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Items 9 of 9
ALX-430-076
Revised 03-Oct-08
Cobalt (III) Protoporphyrin IX chloride
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
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ALX-430-076-M025
25 mg
80.00 USD
Product Specification
FORMULA:
C
34
H
32
CoN
4
O
4
. Cl
MW:
654.5
PURITY:
≥95% (TLC)
APPEARANCE:
Dark purple solid.
SOLUBILITY:
Soluble in acidic or basic aqueous solutions at pH between 8.5-9.0. Once in solution pH can be adjusted to physiological pH.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light and moisture.
ALX-430-048
Revised 03-Oct-08
Copper(II) Protoporphyrin IX (free acid)
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
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ALX-430-048-M025
25 mg
75.00 USD
Product Specification
FORMULA:
C
34
H
32
CuN
4
O
4
MW:
624.2
PURITY:
≥95%
APPEARANCE:
Red to brown solid.
SOLUBILITY:
Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING:
Protect from light and moisture.
Product Description
Negative control for the heme oxygenase inhibitor zinc protoporphyrin IX (Prod. No.
ALX-430-049
).
Product Specific Literature References
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin:
R.J. Chernick, et al.; Hepatology
10
, 365 (1989)
Abstract
Zinc protoporphyrin-IX blocks the effects of metabotropic glutamate receptor activation in the rat nucleus tractus solitarii:
S.R. Glaum & R.J. Miller; Mol. Pharmacol.
43
, 965 (1993)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
ALX-430-092
Revised 28-Jan-05
FeTMPyP . pentachloride
SYNONYMS
Iron (III) tetrakis(N-methyl-4'-pyridyl)porphyrin . 5Cl
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
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Unit Price:
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ALX-430-092-M010
10 mg
43.00 USD
Product Specification
FORMULA:
C
44
H
36
FeN
8
. 5Cl
MW:
732.7 . 177.3
CAS NUMBER:
133314-07-5
PURITY:
≥98%
APPEARANCE:
Black solid.
SOLUBILITY:
Soluble in aqueous buffers or isotonic saline.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 2 years after receipt when stored at –20°C.
HANDLING:
Protect from light and moisture.
Product Description
Synthetic porphyrin complexed with iron which acts as a peroxynitrite decomposition complex. Catalyzes the isomerization of peroxynitrite to nitrate under physiological conditions. Effectively prevents the oxidation of lipid components by peroxynitrite. Also catalytically decomposes superoxide radicals. Irridation of the aqueous solution at 335nm releases hydroxyl radicals. It can also serve as a potential drug for reactive oxygen species (ROS) detoxification.
Product Specific Literature References
Peroxynitrite decomposition catalysts:
M.K. Stern, et al.; JACS
118
, 8735 (1996)
Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies:
J.A. Hunt, et al.; Chem. Biol.
4
, 845 (1997)
Abstract
Peroxynitrite rapidly permeates phospholipid membranes:
S.S. Marla, et al.; PNAS
94
, 14243 (1997)
Abstract
Characterization of the cytoprotective action of peroxynitrite decomposition catalysts:
T.P. Misko, et al.; J. Biol. Chem.
273
, 15646 (1998)
Abstract
;
Full Text
Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage:
D. Salvemini, et al.; Br. J. Pharmacol.
127
, 685 (1999)
Abstract
Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst:
S.Z. Imam, et al.; Brain Res.
837
, 15 (1999)
Abstract
Further Categories Containing This Product:
Peroxynitrite / Scavengers / Detection
ALX-430-069
Revised 31-Oct-08
MnTBAP chloride
SYNONYMS
Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
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ALX-430-069-M010
10 mg
20.00 USD
ALX-430-069-M050
50 mg
60.00 USD
Product Specification
FORMULA:
C
48
H
28
MnN
4
O
8
Cl
MW:
879.2
PURITY:
≥97% (EA, MS)
APPEARANCE:
Black crystalline powder.
SOLUBILITY:
Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light and moisture.
Product Description
Cell permeable SOD mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO).
Product Specific Literature References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo:
K.M. Faulkner, et al.; J. Biol. Chem.
269
, 23471 (1994)
Abstract
;
Full Text
A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro:
B.J. Day, et al.; J. Pharm. Exp. Ther.
