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ALX-106-028 Revised 03-Apr-08
D-Cycloserine
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SYNONYMS R(+)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-028-M050   50 mg 20.00 USD Add To Cart
ALX-106-028-M250   250 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 68-41-7
RTECS: NY2975000
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Partial agonist at the glycine modulatory site of the NMDA receptor.
Further Categories Containing This Product:
Excitatory Amino Acids • Special Amino Acids • NMDA Receptors / Related Products
 
 
ALX-106-037 Revised 09-Oct-07
L-Cycloserine
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SYNONYMS S(-)-4-Amino-3-isoxazolidinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products for Neurological Research
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ALX-106-037-M025   25 mg 50.00 USD Add To Cart
ALX-106-037-M100   100 mg 150.00 USD Add To Cart
Product Specification
FORMULA: C3H6N2O2
MW: 102.1
CAS NUMBER: 339-72-0; 4834-58-6
MERCK INDEX: 14: 2751
RTECS: NY2976000
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Hygroscopic.

Product Description
Excitatory amino acid. Inhibitor of ketosphinganine synthase (serine-palmitoyl-CoA transferase, EC 2.3.1.50), leading to blockade of sphingosine biosynthesis. Partial agonist at the glycine modulatory site of the NMDA receptor.
Product Specific Literature References
Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo: K.S. Sundaram & M. Lev; J. Neurochem. 42, 577 (1984) Abstract
Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine: R.D. Williams, et al.; J. Lipid Res. 28, 1478 (1987) Abstract; Full Text
D-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes: G.B. Watson, et al.; Brain Res. 510, 158 (1990) Abstract
D-cycloserine, a putative cognitive enhancer, facilitates activation of the N-methyl-D-aspartate receptor-ionophore complex in Alzheimer brain: I.P. Chessell, et al.; Brain Res. 565, 345 (1991) Abstract
Rapid kidney changes resulting from glycosphingolipid depletion by treatment with a glucosyltransferase inhibitor: G.S. Shukla, et al.; Biochim. Biophys. Acta 1083, 101 (1991) Abstract
Further Categories Containing This Product:
Special Amino Acids • Excitatory Amino Acids • NMDA Receptors / Related Products
 
 
ALX-162-001 Revised 22-Oct-08
Mastoparan
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-001-M001   1 mg 50.00 USD Add To Cart
ALX-162-001-M005   5 mg 200.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
FORMULA: C70H131N19O15
MW: 1478.9
CAS NUMBER: 72093-21-1
SOURCE/HOST: Synthetic. Originally isolated from wasp venom.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water (1 mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description

Mast cell degranulating peptide. Stimulates glycogenolysis. Stimulates phospholipase D2 (PLD2) activity. Alters G-proteins in brain membranes.
Product Specific Literature References
A new mast cell degranulating peptide "mastoparan" in the venom of Vespula lewisii: Y. Hirai, et al.; Chem. Pharm. Bull. 27, 1942 (1979) Abstract
Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins): T. Higashijima, et al.; J. Biol. Chem. 263, 6491 (1988) Abstract; Full Text
Mastoparan, a peptide toxin from wasp venom, stimulates glycogenolysis mediated by an increase of the cytosolic free Ca2+ concentration but not by an increase of cAMP in rat hepatocytes: M. Tohkin, et al.; FEBS Lett. 260, 179 (1990) Abstract
Interaction of wasp venom mastoparan with biomembranes: T. Katsu, et al.; Biochim. Biophys. Acta 1027, 185 (1990) Abstract
Effects of the wasp venom peptide, mastoparan, on GTP hydrolysis in rat brain membranes: Y. Odagaki, et al.; Br. J. Pharmacol. 121, 1406 (1997) Abstract
Mastoparan selectively activates phospholipase D2 in cell membranes: A. Chahdi, et al.; J. Biol. Chem. 278, 12039 (2003) Abstract
Mastoparan, a G protein agonist peptide, differentially modulates TLR4- and TLR2-mediated signaling in human endothelial cells and murine macrophages: A. Lentschat, et al.; J. Immunol. 174, 4252 (2005) Abstract
Biological applications of the receptor mimetic peptide mastoparan: S. Jones & J. Howl; Curr. Protein Pept. Sci. 7, 501 (2006), Review Abstract
Further Categories Containing This Product:
G-proteins & GTPases Other Products • Peptides
 
