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Natural Products for Cytoskeletal Research
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ALX-350-366 Revised 03-Apr-08
Azaspiracid-1
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SYNONYMS AZA-1
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Other Toxins
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ALX-350-366-C001   1 µg 180.00 USD Add To Cart
Product Specification
FORMULA: C47H71NO12
MW: 842.1
CAS NUMBER: 214899-21-5
SOURCE/HOST: Islolated from marine mussel.
CONCENTRATION:

2μg/ml
PURITY: ≥95%
FORMULATION: Liquid. In methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: VERY TOXIC. MAY BE TERATOGENIC.

Product Description
Activator of JNK (c-Jun-N-terminal kinase). Cellular growth inhibitor and inducer of cytoskeletal alterations. Activator of caspases. Modulator of intracellular cAMP (cyclic adenosine monophosphate) and calcium levels. Inhibitor of cholesterol biosynthesis in human T lymphocyte cells. Potent teratogen to finfish. Cytotoxic to mammalian cells.
Product Specific Literature References
Multiple organ damage caused by a new toxin azaspiracid, isolated from mussels produced in Ireland: E. Ito, et al.; Toxicon 38, 917 (2000) Abstract
Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets: Y. Roman, et al.; Cell. Signal. 14, 703 (2002) Abstract
Teratogenic effects of azaspiracid-1 identified by microinjection of Japanese medaka (Oryzias latipes) embryos: J.R. Coleman, et al.; Toxicon 45, 881 (2005) Abstract
Cytotoxic and cytoskeletal effects of azaspiracid-1 on mammalian cell lines: M.J. Twiner, et al.; Toxicon 45, 891 (2005) Abstract
Azaspiracids modulate intracellular pH levels in human lymphocytes: A. Alfonso, et al.; BBRC 346, 1091 (2006) Abstract
Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies: N. Vilarino, et al.; Chem. Res. Toxicol. 19, 1459 (2006) Abstract
The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1: C. Vale, et al.; Cell Physiol. Biochem. 20, 957 (2007) Abstract
Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study: C. Vale, et al.; J. Med. Chem. 50, 356 (2007) Abstract
Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells: N. Vilarino, et al.; Biochem. Pharmacol. 74, 327 (2007) Abstract
Transcriptional profiling and inhibition of cholesterol biosynthesis in human T lymphocyte cells by the marine toxin azaspiracid: M.J. Twiner, et al.; Genomics 91, 289 (2008) Abstract
Further Categories Containing This Product:
MAPK Pathway Activators • Natural Products for Cytoskeletal Research • Natural Products - Other Signal Transduction Pathway Modulators • Caspases Other Products • cAMP Pathways Other Products • Marine Natural Products
 
 
ALX-351-006 Revised 07-Jan-08
Baccatin III, 10-Deacetyl-
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Antitumor Reagents
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ALX-351-006-M005   5 mg 190.00 USD Add To Cart
ALX-351-006-M025   25 mg 590.00 USD Add To Cart
Product Specification
FORMULA: C29H36O10
MW: 544.6
CAS NUMBER: 32981-86-5
SOURCE/HOST: Isolated from Taxus baccata.
PURITY: ≥95%
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture. Avoid strong oxidizing agents, acids and bases.

Product Description
Intermediate for the preparation of taxol analogs.
Product Specific Literature References
Relationships between the structures of taxol and baccatine III derivatives and their in vitro action on the disassembly of mammalian brain and Physarum amoebal microtubules: H. Lataste, et al.; PNAS 81, 4090 (1984) Abstract
Chemical Studies of 10-Deacetyl Baccatin III. Hemisynthesis of Taxol Derivatives: F. Gueritte-Voegelein, et al.; Tetrahedron Letters 42, 4451 (1986)
A highly efficient, practical approach to natural taxol: J.-N. Denis, et al.; JACS 110, 5917 (1988)
Preclinical evaluation of docetaxel (Taxotere): F. Lavelle, et al.; Semin. Oncol. 22, 3 (1995) Abstract
Further Categories Containing This Product:
Taxol / Related Products • Natural Products for Cytoskeletal Research • Microtubule Modulators
 
 
ALX-350-287 Revised 17-Nov-08
Bistheonellide A
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SYNONYMS Misakinolide A
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-287-C100   100 µg 470.00 USD Add To Cart
Product Specification
FORMULA: C74H128O20
MW: 1337.8
CAS NUMBER: 105304-96-9
SOURCE/HOST: Isolated from the marine sponge Theonella sp.
PURITY: ≥80% (HPLC)
SOLUBILITY: Soluble in methanol.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.