275
, 1227 (1995)
Abstract
Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger:
C. Szabó, et al.; FEBS Lett.
381
, 82 (1996)
Abstract
Mitochondrial nitric-oxide synthase stimulation causes cytochrome c release from isolated mitochondria. Evidence for intramitochondrial peroxynitrite formation:
P. Ghafourifar, et al.; J. Biol. Chem.
274
, 31185 (1999)
Abstract
;
Full Text
Reactive oxygen species regulate activation-induced T cell apoptosis::
D.A. Hildeman, et al.; Immunity
10
, 735 (1999)
Abstract
Doxorubicin-induced apoptosis in endothelial cells and cardiomyocytes is ameliorated by nitrone spin traps and ebselen.:
S. Kotamraju, et al.; J. Biol. Chem.
275
, 33585 (2000)
Abstract
;
Full Text
Endothelial heme oxygenase-1 induction by hypoxia. Modulation by inducible nitric-oxide synthase and S-nitrosothiols:
R. Motterlini, et al.; J. Biol. Chem.
275
, 13613 (2000)
Abstract
;
Full Text
Mitochondrial membrane permeabilization and superoxide production during apoptosis. A single-cell analysis:
H. Dussmann, et al.; J. Biol. Chem.
278
, 12645 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
Superoxide Dismutases [SODs] / Related Products
ALX-430-070
Revised 05-Mar-08
MnTMPyP . pentachloride
SYNONYMS
Manganese (III) tetrakis (1-methyl-4-pyridyl)porphyrin . 5Cl
-
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
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ALX-430-070-M010
10 mg
20.00 USD
ALX-430-070-M050
50 mg
50.00 USD
Product Specification
FORMULA:
C
44
H
36
MnN
8
Cl
5
MW:
909.0
PURITY:
≥95%
APPEARANCE:
Black crystalline powder.
SOLUBILITY:
Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Prepare solutions immediately before experiments. We recommend using fresh preparations each day.
Product Description
Cell permeable SOD mimetic. Catalyzes the dismutation of O
2
-
even in the presence of excess EDTA.
Product Specific Literature References
Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo:
K.M. Faulkner, et al.; J. Biol. Chem.
269
, 23471 (1994)
Abstract
;
Full Text
A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli:
S.I. Liochev & I. Fridovich; Arch. Biochem. Biophys.
321
, 271 (1995)
Abstract
Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells:
P.R. Gardner, et al.; Arch. Biochem. Biophys.
325
, 20 (1996)
Abstract
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic:
Batinic-Haberle, et al.; J. Biol. Chem.
273
, 24521 (1998)
Abstract
;
Full Text
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase:
S. Pfeiffer, et al.; Mol. Pharmacol.
53
, 795 (1998)
Abstract
SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells:
R. Morandini, et al.; Cell. Mol. Biol. (Noisy-le-grand)
45
, 1053 (1999)
Abstract
Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta:
A. MacKenzie, et al.; Br. J. Pharmacol.
127
, 1159 (1999)
Abstract
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure:
A.A. Miller, et al.; Br. J. Pharmacol.
131
, 29 (2000)
Abstract
Further Categories Containing This Product:
Antioxidants, Flavonoids & Free Radical Scavengers Other Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
•
Superoxide Dismutases [SODs] / Related Products
ALX-430-041
Revised 17-Sep-08
Protoporphyrin IX (free acid)
SYNONYMS
8,13-Divinyl-3,7,12,17-tetramethyl-21
H
,23
H
-porphine-2,18-dipropionic acid
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
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Product Numbers:
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ALX-430-041-M300
300 mg
50.00 USD
ALX-430-041-G001
1 g
90.00 USD
Product Specification
FORMULA:
C
34
H
34
N
4
O
4
MW:
562.6
CAS NUMBER:
553-12-8
MERCK INDEX:
14:
7897
PURITY:
≥97% (HPLC)
APPEARANCE:
Purple to dark brown solid.
SOLUBILITY:
Soluble in conc. HCl, DMSO (10mg/ml) or 100% ethanol (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
IDENTITY:
Identity determined by NMR.
Product Description
Protoporphyrin IX free acid, as distinct from its zinc salt (which inhibits heme oxygenase), activates soluble guanylyl cyclase (sGC) by binding directly to the enzyme. A useful reagent in cases where the use of nitric oxide (NO) or nitric oxide donors is undesirable.
Product Specific Literature References
H. Verweij & J. Van Steveninck; Photochem. Photobiol.
35
, 265 (1982)
Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme
:
M.S. Wolin, et al.; J. Biol. Chem.
257
, 13312 (1982)
Abstract
;
Full Text
Porphyrins and chlorophylls as probes for fluoroimmunoassays [letter]:
J.L. Hendrix; Clin. Chem.
