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Neurobiology
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ALX-550-009 Revised 24-Nov-04
cis-1,3-homo-ACPD
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SYNONYMS (±)-cis-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-009-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.
Product Description
Equimolar mixture of (1R,3R)-homo-ACPD (Prod. No. ALX-550-010) and (1S,3S)-homo-ACPD (Prod. No. ALX-550-011). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-006 Revised 16-Feb-05
trans-1,3-homo-ACPD
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SYNONYMS (±)-trans-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-006-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.


(1R,3S)-homo-ACPD
Product Description
Equimolar mixture of (1R,3S)-homo-ACPD (Prod. No. ALX-550-008) and (1S,3R)-homo-ACPD (Prod. No. ALX-550-007). Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-010 Revised 16-Feb-05
(1R,3R)-homo-ACPD
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SYNONYMS (1R,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-010-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Protect from light.

Product Description
Active isomer of cis-1,3-homo-ACPD (Prod. No. ALX-550-009) Selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-008 Revised 24-Feb-05
(1R,3S)-homo-ACPD
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SYNONYMS (1R,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-008-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White crystalline powder.
SOLUBILITY: Soluble in diluted sodium hydroxide solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

(1R,3S)-homo-ACPD
Product Description
Inactive isomer of trans-1,3-homo-ACPD (Prod. No. ALX-550-006).
Product Specific Literature References
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-007 Revised 26-Apr-07
(1S,3R)-homo-ACPD
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SYNONYMS (1S,3R)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-007-M005   5 mg 65.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Active isomer of trans-1,2-homo-ACPD (Prod. No. ALX-550-006). Highly selective agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-550-011 Revised 24-Nov-04
(1S,3S)-homo-ACPD
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SYNONYMS (1S,3S)-1-Amino-1-carboxycyclopentane-3-acetic acid
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-011-M005   5 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C8H13NO4
MW: 187.2
PURITY: ≥97%
APPEARANCE: White powder.
SOLUBILITY: Soluble in dilute aqueous base.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.

Product Description
Isomer of cis-1,3-homo-ACPD (Prod. No. ALX-550-009). Partial agonist for group II mGluRs. Has no effect at ionotropic excitatory amino acid receptors.
Product Specific Literature References
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors: H. Bräuner-Osborne, et al.; Eur. J. Pharmacol. 332, 327 (1997) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Excitatory Amino Acids
 
 
ALX-480-066 Revised 22-Oct-08
Adenosine 5'-O-(3-thiotriphosphate) . tetralithium salt
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SYNONYMS ATP-γS . 4Li
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Adenosine Derivatives Other Products
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ALX-480-066-M001   1 mg 25.00 USD Add To Cart
ALX-480-066-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C10H12N5O12P3S . 4Li
MW: 520.2 . 27.8
CAS NUMBER: 93889-89-5
PURITY: ≥90%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions may be stored at -80°C for up to 1 month. Product is not sterile.
HANDLING: Protect from moisture.
HAZARD: IRRITANT.

Product Description
ATP analog that can substitute ATP in various kinase reactions. Substrate and inhibitor of ATP-dependent enzyme systems. The resulting thiophosphorylated proteins are resistant to dephosphorylation by protein phosphatases. Increases the activity of Ca2+-activated K+ channels.
Product Specific Literature References
The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5'-O-(3-thiotriphosphate): S. Chrysogelos, et al.; J. Biol. Chem. 258, 12624 (1983) Abstract; Full Text
Regulation of phosphoinositide breakdown by guanine nucleotides: I. Litosch & J.N. Fain; Life Sci. 39, 187 (1986) Abstract
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation: J. Chen, et al.; Science 257, 1261 (1992) Abstract
Further Categories Containing This Product:
K+ Channel Activators
 
 
ALX-270-022 Revised 09-Jan-08
AEBSF . hydrochloride
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SYNONYMS 4-(2-Aminoethyl)benzenesulfonylfluoride . HCl
Pefabloc®SC
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Proteases Other Products
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ALX-270-022-M050   50 mg 40.00 USD Add To Cart
ALX-270-022-M250   250 mg 145.00 USD Add To Cart
ALX-270-022-G001   1 g 360.00 USD Add To Cart
Product Specification
FORMULA: C8H10FNO2S . HCl
MW: 203.2 . 36.5
CAS NUMBER: 30827-99-7
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from moisture.

