ALEXIS Biochemicals: Trihydroxyethylrutin

Advanced Search

You are here: Product Lines > Oxidative Stress > Natural Products - Antioxidants

ALX-350-329

Revised 21-May-08

Allicin
SYNONYMS	2-Propene-1-sulfinothioic acid S-2-propenyl ester Diallyl thiosulfinate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-329-M001		1 mg	200.00 USD
ALX-350-329-M005		5 mg	690.00 USD

Product Specification

FORMULA:	C₆H₁₀OS₂
MW:	162.3
CAS NUMBER:	539-86-6
MERCK INDEX:	14: 261
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Clear to slightly yellow liquid.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Active metabolite of garlic. Exhibits antimicrobial, antioxidant, antiproliferative, chemopreventive, antihyperlipidaemic and antihypertensive effects. Inhibits telomerase activity. Induces apoptosis. Also inhibits inducible nitric oxide synthase (iNOS; NOS II) expression.

Product Specific Literature References

Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica: S. Ankri, et al.; Antimicrob. Agents Chemother. 41, 2286 (1997) Abstract
Effect of allicin and ajoene, two compounds of garlic, on inducible nitric oxide synthase: V.M. Dirsch, et al.; Atherosclerosis 139, 333 (1998) Abstract
Antimicrobial properties of allicin from garlic: S. Ankri & D. Mirelman; Microbes Infect. 1, 125 (1999), Review Abstract
Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation: K. Hirsch, et al.; Nutr. Cancer 38, 245 (2000) Abstract
The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats: A. Elkayam, et al.; Am. J. Hypertens. 14, 377 (2001) Abstract
Effects of allicin on both telomerase activity and apoptosis in gastric cancer SGC-7901 cells: L. Sun & X. Wang; World J. Gastroenterol. 9, 1930 (2003) Abstract
Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells: S. Oommen, et al.; Eur. J. Pharmacol. 485, 97 (2004) Abstract
Antibacterial activity of a new, stable, aqueous extract of allicin against methicillin-resistant Staphylococcus aureus: R.R. Cutler & P. Wilson; Br. J. Biomed. Sci. 61, 71 (2004) Abstract
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin: L.J. Macpherson, et al.; Curr. Biol. 15, 929 (2005) Abstract
An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic: S.R. Davis; Mycoses 48, 95 (2005), Review Abstract
Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent: R. Hunter, et al.; Ann. N.Y. Acad. Sci. 1056, 234 (2005), Review Abstract
The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide: L.Y. Chung; J. Med. Food 9, 205 (2006) Abstract
Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial: C.D. Gardner, et al.; Arch. Intern. Med. 167, 346 (2007) Abstract

Further Categories Containing This Product:

Active Substances from Fruit and Vegetables • NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - Chemopreventive Agents • Antitumor Agents (Anti-proliferative) • Natural Products with Antibiotic Activity • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Apoptosis Inducers & Inhibitors • TRPV1 Agonists and Antagonists / Related Products

ALX-350-331

Revised 19-Oct-07

Angoroside C
SYNONYMS	Isoangoroside C
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Anti-inflammatory Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-331-M001		1 mg	30.00 USD
ALX-350-331-M005		5 mg	120.00 USD

Product Specification

FORMULA:	C₃₆H₄₈O₁₉
MW:	784.8
CAS NUMBER:	115909-22-3
SOURCE/HOST:	Isolated from the root of Scrophularia ningpoensis Hemsl (Figwort).
PURITY:	≥98% (HPLC)
APPEARANCE:	White to pale yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Hygroscopic.

Product Description

Potential anti-inflammatory compound. Inhibitor of prostaglandin E₂ release in mouse peritoneal macrophages in vitro. Shows potent antioxidative activity in reducing the oxidized OH adducts of dAMP and dGMP. Reveals some trypanocidal potential.