29
, 1003 (1983)
Abstract
Photodynamic intramolecular crosslinking of myoglobin:
J. van Steveninck and T.M.A.R. Dubbelman; Biochim. Biophys. Acta
791
, 98 (1984)
Further Categories Containing This Product:
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
ALX-430-051
Revised 03-Oct-08
Tin Protoporphyrin IX . dichloride
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
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Product Numbers:
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ALX-430-051-M005
5 mg
45.00 USD
ALX-430-051-M025
25 mg
180.00 USD
Product Specification
FORMULA:
C
34
H
32
N
4
O
4
Sn . 2Cl
MW:
750.3
PURITY:
≥95% (TLC)
APPEARANCE:
Dark red solid.
SOLUBILITY:
Soluble in aqueous base.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
IRRITANT.
Product Description
Potent inhibitor of heme oxygenase.
Product Specific Literature References
Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation:
G.S. Drummond & A. Kappas; PNAS
78
, 6466 (1981)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
ALX-430-050
Revised 13-Jun-03
Zinc(II) Deuteroporphyrin IX-2,4-bisethyleneglycol
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-430-050-M001
1 mg
30.00 USD
ALX-430-050-M005
5 mg
90.00 USD
ALX-430-050-M010
10 mg
150.00 USD
Product Specification
FORMULA:
C
34
H
36
N
4
O
8
Zn
MW:
694.1
PURITY:
≥85%
APPEARANCE:
Dark purple solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Extremely potent inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO).
Product Specific Literature References
Sensitivity of human tissue heme oxygenase to a new synthetic metalloporphyrin:
R.J. Chernick, et al.; Hepatology
10
, 365 (1989)
Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products
ALX-430-049
Revised 25-May-07
Zinc(II) Protoporphyrin IX
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Porphyrins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-430-049-M005
5 mg
20.00 USD
ALX-430-049-M025
25 mg
60.00 USD
ALX-430-049-M100
100 mg
180.00 USD
Product Specification
FORMULA:
C
34
H
32
N
4
O
4
Zn
MW:
626.0
CAS NUMBER:
15442-64-5
PURITY:
≥95% (TLC)
APPEARANCE:
Dark red solid.
SOLUBILITY:
Soluble in pyridine, dimethyl formamide or DMSO. Colloidal in aqueous base; slightly soluble in aqueous base/organic solvent mixtures.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 3 years after receipt when stored at -20°C. Product may be unstable in solution if exposed to light.
HANDLING:
Protect from light and moisture.
Product Description
Potent and selective inhibitor of heme oxygenase, the enzyme that generates carbon monoxide (CO). Inhibits soluble guanylyl cyclase. Produces a time- and concentration-dependent inactivation of all three isoforms of nitric oxide synthase (IC
50
=0.8µM, 4.0µM, and 5.0µM for nNOS (NOS I), iNOS (NOS II) and eNOS (NOS III), respectively). Does not cross the blood-brain barrier.
Product Specific Literature References
Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase:
B. Brune & V. Ullrich; Mol. Pharmacol.
32
, 497 (1987)
Abstract
Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function:
G.S. Marks, et al.; Can. J. Physiol.Pharmacol.
71
, 753 (1993)
Abstract
Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus:
M. Zhuo, et al; Science
260
, 1946 (1993)
Abstract
Preischemic but not postischemic zinc protoporphyrin treatment reduces infarct size and edema accumulation after temporary focal cerebral ischemia in rats:
C. Kadoya, et al.; Stroke
26
, 1035 (1995)
Abstract
;
Full Text
Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase:
L. Ny, et al.; Br. J. Pharmacol.
115
, 186 (1995)
Abstract
Heme oxygenase inhibitor zinc protoporphyrin IX causes an activation of nitric oxide synthase in the rabbit internal anal sphincter:
S. Chakder, et al.; J. Pharmacol. Exp. Ther.
277
, 1376 (1996)
Abstract
Inhibition of nitric oxide synthase isoforms by porphyrins:
D.J. Wolff, et al.; Arch. Biochem. Biophys.
333
, 27 (1996)
Abstract
Pitfalls using metalloporphyrins in carbon monoxide research:
L. Grundemar and L. Ny; TIPS
18
, 193 (1997), (Review)
Abstract
Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock:
S.F. Yet, et al.; J. Biol. Chem.
272
, 4295 (1997)
Abstract
;
Full Text
Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity:
L. Serfass and J.N. Burstyn; Arch. Biochem. Biophys.
359
, 8 (1998)
Abstract
Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX:
S. Rattan, et al.; Am. J. Physiol.
276
, G138 (1999)
Abstract
;
Full Text
Further Categories Containing This Product:
Heme Oxygenase / Related Products
•
Guanylyl Cyclases, Guanosine Phosphate Metabolism / Related Products
•
NOS Inhibitors (NOS Induction & Enzyme Activity)
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