neuropharmacology
48
, 1072 (2005)
Abstract
Anandamide as an intracellular messenger regulating ion channel activity:
M. van der Stelt and V. Di Marzo; Prostaglandins Other Lipid Mediat.
77
, 111 (2005)
Abstract
Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism:
N.J. Underdown, et al.; Br. J. Pharmacol.
146
, 809 (2005)
Abstract
Anandamide inhibits adhesion and migration of breast cancer cells:
C. Grimaldi, et al.; Exp. Cell Res.
312
, 363 (2006)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
Further Categories Containing This Product:
Endocannabinoids
•
Apoptosis Inducers & Inhibitors Other Products
•
MAPK Pathway Activators
•
NF-kB Pathway Inhibitors
•
Endovanilloids
ALX-380-051
Revised 20-Jun-08
Anisomycin
SYNONYMS
2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Other Signal Transduction Pathway Modulators
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-051-M010
10 mg
35.00 USD
ALX-380-051-M050
50 mg
140.00 USD
ALX-380-051-M100
100 mg
250.00 USD
Product Specification
FORMULA:
C
14
H
19
NO
4
MW:
265.3
CAS NUMBER:
22862-76-6
MERCK INDEX:
14:
670
RTECS:
BZ9800000
SOURCE/HOST:
Isolated from
Streptomyces griseolus
.
PURITY:
≥98% (HPLC)
APPEARANCE:
White crystalline solid.
SOLUBILITY:
Soluble in DMSO (25mg/ml), 100% ethanol, methanol or ethyl acetate (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
TOXIC.
Product Description
Antibiotic. Activator of p38 and MAP kinases. Synergistic with growth factors and phorbol esters to superinduce cFos and cJun, by acting as a potent signalling agonist. Induces apoptosis in the human monoblastoid cell line. Used in the eradication of bean mildew. Inhibits other pathogenic fungi in plants.
Product Specific Literature References
Anisomycin, a new anti-protozoan antibiotic:
B. A. Sobin & F. W. Tanner; J. Am. Chem. Soc.
76
, 4053 (1954)
DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis:
S.K. Kochi & R.J. Collier; Exp. Cell. Res.
208
, 296 (1993)
Abstract
The stress-activated protein kinase subfamily of c-Jun kinases:
J.M. Kyriakis, et al.; Nature
369
, 156 (1994)
Abstract
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun:
I. Sanchez, et al.; Nature
372
, 794 (1994)
Abstract
Anisomycin and rapamycin define an area upstream of p70/85S6k containing a bifurcation to histone H3-HMG-like protein phosphorylation and c-fos-c-jun induction:
E. Kardalinou, et al.; Mol. Cell. Biol.
14
, 1066 (1994)
Abstract
Protein synthesis inhibitor phase shifts vasopressin rhythms in long- term suprachiasmatic cultures:
K. Shinohara & T. Oka; NeuroReport
5
, 2201 (1994)
Abstract
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction:
C.A. Hazzalin, et al.; Mol Cell Biol
18
, 1844 (1998)
Abstract
Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala:
P. Okulski, et al.; Neuroscience
114
, 1 (2002)
Abstract
Downregulation of Ski and SnoN co-repressors by anisomycin:
A. Vazquez-Macias, et al.; FEBS Lett.
579
, 3701 (2005)
Abstract
Anisomycin and the reconsolidation hypothesis:
J.W. Rudy, et al.; Learn. Mem.
13
, 1 (2006), Review
Abstract
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis:
I.A. Mawji, et al.; Cancer Res.