Product Description
Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No. ALX-270-184). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.
Product Specific Literature References
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide: B.R. Baker & H.J. Cory; J. Med. Chem. 14, 119 (1971) Abstract
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide: P. Megyeri, et al.; Immunology 86, 629 (1995) Abstract; Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF: M. Citron, et al.; Neuron 17, 171 (1996) Abstract
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor: Y. Nakabo & M.J. Pabst; J. Leukoc. Biol. 60, 328 (1996) Abstract; Full Text
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997) Abstract; Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999) Abstract
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis: R. Buitrago-Rey, et al.; J. Antimicrob. Chemother. 49, 871 (2002) Abstract; Full Text
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes: N. Wijayanti, et al.; J. Biol. Chem. 280, 21820 (2005) Abstract; Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression: T. Hosoi, et al.; Eur. J. Pharmacol. 554, 8 (2007) Abstract
Further Categories Containing This Product:
Heme Oxygenase / Related Products • Cell Stress, Oxidative Stress & Redox Signalling Other Products • MAPK Pathway Activators • Fatty Acid Amide Hydrolase [FAAH] / Related Products
 
 
ALX-630-001 Revised 10-Oct-08
ω-Agatoxin IVA
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-630-001-C100   100 µg 580.00 USD Add To Cart
Product Specification
SEQUENCE: H-Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH
(Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36 and Cys27-Cys34)
FORMULA: C217H360N68O60S10
MW: 5202.3
CAS NUMBER: 145017-83-0
RTECS: AW8050000
SOURCE/HOST: Synthetic. Originally isolated from Agelenopsis aperta.
PURITY: ≥98%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: HARMFUL.
Product Description
Selective P-type Ca2+ channel blocker. Fast acting and potent eurotoxin.
Product Specific Literature References
P-type calcium channels blocked by the spider toxin omega-Aga-IVA: I.M. Mintz, et al.; Nature 355, 827 (1992) Abstract
Calcium channels coupled to glutamate release identified by omega-Aga- IVA: T.J. Turner, et al.; Science 258, 310 (1992) Abstract
Synthesis of omega-agatoxin IVA and its related peptides: H. Nishio, et al.; BBRC 196, 1447 (1993) Abstract
Interactions of polyamines with neuronal ion channels: R.H. Scott, et al.; TINS 16, 153 (1993), (Review) Abstract
Different types of calcium channels mediate central synaptic transmission: T. Takahashi & A. Momiyama; Nature 366, 156 (1993) Abstract
Sequential assignment and structure determination of spider toxin omega- Aga-IVB: H. Yu, et al.; Biochemistry 32, 13123 (1993) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem. 63, 823 (1994) Abstract
Exocytotic Ca2+ channels in mammalian central neurons: K. Dunlap, et al.; TINS 18, 89 (1995), (Review) Abstract
P/Q-type Ca2+ channel blocker omega-agatoxin IVA protects against brain injury after focal ischemia in rats: K. Asakura, et al.; Brain Res. 776, 140 (1997) Abstract
Agatoxin-IVA-sensitive calcium channels mediate the presynaptic and postsynaptic nicotinic activation of cardiac vagal neurons: J. Wang, et al.; J. Neurophysiol. 85, 164 (2001) Abstract
Further Categories Containing This Product:
Ca2+ Channels (P / Q-type)
 
 
ALX-350-315 Revised 03-Apr-08
Agelasine D
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products with Antibiotic Activity
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ALX-350-315-M001   1 mg 185.00 USD Add To Cart
Product Specification
FORMULA: C26H40N5
MW: 422.6
CAS NUMBER: 92664-80-7
SOURCE/HOST: Isolated from the sponge Agelas nakamurai.
PURITY: ≥97% (HPLC)
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
IDENTITY: Identity determined by 1H-NMR, 13C-NMR and MS.

Product Description
Displays broad spectrum of antibacterial activities. Antineoplastic compound. Associated with contractive responses of smooth muscles and inhibition of Na+/K+-ATPase.
Product Specific Literature References
(+)-agelasine D: improved synthesis and evaluation of antibacterial and cytotoxic activities: A. Vik, et al.; J. Nat. Prod. 69, 381 (2006) Abstract
Antimicrobial and cytotoxic activity of agelasine and agelasimine analogs: A. Vik, et al.; Bioorg. Med. Chem. 15, 4016 (2007)