Product Specific Literature References

Fast repairing of oxidized OH radical adducts of dAMP and dGMP by phenylpropanoid glycosides from Scrophularia ningpoensis Hemsl: Y.M. Li, et al.; Acta Pharmacol. Sin. 21, 1125 (2000) Abstract
Phenylpropanoid glycosides from Scrophularia scorodonia: in vitro anti-inflammatory activity: A.M. Diaz, et al.; Life Sci. 74, 2515 (2004) Abstract
Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots: D. Tasdemir, et al.; Phytochemistry 66, 355 (2005) Abstract

Further Categories Containing This Product:

Natural Products - Antioxidants

ALX-385-008

Revised 13-Mar-08

Apigenin
SYNONYMS	4',5,7-Trihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-008-M010		10 mg	35.00 USD
ALX-385-008-M050		50 mg	105.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₅
MW:	270.2
CAS NUMBER:	520-36-5
MERCK INDEX:	14: 730
SOURCE/HOST:	Synthetic.
PURITY:	≥90% (HPLC)
APPEARANCE:	Light yellow to slightly brown powder.
SOLUBILITY:	Soluble in diluted potassium hydroxide or DMSO; slightly soluble in 100% ethanol (hot). Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	IRRITANT.

Product Description

Antioxidant flavonoid. Has chemopreventive and antitumor properties. Induces apoptosis. Inhibits the proliferation of malignant tumor cells by G2/M arrest. MAP kinase (MAPK/ERK) inhibitor. Inhibits hypoxia-inducible factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) expression.

Product Specific Literature References

Apigenin and tangeretin enhance gap junctional intercellular communication in rat liver epithelial cells: C. Chaumontet, et al.; Carcinogenesis 15, 2325 (1994) Abstract
Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells: F. Sato, et al.; BBRC 204, 578 (1994) Abstract
Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting mitogen activated protein kinase and its downstream oncogenes: M.L. Kuo and N.C. Yang; BBRC 212, 767 (1995) Abstract
Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Apigenin inhibits endothelial-cell proliferation in G(2)/M phase whereas it stimulates smooth-muscle cells by inhibiting P21 and P27 expression: V. Trochon, et al.; Int. J. Cancer 85, 691 (2000) Abstract
Induction of caspase-dependent, p53-mediated apoptosis by apigenin in human neuroblastoma: R. Torkin, et al.; Mol. Cancer Ther. 4, 1 (2005) Abstract
Apigenin and cancer chemoprevention: progress, potential and promise: D. Patel, et al.; Int. J. Oncol. 30, 233 (2007), (Review) Abstract
Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression: J. Fang, et al.; Carcinogenesis 28, 858 (2007) Abstract
Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells: S. Shukla & S. Gupta; Cell Cycle 6, 1102 (2007) Abstract
Apigenin blocks lipopolysaccharide-induced lethality in vivo and proinflammatory cytokines expression by inactivating NF-kappaB through the suppression of p65 phosphorylation: C. Nicholas, et al.; J. Immunol. 179, 7121 (2007) Abstract

Further Categories Containing This Product:

MAPK Pathway Inhibitors • Hypoxia-inducible Factor [HIF] / Related Products • Natural Products - Protein Kinase Inhibitors • VEGFs & VEGF-Rs Other Products • Natural Products for Angiogenesis Research • Natural Products - Chemopreventive Agents • Antitumor Agents (Enzyme Inhibitors) • Natural Products - Apoptosis Inducers & Inhibitors • Antitumor Agents (Anti-proliferative) • Natural Products - Antitumor Reagents • Natural Products - Antioxidants

ALX-460-001

Revised 13-Mar-06

L-(+)-Ascorbic acid
SYNONYMS	Vitamin C
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Vitamins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-001-G010		10 g	20.00 USD

Product Specification

FORMULA:	C₆H₈O₆
MW:	176.1
CAS NUMBER:	50-81-7
MERCK INDEX:	14: 830
PURITY:	≥97%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
USE/STABILITY:	Aqueous solutions are easily oxidized. Stable at pH 5.0-6.0.

Further Categories Containing This Product:

Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Chemopreventive Agents • Natural Products - Antioxidants • Active Substances from Fruit and Vegetables

ALX-460-031

Revised 24-Oct-07

Astaxanthin (crystalline)
SYNONYMS	3,3'-Dihydroxy-β,β-carotene-4,4'-dione
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-460-031-M050		50 mg	40.00 USD
ALX-460-031-M250		250 mg	160.00 USD

Product Specification

FORMULA:	C₄₀H₅₂O₄
MW:	596.8
CAS NUMBER:	472-61-7
MERCK INDEX:	14: 855
SOURCE/HOST:	Synthetic.
PURITY:	≥97%
APPEARANCE:	Dark violet powder.
SOLUBILITY:	Soluble in chloroform (0.05%). Insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	Material oxidizes at temperatures above 60°C. Decomposes slowly when exposed to light and high temperatures. Material reacts with acids and may corrode steel. Use stainless steel or polylethylene equipment for mixing purposes.
HANDLING:	Protect from light.