 
ALX-162-002 Revised 09-Oct-08
MCD Peptide
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SYNONYMS Mast Cell Degranulating Peptide
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
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ALX-162-002-MC05   0.5 mg 360.00 USD Add To Cart
Product Specification
SEQUENCE: H-Ile-Lys-Cys-Asn-Cys-Lys-Arg-His-Val-Ile-Lys-Pro-His-Ile-Cys-Arg-Lys-Ile-Cys-Gly-Lys-Asn-NH2
(Disulfide bonds between Cys3-Cys15 and Cys5-Cys19)
FORMULA: C110H192N40O24S4
MW: 2587.2
CAS NUMBER: 83856-13-7
SOURCE/HOST: Synthetic. Originally isolated from Apis mellifera.
PURITY: ≥98%
APPEARANCE: Lyophilized.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
Product Description
Potent anti-inflammatory agent and strong mediator of mast cell degranulation and histamine release. Neurotoxin and voltage-dependent K+ channel blocker. Inhibits the ADP-ribosylation of the small GTP-binding proteins rho.
Product Specific Literature References
Bee and wasp venoms: E. Haberman; Science 177, 314 (1972) Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990) Abstract
Mast cell degranulating peptide: a multi-functional neurotoxin: M.R. Ziai, et al.; J. Pharm. Pharmacol. 42, 457 (1990), Review Abstract
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol. 226, 87 (1992) Abstract
Further Categories Containing This Product:
Peptides • K+ Channel Blockers & Inhibitors • Natural Products - Anti-inflammatory Agents
 
 
ALX-162-006 Revised 07-Apr-08
Melittin (natural)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-162-006-M001   1 mg 40.00 USD Add To Cart
ALX-162-006-M005   5 mg 160.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
FORMULA: C131H229N39O31
MW: 2846.5
CAS NUMBER: 37231-28-0
MERCK INDEX: 14: 5824
RTECS: OS3960000
SOURCE/HOST: Isolated from bee venom.
PURITY: ≥85% (HPLC)
APPEARANCE: Off-white to faint tan powder.
PURITY DETAIL: Phospholipase A2 impurity: <5 units per mg solid.
SOLUBILITY: Soluble in PBS (5mg/ml) or water (5mg/ml).
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Very hygroscopic. Protect from light.
HAZARD: HARMFUL.
Product Description
Causes disruption of normal cellular activity and cell lysis. Binds calmodulin in a calcium-dependent manner. Activates phospholipase A2 (PLA2) and inhibits protein kinase C (PKC) by binding to the catalytic domain in a Mg-ATP sensitive manner. Antirheumatic.
Product Specific Literature References
Rapid purification of calmodulin and S-100 protein by affinity chromatography with melittin immobilized to sepharose: R.L. Kincaid & C.C. Coulson; BBRC 133, 256 (1985) Abstract
Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C: J. Baudier, et al.; Biochemistry 26, 2886 (1987) Abstract
Possible mechanisms of action of cobra snake venom cardiotoxins and bee venom melittin: J.E. Fletcher & M.S. Jiang; Toxicon. 31, 669 (1993) Abstract
Melittin and phospholipase A2 from bee (Apis mellifera) venom cause necrosis of murine skeletal muscle in vivo: C.L. Ownby, et al.; Toxicon. 35, 67 (1997) Abstract
Melittin binds to secretory phospholipase A2 and inhibits its enzymatic activity: S.S. Saini, et al.; BBRC 238, 436 (1997) Abstract
Phospholipase A2-independent Ca2+ entry and subsequent apoptosis induced by melittin in human MG63 osteosarcoma cells: S.T. Chu, et al.; Life Sci. 80, 364 (2007) Abstract
Further Categories Containing This Product:
Calmodulin Other Products • PKC Inhibitors • Peptides • PLA2 Activators
 