Product Description
Inhibits actin polymerization by forming a 1:2 complex with G-actin.
Product Specific Literature References
Cellular changes of rat embryonic fibroblasts by an actin-polymerization inhibitor, bistheonellide A, from a marine sponge: S. Watabe, et al.; Cell. Struct. Func. 21, 199 (1996) Abstract
Misakinolide A is a marine macrolide that caps but does not sever filamentous actin: D.R. Terry, et al.; J. Biol. Chem. 272, 7841 (1997) Abstract
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. (Tokyo) 123, 571 (1998) Abstract
Use of the F-actin-binding drugs, misakinolide A and swinholide A: M.R. Bubb & I. Spector; Meth. Enzymol. 298, 26 (1998) Abstract
A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide: F. Braet, et al.; PNAS 95, 13635 (1998) Abstract
Effects of Bistheonellide A, an Actin-polymerization Inhibitor, on Chinese Hamster V79 Cells and on IL-8 Production in PMA-stimulated HL-60 Cells: T. Oda, et al.; Mar. Drugs 4, 22 (2006)
Further Categories Containing This Product:
Actin / Related Products • Marine Natural Products
 
 
ALX-350-101 Revised 03-Apr-08
Catharanthine . tartrate
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SYNONYMS 3,4-Didehydroibogamine-18-carboxylic acid methyl ester . tartrate
7-Ethyl-9,10,12,13-tetrahydro-6,9-methano-5H-pyrido[1’,2’:1,2]azepino[4,5-b]indole-6(6aH)-carboxylic acid methyl ester . tartrate
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-101-M100   100 mg 160.00 USD Add To Cart
ALX-350-101-G001   1 g 430.00 USD Add To Cart
Product Specification
FORMULA: C21H24N2O2 . C4H6O6
MW: 336.4 . 150.1
CAS NUMBER: 2648-21-5
MERCK INDEX: 14: 1904
SOURCE/HOST: Isolated from Catharanthus roseus.
PURITY: ≥90%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Keep cool and dry.

Product Description

Starting material for the synthesis of the antitumor drugs vinblastine and vincristine.  It is less active as an inhibitor of tubulin self-assembly into microtubules than the latter two compounds.

Product Specific Literature References
Photochemical one-pot synthesis of vinblastine and vincristine: S. Pennanen & A. Huhtikangas; Photochem. Photobiol. 51, 515 (1990) Abstract
Mechanism of interaction of vinca alkaloids with tubulin: catharanthine and vindoline: V. Prakash & S.N. Timasheff; Biochemistry 30, 873 (1991) Abstract
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Further Categories Containing This Product:
Microtubule Modulators • Natural Products - Antitumor Reagents • Alkaloids
 
 
ALX-430-033 Revised 19-Jul-07
Colcemid
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SYNONYMS Demecolcine
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-430-033-M001   1 mg 30.00 USD Add To Cart
ALX-430-033-M005   5 mg 70.00 USD Add To Cart
Product Specification
FORMULA: C21H25NO5
MW: 371.4
CAS NUMBER: 477-30-5
MERCK INDEX: 14: 2887
SOURCE/HOST: Semisynthetic from colchicine (Prod. No. ALX-380-033).
PURITY: ≥99%
APPEARANCE: Light yellow powder.
SOLUBILITY: Soluble in 100% ethanol, chloroform or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY:

Stock solutions are stable for at least 6 months when stored at -20°C.
HAZARD: MAY BE MUTAGENIC. MAY BE TERATOGENIC. TOXIC.

Product Description
Depolymerizes microtubules and inhibits their formation. Induces apoptosis.
Product Specific Literature References
Laminin-induced process outgrowth from isolated fetal rat C-cells: I. Nishiyama & T. Fujii; Exp. Cell. Res. 198, 214 (1992) Abstract
Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992) Abstract
Cytoskeletal elements regulate the distribution of nerve growth factor receptors in PC12 cells: P.E. Spoerri & F.J. Roisen; J. Neurosci. Res. 31, 494 (1992) Abstract
Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules: M.E. Phillips & A. Taylor; J. Physiol. 456, 591 (1992) Abstract
Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994) Abstract
Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994) Abstract
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995) Abstract
Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle: T. Tsuchida, et al.; Cytometry 31, 295 (1998) Abstract
Protein phosphatase-1 activation and association with the retinoblastoma protein in colcemid-induced apoptosis: F. Puntoni & E. Villa-Moruzzi; BBRC 266, 279 (1999) Abstract
Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol. 46, 79 (2000) Abstract
Spontaneous chromosome loss and colcemid resistance in lymphocytes from patients with myotonic dystrophy type 1: M. Casella, et al.; Cytogenet. Genome Res. 100, 224 (2003) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Microtubule Modulators
 
