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Natural Products / Antibiotics
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ALX-380-128 Revised 30-Jun-08 New product
MM 47755
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SYNONYMS 6-Desoxy-8-O-methylrabelomycin
(-)-3,4-Dihydro-3-hydroxy-8-methoxy-3-methylbenz(a)anthracene-1,7,12(2H)-trione
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-128-M001   1 mg 90.00 USD Add To Cart
ALX-380-128-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C20H16O5
MW: 336.3
CAS NUMBER: 117620-87-8
SOURCE/HOST: Isolated from Streptomyces sp. Gö 40/14
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Angucyclinone. Displays antibacterial and antifungal activity.
Product Specific Literature References
6-Deoxy-8-O-methylrabelomycin and 8-O-methylrabelomycin from a Streptomyces species: Y. Shigihara, et al.; J. Antibiot. 41, 1260 (1988) Abstract
MM 47755, a new benz[a]anthracene antibiotic from a streptomycete: M.L. Gilpin, et al.; J. Antibiot. 42, 627 (1989) Abstract
Remote Stereochemical Control in Asymmetric Diels - Alder Reactions: Synthesis of the Angucycline Antibiotics, (-)-Tetrangomycin and MM 47755: J.S. Landells, et al.; THL 44, 5193 (2003)
Total synthesis of (-)-8-O-methyltetrangomycin (MM 47755): C. Kesenheimer & U. Groth; Org. Lett. 8, 2507 (2006) Abstract
Angucyclinone antibiotics: total syntheses of YM-181741, (+)-ochromycinone, (+)-rubiginone B2, (-)-tetrangomycin, and MM-47755: K.P. Kaliappan & V. Ravikumar; J. Org. Chem. 72, 6116 (2007) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-129 Revised 30-Jun-08 New product
Naphthomycin B
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SYNONYMS 2-Demethylnaphthomycin A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-129-M001   1 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C39H44ClNO9
MW: 706.2
CAS NUMBER: 86825-88-9
SOURCE/HOST: Isolated from Streptomyces sp. Gö 40/14
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow to brown solid.
SOLUBILITY: Soluble in DMSO, methanol or acetone.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Ansamycin. Displays antibacterial and antifungal activity.
Product Specific Literature References
Isolation and structural elucidation of naphthomycins B and C: W. Keller-Schierlein, et al.; J. Antibiot. 36, 484 (1983) Abstract
Cineromycins, gamma-butyrolactones and ansamycins by analysis of the secondary metabolite pattern created by a single strain of Streptomyces: H.J. Schiewe & A. Zeeck; J. Antibiot. 52, 635 (1999) Abstract
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-130 Revised 15-Sep-08 New product
Isofusidienol A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-130-M001   1 mg 90.00 USD Add To Cart
ALX-380-130-M005   5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C16H12O6
MW: 300.3
SOURCE/HOST: Isolated from Chalara sp.
PURITY: ≥98% (HPLC)
APPEARANCE: Yellow solid.
SOLUBILITY: Soluble in DMSO or dichloromethane.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
IDENTITY: Identity determined by 1H-NMR.

Product Description

Chromone-3-oxepine. Displays antifungal and antibacterial activity against Gram-positive and Gram-negative bacteria.
Product Specific Literature References
Isofusidienols: Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp: S. Lösgen, et al.; Eur. J. Org. Chem. 2008, 698
Further Categories Containing This Product:
Antibiotics - Antifungal
 
 
ALX-380-215 Revised 08-Apr-08
Paraherquamide A
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SYNONYMS VM 29919
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-215-M001   1 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C28H35N3O5
MW: 493.6
CAS NUMBER: 77392-58-6
RTECS: RV0545000
SOURCE/HOST: Isolated from Penicillium simplicissimum MST-FP116A.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Antibiotic. Selective and competitive cholinergic antagonist that distinguishes subtypes of cholinergic receptors. Anti-helmintic.
Product Specific Literature References
Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity: J.G. Ondeyka, et al.; J. Antibiot. (Tokyo) 43, 1375 (1990) Abstract
Acute toxicity of paraherquamide and its potential as an anthelmintic: W.L. Shoop, et al.; Am. J. Vet. Res. 53, 2032 (1992) Abstract
Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals: E.W. Zinser, et al.; J. Vet. Pharmacol. Ther. 25, 241 (2002) Abstract
Paraherquamide and 2-deoxy-paraherquamide distinguish cholinergic receptor subtypes in Ascaris muscle: A.P. Robertson, et al.; J. Pharmacol. Exp. Ther. 302, 853 (2002) Abstract; Full Text
Further Categories Containing This Product:
Helminth Infections / Related Products • Acetylcholine Receptors Other Products
 