 
ALX-162-007 Revised 12-May-05
Melittin (synthetic)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Natural Products - Protein Kinase Inhibitors
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ALX-162-007-MC05   0.5 mg 70.00 USD Add To Cart
ALX-162-007-M001   1 mg 120.00 USD Add To Cart
Product Specification
SEQUENCE: H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
FORMULA: C131H229N39O31
MW: 2846.5
CAS NUMBER: 37231-28-0
MERCK INDEX: 14: 5824
SOURCE/HOST: Synthetic.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Protect from light.
HAZARD: TOXIC.
Product Description
For technical information see melittin (natural) (Prod. No. ALX-162-006).
Further Categories Containing This Product:
PLA2 Activators • Calmodulin Other Products • PKC Inhibitors • Peptides
 
 
ALX-167-001 Revised 25-Sep-07
Sarafotoxin S6b
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
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Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-167-001-PC01   0.1 mg* 80.00 USD Add To Cart
ALX-167-001-PC05   0.5 mg* 280.00 USD Add To Cart
ALX-167-001-P001   1 mg* 530.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Ser-Cys-Lys-Asp-Met-Thr-Asp-Lys-Glu-Cys-Leu-Tyr-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH
(Disulfide bonds between Cys1-Cys15 and Cys3-Cys11)
FORMULA: C110H159N27O34S5
MW: 2564.0
CAS NUMBER: 116303-65-2
SOURCE/HOST: Synthetic. Originally isolated from Atractaspis engaddensis.
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
Product Description
Potent vasoconstrictor peptide. Causes hydrolysis of phosphoinositides in atrial and brain membranes.
Product Specific Literature References
Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain: Y. Kloog, et al.; Science 242, 268 (1988) Abstract
Similarity of endothelin to snake venom toxin: Nature 335, 303 (1988) Abstract
Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart: C. Takasaki, et al.; Toxicon 26, 543 (1988) Abstract
Competitive interaction between endothelin and sarafotoxin: Binding and phosphoinositides hydrolysis in rat atria and brain: I. Ambar, et al.; BBRC 158, 195 (1989) Abstract
Functional endothelin/sarafotoxin receptors in the rat uterus: D. Bousso-Mittler, et al.; BBRC 162, 952 (1989) Abstract
Immunological and structural characterization of sarafotoxin/endothelin family of peptides: G. Fleminger, et al.; BBRC 162, 1317 (1989) Abstract
Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels: R. Galron, et al.; BBRC 163, 936 (1989) Abstract
Interaction of synthetic sarafotoxin with rat vascular endothelin receptors: Y. Hirata, et al.; BBRC 162, 441 (1989) Abstract
Synthesis of endothelin-1 analogues, endothelin-3, and sarafotoxin S6b: structure-activity relationships: N. Nakajima, et al.; J. Cardiovasc. Pharmacol. 13, S8 (1989) Abstract
Sarafotoxin S6c is a relatively weak displacer of specifically bound 125I-endothelin: W.G. Nayler, et al.; BBRC 161, 89 (1989) Abstract
Vasoconstrictor effects of sarafotoxins in rabbit aorta: structure- function relationships: Z. Wollberg, et al.; BBRC 162, 371 (1989) Abstract
Comparison of the contractile effects and binding kinetics of endothelin-1 and sarafotoxin S6b in rat isolated renal artery: P.S. Devadason & P.J. Henry; Br. J. Pharmacol. 121, 253 (1997) Abstract
Further Categories Containing This Product:
Peptides • Other Toxins
 