 
ALX-380-033 Revised 17-Oct-07
Colchicine
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-380-033-G001   1 g 58.00 USD Add To Cart
Product Specification
FORMULA: C22H25NO6
MW: 399.4
CAS NUMBER: 64-86-8
MERCK INDEX: 14: 2471
RTECS: GH0700000
SOURCE/HOST: Isolated from Colchicum autumnale.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in 100% ethanol or water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light and moisture.
HAZARD: VERY TOXIC.

Product Description
Inhibitor of microtubules by specific binding to tubulin. Induces apoptosis.
Product Specific Literature References
A new colchicine binding assay for tubulin: P. Sherline, et al.; Anal. Biochem. 62, 400 (1974) Abstract
Fluorometric assay of tubulin-colchicine complex: T. Arai & T. Okuyama; Anal. Biochem. 69, 443 (1975) Abstract
Kinetics and mechanism of colchicine binding to tubulin: evidence for ligand-induced conformational change: D.L. Garland; Biochemistry 17, 4266 (1978) Abstract
Proposed mechanism for colchicine poisoning of microtubules reassembled in vitro from Strongylocentrotus purpuratus sperm tail outer doublet tubulin: K.W. Farrell & L. Wilson; Biochemistry 19, 3048 (1980) Abstract
Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine: E.D. Salmon, et al.; J. Cell. Biol. 99, 1066 (1984) Abstract
The effects of microtubule disrupting drugs on the differentiation of HL-60 leukemia cells: M.F. Lueng & A.C. Sartorelli; Leuk. Res. 16, 929 (1992) Abstract
Disruption of microtubules inhibits the stimulation of tissue plasminogen activator expression and promotes plasminogen activator inhibitor type 1 expression in human endothelial cells: L. Santell, et al.; Exp. Cell. Res. 201, 358 (1992) Abstract
Colchicine induces apoptosis in cerebellar granule cells: E. Bonfoco, et al.; Exp. Cell. Res. 218, 189 (1995) Abstract
Inhibition of drug-induced apoptosis by survival factors in PC12 cells: L. Lindenboim, et al.; J. Neurochem. 64, 1054 (1995) Abstract
General features of the recognition by tubulin of colchicine and related compounds: Y. Engelborghs; Eur. Biophys. J. 27, 437 (1998) Abstract
Sustained JNK activation induces endothelial apoptosis: studies with colchicine and shear stress: Y.L. Hu, et al.; Am. J. Physiol. 277, H1593 (1999) Abstract
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells: A.M. Gorman, et al.; Eur. J. Neurosci. 11, 1067 (1999) Abstract
Colchicine protects mice from the lethal effect of an agonistic anti- Fas antibody: G. Feng & N. Kaplowitz; J. Clin. Invest. 105, 329 (2000) Abstract
Update on colchicine and its mechanism of action: Y. Molad; Curr. Rheumatol. Rep. 4, 252 (2002) Abstract
Further Categories Containing This Product:
Natural Products - Apoptosis Inducers & Inhibitors • Microtubule Modulators • Natural Products with Antibiotic Activity • Alkaloids
 
 
ALX-350-357 Revised 05-Apr-08
Hurghadolide A
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-357-C010   10 µg 120.00 USD Add To Cart
Product Specification
FORMULA: C76H130O20
MW: 1363.9
SOURCE/HOST: Isolated from marine sponge Theonella swinhoei.
PURITY: ≥98% (HPLC)
APPEARANCE: Colorless oil.
SOLUBILITY: Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.

