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Lipopolysaccharides [LPS] / Related Products
You are here: Product Lines > Inflammation > Toll-like Receptors [TLRs] / Related Products > TLR Agonists / Related Products > Lipopolysaccharides [LPS] / Related Products
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ALX-581-004 Revised 14-Feb-07
LPS from Salmonella typhimurium - Replaced by Prod. No. ALX-581-011
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PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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not sold in USA
 
 
ALX-581-202 Revised 16-Sep-08
Monophosphoryl Lipid A from Salmonella minnesota R595 (Re) (TLRgrade™) (Ready-to-Use)
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SYNONYMS MPL-A from Salmonella minnesota R595 (Re) (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-202-L001   1 ml 320.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from Salmonella minnesota R595 (Re mutant). Prepared by acid hydrolysis from purified Salmonella minnesota R595 (Re) LPS (isolated by a modification of the PCP extraction method [1,2]), converted to the uniform salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: ≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Activates Toll-like receptor (TLR) 4. Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice. Essentially lacks the endotoxic and pyrogenic activity of lipid A.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep sterile.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Meth. Carbohydr. Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
 
 
ALX-581-203 Revised 16-Sep-08 New product
Monophosphoryl Lipid A from E. coli, Serotype R515 (Re) (TLRgrade™) (Ready-to-Use)
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SYNONYMS MPL-A from E. coli, Serotype R515 (Re) (TLRgrade™) (Ready-to-Use)
PRODUCT LINE Inflammation
PRODUCT CATEGORY Lipopolysaccharides [LPS] / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-581-203-L001   1 ml 395.00 USD Add To Cart
Product Specification
SOURCE/HOST: Isolated from E. coli, Serotype R515 (Re mutant). Prepared by acid hydrolysis from purified E. coli, Serotype R515 (Re) LPS (isolated by a modification of the PCP extraction method [1,2]), converted to the uniform salt form [3] and dissolved in sterile pyrogen-free double distilled water.
CONCENTRATION: 1mg/ml
PURITY: ≥99.9% (regarding protein or DNA contaminants; KDO not detectable)
FORMULATION: Liquid. Sterile, ready-to-use solution in pyrogen-free double distilled water.
ACTIVITY: Activates TLR4 (Toll-like receptor 4). Does not activate TLR2 as determined with splenocytes and macrophages from TLR4 deficient mice. Essentially lacks the endotoxic and pyrogenic activity of lipid A.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Keep sterile.
Product Specific Literature References
[1] A new method for the extraction of R lipopolysaccharides: C. Galanos, et al.; Eur. J. Biochem. 9, 245 (1969) Abstract
[2] Isolation and purification of R-form lipopolysaccharides: C. Galanos & O. Luderitz; Meth. Carbohydr. Chem. 9, 11 (1993)
[3] Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms: C. Galanos & O. Luderitz; Eur. J. Biochem. 54, 603 (1975) Abstract
 
 
ALX-350-227 Revised 28-Apr-08
Myristicin
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Chemopreventive Agents
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ALX-350-227-M100   100 mg 110.00 USD Add To Cart
Product Specification
FORMULA: C11H12O3
MW: 192.2
CAS NUMBER: 607-91-0
MERCK INDEX: 14: 6334
SOURCE/HOST: Isolated from Petroselinium hortense Hoffmann.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless to slightly yellow liquid.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Natural product isolated from parsley oil. Inducer of glutathione S-transferases. Also inhibits chemical carcinogenesis. Induces rat and human cytochrome P450 enzymes. Has very potent hepatoprotective activity. Induces apoptosis.
Product Specific Literature References
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil: G.-Q. Zheng, et al.; J. Agri. Food Chem. 40, 107 (1992)
Inhibition of benzo[a]pyrene-induced tumorigenesis by myristicin, a volatile aroma constituent of parsley leaf oil: G.-Q. Zheng, et al.; Carcinogenesis 13, 1921 (1992) Abstract
Induction of rat hepatic cytochrome P450 enzymes by myristicin: H.G. Jeong & C.H. Yun; BBRC 217, 966 (1995) Abstract
Toxicological evaluation of myristicin: H. Hallstrom & A. Thuvander; Nat. Toxins 5, 186 (1997), Review Abstract
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin: C.H. Yun, et al.; Toxicol. Lett. 137, 143 (2003) Abstract
Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/ d-galactosamine-induced liver injury: T. Morita, et al.; J. Agric. Food Chem. 51, 1560 (2003) Abstract
Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells: B.K. Lee, et al.; Toxicol. Lett. 157, 49 (2005) Abstract
 
 
ALX-505-007 Revised 09-Sep-08
PBS (endotoxin-free)
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PRODUCT LINE Molecular Biology
PRODUCT CATEGORY Buffers / Detergents / Solutions
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ALX-505-007-LD15   1.5 ml 50.00 USD Add To Cart
Product Specification
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
Product Description
Sterile and endotoxin-free PBS for use with TLRgrade™ or endotoxin-free grade reagents. Product has been subjected to multiple rounds of LPS removal by adsorption with activated charcoal [1].