 
ALX-380-227 Revised 05-Apr-08
Geninthiocin
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SYNONYMS 14-Demethylberinamycin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-227-MC05   0.5 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C50H49N15O15S
MW: 1132.1
CAS NUMBER: 158792-27-9
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5991.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white amorphous powder.
SOLUBILITY: Soluble in methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance.
Product Specific Literature References
Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced by Streptomyces sp. DD84: B.S. Yun, et al.; J. Antibiot. (Tokyo) 47, 969 (1994) Abstract
Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators: J.D. Kahmann, et al.; EMBO J. 22, 1824 (2003) Abstract; Full Text
 
 
ALX-380-232 Revised 16-Jun-08
Lydicamycin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-232-MC05   0.5 mg 390.00 USD Add To Cart
Product Specification
FORMULA: C47H74N4O10
MW: 855.1
CAS NUMBER: 133352-27-9
SOURCE/HOST: Isolated from Streptomyces sp. MST-AS5376.
PURITY: ≥95% (HPLC)
APPEARANCE: Colorless film.
SOLUBILITY: Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Shows antibacterial activities against Gram-positive bacteria. Highly active against MRSA.
Product Specific Literature References
Lydicamycin, a new antibiotic of a novel skeletal type. I. Taxonomy, fermentation, isolation and biological activity: Y. Hayakawa, et al.; J. Antibiot. (Tokyo) 44, 282 (1991) Abstract
Lydicamycin, a new antibiotic of a novel skeletal type. II. Physico-chemical properties and structure elucidation: Y. Hayakawa, et al.; J. Antibiot. (Tokyo) 44, 288 (1991) Abstract
 
 
ALX-380-237 Revised 28-Feb-08
Ristocetin A . sulfate
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SYNONYMS Ristocetin . sulfate
Ristomycin III . sulfate
Spontin . sulfate
Riston . sulfate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-237-M010   10 mg 220.00 USD Add To Cart
Product Specification
FORMULA: C95H110N8O44 . H2SO4
MW: 2067.9 . 98.0
CAS NUMBER: 11140-99-1
MERCK INDEX: 14: 8234
RTECS: VJ8595000
SOURCE/HOST: Isolated from Amycolatopsis sp. MST-AS5924.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water, methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Potent antibacterial antibiotic. Induces platelet aggregation by binding to a factor absent in people suffering from von Willebrand’s disease and is therefore an important diagnostic tool. Chiral selector for the separation of enantiomers by HPLC, TLC and electrophoresis.
Product Specific Literature References
Ristocetin A and B, two new antibiotics. Isolation and properties: J.E. Philip, et al.; Antibiot. Annu. 1956-1957, 699 (1957)
Ristocetin--a new tool in the investigation of platelet aggregation: M.A. Howard and B.G. Firkin; Thromb. Diath. Haemorrh. 26, 362 (1971) Abstract
Cooperativity and anti-cooperativity between ligand binding and the dimerization of ristocetin A: asymmetry of a homodimer complex and implications for signal transduction: Y.R. Cho, et al.; Chem. Biol. 3, 207 (1996) Abstract; Full Text
A peptide isolated from alpha B-crystallin is a novel and potent inhibitor of platelet aggregation via dual prevention of PAR-1 and GPIb/V/IX: H. Matsuno, et al.; J. Thromb. Haemost. 1, 2636 (2003) Abstract
HPLC separation of amino acid enantiomers and small peptides on macrocyclic antibiotic-based chiral stationary phases: a review: I. Ilisz, et al.; J. Sep. Sci. 29, 1305 (2006), (Review) Abstract
Further Categories Containing This Product:
Chiral Compounds (Organic) • Coagulation Factors / Related Products
 
 
ALX-380-261 Revised 04-Feb-08
Thiostrepton
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-261-G001   1 g 80.00 USD Add To Cart
ALX-380-261-G005   5 g 320.00 USD Add To Cart
Product Specification
FORMULA: C72H85N19O18S5
MW: 1664.9
CAS NUMBER: 1393-48-2
MERCK INDEX: 14: 9364
RTECS: XN6300100
SOURCE/HOST: Isolated from Streptomyces azureus.
PURITY: ≥95% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in acetic acid, DMSO or dimethyl formamide; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture.