67
, 8307 (2007)
Abstract
Anisomycin abrogates repression of protooncogene c-fos transcription in E1A + cHa-ras-transformed cells through activation of MEK/ERK kinase cascade:
A. N. Kukushkin, et al.; J. Cell. Biochem.
103
, 1005 (2008)
Abstract
Further Categories Containing This Product:
MAPK Pathway Activators
•
Antibiotics - Apoptosis Inducers & Inhibitors
•
JNK [SAPK1] / Related Products
ALX-340-063
Revised 19-Apr-07
N-Arachidonoyl-L-serine
SYNONYMS
N-[(5Z,8Z,11Z,14Z)-1-Oxo-5,8,11,14-eicosatetraenyl)]-L-serine
ARA-S
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Endocannabinoids
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ALX-340-063-M010
10 mg
90.00 USD
Product Specification
FORMULA:
C
23
H
37
NO
4
MW:
391.5
CAS NUMBER:
187224-29-9
PURITY:
≥98%
APPEARANCE:
Waxy solid.
SOLUBILITY:
Soluble in DMSO or dimethyl formamide; sparingly soluble in water.
SHIPPING:
SHIPPED ON DRY ICE
LONG TERM STORAGE:
-80°C
Product Description
Endocannabinoid-like brain constituent with similar biological profile like abnormal cannabidiol. Binds weakly to CB
1
and CB
2
receptors and TRPV1. Produces endothelium-dependent vasodilation. Increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC.
Product Specific Literature References
N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties:
G. Milman, et al.; PNAS
103
, 2428 (2006)
Abstract
;
Full Text
Further Categories Containing This Product:
MAPK Pathway Activators
•
Endovanilloids
•
PI(3)K-Akt-mTOR Pathway Other Products
ALX-350-366
Revised 03-Apr-08
Azaspiracid-1
SYNONYMS
AZA-1
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Other Toxins
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ALX-350-366-C001
1 µg
180.00 USD
Product Specification
FORMULA:
C
47
H
71
NO
12
MW:
842.1
CAS NUMBER:
214899-21-5
SOURCE/HOST:
Islolated from marine mussel.
CONCENTRATION:
2μg/ml
PURITY:
≥95%
FORMULATION:
Liquid. In methanol.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HAZARD:
VERY TOXIC. MAY BE TERATOGENIC.
Product Description
Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alterations. Activator of caspases. Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels. Inhibitor of cholesterol biosynthesis in human T lymphocyte cells. Potent teratogen to finfish. Cytotoxic to mammalian cells.
Product Specific Literature References
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland:
E. Ito, et al.; Toxicon
38
, 917 (2000)
Abstract
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets
:
Y. Roman, et al.; Cell. Signal.
14
, 703 (2002)
Abstract
Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos
:
J.R. Coleman, et al.; Toxicon
45
, 881 (2005)
Abstract
Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines
:
M.J. Twiner, et al.; Toxicon
45
, 891 (2005)
Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes
:
A. Alfonso, et al.; BBRC
346
, 1091 (2006)
Abstract
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies
:
N. Vilarino, et al.; Chem. Res. Toxicol.
19
, 1459 (2006)
Abstract
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1:
C. Vale, et al.; Cell Physiol. Biochem.
20
, 957 (2007)
Abstract
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study
:
C. Vale, et al.; J. Med. Chem.
50
, 356 (2007)
Abstract
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells
:
N. Vilarino, et al.; Biochem. Pharmacol.
74
, 327 (2007)
Abstract
Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid
:
M.J. Twiner, et al.; Genomics
91
, 289 (2008)
Abstract
Further Categories Containing This Product:
MAPK Pathway Activators
•
Natural Products for Cytoskeletal Research
•
Natural Products - Other Signal Transduction Pathway Modulators
•
Caspases Other Products
•
cAMP Pathways Other Products
ALX-270-061
Revised 03-Feb-05
t-Butylhydroquinone
SYNONYMS
tBHQ
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Ca2+-ATPase / Related Products
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ALX-270-061-G010
10 g
30.00 USD
Product Specification
FORMULA:
C
10
H
14
O
2
MW:
166.2
CAS NUMBER:
1948-33-0
PURITY:
≥97%
APPEARANCE:
Off-white solid.
SOLUBILITY:
Soluble in DMSO or methanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+20°C
Product Description
Inhibitor of the endoplasmic reticulum Ca
2+
-ATPase. Activates extracellular signal-regulated protein kinase 2 (ERK2).