 
ALX-167-002 Revised 25-Sep-07
Sarafotoxin S6c
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PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Endothelins [ETs] & Endothelin Receptors / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-167-002-PC01   0.1 mg* 80.00 USD Add To Cart
ALX-167-002-PC05   0.5 mg* 280.00 USD Add To Cart
ALX-167-002-P001   1 mg* 530.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp-OH
(Disulfide bonds between Cys1-Cys15 and Cys3-Cys11)
FORMULA: C103H147N27O37S5
MW: 2515.8
CAS NUMBER: 121695-87-2
SOURCE/HOST: Synthetic. Originally isolated from Atractaspis engaddensis.
QUANTITY: *Sold as net peptide weight.
PURITY: ≥97%
APPEARANCE: White lyophilized powder.
SOLUBILITY: Soluble in 5% acetic acid.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HAZARD: TOXIC.
Product Description
Potent vasoconstrictor peptide. Causes hydrolysis of phosphoinositides in atrial and brain membranes.
Product Specific Literature References
Sarafotoxins S6: several isotoxins from Atractaspis engaddensis (burrowing asp) venom that affect the heart: C. Takasaki, et al.; Toxicon 26, 543 (1988) Abstract
Sarafotoxin S6c is a relatively weak displacer of specifically bound 125I-endothelin: W.G. Nayler, et al.; Biochem. Biophys. Res. Commun. 161, 89 (1989) Abstract
Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes: D.L. Williams, Jr., et al.; Biochem. Biophys. Res. Commun. 175, 556 (1991) Abstract
Endothelium-dependent modulation of venoconstriction to sarafotoxin S6c in human veins in vivo: F.E. Strachan, et al.; J. Cardiovasc. Pharmacol. 26 Suppl. 3, S180 (1995) Abstract
Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea pig isolated gallbladder: influence of indomethacin: A.M. Cardozo, et al.; Can. J. Physiol. Pharmacol. 80, 458 (2002) Abstract
Further Categories Containing This Product:
Peptides • Other Toxins
 
 
ALX-201-240 Revised 16-Sep-08
Elafin (human) (recombinant)
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SYNONYMS ESI (human) (recombinant)
Elastase-specific Inhibitor (human) (recombinant)
SKALP (human) (recombinant)
Skin-derived Antileukoproteinase (human) (recombinant)
Protease Inhibitor WAP3 (human) (recombinant)
PRODUCT LINE Immunology
PRODUCT CATEGORY Antimicrobial Peptides & Proteins / Related Products
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ALX-201-240-C100   100 µg 275.00 USD Add To Cart
Product Specification
MW: ~5.9kDa
SOURCE/HOST: Produced in yeast.
PURITY: ≥90% (HPLC, SDS-PAGE, MS)
APPEARANCE: White to faint yellow powder.
FORMULATION: Lyophilized.
RECONSTITUTION: Reconstitute in sterile distilled water. Further dilutions should be made in aqueous buffers, pH 4.0-8.0.
BIOLOGICAL ACTIVITY: Inhibits human leukocyte elastase (Ki=0.17nM) and human proteinase 3 (Ki=0.42nM) .
SPECIFIC ACTIVITY: Inhibition of human leukocyte elastase: ≥90%
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
HAZARD: HARMFUL.
Product Description
Belongs to the chelonianin family of protease inhibitors and is involved in the physiological control of neutrophil serine proteinases, where it targets NE and proteinase 3. Shows antiprotease, antibacterial and antiinflammatory activity and primes innate immunity.
Product Specific Literature References
[1] Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence: O. Wiedow, et al.; J. Biol. Chem. 265, 14791 (1990) Abstract; Full Text
[2] Skin-derived antileucoproteases (SKALPs): characterization of two new elastase inhibitors from psoriatic epidermis: J. Schalkwijk, et al.; Br. J. Dermatol. 122, 631 (1990) Abstract
[3] Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor: J.M. Sallenave and A.P. Ryle; Biol. Chem. Hoppe Seyler 372, 13 (1991) Abstract
[4] Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment: Saheki, et al.; Biochem. Biophys. Res. Commun. 185, 240 (1992) Abstract
[5] Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin: Q.L. Ying and S.R. Simon; Biochemistry 32, 1866 (1993) Abstract
[6] SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking: H.O. Molhuizen, et al.; J. Biol. Chem. 268, 12028 (1993) Abstract
[7] Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions: J.M. Sallenave and A. Silva; Am. J. Respir. Cell. Mol. Biol. 8, 439 (1993) Abstract
[8] Kinetics of the inhibition of human leukocyte elastase by elafin, a 6-kilodalton elastase-specific inhibitor from human skin: Q.L. Ying and S.R. Simon; Biochemistry 32, 1866 (1993) Abstract
[9] Elastase inhibitor elafin is a new type of proteinase inhibitor which has a transglutaminase-mediated anchoring sequence termed "cementoin": K. Nara, et al.; J. Biochem. (Tokyo) 115, 441 (1994)