Product Description
Thiazole-containing peptide antibiotic. Inhibits protein synthesis by preventing binding of GTP to the 50S ribosomal subunit. Inhibits binding of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome.
Product Specific Literature References
Studies on translocation. VI. Thiostrepton prevents the formation of a ribosome-G factor-guanine nucleotide complex: J.W. Bodley, et al.; BBRC 41, 1406 (1970) Abstract
Similarities and differences in the inhibition patterns of thiostrepton and viomycin: evidence for two functionally different populations of P sites when occupied with AcPhe-tRNA: U.R. Kutay, et al.; Biochim. Biophys. Acta 1050, 193 (1990) Abstract
Alpha-sarcin cleavage of ribosomal RNA is inhibited by the binding of elongation factor G or thiostrepton to the ribosome: S.P. Miller & J.W. Bodley; Nucl. Acids Res. 19, 1657 (1991) Abstract; Full Text
Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton: P.C. Ryan, et al.; J. Mol. Biol. 221, 1257 (1991) Abstract
Characterization of an 8.7-kilobase thiostrepton resistance-encoding plasmid (pGIF3) of Streptomyces incarnatus: H. Malina & M. Robert-Gero; Appl. Environ. Microbiol. 58, 895 (1992) Abstract; Full Text
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A: G. Rosendahl & S. Douthwaite; Nucl. Acids Res. 22, 357 (1994) Abstract; Full Text
Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome: M.V. Rodnina, et al.; PNAS 96, 9586 (1999) Abstract; Full Text
Interaction of thiostrepton and elongation factor-G with the ribosomal protein L11-binding domain: W.S. Bowen, et al.; J. Biol. Chem. 280, 2934 (2005) Abstract; Full Text
Interactions of the N-terminal domain of ribosomal protein L11 with thiostrepton and rRNA: S.L. Bausch, et al.; J. Biol. Chem. 280, 29956 (2005) Abstract; Full Text
In vivo assembling of bacterial ribosomal protein L11 into yeast ribosomes makes the particles sensitive to the prokaryotic specific antibiotic thiostrepton: A. Garcia-Marcos, et al.; Nucl. Acids Res. 35, 7109 (2007) Abstract; Full Text
Further Categories Containing This Product:
Protein Synthesis Other Products
 
 
ALX-380-266 Revised 03-Apr-08
Amikacin . disulfate
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-266-M250   250 mg 30.00 USD Add To Cart
ALX-380-266-G001   1 g 70.00 USD Add To Cart
Product Specification
FORMULA: C22H43N5O13 . 2H2SO4
MW: 585.6 . 196.2
CAS NUMBER: 39831-55-5
MERCK INDEX: 14: 405
RTECS: WK1961200
SOURCE/HOST: Semisynthetic from kanamycin A (Prod. No. ALX-380-275).
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water (50mg/ml).
ACTIVITY: Potency is 647-786µg/ml (on dry basis).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Aminoglycoside antibiotic. Effective against Gram-negative and Gram-positive bacteria.
Product Specific Literature References
BB-K 8, a new semisynthetic aminoglycoside antibiotic: H. Kawaguchi, et al.; J. Antibiot. 25, 695 (1972) Abstract
Comparative pharmacokinetics of BB-K8 and kanamycin in dogs and humans: B.E. Cabana & J.G. Taggart; Antimicrob. Agents Chemother. 3, 478 (1973) Abstract
Comparative in vitro activity of three aminoglycosidic antibiotics: BB-K8, kanamycin, and gentamicin: P.K. Yu & J.A. Washington; Antimicrob. Agents Chemother. 4, 133 (1973) Abstract
Pharmacology of amikacin in humans: G.P. Bodey, et al.; Antimicrob. Agents Chemother. 5, 508 (1974) Abstract
Aminoglycoside antibiotics. VII. Acute toxicity of aminoglycoside antibiotics: K. Fujisawa, et al.; J. Antibiot. 27, 677 (1974) Abstract
Ototoxicity and pharmacokinetically determined dosages of amikacin in granulocytopenic cancer patients: F.J. Danhauer, et al.; Clin. Pharm. 1, 539 (1982) Abstract
Biological transformation of kanamycin A to amikacin (BBK-8): L.M. Cappelletti & R. Spagnoli; J. Antibiot. 36, 328 (1983) Abstract
Related Products
 
 
ALX-380-268 Revised 21-May-08
Ampicillin . sodium salt
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SYNONYMS D-(−)-α-Aminobenzylpenicillin . Na
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics Other Products
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ALX-380-268-G005   5 g 45.00 USD Add To Cart
Product Specification
FORMULA: C16H18N3O4S . Na
MW: 348.4 . 23.0
CAS NUMBER: 69-52-3
MERCK INDEX: 14: 586
RTECS: XH8400000
SOURCE/HOST: Semisynthetic from penicillin.
PURITY: ≥95% (Assay)
APPEARANCE: White to light yellow powder.
SOLUBILITY: Soluble in water (50mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: IRRITANT.

Product Description
β-Lactam antibiotic. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking). Inactivates transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-negative and Gram-positive bacteria. Is inactivated by β-lactamase.
Product Specific Literature References
7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies: J. Med. Chem.; S.K. Sengupta, et al. 18, 1175 (1975) Abstract
N7-Substituted 7-aminoactinomycin D analogues. Synthesis and biological prop