Product Specific Literature References
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants:
R. Yu, et al.; J. Biol. Chem.
272
, 28962 (1997)
Abstract
;
Full Text
Further Categories Containing This Product:
MAPK Pathway Activators
ALX-350-353
Revised 16-Jun-08
Chlorogenic acid
SYNONYMS
1,3,4,5-Tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate)
3-O-Caffeoylquinic acid
Heriguard
NSC 407296
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Chemopreventive Agents
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
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ALX-350-353-M500
500 mg
35.00 USD
ALX-350-353-G001
1 g
65.00 USD
Product Specification
FORMULA:
C
16
H
18
O
9
MW:
354.3
CAS NUMBER:
327-97-9
MERCK INDEX:
14:
2142
RTECS:
GU8480000
SOURCE/HOST:
Isolated from the leaves and fruits of dicotyledonous plants (e.g. coffee beans).
PURITY:
≥95%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
25mg/ml soluble in 100% ethanol, DMSO, dimethyl formamide or PBS (pH 7.2).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
We do not recommend storing the aqueous solution for more than one day.
Product Description
Analog of caffeic acid (Prod. No.
ALX-270-231
). Shows antioxidant, analgesic, antipyretic and chemopreventive activity. Inhibits Bcr-Abl tyrosine kinase and triggers MAP kinases p38-dependent apoptosis. Inhibitor of the tumor promoting activity of phorbol esters.
Product Specific Literature References
[Chlorogenic acid in coffee beans and their change during the roasting process. Report 1. Qualitative studies]:
R. Krasemann; Arch. Pharm.
293
, 721 (1960)
Abstract
Studies on the activities of tannins and related compounds, X. Effects of caffeetannins and related compounds on arachidonate metabolism in human polymorphonuclear leukocytes:
Y. Kimura, et al.; J. Nat. Prod.
50
, 392 (1987)
Abstract
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate:
M.T. Huang, et al.; Cancer Res.
48
, 5941 (1988)
Abstract
;
Full Text
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin:
A.H. Conney, et al.; Adv. Enzyme Regul.
31
, 385 (1991)
Abstract
Chlorogenic acid inhibits Bcr-Abl tyrosine kinase and triggers p38 mitogen-activated protein kinase-dependent apoptosis in chronic myelogenous leukemic cells:
G. Bandyopadhyay, et al.; Blood
104
, 2514 (2004)
Abstract
;
Full Text
Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid:
R. Feng, et al.; J. Biol. Chem.
280
, 27888 (2005)
Abstract
;
Full Text
The chemopreventive properties of chlorogenic acid reveal a potential new role for the microsomal glucose-6-phosphate translocase in brain tumor progression:
A. Belkaid, et al.; Cancer Cell Int.
6
, 7 (2006)
Abstract
;
Full Text
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid:
M.D. dos Santos, et al.; Biol. Pharm. Bull.
29
, 2236 (2006)
Abstract
;
Full Text
Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols:
W.J. Lee & B.T. Zhu; Carcinogenesis
27
, 269 (2006)
Abstract
;
Full Text
Related Products
ALX-270-231
Caffeic acid
Further Categories Containing This Product:
Active Substances from Fruit and Vegetables
•
MAPK Pathway Activators
•
Tyrosine Kinase Inhibitors
•
Natural Products - Protein Kinase Inhibitors
•
Natural Products - Antioxidants
•
Natural Products for Neurological Research
•
Natural Products - Apoptosis Inducers & Inhibitors
•
Analgesic / Anti-nociceptive Agents / Related Products
•
Phenolic Acids
ALX-303-003
Revised 29-Jan-05
D-erythro-Sphingosine, N-Hexanoyl-
SYNONYMS
N-Hexanoyl-D
-erythro
-sphingosine
C
6
-Ceramide
PRODUCT LINE
Neurobiology
PRODUCT CATEGORY
Ceramides / Cerebrosides / Sphingolipids / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-303-003-M001
1 mg
38.00 USD
ALX-303-003-M005
5 mg
70.00 USD
Product Specification
FORMULA:
C
24
H
47
NO
3
MW:
397.6
CAS NUMBER:
124753-97-5
SOURCE/HOST:
Synthetic.