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ODN 1668 (TLRgrade™) (synthetic) (Prod. No. ALX-746-001)    
ODN 1826 (TLRgrade™) (synthetic) (Prod. No. ALX-746-002)      
ODN 1585 (TLRgrade™) (synthetic) (Prod. No. ALX-746-003)     
ODN M362 (TLRgrade™) (synthetic) (Prod. No. ALX-746-004)    
ODN 2216 (TLRgrade™) (synthetic) (Prod. No. ALX-746-005)      
ODN 2006 (TLRgrade™) (synthetic) (Prod. No. ALX-746-006)    
ODN 2395 (TLRgrade™) (synthetic) (Prod. No. ALX-746-020)     
Poly(I:C) . potassium salt (TLRgrade™) (synthetic) (Prod. No. ALX-746-021)
Poly(dA:dT) (endotoxin-free) (synthetic) (Prod. No. ALX-746-022)
Oligo(dA:dT) (endotoxin-free) (synthetic) (Prod. No. ALX-746-023)
AT-ODN-1 (endotoxin-free) (synthetic) (Prod. No. ALX-746-024)
AT-ODN-2 (endotoxin-free) (synthetic) (Prod. No. ALX-746-025)
AT-ODN-3 (endotoxin-free) (synthetic) (Prod. No. ALX-746-026)
ODN 1668 (TLRgrade™) (synthetic) (BULK) (Prod. No. ALX-746-051)
ODN 1826 (TLRgrade™) (synthetic) (BULK) (Prod. No. ALX-746-052)      
ODN 2216 (TLRgrade™) (synthetic) (BULK) (Prod. No. ALX-746-055)      
ODN 2006 (TLRgrade™) (synthetic) (BULK) (Prod. No. ALX-746-056)
ODN 1720 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-200)    
ODN 1982 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-201)     
ODN 2118 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-203)     
ODN M383 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-204)     
ODN 2243 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-205)   
ODN 2137 (TLRgrade™) (synthetic) (Control) (Prod. No. ALX-746-206)
iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse) (Prod. No. ALX-746-250)
iODN (ttaggg)4 (TLRgrade™) (synthetic) (Inhibitory for human) (Prod. No. ALX-746-251)

Product Specific Literature References
The removal of 14C labeled endotoxin by activated charcoal: A.S. Pegues, et al.; Int. J. Artif. Organs 2, 153 (1979) Abstract
Related Products
ALX-746-251   iODN (ttaggg)4 (TLRgrade™) (synthetic) (Inhibitory for human)
ALX-746-250   iODN 2088 (TLRgrade™) (synthetic) (Inhibitory for mouse)
ALX-746-001   ODN 1668 (TLRgrade™) (synthetic)
ALX-746-200   ODN 1720 (TLRgrade™) (synthetic) (Control)
ALX-746-002   ODN 1826 (TLRgrade™) (synthetic)
ALX-746-201   ODN 1982 (TLRgrade™) (synthetic) (Control)
ALX-746-003   ODN 1585 (TLRgrade™) (synthetic)
ALX-746-006   ODN 2006 (TLRgrade™) (synthetic)
ALX-746-203   ODN 2118 (TLRgrade™) (synthetic) (Control)
ALX-746-206   ODN 2137 (TLRgrade™) (synthetic) (Control)
ALX-746-005   ODN 2216 (TLRgrade™) (synthetic)
ALX-746-205   ODN 2243 (TLRgrade™) (synthetic) (Control)
ALX-746-020   ODN 2395 (TLRgrade™) (synthetic)
ALX-746-004   ODN M362 (TLRgrade™) (synthetic)
ALX-746-204   ODN M383 (TLRgrade™) (synthetic) (Control)
ALX-746-021   Polyinosinic-polycytidylic acid . potassium salt (TLRgrade™) (synthetic)
ALX-505-008   ddWater (endotoxin-free)
ALX-746-055   ODN 2216 (TLRgrade™) (synthetic) (BULK)
ALX-746-056   ODN 2006 (TLRgrade™) (synthetic) (BULK)
ALX-746-052   ODN 1826 (TLRgrade™) (synthetic) (BULK)
ALX-746-051   ODN 1668 (TLRgrade™) (synthetic) (BULK)
ALX-746-024   AT-ODN-1 (endotoxin-free) (synthetic)
ALX-746-025   AT-ODN-2 (endotoxin-free) (synthetic)
ALX-746-026   AT-ODN-3 (endotoxin-free) (synthetic)
ALX-746-023   Oligo(deoxyadenosine:deoxythymidine) (endotoxin-free) (synthetic)
ALX-746-022   Poly(deoxyadenosine:deoxythymidine) (endotoxin-free) (synthetic)
Further Categories Containing This Product:
Oligodeoxynucleotides [ODNs]Lipopolysaccharides [LPS] / Related Products
 
 

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