Product Description

Extremely potent antioxidant. Shows anti-inflammatory properties. Has effects on cancer, cardiovascular disease, and diabetes.

Product Specific Literature References

Antioxidant activity of beta-carotene-related carotenoids in solution: J. Terao; Lipids 24, 659 (1989) Abstract
Astaxanthin and canthaxanthin are potent antioxidants in a membrane model: P. Palozza & N.I. Krinsky; Arch. Biochem. Biophys. 297, 291 (1992) Abstract
Antioxidant effects of carotenoids in vivo and in vitro: an overview: P. Palozza & N.I. Krinsky; Meth. Enzymol. 213, 403 (1992) Abstract
Singlet oxygen and peroxyl radicals regulate carotenoid biosynthesis in Phaffia rhodozyma: W.A. Schroeder & E.A. Johnson; J. Biol. Chem. 270, 18374 (1995) Abstract; Full Text
Haematococcus astaxanthin: applications for human health and nutrition: M. Guerin, et al.; Trends Biotechnol. 21, 210 (2003), (Review) Abstract
Astaxanthin, a carotenoid with potential in human health and nutrition: G. Hussein, et al.; J. Nat. Prod. 69, 443 (2006), (Review) Abstract

Further Categories Containing This Product:

Natural Products - Anti-inflammatory Agents

ALX-385-022

Revised 07-Oct-08

Baicalein
SYNONYMS	5,6,7-Trihydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavones

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-022-M005		5 mg	25.00 USD
ALX-385-022-M025		25 mg	100.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₅
MW:	270.2
CAS NUMBER:	491-67-8
MERCK INDEX:	14: 942
PURITY:	≥97%
APPEARANCE:	Yellow to yellow-green crystalline powder.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol; almost insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Inhibitor of 12-lipoxygenase, leukotriene biosynthesis and the release of lysosomal enzymes. Inhibits cellular Ca²⁺ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.

Product Specific Literature References

Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells: J.L. Nadler, et al.; J. Clin. Invest. 80, 1763 (1987) Abstract
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone: K. Ono, et al.; BBRC 160, 982 (1989) Abstract
Biliary excretion of metabolites of baicalin and baicalein in rats: K. Abe, et al.; Chem. Pharm. Bull. 38, 209 (1990) Abstract
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells: H.C. Huang, et al.; Eur. J. Pharmacol. 268, 73 (1994) Abstract
Protective effects of baicalein against cell damage by reactive oxygen species: D. Gao, et al.; Chem. Pharm. Bull. (Tokyo) 46, 1383 (1998) Abstract
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules
: S.L. Hsu, et al.; Eur. J. Pharmacol. 425, 165 (2001) Abstract
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes: Y.C. Shen, et al.; Eur. J. Pharmacol. 465, 171 (2003) Abstract
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells: H.Z. Lee, et al.; Anticancer Res. 25, 959 (2005) Abstract
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 177 (2005), (Review) Abstract
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta 1773, 1073 (2007) Abstract

Further Categories Containing This Product:

Leukotrienes Other Products • Natural Products - Protein Kinase Inhibitors • Tyrosine Kinase Inhibitors • Natural Products - Anti-inflammatory Agents • Natural Products for Angiogenesis Research • Lipoxygenases / Related Products • Natural Products - Apoptosis Inducers & Inhibitors • Natural Products - Antioxidants • Natural Products - Antiviral / anti-HIV Agents • Cell Cycle Blockers & Inhibitors / Related Products • Natural Products for Cell Cycle Research

ALX-350-144

Revised 03-Apr-08

Bakuchiol
SYNONYMS	4-(3-Ethenyl-3,7-dimethyl-1,6-octadienyl)phenol
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-144-M001		1 mg	170.00 USD

Product Specification

FORMULA:	C₁₈H₂₄O
MW:	256.4
CAS NUMBER:	10309-37-2
SOURCE/HOST:	Isolated from plant Psoralea corylifolia.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow to brownish oil.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Inhibitor of protein tyrosine phosphatase 1B (PTB1B). Antioxidant. Inhibitor of mitochondrial lipid peroxidation. Inhibitor of inducible nitric oxide synthase (iNOS; NOS II) expression. DNA polymerase inhibitor. Shows antimicrobial and cytotoxic activity.