PURITY:
≥98%
APPEARANCE:
White powder.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Cell permeable, biologically active, nonphysical ceramide analog. Activates protein phosphatase 2A and MAP kinase (MAPK/ERK). Induces an arrest at the G
0
/G
1
transition of the cell cycle. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis.
Product Specific Literature References
Ceramide stimulates a cytosolic protein phosphatase:
R.T. Dobrowsky & Y.A. Hannun; J. Biol. Chem.
267
, 5048 (1992)
Abstract
;
Full Text
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells:
M. A. Raines, et al.; J. Biol. Chem.
268
, 14572 (1993)
Abstract
;
Full Text
Ceramide activates heterotrimeric protein phosphatase 2A:
R.T. Dobrowsky, et al.; J. Biol. Chem.
268
, 15523 (1993)
Abstract
;
Full Text
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway:
W.D. Jarvis, et al.; PNAS
91
, 73 (1994)
Abstract
;
Full Text
Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence
:
M.E. Venable, et al.; J. Biol. Chem.
269
, 26040 (1994)
Abstract
;
Full Text
Role for ceramide in cell cycle arrest:
S. Jayadev, et al.; J. Biol. Chem.
270
, 2047 (1995)
Abstract
;
Full Text
Further Categories Containing This Product:
Phospholipase D / Related Products
•
Apoptosis Inducers & Inhibitors Other Products
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ALX-550-310
Revised 03-Jun-08
Trifluoperazine . dihydrochloride
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Calmodulin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-550-310-G001
1 g
20.00 USD
ALX-550-310-G005
5 g
75.00 USD
Product Specification
FORMULA:
C
21
H
24
F
3
N
3
S . 2HCl
MW:
407.5 . 73.0
CAS NUMBER:
440-17-5
MERCK INDEX:
14:
9680
RTECS:
SP1750000
PURITY:
≥99%
APPEARANCE:
White to off-white powder.
SOLUBILITY:
Soluble in water (50mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
HAZARD:
HARMFUL.
Product Description
Calmodulin inhibitor. Antipsychotic and sedative dopamine antagonist. Potent and irreversible inhibitor of cAMP-gated cationic channels. Inhibits DNA repair. Potent neurotoxin.
Product Specific Literature References
New drug evaluations amiloride (Midamor, Merck, Sharp and Dohme):
H.L. Macfie, et al.; Drug Intel. Clin. Pharm.
15
, 94 (1981)
Abstract
Trifluoperazine binding to porcine brain calmodulin and skeletal muscle troponin C:
J. Massom, et al.; Biochemistry
29
, 671 (1990)
Abstract
Inhibition of olfactory cyclic nucleotide-activated current by calmodulin antagonists:
S.J. Kleene; Br. J. Pharmacol.
111
, 469 (1994)
Abstract
Trifluoperazine-induced conformational change in Ca(2+)-calmodulin:
M. Vandonselaar, et al.; Nat. Struct. Biol.
1
, 795 (1994)
Abstract
Inhibition of Nav1.7 and Nav1.4 sodium channels by trifluoperazine involves the local anesthetic receptor:
P.L. Sheets, et al.; J. Neurophysiol.
96
, 1848 (2006)
Abstract
Trifluoperazine protects brain plasma membrane Ca(2+)-ATPase from oxidative damaging:
P. Souza dos Santos, et al.; Exp. Brain Res.
177
, 347 (2007)
Abstract
The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death:
A.G. Polischouk, et al.; Mol. Cancer Ther.
6
, 2303 (2007)
Abstract
Trifluoperazine stimulates ionizing radiation in