Product Description

Cytotoxic. Disrupts the actin cytoskeleton. Antifungal.
Product Specific Literature References
Hurghadolide A and swinholide I, potent actin-microfilament disrupters from the Red Sea sponge Theonella swinhoei: D.T. Youssef & S.L. Mooberry; J. Nat. Prod. 69, 154 (2006) Abstract
General Literature References
Marine natural products. XXIII. Three new cytotoxic dimeric macrolides, swinholides B and C and isoswinholide A, congeners of swinholide A, from the Okinawan marine sponge Theonella swinhoei: M. Kobayashi, et al. ; Chem. Pharm. Bull. (Tokyo) 38, 2960 (1990) Abstract
Marine natural products. XXXI. Structure-activity correlation of a potent cytotoxic dimeric macrolide swinholide A, from the Okinawan marine sponge Theonella swinhoei, and its isomers: M. Kobayashi, et al.; Chem. Pharm. Bull. (Tokyo) 42, 19 (1994) Abstract
Swinholide A is a microfilament disrupting marine toxin that stabilizes actin dimers and severs actin filaments: M.R. Bubb, et al.; J. Biol. Chem. 270, 3463 (1995) Abstract; Full Text
Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts: C.A. Bewley, et al.; Experientia 52, 716 (1996) Abstract
Autoregulation of actin synthesis responds to monomeric actin levels: A. Lyubimova, et al.; J. Cell. Biochem. 65, 469 (1997) Abstract
Misakinolide A is a marine macrolide that caps but does not sever filamentous actin: D.R. Terry, et al.; J. Biol. Chem. 272, 7841 (1997) Abstract; Full Text
Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A: S.Y. Saito, et al.; J. Biochem. 123, 571 (1998) Abstract
Structural basis of swinholide A binding to actin: V.A. Klenchin, et al.; Chem. Biol. 12, 187 (2005) Abstract; Full Text
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Further Categories Containing This Product:
Natural Products - Antifungal Agents • Actin / Related Products • Marine Natural Products
 
 
ALX-350-275 Revised 04-Aug-08 New product
Jasplakinolide
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SYNONYMS Jaspamide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Cytoskeletal Research
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ALX-350-275-C050   50 µg 150.00 USD Add To Cart
ALX-350-275-C100   100 µg 250.00 USD Add To Cart
Product Specification
FORMULA: C36H45BrN4O6
MW: 709.7
CAS NUMBER: 102396-24-7
SOURCE/HOST: Isolated from Jaspis splendens.
PURITY: ≥97% (HPLC)
APPEARANCE: Off-white to yellow solid.
SOLUBILITY: Soluble in 100% ethanol, 83% methanol or DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: HARMFUL.
IDENTITY: Identity determined by MS.

Product Description
Cell permeable F-actin probe. Induces actin polymerization. Completely inhibits the binding of phalloidin to F-actin. Antifungal and anti-proliferative agent.
Product Specific Literature References
New class of antifungal agents: jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis species: V.R. Scott, et al.; Antimicrob. Agents Chemother. 32, 1154 (1988) Abstract
In vitro screening of crude extracts and pure metabolites obtained from marine invertebrates for the treatment of breast cancer: J. Stingl, et al.; Cancer Chemother. Pharmacol. 30, 401 (1992) Abstract
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin: M.R. Bubb, et al.; J. Biol. Chem. 269, 14869 (1994) Abstract; Full Text
Growth modulation and differentiation of acute myeloid leukemia cells by jaspamide: I. Fabian, et al.; Exp. Hematol. 23, 583 (1995) Abstract
Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton: A.M. Senderowicz, et al.; J. Natl. Cancer Inst. 87, 46 (1995) Abstract
Jasplakinolide: interaction with radiation and hyperthermia in human prostate carcinoma and Lewis lung carcinoma: H. Takeuchi, et al.; Cancer Chemother. Pharmacol. 42, 491 (1998) Abstract
Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide: L.P. Cramer; Curr. Biol. 9, 1095 (1999) Abstract
Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation: S.C. Posey & B.E. Bierer; J. Biol. Chem. 274, 4259 (1999) Abstract; Full Text
The anti-proliferative agent jasplakinolide rearranges the actin cytoskeleton of plant cells: H. Sawitzky, et al.; Eur. J. Cell Biol. 78, 424 (1999) Abstract
Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observations: M.R. Bubb, et al.;; J. Biol. Chem. 275, 5163 (2000) Abstract; Full Text
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling: J.A. Rosado, et al.; J. Biol. Chem. 275, 7527 (2000) Abstract; Full Text
A simple model for the cooperative stabilisation of actin filaments by phalloidin and jasplakinolide: B. Visegrády, et al.; FEBS Lett. 579, 6 (2005) Abstract
Dynamics of an F-actin aggresome generated by the actin-stabilizing toxin jasplakinolide: F. Lázaro-Diéguez, et al.; J. Cell Sci. 121, 1415 (2008) Abstract
Further Categories Containing This Product:
Actin / Related Products • Marine Natural Products
 
 
ALX-350-130 Revised 07-Apr-08
Latrunculin A
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PRODUCT LINE Natural Products / Antibiotics