Product Specific Literature References

Plant antimutagenic agents, 2. Flavonoids: M.E. Wall, et al.; J. Nat. Prod. 51, 1084 (1988) Abstract
DNA polymerase and topoisomerase II inhibitors from Psoralea corylifolia: N.J. Sun, et al.; J. Nat. Prod. 61, 362 (1998) Abstract
Inhibition of mitochondrial lipid peroxidation by Bakuchiol, a meroterpene from Psoralea corylifolia: H. Haraguchi, et al.; Planta Med. 66, 569 (2000) Abstract
Active constituents isolated from Psoralea glandulosa L. with antiinflammatory and antipyretic activities: C.N. Backhouse, et al.; J. Ethnopharmacol. 78, 27 (2001) Abstract
Bakuchiol: a hepatoprotective compound of Psoralea corylifolia on tacrine-induced cytotoxicity in Hep G2 cells: H. Cho, et al.; Planta Med. 67, 750 (2001) Abstract
In vitro antimicrobial activities of bakuchiol against oral microorganisms: H. Katsura, et al.; Antimicrob. Agents Chemother. 45, 3009 (2001) Abstract; Full Text
Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kappaB in RAW 264.7 macrophages: H.O. Pae, et al.; Int. Immunopharmacol. 1, 1849 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis: S.M. Newton, et al.; J. Ethnopharmacol. 79, 57 (2002) Abstract
Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain: S. Adhikari, et al.; Chem. Res. Toxicol. 16, 1062 (2003) Abstract
Preparation and in vitro evaluation of radioiodinated bakuchiol as an anti tumor agent: K. Bapat, et al.; Appl. Radiat. Isot. 62, 389 (2005) Abstract
In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia: Y.C. Kim, et al.; Planta Med. 71, 87 (2005) Abstract
Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo: E.J. Park, et al.; Planta Med. 71, 508 (2005) Abstract
Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts: E.J. Park, et al.; Eur. J. Pharmacol. 559, 115 (2007) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Natural Products - DNA Replication Inhibitors • Natural Products - Nitric Oxide Pathway Modulators • Natural Products - Topoisomerase Inhibitors • Natural Products with Antibiotic Activity • Protein Tyrosine Phosphatases Other Products • Lipid Peroxidation • Natural Products - Antioxidants

ALX-350-147

Revised 03-Oct-07

Bavachin
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antioxidants

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-147-MC05		0.5 mg	120.00 USD

Product Specification

FORMULA:	C₂₀H₂₀O₄
MW:	324.4
CAS NUMBER:	19879-32-4
SOURCE/HOST:	Isolated from plant Psoralea corylifolia.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
IDENTITY:	Determined by ¹H-NMR, ¹³C-NMR and MS.

Product Description

Weak antioxidant. Antimutagenic. Stimulates bone formation and has potential activity against osteoporosis. Shows inhibitory activities against the antigen-induced degranulation and weak estrogen-like activity.

Product Specific Literature References

Antiplatelet flavonoids from seeds of Psoralea corylifolia: W.J. Tsai, et al.; J. Nat. Prod. 59, 671 (1996) Abstract
Osteoblastic proliferation stimulating activity of Psoralea corylifolia extracts and two of its flavonoids: D. Wang, et al.; Planta Med. 67, 748 (2001) Abstract
Antioxidative components of Psoralea corylifolia (Leguminosae): H. Haraguchi, et al.; Phytother. Res. 16, 539 (2002) Abstract
Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia: H. Matsuda, et al.; Chem. Pharm. Bull. (Tokyo) 55, 106 (2007) Abstract
Synthesis of four natural prenylflavonoids and their estrogen-like activities: X. Dong, et al.; Arch. Pharm. (Weinheim) 340, 372 (2007) Abstract

Further Categories Containing This Product:

Natural Products - Immunomodulators • Estrogen & Estrogen Receptors / Related Products • Flavanones • Bone Metabolism Other Products

ALX-350-246

Revised 07-Oct-08

Butein
SYNONYMS	2',3,4,4'-Tetrahydroxychalcone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-246-M010		10 mg	190.00 USD

Product Specification

FORMULA:	C₁₅H₁₂O₅
MW: